المؤلفون: Dragan Primorac, Jelena Šarac, Dubravka Havaš Auguštin, Natalija Novokmet, Tamer Bego, Ron Pinhasi, Mario Šlaus, Mario Novak, Damir Marjanović

المصدر: Genes, Vol 15, Iss 6, p 748 (2024)

مصطلحات موضوعية: Y chromosome, SEE, Croatia, modern genetic data, ancient genetic data, Genetics, QH426-470

الوصف: Due to its turbulent demographic history, marked by extensive settlement and gene flow from diverse regions of Eurasia, Southeastern Europe (SEE) has consistently served as a genetic crossroads between East and West and a junction for the migrations that reshaped Europe’s population. SEE, including modern Croatian territory, was a crucial passage from the Near East and even more distant regions and human populations in this region, as almost any other European population represents a remarkable genetic mixture. Modern humans have continuously occupied this region since the Upper Paleolithic era, and different (pre)historical events have left a distinctive genetic signature on the historical narrative of this region. Our views of its history have been mostly renewed in the last few decades by extraordinary data obtained from Y-chromosome studies. In recent times, the international research community, bringing together geneticists and archaeologists, has steadily released a growing number of ancient genomes from this region, shedding more light on its complex past population dynamics and shaping the genetic pool in Croatia and this part of Europe.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2073-4425/15/6/748Test; https://doaj.org/toc/2073-4425Test

الوصول الحر: https://doaj.org/article/a3c766d7663b43eabb68f3527b4cd250Test

المؤلفون: Jelena Šarac, Dubravka Havaš Auguštin, Iva Šunić, Mario Lovrić, Natalija Novokmet, Sanja Musić Milanović, Lawrence M. Schell, Saša Missoni

المصدر: Annals of Human Biology, Vol 50, Iss 1, Pp 332-340 (2023)

مصطلحات موضوعية: infant size, infant growth, cribs cohort, maternal lifestyle, breastfeeding, Biology (General), QH301-705.5, Human anatomy, QM1-695, Physiology, QP1-981

الوصف: Background Every third child in Croatia is classed as overweight or obese. Infant growth can represent early warning signs for obesity. Aim To detect early risk factors for obesity by investigating infant size and early growth trajectories and their association with maternal lifestyle and breastfeeding. Subjects and methods Ninety-eight mother–child pairs from the Croatian Islands’ Birth Cohort Study (CRIBS) cohort were included in the study. Data were collected from questionnaires and medical records. Growth data were converted to Z-scores using World Health Organisation (WHO) standards and used as the primary outcome. Results Z-score trajectories in the first year of life were in line with WHO standards. A direct link between infant size and maternal socioeconomic status (SES) or breastfeeding was not detected. However, child weight gain in the first 6 months was associated with maternal body mass index (BMI) before pregnancy (p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/0301-4460Test; https://doaj.org/toc/1464-5033Test

الوصول الحر: https://doaj.org/article/87da10d227014752969c2ef24ccd910eTest

المؤلفون: Dubravka Havaš Auguštin, Jelena Šarac, Maere Reidla, Erika Tamm, Blaženka Grahovac, Miljenko Kapović, Natalija Novokmet, Pavao Rudan, Saša Missoni, Damir Marjanović, Marina Korolija

المصدر: Genes, Vol 14, Iss 8, p 1614 (2023)

مصطلحات موضوعية: rare mitochondrial haplotypes, mitochondrial phylogeny, mitochondrial haplogroup HV2b, N1a, X1-3, Genetics, QH426-470

الوصف: Mitochondrial DNA (mtDNA) has been used for decades as a predominant tool in population genetics and as a valuable addition to forensic genetic research, owing to its unique maternal inheritance pattern that enables the tracing of individuals along the maternal lineage across numerous generations. The dynamic interplay between evolutionary forces, primarily genetic drift, bottlenecks, and the founder effect, can exert significant influence on genetic profiles. Consequently, the Adriatic islands have accumulated a subset of lineages that exhibits remarkable absence or rarity within other European populations. This distinctive genetic composition underscores the islands’ potential as a significant resource in phylogenetic research, with implications reaching beyond regional boundaries to contribute to a global understanding. In the initial attempt to expand the mitochondrial forensic database of the Croatian population with haplotypes from small isolated communities, we sequenced mitogenomes of rare haplogroups from different Croatian island and mainland populations using next-generation sequencing (NGS). In the next step and based on the obtained results, we refined the global phylogeny of haplogroup N1a, HV2, and X by analyzing rare haplotypes, which are absent from the current phylogenetic tree. The trees were based on 16 novel and 52 previously published samples, revealing completely novel branches in the X and HV2 haplogroups and a new European cluster in the ancestral N1a variant, previously believed to be an exclusively African–Asian haplogroup. The research emphasizes the importance of investigating geographically isolated populations and their unique characteristics within a global context.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2073-4425/14/8/1614Test; https://doaj.org/toc/2073-4425Test

الوصول الحر: https://doaj.org/article/2c0f0576e4b54117b47c5ffd117b1c2bTest

المؤلفون: Jelena Šarac, Dubravka Havaš Auguštin, Matea Zajc Petranović, Natalija Novokmet, Luka Bočkor, Lada Stanišić, Emily Petherick, Deni Karelović, Alen Šelović, Rafaela Mrdjen Hodžić, Sanja Musić Milanović, Ellen W. Demerath, Lawrence M. Schell, Noël Cameron, Saša Missoni

المصدر: Annals of Human Biology, Vol 49, Iss 2, Pp 91-99 (2022)

مصطلحات موضوعية: cribs cohort study, pre-pregnancy bmi, gestational weight gain (gwg), biochemical profile lga, mediterranean, eastern adriatic islands, Biology (General), QH301-705.5, Human anatomy, QM1-695, Physiology, QP1-981

الوصف: Background High pre-pregnancy body mass index (BMI) and excessive gestational weight gain (GWG) are significant risk factors for maternal and neonatal health. Aim To assess pre-pregnancy BMI and GWG during pregnancy and their association with different maternal and neonatal characteristics in the transitional Mediterranean population from the Eastern Adriatic islands. Subjects and methods Two hundred and sixty-two mother–child dyads from the CRoatian Islands’ Birth Cohort Study (CRIBS) were included in the study. Chi-square test, ANOVA, and regression analysis were used to test the association between selected characteristics. Results In total, 22% of women entered pregnancy as overweight/obese and 46.6% had excessive GWG. Pre-pregnancy overweight and obesity were significantly associated with elevated triglycerides uric acid levels, and decreased HDL cholesterol in pregnancy. Excessive GWG was associated with elevated fibrinogen and lipoprotein A levels. Women with high pre-pregnancy BMI and GWG values were more likely to give birth to babies that were large for gestational age (LGA), additionally confirmed in the multiple logistic regression model. Conclusion High maternal pre-pregnancy BMI and excessive GWG were both significantly associated with deviated biochemical parameters and neonatal size. More careful monitoring of maternal nutritional status can lead to better pre- and perinatal maternal healthcare.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/0301-4460Test; https://doaj.org/toc/1464-5033Test

الوصول الحر: https://doaj.org/article/f3943ccb495a424590c1ea171fc10f3dTest

المؤلفون: Monica Ubalde-Lopez, Tina Garani-Papadatos, Ghislaine Scelo, Maribel Casas, Claudia Lissåker, Susan Peters, Ellen Aagaard Nohr, Maria Albin, Raquel Lucas, Kyriaki Papantoniou, Kinga Polańska, Cecilia H Ramlau-Hansen, Jelena Šarac, Jenny Selander, Helena Skröder, Elena Vasileiou, Manolis Kogevinas, Ute Bültmann, Ingrid Sivesind Mehlum, Milena Maule

المصدر: Scandinavian Journal of Work, Environment & Health, Vol 47, Iss 7, Pp 550-560 (2021)

مصطلحات موضوعية: parent, life-course, occupational epidemiology, health, birth cohort, well-being, pooled analysis, working life, Public aspects of medicine, RA1-1270

الوصف: OBJECTIVE: Birth cohorts collect valuable and under-utilized information on employment and health of parents before and during pregnancy, at birth, and sometimes after birth. In this discussion paper, we examine how these data could be exploited to study the complex relationships and interactions between parenthood, work, and health among parents themselves. METHODS: Using a web-based database of birth cohorts, we summarize information on maternal employment and health conditions and other potentially related variables in cohorts spread throughout Europe. This provided information on what data are available and could be used in future studies, and what was missing if specific questions are to be addressed, exploiting the opportunity to explore work–health associations across heterogenous geographical and social contexts. RESULTS: We highlight the many potentialities provided by birth cohorts and identify gaps that need to be addressed to adopt a life-course approach and investigate topics specific to the peri-pregnancy period, such as psychosocial aspects. We address the technical difficulties implied by data harmonization and the ethical challenges related to the repurposing of data, and provide scientific, ecological and economic arguments in favor of improving the value of data already available as a result of a serious investment in human and material resources. CONCLUSIONS: There is a hidden treasure in birth cohorts that deserves to be brought out to study the relationships between employment and health among working parents in a time when the boundaries between work and life are being stretched more than ever before.

وصف الملف: electronic resource

العلاقة: https://www.sjweh.fi/show_abstract.php?abstract_id=3980Test; https://doaj.org/toc/0355-3140Test; https://doaj.org/toc/1795-990XTest

الوصول الحر: https://doaj.org/article/e69234652608477eb577cdb83a2be079Test

المؤلفون: Luciana Zaccagni, Barbara Lunghi, Davide Barbieri, Natascia Rinaldo, Sasa Missoni, Tena Šaric, Jelena Šarac, Vesna Babic, Marija Rakovac, Francesco Bernardi, Emanuela Gualdi-Russo

المصدر: Biology of Sport, Vol 36, Iss 1, Pp 17-23 (2018)

مصطلحات موضوعية: sprint performance, personal best, anthropometry, genetic polymorphisms, competitive anxiety, Sports medicine, RC1200-1245, Biology (General), QH301-705.5

الوصف: Elite athletes differ from each other in their characteristics according to their discipline. This study aimed to identify performance predictors in elite Croatian sprinters taking into consideration their anthropometric, psychological and genetic characteristics. One hundred and four elite Croatian sprinters (68 males and 36 females) participated in this study. Of them, 38 are currently competing in the 100-metre dash. The others are former sprinters. The participants underwent direct anthropometric assessment. Participants were also tested by means of the Competitive State Anxiety Inventory-2 and for ACE and ACTN3 polymorphisms. Multiple linear regression analysis was applied to identify the best model for performance prediction. Different models were developed for males and females. Anthropometric traits accounted for 44% of the variance in performance for males, 62% for females. Once other traits (psychological for females) were entered into the model, no additional contribution to the variance was observed. The most significant predictors of higher running velocity were bicristal diameter and foot dimensions in males, and leg length and clean one-repetition maximum in females. The findings suggest that performance in sprinters is associated with anthropometric characteristics, with biomechanical implications that may be used to provide a more complete evaluation of sprinters’ performance.

وصف الملف: electronic resource

العلاقة: https://www.termedia.pl/Performance-prediction-models-based-on-anthropometric-r-ngenetic-and-psychological-traits-of-Croatian-sprinters,78,33945,1,1.htmlTest; https://doaj.org/toc/0860-021XTest; https://doaj.org/toc/2083-1862Test

الوصول الحر: https://doaj.org/article/a0d01e842a2a46ceb7889df6b0c6c2f7Test

المؤلفون: Jelena Šarac, Dubravka Havaš Auguštin, Mario Lovrić, Sarah Stryeck, Iva Šunić, Natalija Novokmet, Saša Missoni

المصدر: Nutrients, Vol 13, Iss 12, p 4564 (2021)

مصطلحات موضوعية: Mediterranean diet, MDSS score, Croatia, Eastern Adriatic islands, westernization, CRIBS cohort, Nutrition. Foods and food supply, TX341-641

الوصف: Previous studies have confirmed the beneficial effect of a Mediterranean diet in mitigating health issues related to cardiovascular disease, diabetes and obesity. However, rapid changes in the traditional way of life and the “westernization” of the diet in Mediterranean populations, especially in younger generations, has led to progressive abandonment of healthy dietary patterns. In order to investigate the generation shift in dietary patterns and lifestyle habits in the Mediterranean part of Croatia, we compared two cohorts of 610 women (266 pregnant and 344 non-pregnant) from the same region, but from different age groups. The MDSS score was derived from food frequency questionnaires. The results showed that the young, reproductively active generation (pregnant women) in Dalmatia, Croatia, although having a higher education and socioeconomic status, exhibits a more adverse eating behaviour (lower adherence to the Mediterranean diet) and lifestyle (excessive smoking in pregnancy) than the older population from the same region. Lower MDSS scores across aggregated age groups in both cohorts showed significant association with higher blood lipid levels and higher smoking frequency. In conclusion, Mediterranean diet adherence is associated with biological markers (age, lipid profile) and lifestyle (smoking) in our study, with a more adverse trend observed in the younger generation.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6643/13/12/4564Test; https://doaj.org/toc/2072-6643Test

الوصول الحر: https://doaj.org/article/49e5352210fb4611842a7b8e36f5cbfeTest

المؤلفون: Jelena Šarac, Dubravka Havaš Auguštin, Ene Metspalu, Natalija Novokmet, Saša Missoni, Pavao Rudan

المصدر: Genetics & Applications, Vol 1, Iss 2, Pp 14-22 (2018)

مصطلحات موضوعية: Genetics, QH426-470

الوصف: Significant mtDNA variation in Southeastern Europe (SEE) reflects the turbulent and complex demographic history of the region, influenced by gene flow from various parts of Eurasia and a long history of intermixing. In this study we present the maternal genetic profile of the Serbian and Montenegrin populations based on the high resolution analysis of 258 mtDNAs, 119 samples from Serbia and 139 samples from Montenegro. Besides the evidence of minor gene flow from distant central/northeastern Asia, the majority of haplogroups place these populations in the broader genetic landscape of Southeastern Europe, close to their neighbors.

وصف الملف: electronic resource

العلاقة: http://www.genapp.ba/index.php/genapp/article/view/17Test; https://doaj.org/toc/2566-2937Test; https://doaj.org/toc/2566-431XTest

الوصول الحر: https://doaj.org/article/388698360de64dcc836ea84a10f8e509Test

المؤلفون: Dubravka Havaš Auguštin, Jelena Šarac, Mario Lovrić, Jelena Živković, Olga Malev, Nives Fuchs, Natalija Novokmet, Mirjana Turkalj, Saša Missoni

المصدر: Nutrients, Vol 12, Iss 8, p 2179 (2020)

مصطلحات موضوعية: Mediterranean diet, Dalmatian islands, pregnancy, CRIBS cohort, socioeconomic factors, lifestyle, Nutrition. Foods and food supply, TX341-641

الوصف: Maternal nutrition and lifestyle in pregnancy are important modifiable factors for both maternal and offspring’s health. Although the Mediterranean diet has beneficial effects on health, recent studies have shown low adherence in Europe. This study aimed to assess the Mediterranean diet adherence in 266 pregnant women from Dalmatia, Croatia and to investigate their lifestyle habits and regional differences. Adherence to the Mediterranean diet was assessed through two Mediterranean diet scores. Differences in maternal characteristics (diet, education, income, parity, smoking, pre-pregnancy body mass index (BMI), physical activity, contraception) with regards to location and dietary habits were analyzed using the non-parametric Mann–Whitney U test. The machine learning approach was used to reveal other potential non-linear relationships. The results showed that adherence to the Mediterranean diet was low to moderate among the pregnant women in this study, with no significant mainland–island differences. The highest adherence was observed among wealthier women with generally healthier lifestyle choices. The most significant mainland–island differences were observed for lifestyle and socioeconomic factors (income, education, physical activity). The machine learning approach confirmed the findings of the conventional statistical method. We can conclude that adverse socioeconomic and lifestyle conditions were more pronounced in the island population, which, together with the observed non-Mediterranean dietary pattern, calls for more effective intervention strategies.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6643/12/8/2179Test; https://doaj.org/toc/2072-6643Test

الوصول الحر: https://doaj.org/article/0ae3910f667048f1ab35b86d340bdf20Test

المؤلفون: Jelena Šarac, Dubravka Havaš Auguštin, Ene Metspalu, Natalija Novokmet, Saša Missoni, Pavao Rudan

المصدر: Genetics & Applications, Vol 1, Iss 2 (2017)

مصطلحات موضوعية: mtDNA, Serbia, Montenegro, Southeastern Europe, haplogroup, Genetics, QH426-470

الوصف: Significant mtDNA variation in Southeastern Europe (SEE) reflects the turbulent and complex demographic history of the region, influenced by gene flow from various parts of Eurasia and a long history of intermixing. In this study we present the maternal genetic profile of the Serbian and Montenegrin populations based on the high resolution analysis of 258 mtDNAs, 119 samples from Serbia and 139 samples from Montenegro. Besides the evidence of minor gene flow from distant central/northeastern Asia, the majority of haplogroups place these populations in the broader genetic landscape of Southeastern Europe, close to their neighbors.

وصف الملف: electronic resource

العلاقة: https://genapp.ba/editions/index.php/journal/article/view/42Test; https://doaj.org/toc/2566-2937Test; https://doaj.org/toc/2566-431XTest

الوصول الحر: https://doaj.org/article/c24e76f1b72c4fd1b1b3960d28f475aaTest