المؤلفون: Sanjana Tewari, Shalini Sahani, Neetu Yaduvanshi, Ritu Painuli, Nalini Sankararamakrishnan, Jaya Dwivedi, Swapnil Sharma, Sung Soo Han

المصدر: Discover Nano, Vol 19, Iss 1, Pp 1-15 (2024)

مصطلحات موضوعية: Persimmon leaves extract, Silver nanoparticles, Mercuric ion, Colorimetric detection, Fluorescence imaging, Antibacterial activity, Materials of engineering and construction. Mechanics of materials, TA401-492

الوصف: Abstract The present research aimed at green synthesis of Ag nanoparticles (AgNPs) based colorimetric sensor using persimmon leaf extract (PLE) for selective detection of mercuric ion (Hg2+). Optimization of reaction conditions viz. pH, concentration of PLE, time was done and further AgNPs were characterized using UV, IR, FE-SEM, EDX, XRD and TEM analysis. The developed AgNPs were evaluated for the selective colorimetric detection of Hg2+ in aqueous medium and fluorescence imaging of Hg2+ ions in liver cell lines. Later, the antibacterial activity of AgNPs was performed against S. aureus and E. coli. The findings of the study revealed that PLE mediated AgNPs exhibited notable limit of detection up to 0.1 ppb, high efficiency, and stability. The antibacterial study indicated that developed AgNPs has impressive bacterial inhibiting properties against the tested bacterial strains. In conclusion, developed biogenic AgNPs has high selectivity and notable sensitivity towards Hg2+ ions and may be used as key tool water remediation. Graphical abstract

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2731-9229Test

الوصول الحر: https://doaj.org/article/654b9e57744544238752042fac3b9d32Test

المؤلفون: Anjali Yadav, Sapna Raghav, Nirmala Kumari Jangid, Anamika Srivastava, Sapana Jadoun, Manish Srivastava, Jaya Dwivedi

المصدر: Polymers, Vol 15, Iss 21, p 4339 (2023)

مصطلحات موضوعية: adsorption, cadmium removal, chitosan, MNPs, wastewater treatment, Organic chemistry, QD241-441

الوصف: Heavy metal contamination in water resources is a major issue worldwide. Metals released into the environment endanger human health, owing to their persistence and absorption into the food chain. Cadmium is a highly toxic heavy metal, which causes severe health hazards in human beings as well as in animals. To overcome the issue, current research focused on cadmium ion removal from the polluted water by using porous magnetic chitosan composite produced from Kaphal (Myrica esculenta) leaves. The synthesized composite was characterized by BET, XRD, FT-IR, FE-SEM with EDX, and VSM to understand the structural, textural, surface functional, morphological-compositional, and magnetic properties, respectively, that contributed to the adsorption of Cd. The maximum Cd adsorption capacities observed for the Fe3O4 nanoparticles (MNPs) and porous magnetic chitosan (MCS) composite were 290 mg/g and 426 mg/g, respectively. Both the adsorption processes followed second-order kinetics. Batch adsorption studies were carried out to understand the optimum conditions for the fast adsorption process. Both the adsorbents could be regenerated for up to seven cycles without appreciable loss in adsorption capacity. The porous magnetic chitosan composite showed improved adsorption compared to MNPs. The mechanism for cadmium ion adsorption by MNPs and MCS has been postulated. Magnetic-modified chitosan-based composites that exhibit high adsorption efficiency, regeneration, and easy separation from a solution have broad development prospects in various industrial sewage and wastewater treatment fields.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2073-4360/15/21/4339Test; https://doaj.org/toc/2073-4360Test

الوصول الحر: https://doaj.org/article/9d995e605ce04910bef59428fee04332Test

المؤلفون: Anjali Banger, Sakshi Gautam, Sapana Jadoun, Nirmala Kumari Jangid, Anamika Srivastava, Indra Neel Pulidindi, Jaya Dwivedi, Manish Srivastava

المصدر: Catalysts, Vol 13, Iss 5, p 858 (2023)

مصطلحات موضوعية: carbon nanodots, synthesis, applications, surface functionality, biocompatibility, low toxicity, Chemical technology, TP1-1185, Chemistry, QD1-999

الوصف: In the recent decade, carbon dots have drawn immense attention and prompted intense investigation. The latest form of nanocarbon, the carbon nanodot, is attracting intensive research efforts, similar to its earlier analogues, namely, fullerene, carbon nanotube, and graphene. One outstanding feature that distinguishes carbon nanodots from other known forms of carbon materials is its water solubility owing to extensive surface functionalization (the presence of polar surface functional groups). These carbonaceous quantum dots, or carbon nanodots, have several advantages over traditional semiconductor-based quantum dots. They possess outstanding photoluminescence, fluorescence, biocompatibility, biosensing and bioimaging, photostability, feedstock sustainability, extensive surface functionalization and bio-conjugation, excellent colloidal stability, eco-friendly synthesis (from organic matter such as glucose, coffee, tea, and grass to biomass waste-derived sources), low toxicity, and cost-effectiveness. Recent advances in the synthesis and characterization of carbon dots have been received and new insight is provided. Presently known applications of carbon dots in the fields of bioimaging, drug delivery, sensing, and diagnosis were highlighted and future applications of these astounding materials are speculated.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2073-4344/13/5/858Test; https://doaj.org/toc/2073-4344Test

الوصول الحر: https://doaj.org/article/770305a2bc8c475a8e6d3df54b40b321Test

المؤلفون: Apoorva Misra, Dharma Kishore, Ved Prakash Verma, Sunil Dubey, Subhash Chander, Neha Gupta, Sameer Bhagyawant, Jaya Dwivedi, Zeid A. Alothman, Saikh Mohammad Wabaidur, Swapnil Sharma

المصدر: Journal of King Saud University: Science, Vol 32, Iss 2, Pp 1486-1495 (2020)

مصطلحات موضوعية: Science (General), Q1-390

الوصف: A new series of Pyrimidine (A, D and F) and quinazoline (B, C and E) analogues of 1,5-benzodiazepines were prepared via its nitrile-derived amidoximes in and nitrilium ions, respectively using one pot Domino reaction with DMAD in presence of DABCO catalyst and benzanilide in presence of Tf2O and 2-chloropyridine. The prepared molecules were examined for their biological property namely apoptotic and antiproliferative effects through cell cycle arrest using breast cancer cell line of human (MCF-7). Receptor-ligand interactions were studied on human epidermal evolution factor receptor (HER-2) with the help of molecular docking using Autodock 4.2.6 molecular modeling software. All the compounds demonstrated inhibitory effects on cell proliferation in a concentration dependent fashion (20–100 μg/mL). Notably, compound C exhibited highest inhibitory activity and caused inhibition of S and G2 phase in cell cycle arrest via caspase dependent apoptotic pathway in MCF-7 cells lines. Keywords: Pyrimidine, Quinazoline, 1,5-Benzodiazepines, Domino reaction, Anticancer agent

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1018364719318579Test; https://doaj.org/toc/1018-3647Test

الوصول الحر: https://doaj.org/article/efa9d90479b646f7b7664dbe43b744bfTest

المؤلفون: Kanika Verma, Malvika Pant, Sarvesh Paliwal, Jaya Dwivedi, Swapnil Sharma

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: angiotensin II, stem cell, biomarkers, hypertrophic markers, cardiac gene regulation, signaling, Therapeutics. Pharmacology, RM1-950

الوصف: The multifaceted nature of the renin-angiotensin system (RAS) makes it versatile due to its involvement in pathogenesis of the cardiovascular disease. Angiotensin II (Ang II), a multifaceted member of RAS family is known to have various potential effects. The knowledge of this peptide has immensely ameliorated after meticulous research for decades. Several studies have evidenced angiotensin I receptor (AT1 R) to mediate the majority Ang II-regulated functions in the system. Functional crosstalk between AT1 R mediated signal transduction cascades and other signaling pathways has been recognized. The review will provide an up-to-date information and recent discoveries involved in Ang II receptor signal transduction and their functional significance in the cardiovascular system for potential translation in therapeutics. Moreover, the review also focuses on the role of stem cell-based therapies in the cardiovascular system.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2021.734917/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/c72ba9b1912e4eed8883eca5b4a09bb4Test

المؤلفون: Shiva Kumar Gudlawar, Nageswara Rao Pilli, Sridhar Siddiraju, Jaya Dwivedi

المصدر: Journal of Pharmaceutical Analysis, Vol 7, Iss 3, Pp 196-202 (2017)

مصطلحات موضوعية: Desmopressin, Solid-phase extraction (SPE), Ultra performance liquid chromatography–tandem mass spectrometry, Method validation, Pharmacokinetics, Therapeutics. Pharmacology, RM1-950

الوصف: An analytical method based on ultra-performance liquid chromatography with positive ion electrospray ionization (ESI) coupled with tandem mass spectrometry detection (UPLC–MS/MS) was developed and validated for the determination of therapeutic peptide desmopressin in human plasma. A desmopressin stable labeled isotope (desmopressin d8) was used as an internal standard. Analyte and the internal standard were extracted from 200 µL of human plasma via solid-phase extraction technique using Oasis WCX cartridges. The chromatographic separation was achieved on an Aquity UPLC HSS T3 column by using a gradient mixture of methanol and 1 mM ammonium formate buffer as the mobile phase. The calibration curve obtained was linear (r2≥0.99) over the concentration range of 1.01–200 pg/mL. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. The results of the intra- and inter-day precision and accuracy studies were well within the acceptable limits. The proposed method was successfully applied to pharmacokinetic studies in humans.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2095177913001329Test; https://doaj.org/toc/2095-1779Test

الوصول الحر: https://doaj.org/article/baa65d3e10514aac830d24a2a2dda04bTest

المؤلفون: Swapnil Sharma, Vivek Dave, Sarvesh Paliwal, Jaya Dwivedi, Sonika Jain

المصدر: Ancient Science of Life, Vol 34, Iss 2, Pp 103-108 (2014)

مصطلحات موضوعية: Citrullus lanatus, gastroprotective, indomethacin-induced ulcer, pyloric ligation, Medicine

الوصف: Aim: This study was carried out to evaluate the gastroprotective potential of the aqueous fruit pulp concentrate of Citrullus lanatus citroides (CLC) on pyloric ligation and indomethacin-induced ulcer in Wistar albino rats. Materials and methods: In indomethacin-induced ulcer model, CLC was administered in the doses of 250 mg/kg, 500 mg/kg and 1000 mg/kg body weight orally, tds for 5 days. The antiulcer activity was determined via observing reduction in ulcer index whereas in the pyloric ligation model, the gastroprotective effect of CLC was assessed from the alteration in volume of gastric juice, pH, free and total acidity, protein concentration in gastric juice. Further lipid peroxide (LPO), and activities of enzymic antioxidants such as superoxide dismutase (SOD) and catalase (CAT) was also determined along with the levels of hexose, hexosamine, sialic acid, fucose in gastric mucosa. Results: In both models, treatment with CLC caused a significant reduction in lesion index when compared to vehicle treated group, providing evidence for antiulcer capacity. In pyloric ligation model, pretreatment with CLC resulted in significant increase in pH, enzymic antioxidants, that is, SOD, CAT, with a significant decrease in volume of gastric juice, free and total acidity, protein concentration, acid output, and LPO levels respectively. The presence of the flavonoids and polyphenols may be responsible for the gastroprotective effect of CLC. Conclusions: The aqueous fruit pulp concentrate of CLC showed significant gastroprotective potential against pyloric ligation and indomethacin-induced ulceration in rats.

وصف الملف: electronic resource

العلاقة: http://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2014;volume=34;issue=2;spage=103;epage=108;aulast=SharmaTest; https://doaj.org/toc/0257-7941Test

الوصول الحر: https://doaj.org/article/43317e5a119f42a4a10feab4a958f7a3Test

المؤلفون: Jaya Dwivedi, Kavita Devi, Yumna Asmat, Sonika Jain, Swapnil Sharma

المصدر: Journal of Saudi Chemical Society, Vol 20, Iss S1, Pp S16-S20 (2016)

مصطلحات موضوعية: Synthesis, 4-7-Dichloroquinoline, 1-3-Diaminopropane, Thiazolidinone, Antimicrobial activity and antiepileptic study, Chemistry, QD1-999

الوصف: In the quest of finding new drug leads with potential antibacterial and antiepileptic activities, synthesis of thiazolidinone derivatives 6(a–c) is reported which are obtained from 5-(4-chlorobenzylidine)-3-[4-(7-chloroquinoline-4-ylamino]propyl)-2-imino-thiazolidin-4-one derivatives by applying appropriate synthetic route. These compounds 6(a–c) were evaluated for antibacterial and antiepileptic activities. Compound 6a having good lipophilicity is found to be most active.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1319610312001305Test; https://doaj.org/toc/1319-6103Test

الوصول الحر: https://doaj.org/article/e77fdb04813a461e93442f4fdcad1445Test

المؤلفون: Navneet Goel, Sunil Kumar Sirohi, Jaya Dwivedi

المصدر: Journal of Advanced Veterinary Research, Vol 2, Iss 2, Pp 120-126 (2012)

مصطلحات موضوعية: Veterinary medicine, SF600-1100

الوصف: The present experiment was carried out to estimate the total saponins and evaluate their effect on methanogenesis and rumen fermentation by in vitro gas production techniques. Three plant material, rough chaff tree seed (Achyranthus aspara, T1), gokhru seed (Tribulus terrestris, T2) and Siris seed (Albizia lebbeck, T3) were selected for present study. The total saponins content in T1, T2 and T3 were 45.75, 25.65 and 48.26% (w/w), respectively. Three levels of each saponins (3, 6 and 9% on DM basis) and wheat straw based (50R:50C) medium fiber diet (200±10 mg) were used for the evaluation of their effect on methanogenesis and rumen fermentation pattern. Results showed the maximum methane reduction (49.66% in term of mM/gDDM) and acetate propionate ration (35.08%) were found in T1 at 6 and 3% levels. Result show that propionate production (mM/ml) was increased; protozoa population decreased (75%) significantly on addition with T3 at 6% level. No significant variation was found in dry matter digestibility in all cases. The present results demonstrate that total saponins extracted from different herbal plants are a promising rumen modifying agent. They have the potential to modulate the methane production, dry matter digestibility and microbial biomass synthesis.

وصف الملف: electronic resource

العلاقة: http://advetresearch.com/index.php/AVR/article/view/168Test; https://doaj.org/toc/2090-6269Test; https://doaj.org/toc/2090-6277Test

الوصول الحر: https://doaj.org/article/6faeacf492af400c8c0d7e080f0cbecfTest

المؤلفون: Kavita Devi, Yumna Asmat, Sonika Jain, Swapnil Sharma, Jaya Dwivedi

المصدر: Journal of Chemistry, Vol 2013 (2013)

مصطلحات موضوعية: Chemistry, QD1-999

الوصف: Oxazolidinone, either mononuclear or condensed with other heterocyclics, has established its importance in medicinal chemistry. A variety of biological activities have been reported by oxazolidinone derivatives. The present work describes the synthesis of several oxazolidinone derivatives, 3-(2-(7-chloroquinoline-4-ylamino)ethyl)-2-imino-5-(4-chloro/nitro/methoxy benzylidene)oxazolidin-4-one 4(a–c) and 4-(2-(7-chloroquinolin-4-ylamino)ethyl)-2(4-chloro/nitro/methoxy-benzylidene)-1,6-diox-4,9-di-azaspiro[4,4]nonane-3,8-dione 5(a–c). Synthesized compounds (1, 3, 4a, 5a, and 5c) were screened against bacterial strains such as S. aureus (MTCC 96) and E. coli (MTCC119) and fungal strains A. niger (MTCC 1344) and C. albicans (MTCC 871) compared with penicillin for bacteria and fluconazole for fungi as reference drugs by disk diffusion method. All synthesized compounds were identified by the means of IR, NMR, and MS.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2090-9063Test; https://doaj.org/toc/2090-9071Test

الوصول الحر: https://doaj.org/article/744f499868d543db8af39001619e4de6Test