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المؤلفون: A. Becker, Jay P. Powers, L. Jin, D. Swinarski, K. Zhang, S. Young, Matthew J. Walters, A. Chen, Jenna L. Jeffrey, F. Yin, J. Tan, Ulrike Schindler, Jaroslaw Kalisiak, Kenneth V. Lawson
المصدر: European Journal of Cancer. 92:S14
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Chemistry, Immune checkpoint inhibitors, Adenosine, Small molecule, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Immune effector cell, medicine, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6dd715f9c2de9baef95f5ee759f0d620Test
https://doi.org/10.1016/j.ejca.2018.01.036Test -
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المؤلفون: Jinsong Liu, Daqing Sun, Tracy Bostick, Randall W. Hungate, Dustin McMinn, Xiao He, Michael DeGraffenreid, Lisa Julian, Juan C. Jaen, Mario Monshouwer, Qiuping Ye, Athena Sudom, Rebekah Choi, Yongmei Di, Yosup Rew, Zhulun Wang, Stefania Ursu, Xuelei Yan, Hua Tu, Seb Caille, Nigel Walker, Jay P. Powers
المصدر: Journal of Medicinal Chemistry. 51:3953-3960
مصطلحات موضوعية: Models, Molecular, Administration, Oral, Dehydrogenase, Crystallography, X-Ray, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Benzamide, chemistry.chemical_classification, Molecular Structure, biology, In vitro, Rats, Macaca fascicularis, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Benzamides, Models, Animal, biology.protein, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6649ad04f55e4735a38d9578744fec1fTest
https://doi.org/10.1021/jm800310gTest -
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المؤلفون: Qiuping Ye, Daqing Sun, Jay P. Powers, Liang Tang, Craig Tomooka, Stefania Ursu, Hua Tu, Yongmei Di, Athena Sudom, Xuelei Yan, Juan C. Jaen, Shichang Miao, Nigel Walker, Ji Ma, Zhulun Wang, Marc Labelle
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3513-3516
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Nitro compound, Pharmaceutical Science, Dehydrogenase, Crystallography, X-Ray, Biochemistry, Isozyme, Chemical synthesis, Piperazines, Small Molecule Libraries, Mice, Structure-Activity Relationship, Oxidoreductase, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Animals, Humans, Sulfhydryl Compounds, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Chemistry, Organic Chemistry, Stereoisomerism, Molecular Weight, Enzyme, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feda87be89ed15aa5be09784f6a201c2Test
https://doi.org/10.1016/j.bmcl.2008.05.025Test -
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المؤلفون: Felix Gonzalez-Lopez de Turiso, Daqing Sun, Yosup Rew, Sarah Bennett, Michael DeGraffenreid, Lisa Julian, Randall W. Hungate, Xuelei Yan, Sebastien Caille, Jay P. Powers, Jacob Kaizerman, Dustin McMinn
المصدر: The Journal of Organic Chemistry. 72:7455-7458
مصطلحات موضوعية: Cyclohexane, Nitrile, Cyclohexanones, Organic Chemistry, Esters, Condensation reaction, Chemical synthesis, Dieckmann condensation, chemistry.chemical_compound, chemistry, Cascade reaction, Michael reaction, Organic chemistry, Methyl acrylate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e46df816992780e17801d24874b04bTest
https://doi.org/10.1021/jo071202hTest -
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المؤلفون: H. DiMaio, Xi Chen, Jay P. Powers, Lingming Liang, Matt Wright, C. Stein, M.G. Peterson, J. Adrian, V. Mayorga, F. Spector, D. Xu, Timothy D. Cushing, Juan C. Jaen, Shichang Miao, Qiuping Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2188-2192
مصطلحات موضوعية: DNA Replication, Ganciclovir, Human cytomegalovirus, Drug-Related Side Effects and Adverse Reactions, viruses, Clinical Biochemistry, Administration, Oral, Biological Availability, Cytomegalovirus, Pharmaceutical Science, DNA Primase, Antiviral Agents, Biochemistry, Virus, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Cytotoxicity, Molecular Biology, Organic Chemistry, virus diseases, Viral Load, medicine.disease, Virology, In vitro, Rats, Pyrimidines, chemistry, Molecular Medicine, Primase, DNA, medicine.drug, Cidofovir
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162f4c78a289c611f72251a3cfad2530Test
https://doi.org/10.1016/j.bmcl.2007.01.109Test -
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المؤلفون: Zhaodan Cao, Zhulun Wang, Xiong Gao, Shichang Miao, Nigel Walker, Daqing Sun, Jingqian Liu, Xuelei Yan, Juan C. Jaen, Jay P. Powers, Sheree Johnstone, Matt Wright, Sarah E. Lively, Craig Tomooka, Athena Sudom, Qiuping Ye
المصدر: Bioorganicmedicinal chemistry letters. 25(23)
مصطلحات موضوعية: Benzimidazole, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Plasma protein binding, Interleukin-1 receptor, Biochemistry, Enzyme activator, chemistry.chemical_compound, Structure-Activity Relationship, Interleukin-1 Receptor-Associated Kinases, Drug Discovery, Structure–activity relationship, Animals, Molecular Biology, Protein Kinase Inhibitors, Molecular Structure, Kinase, Drug discovery, Organic Chemistry, Rats, Enzyme Activation, chemistry, Molecular Medicine, Benzimidazoles, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd44dcd29b0a637c7841b3cba44835baTest
https://pubmed.ncbi.nlm.nih.gov/26526214Test -
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المؤلفون: Jinsong Liu, Holger Wesche, Shyun Li, Zhulun Wang, Merrill Ayres, Athena Sudom, Nigel Walker, Jay P. Powers
المصدر: Structure. 14(12):1835-1844
مصطلحات موضوعية: Protein Conformation, Molecular Sequence Data, Glutamic Acid, Biology, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, Protein Structure, Secondary, Receptor tyrosine kinase, Phosphates, MAP2K7, Adenosine Triphosphate, Structural Biology, Humans, Amino Acid Sequence, c-Raf, Enzyme Inhibitors, MOLIMMUNO, Molecular Biology, Serine/threonine-specific protein kinase, Binding Sites, MAP kinase kinase kinase, Protein-Tyrosine Kinases, Interleukin-1 Receptor-Associated Kinases, Biochemistry, SIGNALING, biology.protein, Tyrosine, Cyclin-dependent kinase 9, Tyrosine kinase, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc3d6695128b610622c4cd20aea485fTest
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المؤلفون: Juan C. Jaen, Jay P. Powers, Nigel Walker, Zhulun Wang, Holger Wesche, Jinqian Liu, Shyun Li
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:2842-2845
مصطلحات موضوعية: Alkylation, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Interleukin-1 receptor, Biochemistry, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Molecular Structure, biology, Kinase, Chemistry, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Amides, Small molecule, Cross-Linking Reagents, Interleukin-1 Receptor-Associated Kinases, Enzyme inhibitor, biology.protein, Cancer research, Molecular Medicine, Benzimidazoles, Signal transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafa1dfbff1d49a203522f7ff6c7cd8cTest
https://doi.org/10.1016/j.bmcl.2006.03.020Test -
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المؤلفون: Zhulun Wang, Yang Li, M Greg Peterson, Derek E. Piper, Jinqian Liu, George Tonn, Jay P. Powers, Juan C. Jaen, Veronica Mayorga, Nigel Walker, Qiuping Ye, Gary Lee, John Anzola, James M Chen
المصدر: Journal of Medicinal Chemistry. 49:1034-1046
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, viruses, Hepatitis C virus, Allosteric regulation, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Structure-Activity Relationship, chemistry.chemical_compound, RNA polymerase, Drug Discovery, medicine, Binding site, Mode of action, NS5B, Polymerase, chemistry.chemical_classification, Avian Myeloblastosis Virus, Binding Sites, Diarrhea Viruses, Bovine Viral, biology, Thiones, virus diseases, DNA-Directed RNA Polymerases, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Thiazoles, Enzyme, chemistry, Biochemistry, biology.protein, Reverse Transcriptase Inhibitors, Molecular Medicine, Allosteric Site
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79e164edd2f87317ae0876979cd0916Test
https://doi.org/10.1021/jm050859xTest -
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المؤلفون: James Campbell, Linda S. Ertl, Matthew J. Walters, Robert D. Berahovich, Pirow Bekker, Jay P. Powers, Timothy J. Sullivan, Trevor T. Charvat, Sreenivas Punna, Juan C. Jaen, Karen Ebsworth, Thomas J. Schall
المصدر: Mediators of Inflammation
Mediators of Inflammation, Vol 2015 (2015)مصطلحات موضوعية: Chemokine, ATP Binding Cassette Transporter, Subfamily B, Article Subject, Immunology, CCR9, Inflammation, Biology, In Vitro Techniques, Proinflammatory cytokine, Chemokine receptor, Mice, Receptors, CCR, lcsh:Pathology, medicine, Animals, Humans, Colitis, Mice, Knockout, Sulfonamides, Cell Biology, medicine.disease, Ulcerative colitis, digestive system diseases, Chemokines, CC, biology.protein, Colitis, Ulcerative, Female, medicine.symptom, CCL25, lcsh:RB1-214, Research Article
وصف الملف: text/xhtml
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54b906299fa1a2c0676b12e2c2fe092Test
https://pubmed.ncbi.nlm.nih.gov/26457007Test