المؤلفون: Lucie Malikova, Matej Malik, Jan Pavlik, Milos Ulman, Eva Pechouckova, Milos Skrivan, Ladislav Kokoska, Pavel Tlustos

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: Medicine, Science

الوصف: Abstract Antibiotic resistance in staphylococcal strains and its impact on public health and agriculture are global problems. The development of new anti-staphylococcal agents is an effective strategy for addressing the increasing incidence of bacterial resistance. In this study, ethanolic extracts of Cannabis sativa L. made from plant parts harvested during the whole vegetation cycle under various nutritional treatments were assessed for in vitro anti-staphylococcal effects. The results showed that all the cannabis extracts tested exhibited a certain degree of growth inhibition against bacterial strains of Staphylococcus aureus, including antibiotic-resistant and antibiotic-sensitive forms. The highest antibacterial activity of the extracts was observed from the 5th to the 13th week of plant growth across all the nutritional treatments tested, with minimum inhibitory concentrations ranging from 32 to 64 µg/mL. Using HPLC, Δ9-tetrahydrocannabinolic acid (THCA) was identified as the most abundant cannabinoid in the ethanolic extracts. A homolog of THCA, tetrahydrocannabivarinic acid (THCVA), reduced bacterial growth by 74%. These findings suggest that the cannabis extracts tested in this study can be used for the development of new anti-staphylococcal compounds with improved efficacy.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/a539f57d73dd40c18904bafd4ea8b691Test

المؤلفون: Patrik Oleksak, Michal Novotny, Jiri Patocka, Eugenie Nepovimova, Jakub Hort, Jan Pavlik, Blanka Klimova, Martin Valis, Kamil Kuca

المصدر: International Journal of Molecular Sciences, Vol 22, Iss 16, p 8908 (2021)

مصطلحات موضوعية: cevimeline, evoxac, AF102B, SNI2011, cholinergic agonist, muscarinic receptors, Biology (General), QH301-705.5, Chemistry, QD1-999

الوصف: At present, Alzheimer’s disease (AD) and related dementias cannot be cured. Therefore, scientists all over the world are trying to find a new approach to prolong an active life of patients with initial dementia. Both pharmacological and non-pharmacological pathways are investigated to improve the key symptom of the disease, memory loss. In this respect, influencing the neuromodulator acetylcholine via muscarinic receptors, such as cevimeline, might be one of the therapeutic alternatives. The purpose of this study is to explore the potential of cevimeline on the cognitive functions of AD patients. The methodology is based on a systematic literature review of available studies found in Web of Science, PubMed, Springer, and Scopus on the research topic. The findings indicate that cevimeline has shown an improvement in experimentally induced cognitive deficits in animal models. Furthermore, it has demonstrated to positively influence tau pathology and reduce the levels of amyloid-β (Aβ) peptide in the cerebral spinal fluid of Alzheimer’s patients. Although this drug has not been approved by the FDA for its use among AD patients and there is a lack of clinical studies confirming and extending this finding, cevimeline might represent a breakthrough in the treatment of AD.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/22/16/8908Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/3ba7a53834fd46ae916f5fc9086860f4Test

المؤلفون: Pavel SIMEK, Jiri VANEK, Michal STOCES, Jan JAROLIMEK, Jan PAVLIK

المصدر: Agricultural Economics (AGRICECON), Vol 63, Iss 5, Pp 197-203 (2017)

مصطلحات موضوعية: agrarian sector, information source, mobile access, mobile device, native application, web application, Agriculture

الوصف: The article analyses the potential expenditures that would be required in order to make the agrarian web information source (the areas of agriculture, food industry, forestry, water management) accessible from the mobile devices. The following approaches were analysed: creating of the responsive layout for mobile web browsers, creating a native application for the Android platform, and creating three native applications in the cross platform environment for the Android, iOS and Windows Phone. The experimental evaluation was performed using the Agrarian WWW portal AGRIS (www.agris.cz), which is one of the most visited online information source in the Czech Republic for covering the areas of agriculture, regional, and countryside development.

وصف الملف: electronic resource

العلاقة: https://agricecon.agriculturejournals.cz/artkey/age-201705-0001_mobile-accessibility-expense-analysis-of-the-agrarian-www-portal.phpTest; https://doaj.org/toc/0139-570XTest; https://doaj.org/toc/1805-9295Test

الوصول الحر: https://doaj.org/article/a3477e1afd2e4044a35e2e04588e6474Test

المؤلفون: Peter Segľa, Ján Pavlik

المصدر: Inorganics; Volume 11; Issue 6; Pages: 250

مصطلحات موضوعية: n/a

الوصف: The following Special Issue of Inorganics is based on the discussions initiated at the International Conference on Coordination and Bioinorganic Chemistry (ICCBIC), which has been organized and held biennially since 1964 [.]

وصف الملف: application/pdf

العلاقة: Coordination Chemistry; https://dx.doi.org/10.3390/inorganics11060250Test

الإتاحة: https://doi.org/10.3390/inorganics11060250Test

المؤلفون: Marek Brezovan, Jana Juráková, Ján Moncol, Ľubor Dlháň, Maria Korabik, Ivan Šalitroš, Ján Pavlik, Peter Segľa

المصدر: Inorganics; Volume 10; Issue 9; Pages: 128

مصطلحات موضوعية: single-ion magnet, cobalt(II) coordination polymer, ab-initio calculations

الوصف: Two previously synthesized cobalt(II) coordination polymers; {[Co(μ2-suc)(nia)2(H2O)2]·2H2O}n (suc = succinate(2−), nia = nicotinamide) and [Co(μ2-fum)(nia)2(H2O)2]n (fum = fumarate(2−)) were prepared and thoroughly characterized. Both complexes form 1D coordination chains by bonding of Co(nia)2(H2O)2 units through succinate or fumarate ligands while these chains are further linked through hydrogen bonds to 3D supramolecular networks. The intermolecular interactions of both complexes are quantified using Hirshfeld surface analysis and their infrared spectra, electronic spectra and static magnetic properties are confronted with DFT and state-of-the-art ab-initio calculations. Dynamic magnetic measurements show that both complexes exhibit single-ion magnet behaviour induced by a magnetic field. Since they possess very similar chemical structure, differing only in the rigidity of the bridge between the magnetic centres, this chemical feature is put into context with changes in their magnetic relaxation.

وصف الملف: application/pdf

العلاقة: Coordination Chemistry; https://dx.doi.org/10.3390/inorganics10090128Test

الإتاحة: https://doi.org/10.3390/inorganics10090128Test

المؤلفون: Jan Pavlík, Markéta Hrnčírová, Michal Stočes, Jan Masner, Jiří Vaněk

المصدر: ISPRS International Journal of Geo-Information; Volume 9; Issue 10; Pages: 591

مصطلحات موضوعية: GIS, open data, IoT, diffuse water pollution, spatial data, watershed monitoring, factor analysis

جغرافية الموضوع: agris

الوصف: Recently, the process of data opening has intensified, especially thanks to the involvement of many institutions that have not yet shared their data. Some entities provided data to the public long before the trend of open data was pushed to a wider level, but many institutions have only engaged in this process recently thanks to a systemic state-level effort to make data repositories available to the public. Therefore, there are many new potential sources of data available for research, including the area of water management. This article analyses the current state of available data in the Czech Republic—their content, structure, format, availability, costs and other indicators that affect the usability of these data for independent researchers in the area of water management. The case study was conducted to ascertain the levels of accessibility and usability of data in open data repositories and the possibilities of obtaining data from IoT (Internet of Things) devices such as networked sensors where required data is either not available from existing sources, too costly, or otherwise unsuitable for the research. The goal of the underlying research was to assess the impact/ratio of various watershed factors based on monitored indicators of water pollution in a model watershed. Such information would help propose measures for reducing the volume of pollution resulting in increased security in terms of available drinking water for the capital city Prague.

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/ijgi9100591Test

الإتاحة: https://doi.org/10.3390/ijgi9100591Test

المؤلفون: Jiří Vaněk, Jan Jarolímek, Jan Pavlík, Jan Masner, Michal Stočes

المصدر: ISSN: 1314-8591.

مصطلحات موضوعية: precision agriculture, smart farming, technological sophistication, user accessibility

الوصف: Finding the relationship between technological innovation, economic efficiency and practical usability is being tackled since the beginning of the development of precision farming. There are many technologically advanced technologies whose use in practice is not as expected. On the other hand, farmers' real demand for technological development is in a whole range of areas. Efficiency and usability derives from local conditions, crops and varies in different countries.

وصف الملف: application/pdf

العلاقة: https://www.scientific-publications.net/en/article/1001637Test/

الإتاحة: https://www.scientific-publications.net/en/article/1001637Test/

المؤلفون: Štefan PAVLÍK, Ján PAVLÍK, Matej PAVLÍK

المصدر: Tichodroma, Vol 30, Pp 48-57 (2018)

مصطلحات موضوعية: garrulus glandarius, acorn dispersal, shrubs with oaks, breeding bird assemblages, agricultural landscape, Zoology, QL1-991

الوصف: The European jay (Garrulus glandarius) is a very efficient acorn disperser, and most of the Quercus seeds, especially at medium to large distances, are jay-dispersed. Jays disperse acorns effectively also into shrub belts in agricultural land, and thus they create new habitats. Such new structures enable to some forest birds, that do not nest within treeless shrub belts, to penetrate into shrub belts with oaks and to spread in open agricultural land. We compared the species composition of breeding bird assemblages in three hazel-blackthorn shrub belts with different proportion of oaks (belts B–D) with those in a shrub belt without trees (belt A) and at an oak forest edge (belt E). From 21 bird species nesting in shrub belts A–D, eight ones were forest birds (Parus major, Sturnus vulgaris, Jynx torquilla, Coccothraustes coccothraustes, G. glandarius, Oriolus oriolus, Phylloscopus collybita, Streptopelia turtur) which did not nest in the shrub belt A without trees. Only one forest bird species (P. major) nested in the shrub belt B with low proportion of oaks, and 6–8 ones in the shrub belts C and D with higher proportion of oaks. On the other hand, up to 11 bird species nesting at the oak forest edge (belt E) did not nest in the shrub belts with oaks in open agricultural land.

العلاقة: http://www.tichodroma.sk/pdfs/30/Tichodroma_30_pavlik.pdfTest; https://doaj.org/toc/1337-026XTest; https://doaj.org/toc/2644-4992Test; https://doaj.org/article/3991fc1ca24e4161944e78f594dd3badTest

الإتاحة: https://doaj.org/article/3991fc1ca24e4161944e78f594dd3badTest

المؤلفون: Ján Pavlik, Jorge Linares

وصف الملف: application/pdf; image/vnd.djvu

العلاقة: CRCHIM_2018__21_12_1170_0; https://comptes-rendus.academie-sciences.fr/chimie/articles/10.1016/j.crci.2018.05.001Test/; oai:centre-mersenne.org:CRCHIM_2018__21_12_1170_0; citation: Comptes Rendus. Chimie, 21, no. 12 (2018) p 1170-1178

المؤلفون: Jozef VAKULA, Milan ZÚBRIK, Juraj GALKO, Andrej GUBKA, Andrej KUNCA, Ján PAVLÍK, Christo NIKOLOV

المصدر: Plant Protection Science, Vol 52, Iss 4, Pp 277-282 (2016)

مصطلحات موضوعية: great spruce bark beetle, urban forestry, pests, picea orientalis, picea pungens, Plant culture, SB1-1110

الوصف: In 2015, we recorded the first attack of the great spruce bark beetle, Dendroctonus micans (Kugelann) (Coleoptera: Curculionidae, Scolytinae) on non-native Picea orientalis (L.) and Picea pungens (Engelmann) in Slovakia. To our knowledge, the occurrence of D. micans on P. orientalis in Central Europe has not been described yet. We found that D. micans preferred P. orientalis over P. pungens and other coniferous trees in urban areas. In laboratory conditions, 352 adults of D. micans emerged and only 1 predator, Rhizophagus grandis (Gyllenhal) (Coleoptera: Monotomidae), was recorded. D. micans has a potential to become a serious pest of P. orientalis and P. pungens in urban, and in air-polluted areas.

العلاقة: https://pps.agriculturejournals.cz/artkey/pps-201604-0009_first-record-of-dendroctonus-micans-kugelann-1794-on-non-native-spruces-in-slovakia-short-communication.phpTest; https://doaj.org/toc/1212-2580Test; https://doaj.org/toc/1805-9341Test; https://doaj.org/article/6d39504c2a8f434f993172ecf8e5fa44Test

الإتاحة: https://doi.org/10.17221/60/2016-PPSTest
https://doaj.org/article/6d39504c2a8f434f993172ecf8e5fa44Test