المؤلفون: Abigail B. Zinn, Mary Beth Brown, Robert G. Presson, Jagadeshwar G. Reddy, Tsungai J. Chingombe, Tim Lahm, Amanda Fisher, Irina Petrache, Rachel Novack, Sean Cooney

المصدر: Experimental Physiology. 100:742-754

مصطلحات موضوعية: medicine.medical_specialty, Lung, business.industry, Hemodynamics, General Medicine, medicine.disease, Pulmonary hypertension, Muscle hypertrophy, Surgery, Blood pressure, medicine.anatomical_structure, Internal medicine, medicine.artery, Pulmonary artery, Ventricular pressure, Cardiology, Medicine, business, Exercise prescription

الوصف: New Findings What is the central question of this study? The acute effect of exercise at moderately high intensity on already-elevated pulmonary arterial pressures and right ventricular wall stress in a rat model of pulmonary arterial hypertension (PAH) is unknown. What is the main finding and its importance? We show, for the first time, that in a rat model of PAH, exercise induces an acute reduction in pulmonary artery pressure associated with lung endothelial nitric oxide synthase activation, without evidence of acute right ventricular inflammation or myocyte apoptosis. Haemodynamic measures obtained with traditional invasive methodology as well as novel implantable telemetry reveal an exercise-induced ‘window’ of pulmonary hypertension alleviation, supporting future investigations of individualized exercise as therapy in PAH. Exercise improves outcomes of multiple chronic conditions, but controversial results, including increased pulmonary artery (PA) pressure, have prevented its routine implementation in pulmonary arterial hypertension (PAH), an incurable disease that drastically reduces exercise tolerance. Individualized, optimized exercise prescription for PAH requires a better understanding of disease-specific exercise responses. We investigated the acute impact of exercise on already-elevated PA pressure and right ventricular (RV) wall stress and inflammation in a rat model of PAH (PAH group, n = 12) induced once by monocrotaline (50 mg kg−1, i.p.; 2 weeks), compared with healthy control animals (n = 8). Single bouts of exercise consisted of a 45 min treadmill run at 75% of individually determined aerobic capacity (VO2max). Immediately after exercise, measurements of RV systolic pressure and systemic pressure were made via jugular and carotid cannulation, and were followed by tissue collection. Monocrotaline induced moderate PAH, evidenced by RV hypertrophy, decreased VO2max, PA muscularization, and RV and skeletal muscle cytoplasmic glycolysis detected by increased expression of glucose transporter-1. Acute exercise normalized the monocrotaline-induced elevation in RV systolic pressure and augmented pulmonary endothelial nitric oxide synthase activation, without evidence of increased RV inflammation or apoptosis. Real-time recordings of pulmonary and systemic pressures during and after single bouts of exercise made using novel implantable telemetry in the same animal for up to 11 weeks after monocrotaline (40 mg kg−1) corroborated the finding of acute PA pressure decreases with exercise in PAH. The PA pressure-lowering effects of individualized exercise associated with RV-neutral effects and increases in vasorelaxor signalling encourage further development of optimized exercise regimens as adjunctive PAH therapy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f932cf949e55e6fd5461b4f8c608de1eTest
https://doi.org/10.1113/ep085182Test

المؤلفون: Tim Lahm, Kevin M. Trulock, Mary J. Van Demark, Dino Dieudonne, M. Beth Brown, Neel Patel, Amanda Fisher, Jagadeshwar G. Reddy, Irina Petrache, Marjorie Albrecht, Mona Selej, Jordan A. Brown, Matthew J. Justice, Robert G. Presson

المصدر: American Journal of Respiratory and Critical Care Medicine. 185:965-980

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Estrogen receptor, Hypoxia (medical), Critical Care and Intensive Care Medicine, medicine.disease, Pulmonary hypertension, Vascular endothelial growth factor, chemistry.chemical_compound, Endocrinology, chemistry, In vivo, Internal medicine, Hypoxic pulmonary vasoconstriction, medicine, medicine.symptom, Receptor, business, Ventricular remodeling

الوصف: Rationale: 17β-Estradiol (E2) attenuates hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension (HPH) through an unknown mechanism that may involve estrogen receptors (ER) or E2 conversion to catecholestradiols and methoxyestradiols with previously unrecognized effects on cardiopulmonary vascular remodeling. Objectives: To determine the mechanism by which E2 exerts protective effects in HPH. Methods: Male rats were exposed to hypobaric hypoxia while treated with E2 (75 μg/kg/d) or vehicle. Subgroups were cotreated with pharmacologic ER-antagonist or with inhibitors of E2-metabolite conversion. Complementary studies were performed in rats cotreated with selective ERα- or ERβ-antagonist. Hemodynamic and pulmonary artery (PA) and right ventricular (RV) remodeling parameters, including cell proliferation, cell cycle, and autophagy, were measured in vivo and in cultured primary rat PA endothelial cells. Measurements and Main Results: E2 significantly attenuated HPH endpoints. Hypoxia increased ERβ but not ERα lung vascular expression. Co-treatment with nonselective ER inhibitor or ERα-specific antagonist rendered hypoxic animals resistant to the beneficial effects of E2 on cardiopulmonary hemodynamics, whereas ERα- and ERβ-specific antagonists opposed the remodeling effects of E2. In contrast, inhibition of E2-metabolite conversion did not abolish E2 protection. E2-treated hypoxic animals exhibited reduced ERK1/2 activation and increased expression of cell-cycle inhibitor p27Kip1 in lungs and RV, with up-regulation of lung autophagy. E2-induced signaling was recapitulated in hypoxic but not normoxic endothelial cells, and was associated with decreased vascular endothelial growth factor secretion and cell proliferation. Conclusions: E2 attenuates hemodynamic and remodeling parameters in HPH in an ER-dependent manner, through direct antiproliferative mechanisms on vascular cells, which may provide novel nonhormonal therapeutic targets for HPH.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::55292bcd0509b44175a0ca8b24500827Test
https://doi.org/10.1164/rccm.201107-1293ocTest

المؤلفون: Mary Beth, Brown, Tsungai J, Chingombe, Abigail B, Zinn, Jagadeshwar G, Reddy, Rachel A, Novack, Sean A, Cooney, Amanda J, Fisher, Robert G, Presson, Tim, Lahm, Irina, Petrache

المصدر: Experimental physiology. 100(6)

مصطلحات موضوعية: Male, Monocrotaline, Hypertrophy, Right Ventricular, Nitric Oxide Synthase Type III, Hypertension, Pulmonary, Myocardium, Hemodynamics, Blood Pressure Monitoring, Ambulatory, Pulmonary Artery, Exercise Therapy, Enzyme Activation, Rats, Sprague-Dawley, Disease Models, Animal, Kinetics, Predictive Value of Tests, Ventricular Function, Right, Ventricular Pressure, Animals, Telemetry, Arterial Pressure, Muscle, Skeletal, Glycolysis

الوصف: What is the central question of this study? The acute effect of exercise at moderately high intensity on already-elevated pulmonary arterial pressures and right ventricular wall stress in a rat model of pulmonary arterial hypertension (PAH) is unknown. What is the main finding and its importance? We show, for the first time, that in a rat model of PAH, exercise induces an acute reduction in pulmonary artery pressure associated with lung endothelial nitric oxide synthase activation, without evidence of acute right ventricular inflammation or myocyte apoptosis. Haemodynamic measures obtained with traditional invasive methodology as well as novel implantable telemetry reveal an exercise-induced 'window' of pulmonary hypertension alleviation, supporting future investigations of individualized exercise as therapy in PAH. Exercise improves outcomes of multiple chronic conditions, but controversial results, including increased pulmonary artery (PA) pressure, have prevented its routine implementation in pulmonary arterial hypertension (PAH), an incurable disease that drastically reduces exercise tolerance. Individualized, optimized exercise prescription for PAH requires a better understanding of disease-specific exercise responses. We investigated the acute impact of exercise on already-elevated PA pressure and right ventricular (RV) wall stress and inflammation in a rat model of PAH (PAH group, n = 12) induced once by monocrotaline (50 mg kg(-1) , i.p.; 2 weeks), compared with healthy control animals (n = 8). Single bouts of exercise consisted of a 45 min treadmill run at 75% of individually determined aerobic capacity (V̇O2max). Immediately after exercise, measurements of RV systolic pressure and systemic pressure were made via jugular and carotid cannulation, and were followed by tissue collection. Monocrotaline induced moderate PAH, evidenced by RV hypertrophy, decreased V̇O2max, PA muscularization, and RV and skeletal muscle cytoplasmic glycolysis detected by increased expression of glucose transporter-1. Acute exercise normalized the monocrotaline-induced elevation in RV systolic pressure and augmented pulmonary endothelial nitric oxide synthase activation, without evidence of increased RV inflammation or apoptosis. Real-time recordings of pulmonary and systemic pressures during and after single bouts of exercise made using novel implantable telemetry in the same animal for up to 11 weeks after monocrotaline (40 mg kg(-1) ) corroborated the finding of acute PA pressure decreases with exercise in PAH. The PA pressure-lowering effects of individualized exercise associated with RV-neutral effects and increases in vasorelaxor signalling encourage further development of optimized exercise regimens as adjunctive PAH therapy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::6eb772c3cbf9116f8561eb072c0dd1e3Test
https://pubmed.ncbi.nlm.nih.gov/25867528Test

المؤلفون: Jagadeshwar G. Reddy, Mary Van Demark, Jonathan Goya, Changyu Shen, Irina Gorshkova, Irina Petrache, Evgeny Berdyshev

المصدر: A13. ADVANCES IN COPD PATHOGENESIS AND EXACERBATION SUSCEPTIBILITY.

مصطلحات موضوعية: Ceramide, chemistry.chemical_compound, COPD, chemistry, medicine, Sphingosine-1-phosphate, Pharmacology, medicine.disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bf76b82b7029b18c6fb57b67c9cb3746Test
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1005Test

المؤلفون: Kelli M. McCauley, Changyu Shen, Mary Van Demark, Jonathan Goya, Jagadeshwar G. Reddy, Evgeny Berdyshev, Irina Petrache

المصدر: A69. LIPID-MEDIATED SIGNALING.

مصطلحات موضوعية: Ceramide, chemistry.chemical_compound, COPD, Lung, medicine.anatomical_structure, chemistry, business.industry, Cancer research, Medicine, business, medicine.disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9986a8266a710433e76ac0de0ec1e4a2Test
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6368Test

المؤلفون: Jagadeshwar G, Reddy, Jon O, Ebbert, Lisa M, Klesges, Felicity T B, Enders, Robert C, Klesges, Jennifer Q, Lanctot, Barbara S, McClanahan

المصدر: Ethnicitydisease. 18(3)

مصطلحات موضوعية: Adolescent, Sodium, Dietary, Body Mass Index, Diet, Black or African American, Cohort Studies, Cross-Sectional Studies, Risk Factors, Caffeine, Hypertension, Humans, Central Nervous System Stimulants, Female, Child

الوصف: While high caffeine consumption has been shown to be associated with increased blood pressure in controlled experiments, the relationship between caffeine consumption and blood pressure in preadolescent (ages 6-11 years) and adolescent (ages 12-19 years) children has not been well studied. The primary objective of this study was to assess the cross-sectional relationship between caffeine intake and blood pressure in 8- to 10-year-old African American girls who eat an unrestricted diet.Demographic, 24-hour dietary recall, and blood pressure data collected at baseline from 303 African American girls aged 8-10 years in the Girls health Enrichment Multisite Studies (GEMS) cohort were analyzed by using linear and multiple regression models.Dietary caffeine intake was not associated with either systolic or diastolic blood pressure (P=.33 and P=.36, respectively). However, consistent with the literature, height and body mass index were each positively and independently associated with systolic blood pressure (both P.0001). Height and amount of sodium intake were positively associated with diastolic blood pressure (P=.01 and P=.02, respectively).Dietary caffeine intake in low amounts is not associated with elevated blood pressure in 8- to 10-year-old African American girls who eat an unrestricted diet.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::444230200f0f5a51e5e691d02a62b989Test
https://pubmed.ncbi.nlm.nih.gov/18785440Test

المؤلفون: Jagadeshwar G. Reddy, Jeffrey A. Schmoll, Felicity T. Boyd-Enders, Ganapathy A. Prasad, Jason T. Lewis, Louis Michel Wongkeesong

المصدر: Journal of clinical gastroenterology. 42(7)

مصطلحات موضوعية: Adult, Male, Pediatrics, medicine.medical_specialty, Meat, Esophagus, Recurrence, Risk Factors, Intervention (counseling), medicine, Esophagitis, Humans, Hernia, Eosinophilic esophagitis, Aged, Aged, 80 and over, medicine.diagnostic_test, Esophageal disease, business.industry, Gastroenterology, Case-control study, Middle Aged, medicine.disease, Foreign Bodies, Endoscopy, Surgery, medicine.anatomical_structure, Hernia, Hiatal, Food, Case-Control Studies, Esophageal Stenosis, Female, Esophagoscopy, business

الوصف: Esophageal food impaction (FI) is a distressing condition requiring urgent endoscopic intervention, with a reported recurrence rate between 10% and 20%. Knowledge of factors predisposing to recurrent FI may enable preventive measures to minimize the risk of recurrence.To identify risk factors associated with recurrent FI.Retrospective case-control study.Tertiary referral center.A prospectively maintained database and medical records of all patients undergoing emergent endoscopy for FI from 1989 to 2000 were reviewed. Cases were defined as those presenting with more than 1 episode of FI, whereas controls were defined as those without recurrence within 5 years of the index episode. Several demographic, clinical, endoscopic, and follow-up variables were extracted. Statistical analysis included chi2 tests and t tests for univariate analysis, and stepwise logistic regression for multivariate analysis.NA.Predictors of recurrent FI.A total of 52 cases and 124 controls were identified (recurrence rate 30%). Presence of a diaphragmatic hernia [odds ratio (OR) 2.65; confidence interval (CI) 1.19-5.89], disimpaction by piecemeal extraction (OR 2.32; CI 1.09-4.97), and acquisition of esophageal biopsies (OR 3.69; CI 1.42-9.66) increased odds for recurrent FI. Physician follow-up after FI decreased the odds for recurrent FI (OR 0.38; CI 0.18-0.80).Retrospective study.The presence of a diaphragmatic hernia, complexity of endoscopic disimpaction technique, and lack of follow-up increased risk for recurrent FI. Collection of esophageal biopsies as a risk factor suggests a visibly more severe esophageal disorder as a potential cause for recurrent FI.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c81cececce3a749a13752e4d70776bTest
https://pubmed.ncbi.nlm.nih.gov/18580498Test

المؤلفون: Tim Lahm, Marjorie Albrecht, A J. Fisher, Mona Selej, Neel G. Patel, Jordan A. Brown, Matthew J. Justice, M. Beth Brown, Mary Van Demark, Kevin M. Trulock, Dino Dieudonne, Jagadeshwar G. Reddy, Robert G. Presson, Irina Petrache

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359941/pdf/AJRCCM1859965.pdfTest.

الوصف: Rationale: 17b-Estradiol (E2) attenuates hypoxic pulmonary vasocon-striction and hypoxic pulmonary hypertension (HPH) through an un-known mechanism that may involve estrogen receptors (ER) or E2 conversion to catecholestradiols and methoxyestradiols with previ-ously unrecognized effects on cardiopulmonary vascular remodeling. Objectives: To determine themechanismbywhich E2 exerts protective effects in HPH. Methods: Male rats were exposed to hypobaric hypoxia while treated with E2 (75 mg/kg/d) or vehicle. Subgroups were cotreated with phar-macologicER-antagonistorwith inhibitorsofE2-metaboliteconversion. Complementary studies were performed in rats cotreated with selectiveERa- or ERb-antagonist.Hemodynamicandpulmonaryartery (PA) and right ventricular (RV) remodeling parameters, including cell proliferation, cell cycle, and autophagy, were measured in vivo and in cultured primary rat PA endothelial cells.

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.668.832Test; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359941/pdf/AJRCCM1859965.pdfTest

الإتاحة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359941/pdf/AJRCCM1859965.pdfTest

المؤلفون: Ganapathy A. Prasad, Jagadeshwar G. Reddy, Felicity B. Enders, Jeffrey A. Schmoll, Louis-Michel Wongkeesong

المصدر: American Journal of Gastroenterology. 100:S43-S44

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Hepatology, business.industry, Food impaction, Gastroenterology, Case-control study, Medicine, Population based, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5e209c2ae20653c1b56f4094fb631204Test
https://doi.org/10.14309/00000434-200509001-00062Test

المؤلفون: Jagadeshwar G. Reddy, Tim Lahm

المصدر: Chest. 138:76A

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.anatomical_structure, Local anesthetic toxicity, Intravenous lipid emulsion, business.industry, Anesthesia, Central nervous system, medicine, Pharmacology, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6c296c199dac6c50d5c1a78ffee99e59Test
https://doi.org/10.1378/chest.10944Test