المؤلفون: Johannesen, Thor Bech, Munkstrup, Charlotte, Edslev, Sofie Marie, Baig, Sharmin, Nielsen, Stine, Funk, Tjede, Kristensen, Dennis Karsten, Jacobsen, Lars Hervig, Ravn, Signe Fischer, Bindslev, Niels, Gubbels, Sophie, Voldstedlund, Marianne, Jokelainen, Pikka, Hallstrøm, Søren, Rasmussen, Astrid, Kristinsson, Karl Gústaf, Fuglsang-Damgaard, David, Dessau, Ram B, Olsén, Agnieszka Barbara, Jensen, Christian Salgaard, Skovby, Annette, Ellermann-Eriksen, Svend, Jensen, Thøger Gorm, Dzajic, Esad, Østergaard, Claus, Lomborg Andersen, Steen, Hoffmann, Steen, Andersen, Peter Henrik, Stegger, Marc

المصدر: Johannesen , T B , Munkstrup , C , Edslev , S M , Baig , S , Nielsen , S , Funk , T , Kristensen , D K , Jacobsen , L H , Ravn , S F , Bindslev , N , Gubbels , S , Voldstedlund , M , Jokelainen , P , Hallstrøm , S , Rasmussen , A , Kristinsson , K G , Fuglsang-Damgaard , D , Dessau , R B , Olsén , A B , Jensen , C S , Skovby , A , Ellermann-Eriksen , S , Jensen , ....

مصطلحات موضوعية: Humans, COVID-19, Streptococcus pyogenes/genetics, Seasons, Streptococcal Infections/epidemiology, Denmark/epidemiology

الوصف: A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A Streptococcus. An increase in incidence rates of invasive (iGAS) and non-invasive (nGAS) group A Streptococcus infection has been reported by several countries across Europe during the 2022/23 winter season [1-3]. Through analysis of all whole genome sequencing (WGS) data acquired for national surveillance of iGAS in Denmark since 2018, we aimed to investigate current genomic developments and the impact of emerging lineages on iGAS incidence rates in 2023. In Denmark, iGAS is not notifiable except in case of meningitis, however, test results from all 10 Departments of Clinical Microbiology (DCMs) are submitted to the Danish Microbiology Database (MiBa) [4] and can be used to monitor incidence rates. Iceland also experienced a higher iGAS incidence in early 2023, and we also present Icelandic WGS data on iGAS isolates from 2022 and 2023.

العلاقة: https://pure.au.dk/portal/en/publications/6c8819e7-1c27-4e63-b694-3044362a1249Test

الإتاحة: https://doi.org/10.2807/1560-7917.ES.2023.28.26.2300291Test
https://pure.au.dk/portal/en/publications/6c8819e7-1c27-4e63-b694-3044362a1249Test

المؤلفون: Hansen, Nadja Skadkær, Byberg, Stine, Jacobsen, Lars Hervig, Bjerregaard-Andersen, Morten, Jensen, Aksel Karl Georg, Martins, Cesario, Aaby, Peter, Jensen, Jørgen Skov, Benn, Christine Stabell, Whittle, Hilton

المصدر: PLOS ONE ; volume 14, issue 10, page e0224782 ; ISSN 1932-6203

الإتاحة: https://doi.org/10.1371/journal.pone.0224782Test