المؤلفون: C. A. M. Wegh, N. M. de Roos, R. Hovenier, J. Meijerink, I. Besseling-van der Vaart, S. van Hemert, B. J. M. Witteman

المصدر: Journal of Nutrition and Metabolism, Vol 2019 (2019)

مصطلحات موضوعية: Nutritional diseases. Deficiency diseases, RC620-627

الوصف: Background and Aims. Ulcerative colitis (UC) is associated with an increased intestinal permeability, possibly through a dysbiosis of intestinal bacteria. We investigated which markers are most relevant to assess intestinal permeability in UC patients and whether probiotics had an effect on these markers. Methods. In this twelve-week placebo-controlled randomized double-blind study, twenty-five subjects with UC in remission received either placebo or a multispecies probiotics. Samples of blood, urine, and faeces were taken at baseline, week 6, and week 12 to assess intestinal permeability and inflammation. Diaries and Bristol stool scale were kept to record stool frequency and consistency. Quality of life was scored from 32–224 with the inflammatory bowel disease questionnaire (IBD-Q). Results. This group of UC patients, in clinical remission, did not show increased intestinal permeability at baseline of this study. During the study, no significant group or time effects were found for intestinal permeability measured by the 5-sugar absorption test, serum zonulin, and faecal zonulin. Likewise, the inflammatory markers C-reactive protein (CRP), calprotectin, and the cytokines IFNγ, TNFα, IL-6, and IL-10 were not significantly affected. Stool frequency and consistency were not significantly affected either. The IBD-Q score, 194 for the probiotics group and 195 for the placebo group, remained unaffected. Correlations were tested between all outcomes; urinary sucrose excretion was significantly correlated with serum zonulin (r = 0.62) and faecal calprotectin (r = 0.55). Faecal zonulin was not significantly correlated with any of the other markers. Conclusion. Serum zonulin may be a more relevant biomarker of intestinal permeability than faecal zonulin, due to its correlation with other biomarkers of intestinal permeability. UC patients in remission did not show an effect of the probiotic treatment or a change in gut permeability. This should not discourage further studies because effects might be present during active disease or shortly after a flare up.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2090-0724Test; https://doaj.org/toc/2090-0732Test

الوصول الحر: https://doaj.org/article/92519bd96922475d9487b40b7433a349Test

المؤلفون: Dieuwke Strijker, Wilhelmus J. H. J. Meijerink, Linda A. G. van Heusden-Schotalbers, Manon G. A. van den Berg, Monique J. M. D. van Asseldonk, Luuk D. Drager, Johannes H. W. de Wilt, Kees J. H. M. van Laarhoven, Baukje van den Heuvel

المصدر: Cancers; Volume 15; Issue 6; Pages: 1870

مصطلحات موضوعية: colorectal neoplasm MeSH, neoplasm metastasis MeSH, hyperthermic intraperitoneal chemotherapy, colorectal surgery MeSH, postoperative complications MeSH, prehabilitation, perioperative care

الوصف: Background: Surgery for complex primary and metastatic colorectal cancer (CRC), such as liver resection and hyperthermic intraperitoneal chemotherapy (HIPEC), in academic settings has led to improved survival but is associated with complications up to 75%. Prehabilitation has been shown to prevent complications in non-academic hospitals. This pilot study aimed to determine the feasibility and potential efficacy of a multimodal prehabilitation program in patients undergoing surgery in an academic hospital for complex primary and metastatic CRC. Methods: All patients awaiting complex colorectal surgery, liver resection, or HIPEC from July 2019 until January 2020 were considered potentially eligible. Feasibility was measured by accrual rate, completion rate, adherence to the program, satisfaction, and safety. To determine potential efficacy, postoperative outcomes were compared with a historical control group. Results: Sixteen out of twenty-five eligible patients (64%) commenced prehabilitation, and fourteen patients fully completed the intervention (88%). The adherence rate was 69%, as 11 patients completed >80% of prescribed supervised trainings. No adverse events occurred, and all patients expressed satisfaction with the program. The complication rate was significantly lower in the prehabilitation group (37.5%) than the control group (70.2%, p = 0.020). There was no difference in the type of complications. Conclusion: This pilot study illustrates that multimodal prehabilitation is feasible in the majority of patients undergoing complex colorectal cancer, liver resection, and HIPEC in an academic setting.

وصف الملف: application/pdf

العلاقة: Cancer Therapy; https://dx.doi.org/10.3390/cancers15061870Test

الإتاحة: https://doi.org/10.3390/cancers15061870Test

المؤلفون: A H Mirnezami, I Drami, T Glyn, P A Sutton, J Tiernan, C Behrenbruch, G Guerra, P S Waters, N Woodward, S Applin, S J Charles, S A Rose, A Denys, E Pape, G H van Ramshorst, D Baker, E Bignall, I Blair, P Davis, T Edwards, K Jackson, P G Leendertse, E Love-Mott, L MacKenzie, F Martens, D Meredith, S E Nettleton, M P Trotman, J J M van Hecke, A M J Weemaes, N Abecasis, E Angenete, O Aziz, N Bacalbasa, D Barton, G Baseckas, A Beggs, K Brown, P Buchwald, D Burling, E Burns, A Caycedo-Marulanda, G J Chang, P E Coyne, R S Croner, I R Daniels, Q D Denost, E Drozdov, T Eglinton, E Espín-Basany, M D Evans, K Flatmark, J Folkesson, F A Frizelle, M A Gallego, A Gil-Moreno, P Goffredo, B Griffiths, F Gwenaël, D A Harris, L H Iversen, G V Kandaswamy, M Kazi, M E Kelly, R Kokelaar, M Kusters, M C Langheinrich, T Larach, M L Lydrup, A Lyons, C Mann, F D McDermott, J R T Monson, H Neeff, I Negoi, J L Ng, M Nicolaou, G Palmer, C Parnaby, G Pellino, A C Peterson, A Quyn, A Rogers, J Rothbarth, F Abu Saadeh, A Saklani, T Sammour, R Sayyed, N J Smart, T Smith, L Sorrentino, S R Steele, K Stitzenberg, C Taylor, J Teras, M R Thanapal, E Thorgersen, W Vasquez-Jimenez, J Waller, K Weber, A Wolthuis, D C Winter, G Brangan, D Vimalachandran, A G J Aalbers, N Abdul Aziz, M Abraham-Nordling, T Akiyoshi, R Alahmadi, W Alberda, M Albert, M Andric, M Angeles, A Antoniou, J Armitage, R Auer, K K Austin, E Aytac, R P Baker, M Bali, S Baransi, B Bebington, M Bedford, B K Bednarski, G L Beets, P L Berg, C Bergzoll, S Biondo, K Boyle, L Bordeianou, E Brecelj, A B Bremers, M Brunner, A Bui, A Burgess, J W A Burger, N Campain, S Carvalhal, L Castro, W Ceelen, K K L Chan, M H Chew, A K Chok, P Chong, H K Christensen, H Clouston, D Collins, A J Colquhoun, J Constantinides, A Corr, M Coscia, M Cosimelli, C Cotsoglou, L Damjanovic, M Davies, R J Davies, C P Delaney, J H W de Wilt, C Deutsch, D Dietz, S Domingo, E J Dozois, M Duff, E Egger, J M Enrique-Navascues, B Eyjólfsdóttir, M Fahy, N S Fearnhead, S Fichtner-Feigl, F Fleming, B Flor, K Foskett, J Funder, E García-Granero, J L García-Sabrido, M Gargiulo, V G Gava, L Gentilini, M L George, V George, P Georgiou, A Ghosh, L Ghouti, F Giner, N Ginther, T Glover, T Golda, C M Gomez, C Harris, J A W Hagemans, V Hanchanale, D P Harji, C Helbren, R M Helewa, G Hellawell, A G Heriot, D Hochman, W Hohenberger, T Holm, A Holmström, R Hompes, B Hornung, S Hurton, E Hyun, M Ito, J T Jenkins, K Jourand, S Kaffenberger, S Kapur, Y Kanemitsu, M Kaufman, S R Kelley, D S Keller, S Kersting, S H J Ketelaers, M S Khan, J Khaw, H Kim, H J Kim, R Kiran, C E Koh, N F M Kok, C Kontovounisios, F Kose, M Koutra, M Kraft, H Ø Kristensen, S Kumar, V Lago, Z Lakkis, B Lampe, S G Larsen, D W Larson, W L Law, S Laurberg, P J Lee, M Limbert, A Loria, A C Lynch, M Mackintosh, C Mantyh, K L Mathis, C F S Margues, A Martinez, A Martling, W J H J Meijerink, A Merchea, S Merkel, A M Mehta, D R McArthur, J J McCormick, J S McGrath, A McPhee, J Maciel, S Malde, S Manfredelli, S Mikalauskas, D Modest, J R Morton, T G Mullaney, A S Navarro, J W M Neto, B Nguyen, M B Nielsen, G A P Nieuwenhuijzen, P J Nilsson, S Nordkamp, S T O'Dwyer, K Paarnio, E Pappou, J Park, D Patsouras, O Peacock, F Pfeffer, F Piqeur, J Pinson, G Poggioli, D Proud, M Quinn, A Oliver, R W Radwan, N Rajendran, C Rao, S Rasheed, P C Rasmussen, E Rausa, S E Regenbogen, H M Reims, A Renehan, J Rintala, R Rocha, M Rochester, J Rohila, M Rottoli, C Roxburgh, H J T Rutten, B Safar, P M Sagar, A Sahai, A M P Schizas, E Schwarzkopf, D Scripcariu, V Scripcariu, G Seifert, C Selvasekar, M Shaban, I Shaikh, D Shida, A Simpson, T Skeie-Jensen, P Smart, J J Smith, A M Solbakken, M J Solomon, M M Sørensen, M Spasojevic, D Steffens, L Stocchi, N A Stylianides, T Swartling, H Sumrien, T Swartking, H Takala, E J Tan, D Taylor, P Tejedor, A Tekin, P P Tekkis, H V Thaysen, R Thurairaja, E L Toh, P Tsarkov, J Tolenaar, Y Tsukada, S Tsukamoto, J J Tuech, G Turner, W H Turner, J B Tuynman, M Valente, J van Rees, D van Zoggel, W Vásquez-Jiménez, C Verhoef, M Vierimaa, G Vizzielli, E L K Voogt, K Uehara, C Wakeman, S Warrier, H H Wasmuth, M R Weiser, O L Westney, J M D Wheeler, J Wild, M Wilson, H Yano, B Yip, J Yip, R N Yoo, M A Zappa

المساهمون: H Mirnezami, A, Drami, I, Glyn, T, A Sutton, P, Tiernan, J, Behrenbruch, C, Guerra, G, S Waters, P, Woodward, N, Applin, S, J Charles, S, A Rose, S, Denys, A, Pape, E, H van Ramshorst, G, Baker, D, Bignall, E, Blair, I, Davis, P, Edwards, T, Jackson, K, G Leendertse, P, Love-Mott, E, Mackenzie, L, Martens, F, Meredith, D, E Nettleton, S, P Trotman, M, M van Hecke, J J, J Weemaes, A M, Abecasis, N, Angenete, E, Aziz, O, Bacalbasa, N, Barton, D, Baseckas, G, Beggs, A, Brown, K, Buchwald, P, Burling, D, Burns, E, Caycedo-Marulanda, A, J Chang, G, E Coyne, P, S Croner, R, R Daniels, I, D Denost, Q, Drozdov, E, Eglinton, T, Espín-Basany, E, D Evans, M, Flatmark, K, Folkesson, J, A Frizelle, F, A Gallego, M, Gil-Moreno, A, Goffredo, P, Griffiths, B, Gwenaël, F, A Harris, D, H Iversen, L, V Kandaswamy, G, Kazi, M, E Kelly, M, Kokelaar, R, Kusters, M, C Langheinrich, M, Larach, T, L Lydrup, M, Lyons, A, Mann, C, D McDermott, F, T Monson, J R, Neeff, H, Negoi, I, L Ng, J, Nicolaou, M, Palmer, G, Parnaby, C, Pellino, G, C Peterson, A, Quyn, A, Rogers, A, Rothbarth, J, Abu Saadeh, F, Saklani, A, Sammour, T, Sayyed, R, J Smart, N, Smith, T, Sorrentino, L, R Steele, S, Stitzenberg, K, Taylor, C, Teras, J, R Thanapal, M, Thorgersen, E, Vasquez-Jimenez, W, Waller, J, Weber, K

الوصف: Background: Empty pelvis syndrome (EPS) is a significant source of morbidity following pelvic exenteration (PE), but is undefined. EPS outcome reporting and descriptors of radicality of PE are inconsistent; therefore, the best approaches for prevention are unknown. To facilitate future research into EPS, the aim of this study is to define a measurable core outcome set, core descriptor set and written definition for EPS. Consensus on strategies to mitigate EPS was also explored. Method: Three-stage consensus methodology was used: longlisting with systematic review, healthcare professional event, patient engagement, and Delphi-piloting; shortlisting with two rounds of modified Delphi; and a confirmatory stage using a modified nominal group technique. This included a selection of measurement instruments, and iterative generation of a written EPS definition. Results: One hundred and three and 119 participants took part in the modified Delphi and consensus meetings, respectively. This encompassed international patient and healthcare professional representation with multidisciplinary input. Seventy statements were longlisted, seven core outcomes (bowel obstruction, enteroperineal fistula, chronic perineal sinus, infected pelvic collection, bowel obstruction, morbidity from reconstruction, re-intervention, and quality of life), and four core descriptors (magnitude of surgery, radiotherapy-induced damage, methods of reconstruction, and changes in volume of pelvic dead space) reached consensus-where applicable, measurement of these outcomes and descriptors was defined. A written definition for EPS was agreed. Conclusions: EPS is an area of unmet research and clinical need. This study provides an agreed definition and core data set for EPS to facilitate further research.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38456677; volume:111; issue:3; journal:BRITISH JOURNAL OF SURGERY; https://hdl.handle.net/11591/522719Test

الإتاحة: https://doi.org/10.1093/bjs/znae042Test
https://hdl.handle.net/11591/522719Test

المؤلفون: A. J. Heideveld‐Chevalking, H. Calsbeek, J. Hofland, W. J. H. J. Meijerink, A. P. Wolff

المصدر: BJS Open, Vol 4, Iss 2, Pp 197-205 (2020)

مصطلحات موضوعية: Surgery, RD1-811

الوصف: Background Serious preventable surgical events still occur despite considerable efforts to improve patient safety. In addition to learning from retrospective analyses, prospective risk‐assessment methods may help to decrease preventable events further by targeting perioperative hazards. The aim of this systematic review was to assess the methods used to identify perioperative patient safety risks prospectively, and to describe the risk areas targeted, the quality characteristics and feasibility of methods. Methods MEDLINE, Embase, CINAHL and Cochrane databases were searched, adhering to PRISMA guidelines. All studies describing the development and results of prospective methods to identify perioperative patient safety risks were included and assessed on methodological quality. Exclusion criteria were interventional studies, studies targeting one specific issue, studies reporting on structural factors relating to fundamental hospital items, and non‐original or case studies. Results The electronic search resulted in 16 708 publications, but only 20 were included for final analysis, describing five prospective risk‐assessment methods. Direct observation was used in most studies, often in combination. Direct (16 studies) and indirect (4 studies) observations identified (potential) adverse events (P)AEs, process flow disruptions, poor protocol compliance and poor practice performance. (Modified) Healthcare Failure Mode and Effect Analysis (HFMEA™) (5 studies) targeted potential process flow disruption failures, and direct (P)AE surveillance (3 studies) identified (P)AEs prospectively. Questionnaires (3 studies) identified poor protocol compliance, surgical flow disturbances and patients' willingness to ask questions about their care. Overall, quality characteristics and feasibility of the methods were poorly reported. Conclusion The direct (in‐person) observation appears to be the primary prospective risk‐assessment method that currently may best help to target perioperative hazards. This is a reliable method and covers a broad spectrum of perioperative risk areas.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2474-9842Test

الوصول الحر: https://doaj.org/article/128d7193e8624eb59c7527da65ffc7abTest

المؤلفون: Janine F. J. Meijerink, Marieke Pronk, Birgit I. Lissenberg-Witte, Vera Jansen, Sophia E. Kramer

المصدر: Frontiers in Medicine, Vol 8 (2021)

مصطلحات موضوعية: process evaluation, communication program, eHealth, hearing aid users, implementation, hearing aid dispensing practice, Medicine (General), R5-920

الوصف: Objectives: To evaluate the process of implementing a web-based support program (SUPR) for hearing aid users in the Dutch dispensing setting in order to allow interpretation of the randomized controlled trial's results (positive effects on hearing-aid related outcomes; no effects on psychosocial outcomes).Design: Measures: context of implementation, recruitment, SUPR's: reach, implementation fidelity, dose delivered, dose received, satisfaction, and benefit. Data collection: quantitative and qualitative.Study Sample: One hundred thirty-eight clients (mean age 68.1 years; 60% male) and 44 dispensers completed questionnaires. Five clients and 6 dispensers participated in interviews and focus groups.Results: Clients and dispensers were generally satisfied with SUPR's usefulness. SUPR-videos were watched by 7–37% of the clients. Around half of the dispensers encouraged clients to watch them or informed them about SUPR. Some clients found the SUPR-materials suboptimal, and changes in personnel and limited dispenser-training were barriers acting on a contextual level.Conclusions: This study identified several factors that contributed to the success of SUPR. Others factors, acting on various levels (e.g., intervention material, dispensers, and implementation context), were suboptimal and may explain the absent psychosocial effects. The identified factors are important to consider in further development of SUPR, and in other web-based support programs.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmed.2021.725388/fullTest; https://doaj.org/toc/2296-858XTest

الوصول الحر: https://doaj.org/article/fa8cfb12bd1e4e74a676a281428d7022Test

المؤلفون: Lennert Molenaar, Melissa M. Horstman van de Loosdrecht, Lejla Alic, Joop van Baarlen, Jeroen J. H. J. Meijerink, Bennie ten Haken, Ivo A. M. J. Broeders, Daan J. Lips

المساهمون: Magnetic Detection and Imaging, TechMed Centre, Robotics and Mechatronics

المصدر: Nano LIFE, 12(03):2250006. World Scientific Press
Nano Life, 12, 03
Nano Life, 12

مصطلحات موضوعية: Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Environmental Engineering, All institutes and research themes of the Radboud University Medical Center

الوصف: En-bloc tumor resection is the standard treatment for locally advanced colorectal cancer (CRC). An extensive histopathological assessment is necessary to evaluate the metastatic spread and adjuvant therapy. Sentinel lymph node biopsy decreases the histopathological burden when only sentinel lymph nodes (SLNs) are examined. This study aims to evaluate the spread of a magnetic tracer throughout the lymphatic system after ex vivo injection in en-bloc resected specimens of patients with CRC. To achieve this, lymph nodes (LNs) were quantified using a new magnetic detection method. Fifteen patients with CRC diagnosed with clinically negative LNs were included in this study and received 2–4 ex vivo magnetic tracer injections (total volume of 2[Formula: see text]mL). Magnetic sample series were acquired to create a look-up table for magnetic tracer quantification. In 80% of the patients, at least one magnetic LN was detected. A total of 33 LNs were marked as magnetic, containing an average of 8.1[Formula: see text][Formula: see text]g iron. In 71% of the patients, metastases were found in nonmagnetic LNs. Ex vivo injection leads to sub-optimal tracer spread and therefore inaccurate diagnosis. This study presents a novel magnetic detection method to quantify magnetic tracer in lymph nodes. Detecting the SLNs in en-bloc resected specimens and involving only these LNs in histopathological investigation enable a decrease in healthcare costs or an increased diagnostic potential.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32f4a2a0992f5624755b98914ec94d8Test
https://doi.org/10.1142/s1793984422500064Test

المؤلفون: Marieke Pronk, Birgit I. Lissenberg-Witte, Sophia E. Kramer, Janine F. J. Meijerink, Vera Jansen

المساهمون: Otolaryngology / Head & Neck Surgery, APH - Quality of Care, APH - Aging & Later Life, Epidemiology and Data Science, APH - Methodology

المصدر: Meijerink, J F J, Pronk, M, Lissenberg-Witte, B I, Jansen, V & Kramer, S E 2022, ' Effectiveness of a web-based SUpport PRogramme (SUPR) for communication partners of persons with hearing loss: results of a two-arm, cluster randomised controlled trial and process evaluation ', International Journal of Audiology, vol. 61, no. 7, 61(7), pp. 539-550 . https://doi.org/10.1080/14992027.2021.1937718Test
International Journal of Audiology, 61(7):61(7), 539-550. Taylor and Francis

مصطلحات موضوعية: Linguistics and Language, medicine.medical_specialty, Internet, business.industry, Hearing loss, Communication, Cost-Benefit Analysis, Audiology, Deafness, Language and Linguistics, law.invention, Speech and Hearing, Hearing Aids, Randomized controlled trial, Audiologic Rehabilitation, law, Physical therapy, Medicine, Web application, Humans, Cluster randomised controlled trial, medicine.symptom, Process evaluation, business, Hearing Loss

الوصف: Objectives: To examine the effects of web-based SUpport PRogram (SUPR) for communication partners (CPs) of persons with hearing loss (PHLs) in a HA dispensing setting. Design: Cluster randomised controlled trial (cRCT) with two arms (SUPR: Booklet, online videos; care as usual: no support) plus process evaluation. Measurements: baseline, and immediately-, six, and 12 months post-intervention. Outcomes: Significant Other Scale for Hearing Disability (SOS-HEAR), International Outcome Inventory for HAs/Alternative Interventions for Significant Others (IOI-HA/AI-SO). Process evaluation: dose-received, satisfaction, and benefit. Study sample: The cRCT included 73 (SUPR) and 57 (care as usual) CPs. In the process evaluation study, 41 CPs (SUPR) participated. Results: There were no significant effects of SUPR for third-party disability (SOS-HEAR), the proxy report (IOI-HA-SO item “use”), and third-party disability (IOI-HA-SO items “satisfaction”, and “quality of life”). SUPR-videos were watched by 15-22% of the CPs. SUPR materials were rated as moderately beneficial and useful. Conclusions: Low baseline disability (floor effect) and low intervention dose-received may explain the findings. Directly targeting CPs rather than via their PHLs and providing intervention materials specifically for CPs may improve their engagement and contribute to SUPR’s value supplementary to standard HA care.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab7e8feceb7255f4339d51e22a2a127Test
https://research.vumc.nl/en/publications/224a313a-52fc-46e6-bd1c-9388f3106a43Test

المؤلفون: Sophia E. Kramer, Janine F. J. Meijerink, Marieke Pronk

المساهمون: Otolaryngology / Head & Neck Surgery, APH - Aging & Later Life, APH - Quality of Care

المصدر: Meijerink, J F J, Pronk, M & Kramer, S E 2020, ' Experiences with and lessons learned from developing, implementing, and evaluating a support program for older hearing aid users and their communication partners in the hearing aid dispensing setting ', American Journal of Audiology, vol. 29, no. 3 Special Issue, pp. 638-647 . https://doi.org/10.1044/2020_AJA-19-00072Test
American Journal of Audiology, 29(3 Special Issue), 638-647. American Speech-Language-Hearing Association (ASHA)

مصطلحات موضوعية: Hearing aid, Research design, medicine.medical_specialty, 020205 medical informatics, Computer science, medicine.medical_treatment, Psychological intervention, Context (language use), 02 engineering and technology, Audiology, 03 medical and health sciences, Speech and Hearing, 0302 clinical medicine, Hearing Aids, Patient Education as Topic, 0202 electrical engineering, electronic engineering, information engineering, medicine, Humans, Correction of Hearing Impairment, Program Development, 030223 otorhinolaryngology, Hearing Loss, Implementation Science, Randomized Controlled Trials as Topic, Medical education, Self-Management, Process Assessment, Health Care, Aural rehabilitation, General partnership, Scale (social sciences), Strengths and weaknesses, Internet-Based Intervention, Program Evaluation

الوصف: Purpose The SUpport PRogram (SUPR) study was carried out in the context of a private academic partnership and is the first study to evaluate the long-term effects of a communication program (SUPR) for older hearing aid users and their communication partners on a large scale in a hearing aid dispensing setting. The purpose of this research note is to reflect on the lessons that we learned during the different development, implementation, and evaluation phases of the SUPR project. Procedure This research note describes the procedures that were followed during the different phases of the SUPR project and provides a critical discussion to describe the strengths and weaknesses of the approach taken. Conclusion This research note might provide researchers and intervention developers with useful insights as to how aural rehabilitation interventions, such as the SUPR, can be developed by incorporating the needs of the different stakeholders, evaluated by using a robust research design (including a large sample size and a longer term follow-up assessment), and implemented widely by collaborating with a private partner (hearing aid dispensing practice chain).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78e8a21351ee8ca31d0035bd1133febTest
https://doi.org/10.1044/2020_aja-19-00072Test

المؤلفون: Andreas J A Bremers, Wilhelmus J. H. J. Meijerink, P.R. de Reuver, C.J.H.M. van Laarhoven, D. Strijker, B. van den Heuvel

المصدر: European Journal of Surgical Oncology, 48, 3, pp. 657-665
European Journal of Surgical Oncology, 48, 657-665

مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, Prehabilitation, Hyperthermic Intraperitoneal Chemotherapy, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], medicine, Humans, In patient, Intensive care medicine, Peritoneal Neoplasms, business.industry, Mortality rate, Postoperative complication, Preoperative Exercise, General Medicine, Cytoreduction Surgical Procedures, Hyperthermia, Induced, Combined Modality Therapy, Colorectal surgery, Peritoneal carcinomatosis, Survival Rate, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Oncology, Quality of Life, Smoking cessation, Surgery, Hyperthermic intraperitoneal chemotherapy, business

الوصف: Contains fulltext : 248643.pdf (Publisher’s version ) (Open Access) BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) leads to increased survival rates in patients with peritoneal carcinomatosis, but is associated with considerable morbidity and mortality rates. Prehabilitation, a process to optimize a patient's preoperative functional capacity, has a positive impact on recovery after colorectal surgery. The impact of prehabilitation in patients undergoing HIPEC is scarcely investigated. This scoping review and narrative synthesis aims to summarize and evaluate what is currently reported about the effect of prehabilitation on postoperative outcomes after HIPEC. METHODS: A literature search of studies reporting on the effect of prehabilitation on outcomes after HIPEC was performed (August 2020). Study characteristics, patient demographics, composition of prehabilitation programs, and reported outcomes used to quantify the effect of prehabilitation were recorded. RESULTS: The literature search did not yield any studies on the effect of prehabilitation programs on outcomes after HIPEC. As an alternative, studies identifying modifiable risk factors for poor postoperative outcomes after HIPEC that can be targeted by prehabilitation were reviewed to evaluate starting points for prehabilitation. Fourteen studies identify the following preoperative factors: poor nutritional status, poor performance status, low health related quality of life and an history of smoking. CONCLUSION: No research has been published on the effect of prehabilitation prior to HIPEC. This review demonstrates that preoperative modifiable risk factors for outcomes in patients undergoing HIPEC are multifactorial. A multimodal prehabilitation program prior to HIPEC, including nutritional support, psychical exercise, psychological support and smoking cessation, might therefore be a promising approach to improve postoperative outcomes.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819a23330439618a01d22bd8ea6b3dceTest
https://doi.org/10.1016Test/j.ejso.2021.10.006

المؤلفون: Wilhelmus J. H. J. Meijerink, J. Hofland, André Wolff, Anita J Heideveld-Chevalking, H Calsbeek

المصدر: BJS Open, Vol 4, Iss 2, Pp 197-205 (2020)
BJS Open, 4, 197-205
BJS Open
BJS Open, 4, 2, pp. 197-205

مصطلحات موضوعية: medicine.medical_specialty, Systematic Reviews, MEDLINE, lcsh:Surgery, CINAHL, 030230 surgery, Risk Assessment, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 03 medical and health sciences, Patient safety, 0302 clinical medicine, Risk Factors, Health care, Medicine, Humans, Prospective Studies, Adverse effect, Intensive care medicine, Prospective cohort study, General, Perioperative Period, business.industry, Other Research Radboud Institute for Health Sciences [Radboudumc 0], General Medicine, Perioperative, lcsh:RD1-811, Surgical Procedures, Operative, Systematic Review, Patient Safety, business, Risk assessment

الوصف: Background Serious preventable surgical events still occur despite considerable efforts to improve patient safety. In addition to learning from retrospective analyses, prospective risk‐assessment methods may help to decrease preventable events further by targeting perioperative hazards. The aim of this systematic review was to assess the methods used to identify perioperative patient safety risks prospectively, and to describe the risk areas targeted, the quality characteristics and feasibility of methods. Methods MEDLINE, Embase, CINAHL and Cochrane databases were searched, adhering to PRISMA guidelines. All studies describing the development and results of prospective methods to identify perioperative patient safety risks were included and assessed on methodological quality. Exclusion criteria were interventional studies, studies targeting one specific issue, studies reporting on structural factors relating to fundamental hospital items, and non‐original or case studies. Results The electronic search resulted in 16 708 publications, but only 20 were included for final analysis, describing five prospective risk‐assessment methods. Direct observation was used in most studies, often in combination. Direct (16 studies) and indirect (4 studies) observations identified (potential) adverse events (P)AEs, process flow disruptions, poor protocol compliance and poor practice performance. (Modified) Healthcare Failure Mode and Effect Analysis (HFMEA™) (5 studies) targeted potential process flow disruption failures, and direct (P)AE surveillance (3 studies) identified (P)AEs prospectively. Questionnaires (3 studies) identified poor protocol compliance, surgical flow disturbances and patients' willingness to ask questions about their care. Overall, quality characteristics and feasibility of the methods were poorly reported. Conclusion The direct (in‐person) observation appears to be the primary prospective risk‐assessment method that currently may best help to target perioperative hazards. This is a reliable method and covers a broad spectrum of perioperative risk areas.
Serious preventable surgical events continue to occur despite considerable efforts to improve patient safety. This systematic literature review provides an overview of prospective risk‐assessment methods used proactively to identify and target hazardous failures and preventable patient harm in perioperative patient care. Patient safety risk factors

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe6911c34b3a2ae93246f980469a244Test
https://hdl.handle.net/2066/218905Test