المؤلفون: Campbell P. J. a, abpEmail Author, Getz G. b, c d, eEmail Author, Korbel J. O. f, gEmail Author, Stuart, J. M. hEmail Author, Jennings J. L. i, j Stein, L. D. k, lEmail Author, Perry M. D. m, n Nahal-Bose, H. K. n Ouellette, B. F. F. o p, Li C. H. k, q Rheinbay, E. b e, r Nielsen, G. P. r Sgroi, D. C. r Wu, C. -L. r, Faquin W. C. r, Deshpande V. r, Boutros P. C. k, q s, t Lazar, A. J. u Hoadley, K. A. v w, Louis D. N. r, Dursi L. J. k, x Yung, C. K. n Bailey, M. H. y z, Saksena G. b, Raine, K. M. abp, Buchhalter, I. aa, ab ac, Kleinheinz, K. aa, ac Schlesner, M. aa, ad Zhang, J. n Wang, W. ae, Wheeler, D. A. af, ag Ding, L. y z, ah Simpson, J. T. k ai, O’Connor B. D. n, aj Yakneen, S. g Ellrott, K. ak, Miyoshi, N. al, Butler, A. P. abp, Royo, R. am, Shorser S. I. k, Vazquez, M. am, an Rausch, T. g Tiao, G. b Waszak, S. M. g Rodriguez-Martin, B. ao, ap aq, Shringarpure, S. ar, Wu, D. -Y. as, Demidov, G. M. at, au av, Delaneau, O. aw, ax ay, Hayashi, S. al, Imoto, Habermann N. g, Segre A. V. b, az Garrison, E. abp, Cafferkey A. f, Alvarez, E. G. ao, Heredia-Genestar, J. M. ba, Muyas, F. at, Drechsel, O. at, av Bruzos, A. L. ao, Temes, J. ao, ap Zamora, abp Baez-Ortega, A. bb, Kim, H. -L. bc, Mashl R. J. z, bd Ye, K. be, bf DiBiase, A. bg, Huang, K. -L. z, bh Letunic, I. bi, McLellan M. D. y, z ah, Newhouse S. J. f, Shmaya, T. as, Kumar, S. bj, bk Wedge, D. C. bl, bm abp, Wright, M. H. ar, Yellapantula, V. D. bn, bo Gerstein, M. bj, bk bp, Khurana, E. bq, br bs, bt Marques-Bonet, T. bu, bv bw, bx Navarro, A. bu, Bustamante, C. D. ar, by Siebert, R. bz, ca Nakagawa, H. cb, Easton, D. F. cc, cd Ossowski, S. at, Tubio, J. M. C. ao, De La Vega, F. M. ar, as by, Estivill, X. at, ce Yuen, D. k Mihaiescu, G. L. n Omberg, L. cf, Ferretti V. n, cg Sabarinathan, R. ch, ci cj, Pich, O. ch, cj Gonzalez-Perez, A. ch, cj Taylor-Weiner, A. ck, Fittall, M. W. cl, Demeulemeester, J. cl, cm Tarabichi, M. cl, abp Roberts, N. D. abp, Van Loo, P. cl, cm Cortés-Ciriano, I. cn, co cp, Urban L. f, g Park, P. co, cp Zhu, B. cq, Pitkänen E. g, Li, Y. abp, Saini, N. cr, Klimczak, L. J. cs, Weischenfeldt J. g, ct cu, Sidiropoulos, N. cu, Alexandrov, L. B. cv, abp Rabionet, R. at, av cw, Escaramis, G. at, cx cy, Bosio, at av, Holik, A. Z. at, Susak, H. at, av Prasad, A. av, Erkek S. g, Calabrese C. f, g Raeder, B. g Harrington, E. cz, Mayes, S. da, Turner, D. da, Juul, S. cz, Roberts, S. A. db, Song, L. cq, Koster, R. dc, Mirabello, Hua, X. cq, Tanskanen, T. J. dd, Tojo, M. aq, Chen, J. bk, de Aaltonen, L. A. df, Rätsch, G. dg, dh di, dj dk, dl Schwarz, R. F. f dm, dn do, Butte, A. J. dp, Brazma A. f, Chanock, S. J. cq, Chatterjee, N. dq, dr Stegle, O. f g, ds Harismendy, O. dt, Bova, G. S. du, Gordenin, D. A. cr, Haan D. h, Sieverling, L. dv, dw Feuerbach, Chalmers, D. dx, Joly, Y. dy, Knoppers, B. dy, Molnár-Gábor, F. dz, Phillips, M. dy, Thorogood, A. dy, Townend, D. dy, Goldman, M. ea, Fonseca N. A. f, eb Xiang, Q. n Craft, B. ea, Piñeiro-Yáñez, E. ec, Muñoz A. f, Petryszak R. f, Füllgrabe A. f, Al-Shahrour, F. ec, Keays M. f, Haussler, D. ea, ed Weinstein, J. ee, ef Huber, W. g Valencia, A. am, bw Papatheodorou, I. f Zhu, J. ea, Fan, Y. ae, Torrents, D. am, bw Bieg, M. eg, eh Chen, K. ei, Chong, Z. ej, Cibulskis K. b, Eils, R. aa, ac ek, el Fulton, R. S. y z, ah Gelpi, J. L. am, em Gonzalez, S. f g, Gut, I. G. av, bu Hach, F. en, eo Heinold, ac Hu, T. ep, Huang V. k, Hutter, B. eh, eq er, Jäger, N. aa, Jung, J. es, Y. ep, Lalansingh C. k, Leshchiner I. b, Livitz D. b, Ma, E. Z. ep, Maruvka Y. E. b, r et, Milovanovic, Nielsen, M. M. eu, Paramasivam, eh Pedersen, J. S. eu, ev Puiggròs, Sahinalp, S. C. eo, ew ex, Sarrafi, I. eo, ex Stewart, C. b Stobbe, M. D. av, bu Wala, J. A. b e, ey Wang, J. z be, ez Wendl, M. z fa, fb Werner, J. aa, fc Wu, Z. ep, Xue, H. ep, Yamaguchi T. N. k, V. bn, bo Davis-Dusenbery, B. N. fd, Grossman, R. L. fe, Y. ff, fg Heinold, M. C. aa, ac Hinton, J. abp, Jones, D. R. abp, Menzies, A. abp, Stebbings, L. abp, Hess J. M. b, et Rosenberg, M. b r, Dunford A. J. b, Gupta M. b, Imielinski, M. fh, fi Meyerson, M. b e, ey Beroukhim, R. b e, fj Reimand, J. k q, Dhingra, P. br, bt Favero, F. fk, Dentro, S. bl, cl abp, Wintersinger, J. fl, fm fn, Rudneva V. g, Park, J. W. fo, Hong, E. P. fo, Heo, S. G. fo, Kahles, A. dg, Lehmann, K. -V. dg, di dj, fp fq, Soulette, C. M. aj, Shiraishi, Y. al, Liu, F. fr, fs He, Y. fr, Demircioğlu, D. ft, fu Davidson, N. R. dg, dl fp, Greger L. f, S. fv, fw Liu, D. fv, fw Stark, S. G. dj, fp fx, fy Zhang, Amin, S. B. fz, ga gb, Bailey, P. gc, Chateigner A. n, Frenkel-Morgenstern, M. gd, Hou, Y. fv, fw Huska, M. R. dm, Kilpinen, H. ge, Lamaze F. C. k, C. fv, fw Li, X. fv, fw Marin, M. G. aj, Markowski, J. dm, Nandi, T. gf, Ojesina, A. I. gg, gh gi, Pan-Hammarström, Q. fv, gj Park, P. J. co, cp Pedamallu, C. S. b e, fj Su, H. fv, fw Tan, P. gf, gk gl, gm Teh, B. T. gk, gl gm, gn go, Wang, J. fv, Xiong, fw Ye, fw Yung, C. n Zhang, Zheng, L. fr, Zhu, fw Awadalla, P. k l, Creighton, C. J. gp, K. fv, fw Yang, Göke, J. ft, gq Zhang, Z. fr, gr Brooks, A. N. b aj, ey Fittall, Martincorena, I. abp, Rubio-Perez, C. ch, cj gs, M. eu, Schumacher S. b, gt Shapira, O. b ey, Tamborero, D. ch, cj Mularoni, L. ch, cj Hornshøj, H. eu, Deu-Pons, J. cj, gu Muiños, F. ch, cj Bertl, J. eu, gv Guo, Q. ev, Gonzalez-Perez, cj gw, Xiang, Q. gx, Bazant W. f, Barrera E. f, Al-Sedairy, S. T. gy, Aretz, A. gz, Bell, C. ha, Betancourt, M. hb, Buchholz, C. hc, Calvo, F. hd, Chomienne, C. he, Dunn, M. hf, Edmonds, S. hg, Green, E. hh, Gupta, S. hi, C. M. hh, Jegalian, K. hj, N. hk, Lu, Y. hl, hm hn, Nakagama, H. ho, Nettekoven, G. hp, Planko, L. hp, Scott, D. hk, Shibata, T. hq, hr Shimizu, K. hs, Stratton, M. R. abp, Yugawa, T. hs, Tortora, G. ht, hu VijayRaghavan, K. hi, Zenklusen, J. C. hv, D. hw, B. M. dy, Aminou B. n, Bartolome, J. am, Boroevich, K. A. cb, hx Boyce, R. f Buchanan, A. ak, Byrne N. J. n, Z. hy, Cho, S. hz, Choi, W. ia, Clapham, P. abp, Dow, M. T. hy, x Eils, J. ek, el Farcas, C. hy, Fayzullaev N. n, Flicek P. f, Heath, A. P. ib, Hofmann, O. ic, J. H. id, Hudson, T. J. ie, if Hübschmann, D. ac, do ek, ig ih, Ivkovic, S. ii, Jeon, S. -H. ia, Jiao W. k, Kabbe, dj fq, Kerssemakers, J. N. A. aa, H. ia, J. ij, Koscher, M. ik, Koures, A. hy, Kovacevic, M. ii, Lawerenz, C. el, J. il, Mijalkovic, Mijalkovic-Lazic, A. M. ii, Miyano, Nastic, Nicholson, Ocana D. f, Ohi, K. al, Ohno-Machado, L. hy, Pihl, T. D. im, Prinz, Radovic, P. ii, Short C. f, Sofia, H. J. hh, Spring, J. fe, Struck, A. J. ak, Tijanic, N. ii, Vicente, Z. hv, Williams, Woo, Y. ia, Wright A. J. k, Yang, L. hv, Hamilton, M. P. in, Johnson, T. A. hx, Kahraman, A. io, ip iq, Kellis M. b, ir Polak, P. b c, e Sallari, R. b Sinnott-Armstrong, N. b ar, von Mering, C. iq, is Beltran, S. av, bu Gerhard, D. S. it, M. av, bu Trotta, J. -R. bu, Whalley, J. P. bu, Niu, B. iu, Espiritu S. M. G. k, Gao, Y. ez, iv Lalansingh, C. M. k Teague, J. W. abp, Wendl M. C. z, fa fb, Abascal, F. abp, Bader G. D. l, Bandopadhayay P. b, iw ix, Barenboim J. k, Brunak, S. iy, iz Carlevaro-Fita, J. ja, jb jc, Chakravarty, D. jd, je Chan, C. W. Y. aa, dw Choi, J. K. jf, Diamanti, K. jg, Fink, jh Frigola, J. gu, Gambacorti-Passerini, C. ji, Garsed, D. W. jj, Haradhvala N. J. b, r Harmanci, A. O. bk, jk Helmy, M. fm, Herrmann, C. aa, ac jl, Hobolth, A. ev, gv Hodzic, E. ex, C. dv, dw Isaev, K. k q, Izarzugaza, J. M. G. iy, R. jb, jm Juul, R. I. eu, Kim J. b, J. K. jn, Jan Komorowskijg, jo Lanzós, A. jb, jc jm, Larsson, E. dg, Lee, D. bk, S. bk, X. bk, Lin Z. b, jp Liu, E. M. br, bt jq, Lochovsky, L. bj, bk gb, Lou, bk Madsen, T. eu, Marchal, K. jr, js Martinez-Fundichely, A. br, bs bt, McGillivray, P. D. bj, Meyerson, W. bk, jt Paczkowska, M. k Park, K. ju, jv Park, K. jw, Pons, T. jx, Pulido-Tamayo, S. jr, js Reyes-Salazar, I. ch, Reyna, M. A. jy, Rubin, M. A. jm, jz ka, kb kc, Salichos, bk Sander, C. dg, ey kd, ke Schumacher, S. E. b gt, Shackleton, M. jj, Shen, C. ke, kf Shrestha, R. eo, Shuai S. k, l Tsunoda, T. hx, kg kh, ki Umer, H. M. jg, kj Uusküla-Reimand, L. kk, kl Verbeke, L. P. C. js, km Wadelius, C. kn, Wadi L. k, Warrell, J. bj, bk Wu, G. ko, Yu, J. kp, Zhang, X. ez, kq Zhang, Y. bk, kr ks, Zhao, Z. kt, Zou, L. ku, Lawrence M. S. b, r hx, Raphael, B. J. jy, P. J. gc, Craft D. b, kv Goldman, M. J. ea, Aburatani, H. kw, Binder, H. kx, ky Dinh, H. Q. kz, S. C. av, bu Hoffmann, S. kx, ky la, lb Imbusch, C. D. dv, Kretzmer, H. ky, lb Laird, P. W. lc, Martin-Subero, J. I. bw, ld Nagae, G. kw, le Shen, H. lf, Q. ik, Weichenhan, D. lg, Zhou, W. lf, Berman, B. P. kz, lh li, Brors, B. dv, er lj, Plass, C. lg, Akdemir, K. C. ei, Bowtell, D. D. L. jj, Burns, K. H. lk, ll Busanovich, J. b lm, Chan, K. ln, Dueso-Barroso, Edwards, P. A. lo, lp Etemadmoghadam, D. jj, Haber, J. E. lq, D. T. W. lr, ls Ju, Y. S. jf, abp Kazanov, M. D. lt, lu lv, Koh, Y. lw, lx Kumar, K. b Lee, E. A. ly, J. J. -K. co, cp Lynch, A. G. lo, lp lz, Macintyre, G. lo, Markowetz, F. lo, lp Navarro, F. C. P. bj, Pearson, J. V. ma, mb Rippe, K. do, Scully, R. mc, Villasante, I. am, Waddell, N. ma, mb Yang, L. md, Yao, X. fh, me Yoon, S. -S. lx, C. -Z. b, e ey, Bergstrom, E. N. mf, Boot, A. gl, mg Covington, K. ag, Fujimoto, A. cb, M. N. gl, mg Islam, S. M. A. cv, McPherson, J. R. gl, mg Morganella, S. abp, Mustonen, V. mh, mi mj, Ng, A. W. T. mk, Prokopec S. D. k, Vázquez-García, I. bn, ml mm, abp Wu, Y. gl, mg Yousif, F. k Yu, W. mn, Rozen, S. G. gl, gm mg, Rudneva V. A. g, S. S. ar, D. J. da, Xia, T. mo, Atwal G. k, l fn, Chang, D. K. gc, mp Cooke, S. L. gc, Faltas, B. M. dl, Haider S. k, Kaiser, V. B. mq, Karlić, R. mr, Kato, M. ms, Kübler K. b, e r, Margolin, Martin, S. mt, abp Nik-Zainal, S. mu, mv mw, abp P’ng, C. k Semple, C. A. mq, Smith, J. ak, Sun R. X. k, Thai K. n, D. W. mx, my Yuan, K. lo, mt mz, Biankin, A. V. gc, mp na, nb Garraway, L. ey, Grimmond, S. M. nc, Adams, D. J. abp, Anur, P. nd, Cao, S. ae, Christie, E. L. jj, Cmero, M. ne, nf ng, Cun, Y. nh, Dawson, K. J. abp, S. C. bl, Deshwar, A. G. ni, Donmez, N. eo, ex Drews, R. M. lo, Gerstung M. f, g Ha, G. b Haase, K. cl, Jerman L. g, nj Ji, Y. nk, nl Jolly, C. cl, J. nm, Lee-Six, H. abp, Malikic, S. eo, ex Mitchell, T. J. lp, nn abp, Morris, Q. D. fn, no Oesper, L. np, Peifer, M. nh, Peto, M. nq, Rosebrock D. b, Rubanova, Y. ai, fn Salcedo, A. k Sengupta, S. nr, Shi, R. no, Shin, S. J. fy, Spiro O. b, Vembu, S. no, ns Wintersinger, J. A. fl, T. -P. nh, K. nt, H. nu, nv Spellman, P. T. nw, Weinstein, J. N. ee, ef Chen, Fujita, M. cb, Han, L. kq, Hasegawa, T. al, Komura, M. al, J. ae, Mizuno, S. nx, Shimizu, E. al, ny Xu, Y. nz, Yamaguchi, R. al, F. no, Y. kq, Yoon, C. J. jf, Yuan, Liang, H. ae, Alawi, M. oa, ob Borozan, I. k Brewer, D. S. oc, od Cooper, C. S. od, oe of, Desai N. n, Grundhoff, A. oa, og Iskar, M. oh, Su, X. oi, Zapatka, Lichter, P. eq, oh Alsop, K. jj, Bruxner, T. J. C. jh, Christ, A. N. jh, Cordner, S. M. oj, Cowin, P. A. ok, Drapkin, R. ol, Fereday, S. ok, George, J. gb, A. ok, Holmes, O. ma, mb Hung, J. A. om, on Kassahn, K. S. jh, oo Kazakoff, S. H. ma, mb Kennedy, C. J. op, oq Leonard, C. R. ma, mb Mileshkin, L. jj, Miller, D. K. jh, mp or, Arnau, G. M. ok, Mitchell, C. ok, Newell, F. ma, mb Nones, K. ma, mb Patch, A. -M. ma, mb Quinn, M. C. ma, mb Taylor, D. F. jh, Thorne, H. ok, Traficante, N. ok, Vedururu, R. ok, N. M. mb, Waring, P. M. os, Wood, S. ma, mb Xu, Q. ma, mb deFazio, A. ot, ou ov, Anderson, M. J. jh, Antonello, D. ow, Barbour, A. P. ox, oy Bassi, C. ow, Bersani, S. oz, Cataldo, I. oz, pa Chantrill, L. A. mp, pb Chiew, Y. -E. ot, Chou, A. mp, pc Cingarlini, S. ht, Cloonan, N. pd, Corbo, V. pa, pe Davi, M. V. pf, Duthie, F. R. gc, pg Gill, A. J. mp, pc Graham, J. S. gc, ph Harliwong, I. jh, Jamieson, N. B. gc, nb pi, Johns, A. L. mp, or Kench, J. G. mp, pc pj, Landoni, L. ow, Lawlor, R. T. pa, Mafficini, A. pa, Merrett, N. D. ow, pk Miotto, M. ow, Musgrove, E. A. gc, Nagrial, A. M. mp, Oien, K. A. os, pl Pajic, M. mp, Pinese, M. pm, Robertson, A. J. jh, Rooman, I. mp, Rusev, B. C. pa, Samra, J. S. ow, pc Scardoni, M. oz, Scarlett, C. J. mp, pn Scarpa, Sereni, E. ow, Sikora, K. O. pa, Simbolo, M. pe, Taschuk M. L. n, Toon, C. W. mp, Vicentini, C. pa, J. mp, Zeps, N. po, pp Behren, A. pq, Burke, H. pr, Cebon, J. pq, Dagg, R. A. ps, De Paoli-Iseppi, R. pt, Dutton-Regester, Field, M. A. pu, Fitzgerald, A. pv, Hersey, P. pr, Jakrot, V. pr, Johansson, P. A. ma, Kakavand, H. pt, Kefford, R. F. pw, Lau, L. M. S. px, Long, G. V. py, Pickett, H. A. px, Pritchard, A. L. ma, Pupo, G. M. pz, Saw, R. P. M. py, Schramm, S. -J. qa, Shang, C. A. pv, P. py, Spillane, A. J. py, Stretch, J. R. py, Tembe, V. ot, qa Thompson, J. F. py, Vilain, R. E. qb, Wilmott, J. S. py, J. Y. qc, Hayward, N. K. ma, pr Mann, G. J. ot, qd Scolyer, R. A. ou, py qb, qe Bartlett, J. qf, qg Bavi, P. qh, Chadwick, D. E. qi, Chan-Seng-Yue, M. qh, Cleary, S. qh, qj Connor, A. A. qj, qk Czajka, K. if, Denroche, R. E. qh, Dhani, N. C. ql, Eagles, J. if, Gallinger, qj qk, Grant, R. C. qh, qk Hedley, D. ql, Hollingsworth, M. A. qm, Jang, G. H. qh, Kalimuthu, S. -B. qn, Lungu, I. qh, qo Luo, X. k Mbabaali, F. if, T. A. qk, J. K. if, Moore, M. J. ql, Notta, F. qh, qp Pasternack, D. if, Petersen, G. M. qq, Roehrl M. H. A. q, qh qr, qs qt, Sam, M. if, Selander, I. qk, Serra, S. os, Shahabi, S. qn, Thayer, S. P. qm, Timms, L. E. if, Wilson G. W. k, qh Wilson, J. M. qh, Wouters, B. G. qu, J. D. if, qh qv, Beck T. A. n, qw Bhandari, V. k Collins, C. C. eo, Fleshner, N. E. qx, Fox N. S. k, Fraser M. k, Heisler, L. E. qy, Lalonde E. k, Livingstone J. k, Meng, A. qz, Sabelnykova V. Y. k, Shiah, Y. -J. k, Van der Kwast, T. ra, Bristow R. G. q, rb rc, rd re, Ding, S. rf, D. rg, L. fv, Nie, Y. rg, rh Xiao, Xing, R. hm, ri Yang, Y. rj, Banks, R. E. rk, Bourque, G. rl, rm Brennan, P. rn, Letourneau, L. ro, Riazalhosseini, Y. rm, Scelo, G. rn, Vasudev, N. rk, rp Viksna, J. rq, Lathrop, M. rm, Tost, J. rr, Ahn, S. -M. rs, Aparicio, S. rt, Arnould, L. ru, Aure, M. R. rv, Bhosle, S. G. abp, Birney E. f, Borg, A. rw, Boyault, S. rx, Brinkman, A. B. ry, Brock, J. E. rz, Broeks, A. sa, Børresen-Dale, A. -L. rv, Caldas, C. sb, sc Chin, S. -F. sb, sc Davies, H. mu, mv abp, Desmedt, C. sd, se Dirix, L. sf, Dronov, Ehinger, A. sg, Eyfjord, J. E. sh, Fatima, A. gt, Foekens, J. A. si, Futreal, P. A. sj, Garred, Ø. sk, sl Giri, D. D. sm, Glodzik, D. abp, Grabau, D. sn, Hilmarsdottir, H. sh, Hooijer, G. K. so, Jacquemier, J. sp, S. J. sq, Jonasson, J. G. sh, Jonkers, J. sr, H. -Y. sp, King, T. A. ss, st Knappskog, S. su, abp Kong, G. sp, Krishnamurthy, S. sv, Lakhani, S. R. sw, Langerød, A. rv, Larsimont, D. sx, H. J. sq, J. -Y. sy, M. T. M. sj, Lingjærde, O. C. sz, MacGrogan, G. ta, Martens, J. W. M. si, O’Meara, Pauporté, I. he, Pinder, S. tb, Pivot, X. tc, Provenzano, E. td, Purdie, C. A. te, Ramakrishna, M. abp, Ramakrishnan, K. abp, Reis-Filho, J. sm, Richardson, A. L. gt, Ringnér, M. rw, Rodriguez, J. B. am, Rodríguez-González, F. G. iz, Romieu, G. tf, Salgado, R. os, Sauer, T. sz, Shepherd, R. abp, Sieuwerts, A. M. si, Simpson, P. T. sw, Smid, M. si, Sotiriou, Span, P. N. tg, Stefánsson, Ó. A. th, Stenhouse, A. ti, Stunnenberg, H. G. fw, tj Sweep, F. tk, Tan, B. K. T. tl, Thomas, G. tm, Thompson, A. M. ti, Tommasi, S. tn, Treilleux, I. to, tp Tutt, Ueno, N. T. nv, Van Laere, S. sf, Van den Eynden, G. G. sf, Vermeulen, P. sf, Viari, Vincent-Salomon, A. tj, Wong, B. H. tq, Yates, X. abp, van Deurzen, C. H. M. tr, van de Vijver, M. J. os, van’t Veer, L. ts, Ammerpohl, O. tt, tu tv, Aukema, S. tu, tv tw, Bergmann, A. K. tx, Bernhart, S. H. kx, ky lb, Borkhardt, A. ty, Borst, C. tz, Burkhardt, B. ua, Claviez, A. ub, Goebler, M. E. uc, Haake, A. tt, Haas, S. tz, Hansmann, M. ud, Hoell, J. I. ty, Hummel, M. ue, Karsch, D. uf, Klapper, W. tw, Kneba, M. uf, Kreuz, M. ug, Kube, D. uh, Küppers, R. ui, Lenze, D. ue, Loeffler, López, C. ca, tt Mantovani-Löffler, L. uj, Möller, P. uk, Ott, G. ul, Radlwimmer, B. oh, Richter, J. tt, tw Rohde, M. um, Rosenstiel, P. C. un, Rosenwald, A. uo, Schilhabel, M. B. un, Schreiber, S. up, Stadler, P. F. kx, Staib, P. uq, Stilgenbauer, S. ur, Sungalee S. g, Szczepanowski, M. tw, Toprak, U. H. ac, us Trümper, L. H. P. uh, Wagener, R. ca, tt Zenz, T. er, Hovestadt, V. oh, von Kalle, C. do, Kool, lr Korshunov, A. ik, Landgraf, P. ut, uu Lehrach, H. uv, Northcott, P. A. uw, Pfister, S. M. ik, lr ux, Reifenberger, G. uu, Warnatz, H. -J. uv, Wolf, S. uy, Yaspo, M. -L. uv, Assenov, Y. uz, Gerhauser, Minner, S. va, Schlomm, T. ct, vb Simon, R. vc, Sauter, G. vc, Sültmann, H. er, vd Biswas, N. K. ve, Maitra, A. ve, Majumder, P. P. ve, Sarin, R. vf, Barbi, S. pe, Bonizzato, G. pa, Cantù, Dei Tos, A. P. vg, Fassan, M. vh, Grimaldi, S. pa, Luchini, C. oz, Malleo, G. ow, Marchegiani, Milella, M. ht, Paiella, S. ow, Pea, A. ow, Pederzoli, P. ow, Ruzzenente, Salvia, R. ow, Sperandio, N. pa, Arai, Y. hq, Hama, N. hq, Hiraoka, N. vi, Hosoda, F. hq, Nakamura, H. hq, Ojima, H. vj, Okusaka, T. vk, Totoki, Urushidate, T. hr, Fukayama, M. vl, Ishikawa, S. vm, Katai, H. vn, Katoh, H. vm, D. vm, Rokutan, H. ms, Saito-Adachi, Suzuki, A. kw, vo Taniguchi, H. vp, Tatsuno, K. kw, Ushiku, T. vl, Yachida, S. hq, vq Yamamoto, S. kw, Aikata, H. vr, Arihiro, K. vr, Ariizumi, S. -I. vs, Chayama, Furuta, Gotoh, K. vt, Hayami, S. vu, Hirano, S. vv, Kawakami, Y. vr, Maejima, K. cb, T. vv, Nakano, Ohdan, Sasaki-Oku, Tanaka, H. al, M. vu, Yamamoto, M. vs, Yamaue, H. vu, Choo, S. P. vw, Cutcutache, I. gl, mg Khuntikeo, N. ow, vx Ong, C. K. vy, Pairojkul, C. os, Popescu, I. vz, K. S. wa, Aymerich, M. wb, Lopez-Guillermo, A. wc, López-Otín, C. wd, Puente, X. S. wd, Campo, E. we, wf Amary, F. wg, Baumhoer, D. wh, Behjati, Bjerkehagen, B. wh, wi Futreal, Myklebost, O. su, Pillay, N. wj, Tarpey, P. wk, Tirabosco, R. wl, Zaikova, O. wm, Flanagan, A. M. wn, Boultwood, J. wo, Bowen, D. T. abp, Cazzola, M. wp, A. R. lp, Hellstrom-Lindberg, E. wq, Malcovati, L. wp, Nangalia, J. wr, Papaemmanuil, Vyas, P. ma, ws Ang, Y. wt, Barr, H. wu, Beardsmore, D. wv, Eldridge, M. lo, Gossage, J. ww, Grehan, N. mv, Hanna, G. B. wx, Hayes, S. J. wy, wz Hupp, T. R. xa, Khoo, D. xb, Lagergren, J. wq, xc Lovat, L. B. ge, MacRae, S. ee, O’Donovan, M. mv, O’Neill, J. R. xd, Parsons, S. L. xe, Preston, S. R. xf, Puig, S. xg, Roques, T. xh, Sanders G. w, Sothi, S. xi, Tavaré, S. lo, Tucker, O. xj, Turkington, R. xk, Underwood, T. J. xl, Welch, I. xm, R. C. mv, Berney, D. M. xn, De Bono, J. S. oe, Cahill, D. xo, Camacho, N. oe, Dennis, N. M. xo, Dudderidge, T. xo, xp Edwards, S. E. oe, Fisher, C. xo, Foster, C. S. xq, xr Ghori, Gill, P. ws, Gnanapragasam, V. J. nn, xs Gundem, G. jq, Hamdy, F. C. xt, Hawkins, Hazell, S. xo, Howat, W. nn, Isaacs, W. B. xu, Karaszi, K. ws, Kay, J. D. ge, V. xo, Kote-Jarai, Z. oe, Kremeyer, B. abp, P. xo, Lambert, A. ws, Leongamornlert, D. A. oe, abp Livni, N. xo, Y. -J. xn, xv Luxton, H. J. ge, Marsden, L. ws, Massie, C. E. lo, Matthews, L. oe, Mayer, E. xo, xw McDermott, U. abp, Merson, S. oe, Neal, D. E. lo, nn Ng, A. xx, Nicol, Ogden, Rowe, E. W. xo, Shah, N. C. nn, A. xo, Verrill, C. ws, xy Visakorpi, T. du, Warren, A. Y. nn, xz Whitaker, H. C. ge, H. xv, van As, Eeles, R. A. oe, xo Abeshouse, A. jq, Agrawal, N. fe, Akbani, R. mv, ya Al-Ahmadie, H. jq, Albert, M. qg, Aldape, K. oi, yb Ally, A. yc, Appelbaum E. L. z, ge Armenia, J. yd, Asa, S. xe, ye Auman, J. T. yf, Balasundaram, M. yc, Balu S. w, Barnholtz-Sloan, J. yg, yh Bathe, O. F. yi, yj Baylin, S. B. dr, xp Benz, C. yk, Berchuck, A. yl, Berrios, M. ym, Bigner, D. yn, Birrer M. r, Bodenheimer T. w, Boice, L. xg, Bootwalla, M. S. ym, Bosenberg, M. yo, Bowlby, R. yc, Boyd, J. yp, Broaddus, R. R. oi, M. yq, Brooks, D. yc, Bullman S. b, fj Caesar-Johnson, S. J. hv, Carey, T. E. yr, Carlsen, Cerfolio, R. ys, Chandan, V. S. yt, H. -W. wt, yd Cherniack, A. D. b ey, fj Chien, J. yu, Cho J. b, Chuah, E. yc, Cibulskis C. b, Cope, L. yv, Cordes M. G. z, xh Curley, E. yw, Czerniak, B. oi, xb Danilova, Davis, I. J. yx, Defreitas T. b, Demchok, J. A. hv, Dhalla, N. yc, Dhir, R. yy, Doddapaneni, H. V. ag, El-Naggar, A. oi, xb Felau, I. hv, Ferguson, M. L. yz, Finocchiaro, G. za, Fong, K. M. zb, Frazer S. b, Friedman, W. zc, Fronick C. C. z, xh Fulton, L. A. z Gabriel, S. B. b Gao, Gehlenborg N. b, zd Gershenwald, J. E. ze, zf Ghossein, R. sm, Giama, N. H. zg, Gibbs, R. A. ag, Gomez, C. zh, Govindan R. y, Hayes D. N. w, zi zj, Hegde, A. M. ee, ef Heiman, D. I. b Heins, Z. jq, Hepperla A. J. w, Holbrook, A. ym, Holt, R. A. yc, Hoyle A. P. w, Hruban, R. H. yv, Hu, J. ag, M. xg, Huntsman, D. zk, Huse, J. jq, Iacobuzio-Donahue, C. A. sm, Ittmann, M. zl, zm Jayaseelan, J. C. ag, Jefferys S. R. w, C. D. zn, S. J. M. zo, Juhl, H. zp, Kang, K. J. zq, Karlan, B. zr, Kasaian, K. zo, Kebebew, E. zs, zt Kim, H. K. zu, Korchina, V. ag, Kundra, R. wt, yd Lai, P. H. ym, Lander E. b, Le, X. zv, Levine, D. A. jq, zw Lewis, L. ag, Ley, T. zx, H. I. yc, Lin P. b, Linehan, W. M. zy, F. F. no, Y. ef, Lype, L. zz, Y. yc, Maglinte, D. T. ym, aaa Mardis, E. R. z yp, aab Marks, J. ow, aac Marra, M. A. yc, Matthew, T. J. aj, Mayo, McCune, K. aad, Meier S. R. b, Meng S. w, Mieczkowski P. A. v, Mikkelsen, T. aae, Miller C. A. z, Mills, G. B. aaf, Morrison, aag Mose, L. E. w Moser, C. D. zg, Mungall, A. J. yc, K. yc, Mutch, D. aah, Muzny, D. M. aai, Myers, J. aaj, Newton, Y. aj, Noble M. S. b, O’Donnell, P. aak, B. P. aal, Ochoa, J. -W. aam, Parker, J. S. aan, Pass, H. aao, Pastore, Pennell, N. A. aap, Perou, C. M. aaq, Petrelli, N. aar, Potapova, O. aas, Rader, J. S. aat, Ramalingam, S. aau, Rathmell, W. K. aav, Reuter, V. sm, Reynolds, S. M. zz, Ringel, M. aaw, Roach, J. aax, L. R. zg, A. G. yc, Sadeghi, S. yc, Saller, C. aay, Sanchez-Vega, F. wt, yd Schadendorf, D. eq, aaz Schein, J. E. yc, Schmidt H. K. z, Schultz, N. yd, Seethala, R. aba, Senbabaoglu, Y. dg, Shelton, T. yw, Shi Y. w, Shih J. b, fj Shmulevich, I. zz, Shriver, C. abb, Signoretti, S. fj, jb abc, Simons J. V. w, Singer, abd Sipahimalani, P. yc, Skelly T. J. v, Smith-McCune, Socci, N. D. dg, Soloway, M. G. aan, Sood, A. K. abe, Tam, Tan D. v, Tarnuzzer, R. hv, Thiessen, R. H. abf, L. B. xg, Tsao, M. xe, ye Umbricht, C. lk, wv abg, Van Den Berg, D. J. ym, Van Meir, E. G. abh, Veluvolu U. v, Voet D. b, Weinberger, P. abi, Weisenberger, Wigle, D. abj, Wilkerson M. D. v, Wilson R. K. z, abk Winterhoff, B. abl, Wiznerowicz, M. abm, abn Wong, T. z yc, W. abo, Xi, Yau, Zhang H. b, H. yd, J. hv, The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)

المساهمون: Campbell, P. J. a., Abpemail, Author, Getz, G. b., C, D, Eemail, Author, Korbel, J. O. f., Gemail, Author, Stuart, J. M., hEmail Author, Jennings, J. L. i., J, Stein, L. D., K., Lemail, Author, Perry, M. D. m., N, Nahal-Bose, Ouellette, H. K. n., B. F. F. o., P, Li, C. H. k., Q, Rheinbay, E, E. b., R, Nielsen, Sgroi, G. P. r., D. C. r., Wu, C. -L., R., Faquin, W. C. r., Deshpande, V. r., Boutros, P. C. k., Q, S, T, Lazar, Hoadley, A. J. u., K. A. v., W, Louis, D. N. r., Dursi, L. J. k., X, Yung, Bailey, C. K. n., M. H. y., Z, Saksena, G. b., Raine, K. M., Abp, Buchhalter, I., Aa, Ab, Ac, Kleinheinz, K., Aa, Ac, Schlesner, M., Aa, Ad, Zhang, Wang, J. n., W., Ae, Wheeler, D. A., Af, Ag, Ding, L. y., Z, Ah, Simpson, J. T. k., Ai, O’Connor, B. D. n., Aj, Yakneen, Ellrott, S. g., K., Ak, Miyoshi, N., Al, Butler, A. P., Abp, Royo, R., Am, Shorser, S. I. k., Vazquez, M., Am, An, Rausch, Tiao, T. g., Waszak, G. b., Rodriguez-Martin, S. M. g., B., Ao, Ap, Aq, Shringarpure, S., Ar, Wu, D. -Y., A, Demidov, G. M., At, Au, Av, Delaneau, O., Aw, Ax, Ay, Hayashi, S., Al, Imoto, Habermann, N. g., Segre, A. V. b., Az, Garrison, E., Abp, Cafferkey, A. f., Alvarez, E. G., Ao, Heredia-Genestar, J. M., Ba, Muyas, F., At

مصطلحات موضوعية: genomics, cancer, profiling

الوصف: Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3. Here we report the integrative analysis of 2,658whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10-18.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32025007; info:eu-repo/semantics/altIdentifier/wos/WOS:000511282900007; volume:578; issue:7793; firstpage:82; lastpage:93; numberofpages:12; journal:NATURE; http://hdl.handle.net/11562/1012964Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85079038817

الإتاحة: https://doi.org/10.1038/s41586-020-1969-6Test
http://hdl.handle.net/11562/1012964Test

المؤلفون: Campbell, P. J. a., Abpemail, Author, Getz, G. b., C, D, Eemail, Author, Korbel, J. O. f., Gemail, Author, Stuart, hEmail Author, J. M., Jennings, J. L. i., Stein, J, L. D. k., Lemail, Author, Perry, M. D. m., Nahal-Bose, N, Ouellette, H. K. n., B. F. F. o., P, C. H. k., Li, Rheinbay, Q, E. b., E, Nielsen, R, Sgroi, G. P. r., D. C. r., Wu, C. -L. r., Faquin, W. C. r., Deshpande, V. r., Boutros, P. C. k., Q, S, Lazar, T, Hoadley, A. J. u., K. A. v., W, Louis, D. N. r., Dursi, L. J. k., Yung, X, Bailey, C. K. n., M. H. y., Z, Saksena, G. b., Raine, Abp, K. M., Buchhalter, Aa, I., Ab, Ac, Kleinheinz, Aa, K., Schlesner, Ac, Aa, M., Zhang, Ad, Wang, J. n., Ae, W., Wheeler, D. A., Af, Ding, Ag, L. y., Z, Simpson, Ah, J. T. k., Ai, O’Connor, B. D. n., Yakneen, Aj, Ellrott, S. g., Ak, K., Miyoshi, Al, N., Butler, Abp, A. P., Royo, Am, R., Shorser, S. I. k., Vazquez, Am, M., Rausch, An, Tiao, T. g., Waszak, G. b., Rodriguez-Martin, S. M. g., Ao, B., Ap, Aq, Shringarpure, Ar, S., D. -Y., As, Demidov, G. M., At, Au, Av, Delaneau, Aw, O., Ax, Ay, Hayashi, Al, S., Imoto, Habermann, N. g., Segre, A. V. b., Garrison, Az, Abp, E., Cafferkey, A. f., Alvarez, E. G., Ao, Heredia-Genestar, J. M., Ba, Muyas, At, F., Drechsel, At, O., Bruzos, Av, A. L., Ao, Temes, Ao, J., Zamora, Ap, Abp, Baez-Ortega, Bb, A., Kim, H. -L., Bc, Mashl, R. J. z., Bd, Ye, Be, K., Dibiase, Bf, Bg, A., Huang, K. -L. z., Letunic, Bh, Bi, I., Mclellan, M. D. y., Z, Ah, Newhouse, S. J. f., Shmaya, As, T., Kumar, Bj, S., Wedge, Bk, D. C., Bl, Abp, Bm, Wright, M. H., Ar, Yellapantula, V. D., Bn, Gerstein, Bo, Bj, M., Bk, Bp, Khurana, Bq, E., Br, Bs, Marques-Bonet, Bt, Bu, T., Bv, Bw, Navarro, Bx, Bu, A., Bustamante, C. D., Ar, Siebert, By, Bz, R., Nakagawa, Ca, Cb, H., Easton, D. F., Cc, Ossowski, Cd, At, S., Tubio, J. M. C., Ao, De La Vega, F. M., Ar, As, By, Estivill, At, X., Yuen, Ce, Mihaiescu, D. k., Omberg, G. L. n., Cf, L., Ferretti, V. n., Sabarinathan, Cg, Ch, R., Ci, Cj, Pich, Ch, O., Gonzalez-Perez, Cj, Ch, A., Taylor-Weiner, Cj, Ck, A., Fittall, M. W., Cl, Demeulemeester, Cl, J., Tarabichi, Cm, Cl, M., Abp, Roberts, Abp, N. D., Van, Loo, Cl, P., Cortés-Ciriano, Cm, Cn, I., Co, Cp, Urban, L. f., Park, G, Co, P., Zhu, Cp, Cq, B., Pitkänen, E. g., Abp, Y., Saini, Cr, N., Klimczak, L. J., Cs, Weischenfeldt, J. g., Ct, Cu, Sidiropoulos, Cu, N., Alexandrov, L. B., Cv, Abp, Rabionet, At, R., Av, Cw, Escaramis, At, G., Cx, Cy, Bosio, At, Av, Holik, A. Z., At, Susak, At, H., Prasad, Av, Av, A., Erkek, S. g., Calabrese, C. f., Raeder, G, Harrington, B. g., Cz, E., Mayes, Da, S., Turner, Da, D., Juul, Cz, S., Roberts, S. A., Db, Song, Cq, L., Koster, Dc, R., Mirabello, Hua, Cq, X., Tanskanen, T. J., Dd, Tojo, Aq, M., Chen, Bk, J., Aaltonen, De, L. A., Df, Rätsch, Dg, G., Dh, Di, Dj, Dk, Schwarz, Dl, R. F. f., Dm, Dn, Do, Butte, A. J., Dp, Brazma, A. f., Chanock, S. J., Cq, Chatterjee, Dq, N., Stegle, Dr, O. f., G, Harismendy, Ds, Dt, O., Bova, G. S., Du, Gordenin, D. A., Cr, Haan, D. h., Sieverling, Dv, L., Feuerbach, Dw, Chalmers, Dx, D., Joly, Dy, Y., Knoppers, Dy, B., Molnár-Gábor, Dz, F., Phillips, Dy, M., Thorogood, Dy, A., Townend, Dy, D., Goldman, Ea, M., Fonseca, N. A. f., Xiang, Eb, Craft, Q. n., Ea, B., Piñeiro-Yáñez, Ec, E., Muñoz, A. f., Petryszak, R. f., Füllgrabe, A. f., Al-Shahrour, Ec, F., Keays, M. f., Haussler, Ea, D., Weinstein, Ed, Ee, J., Huber, Ef, Valencia, W. g., Am, A., Papatheodorou, Bw, Zhu, I. f., Ea, J., Fan, Ae, Y., Torrents, Am, D., Bieg, Bw, Eg, M., Chen, Eh, Ei, K., Chong, Ej, Z., Cibulskis, K. b., Eils, Aa, R., Ac, Ek, Fulton, El, R. S. y., Z, Gelpi, Ah, J. L., Am, Gonzalez, Em, S. f., G, Gut, I. G., Av, Hach, Bu, En, F., Heinold, Eo, Ac, Hu, Ep, T., Huang, V. k., Hutter, Eh, B., Eq, Er, Jäger, Aa, N., Jung, Es, J., Ep, Y., Lalansingh, C. k., Leshchiner, I. b., Livitz, D. b., E. Z., Ep, Maruvka, Y. E. b., R, Et, Milovanovic, Nielsen, M. M., Eu, Paramasivam, Pedersen, Eh, J. S., Eu, Puiggròs, Ev, Sahinalp, S. C., Eo, Ew, Ex, Sarrafi, Eo, I., Stewart, Ex, Stobbe, C. b., M. D., Av, Wala, Bu, J. A. b., E, Wang, Ey, J. z., Be, Wendl, Ez, M. z., Fa, Werner, Fb, Aa, J., Fc, Wu, Ep, Z., Xue, Ep, H., Yamaguchi, T. N. k., Bn, V., Davis-Dusenbery, Bo, B. N., Fd, Grossman, R. L., Fe, Ff, Y., Heinold, Fg, M. C., Aa, Hinton, Ac, Abp, J., Jones, Abp, D. R., Menzies, Abp, A., Stebbings, Abp, L., Hess, J. M. b., Rosenberg, Et, M. b., R, Dunford, A. J. b., Gupta, M. b., Imielinski, Fh, M., Meyerson, Fi, M. b., E, Beroukhim, Ey, R. b., E, Reimand, Fj, J. k., Q, Dhingra, Br, P., Favero, Bt, Fk, F., Dentro, Bl, S., Abp, Cl, Wintersinger, Fl, J., Fm, Fn, Rudneva, V. g., Park, J. W., Fo, Hong, E. P., Fo, Heo, S. G., Fo, Kahles, Dg, A., Lehmann, K. -V., Dg, Di, Dj, Fp, Fq, Soulette, C. M., Aj, Shiraishi, Al, Y., Liu, Fr, F., Fs, He, Fr, Y., Demircioğlu, Ft, D., Davidson, Fu, N. R., Dg, Dl, Fp, Greger, L. f., Fv, S., Liu, Fw, Fv, D., Stark, Fw, S. G., Dj, Fp, Fx, Zhang, Fy, Amin, S. B., Fz, Ga, Gb, Bailey, Gc, P., Chateigner, A. n., Frenkel-Morgenstern, Gd, M., Hou, Fv, Y., Huska, Fw, M. R., Dm, Kilpinen, Ge, H., Lamaze, F. C. k., Fv, C., Fw, Li, Fv, X., Marin, Fw, M. G., Aj, Markowski, Dm, J., Nandi, Gf, T., Ojesina, A. I., Gg, Gh, Gi, Pan-Hammarström, Fv, Q., Park, Gj, P. J., Co, Pedamallu, Cp, C. S. b., E, Fj, Su, Fv, H., Tan, Fw, Gf, P., Gk, Gl, Teh, Gm, B. T., Gk, Gl, Gm, Gn, Go, Wang, Fv, J., Xiong, Fw, Ye, Yung, Fw, Zhang, C. n., Zheng, Fr, L., Zhu, Awadalla, Fw, P. k., L, Creighton, C. J., Gp, Fv, K., Yang, Fw, Göke, Ft, J., Zhang, Gq, Fr, Z., Brooks, Gr, A. N. b., Aj, Fittall, Ey, Martincorena, Abp, I., Rubio-Perez, Ch, C., Cj, Gs, Eu, M., Schumacher, S. b., Shapira, Gt, O. b., Ey, Tamborero, Ch, D., Mularoni, Cj, Ch, L., Hornshøj, Cj, Eu, H., Deu-Pons, Cj, J., Muiños, Gu, Ch, F., Bertl, Cj, Eu, J., Guo, Gv, Ev, Q., Gonzalez-Perez, Cj, Gw, Xiang, Gx, Q., Bazant, W. f., Barrera, E. f., Al-Sedairy, S. T., Gy, Aretz, Gz, A., Bell, Ha, C., Betancourt, Hb, M., Buchholz, Hc, C., Calvo, Hd, F., Chomienne, He, C., Dunn, Hf, M., Edmonds, Hg, S., Green, Hh, E., Gupta, Hi, S., C. M., Hh, Jegalian, Hj, K., Hk, N., Hl, Y., Hm, Hn, Nakagama, Ho, H., Nettekoven, Hp, G., Planko, Hp, L., Scott, Hk, D., Shibata, Hq, T., Shimizu, Hr, Hs, K., Stratton, Abp, M. R., Yugawa, Hs, T., Tortora, Ht, G., Vijayraghavan, Hu, Hi, K., Zenklusen, J. C., Hv, Hw, D., B. M., Dy, Aminou, B. n., Bartolome, Am, J., Boroevich, K. A., Cb, Boyce, Hx, Buchanan, R. f., Ak, A., Byrne, N. J. n., Hy, Z., Cho, Hz, S., Choi, Ia, W., Clapham, Abp, P., Dow, M. T., Hy, Eils, X, Ek, J., Farcas, El, Hy, C., Fayzullaev, N. n., Flicek, P. f., Heath, A. P., Ib, Hofmann, Ic, O., J. H., Id, Hudson, T. J., Ie, Hübschmann, If, Ac, D., Do, Ek, Ig, Ih, Ivkovic, Ii, S., Jeon, S. -H., Ia, Jiao, W. k., Kabbe, Dj, Fq, Kerssemakers, J. N. A., Aa, Ia, H., Ij, J., Koscher, Ik, M., Koures, Hy, A., Kovacevic, Ii, M., Lawerenz, El, C., Il, J., Mijalkovic, Mijalkovic-Lazic, A. M., Ii, Miyano, Nastic, Nicholson, Ocana, D. f., Ohi, Al, K., Ohno-Machado, Hy, L., Pihl, T. D., Im, Prinz, Radovic, Ii, P., Short, C. f., Sofia, H. J., Hh, Spring, Fe, J., Struck, A. J., Ak, Tijanic, Ii, N., Vicente, Hv, Z., Williams, Woo, Ia, Y., Wright, A. J. k., Yang, Hv, L., Hamilton, M. P., In, Johnson, T. A., Hx, Kahraman, Io, A., Ip, Iq, Kellis, M. b., Polak, Ir, P. b., C, Sallari, E, Sinnott-Armstrong, R. b., N. b., Ar, Von, Mering, Iq, C., Beltran, Is, Av, S., Gerhard, Bu, D. S., It, Av, M., Trotta, Bu, J. -R., Bu, Whalley, J. P., Bu, Niu, Iu, B., Espiritu, S. M. G. k., Gao, Ez, Y., Lalansingh, Iv, Teague, C. M. k., Abp, J. W., Wendl, M. C. z., Fa, Fb, Abascal, Abp, F., Bader, G. D. l., Bandopadhayay, P. b., Iw, Ix, Barenboim, J. k., Brunak, Iy, S., Carlevaro-Fita, Iz, Ja, J., Jb, Jc, Chakravarty, Jd, D., Chan, Je, C. W. Y., Aa, Choi, Dw, J. K., Jf, Diamanti, Jg, K., Fink, Frigola, Jh, Gu, J., Gambacorti-Passerini, Ji, C., Garsed, D. W., Jj, Haradhvala, N. J. b., Harmanci, R, A. O., Bk, Helmy, Jk, Fm, M., Herrmann, Aa, C., Ac, Jl, Hobolth, Ev, A., Hodzic, Gv, Ex, E., Dv, C., Isaev, Dw, K. k., Q, Izarzugaza, J. M. G., Iy, Jb, R., Juul, Jm, R. I., Eu, Kim, J. b., J. K., Jn, Jan, Komorowskijg, Lanzós, Jo, Jb, A., Jc, Jm, Larsson, Dg, E., Lee, Bk, D., Bk, S., Bk, X., Lin, Z. b., Liu, Jp, E. M., Br, Bt, Jq, Lochovsky, Bj, L., Bk, Gb, Lou, Madsen, Bk, Eu, T., Marchal, Jr, K., Martinez-Fundichely, Js, Br, A., Bs, Bt, Mcgillivray, P. D., Bj, Meyerson, Bk, W., Paczkowska, Jt, Park, M. k., Ju, K., Park, Jv, Jw, K., Pons, Jx, T., Pulido-Tamayo, Jr, S., Reyes-Salazar, Js, Ch, I., Reyna, M. A., Jy, Rubin, M. A., Jm, Jz, Ka, Kb, Kc, Salichos, Sander, Bk, Dg, C., Ey, Kd, Schumacher, Ke, S. E. b., Gt, Shackleton, Jj, M., Shen, Ke, C., Shrestha, Kf, Eo, R., Shuai, S. k., Tsunoda, L, Hx, T., Kg, Kh, Umer, Ki, H. M., Jg, Uusküla-Reimand, Kj, Kk, L., Verbeke, Kl, L. P. C., Js, Wadelius, Km, Kn, C., Wadi, L. k., Warrell, Bj, J., Bk, Wu, Ko, G., Kp, J., Zhang, Ez, X., Zhang, Kq, Bk, Y., Kr, Ks, Zhao, Kt, Z., Zou, Ku, L., Lawrence, M. S. b., R, Hx, Raphael, B. J., Jy, P. J., Gc, Craft, D. b., Goldman, Kv, M. J., Ea, Aburatani, Kw, H., Binder, Kx, H., Dinh, Ky, H. Q., Kz, S. C., Av, Hoffmann, Bu, Kx, S., Ky, La, Imbusch, Lb, C. D., Dv, Kretzmer, Ky, H., Laird, Lb, P. W., Lc, Martin-Subero, J. I., Bw, Nagae, Ld, Kw, G., Shen, Le, Lf, H., Ik, Q., Weichenhan, Lg, D., Zhou, Lf, W., Berman, B. P., Kz, Lh, Li, Brors, Dv, B., Er, Lj, Plass, Lg, C., Akdemir, K. C., Ei, Bowtell, D. D. L., Jj, Burns, K. H., Lk, Busanovich, Ll, J. b., Lm, Chan, Ln, K., Dueso-Barroso, Edwards, P. A., Lo, Etemadmoghadam, Lp, Jj, D., Haber, J. E., Lq, D. T. W., Lr, Ls, Ju, Y. S., Jf, Abp, Kazanov, M. D., Lt, Lu, Lv, Koh, Lw, Y., Kumar, Lx, Lee, K. b., E. A., Ly, J. J. -K., Co, Lynch, Cp, A. G., Lo, Lp, Lz, Macintyre, Lo, G., Markowetz, Lo, F., Navarro, Lp, F. C. P., Bj, Pearson, J. V., Ma, Rippe, Mb, Do, K., Scully, Mc, R., Villasante, Am, I., Waddell, Ma, N., Yang, Mb, Md, L., Yao, Fh, X., Yoon, Me, S. -S., Lx, C. -Z. b., E, Ey, Bergstrom, E. N., Mf, Boot, Gl, A., Covington, Mg, Ag, K., Fujimoto, Cb, A., M. N., Gl, Islam, Mg, S. M. A., Cv, Mcpherson, J. R., Gl, Morganella, Mg, Abp, S., Mustonen, Mh, V., Mi, Mj, A. W. T., Mk, Prokopec, S. D. k., Vázquez-García, Bn, I., Ml, Mm, Abp, Wu, Gl, Y., Yousif, Mg, F. k., Yu, Mn, W., Rozen, S. G., Gl, Gm, Mg, Rudneva, V. A. g., S. S., Ar, D. J., Da, Xia, Mo, T., Atwal, G. k., L, Fn, Chang, D. K., Gc, Cooke, Mp, S. L., Gc, Faltas, B. M., Dl, Haider, S. k., Kaiser, V. B., Mq, Karlić, Mr, R., Kato, Ms, M., Kübler, K. b., E, R, Margolin, Martin, Mt, S., Abp, Nik-Zainal, Mu, S., Mv, Mw, Abp, P’Ng, Semple, C. k., C. A., Mq, Smith, Ak, J., Sun, R. X. k., Thai, K. n., D. W., Mx, Yuan, My, Lo, K., Mt, Mz, Biankin, A. V., Gc, Mp, Na, Garraway, Nb, Ey, L., Grimmond, S. M., Nc, Adams, Abp, D. J., Anur, Nd, P., Cao, Ae, S., Christie, E. L., Jj, Cmero, Ne, M., Nf, Ng, Cun, Nh, Y., Dawson, Abp, K. J., S. C., Bl, Deshwar, A. G., Ni, Donmez, Eo, N., Drews, Ex, R. M., Lo, Gerstung, M. f., G, Ha, Haase, G. b., Cl, K., Jerman, L. g., Nj, Ji, Nk, Y., Jolly, Nl, Cl, C., Nm, J., Lee-Six, Abp, H., Malikic, Eo, S., Mitchell, Ex, T. J., Lp, Abp, Nn, Morris, Q. D., Fn, Oesper, No, Np, L., Peifer, Nh, M., Peto, Nq, M., Rosebrock, D. b., Rubanova, Ai, Y., Salcedo, Fn, Sengupta, A. k., Nr, S., Shi, No, R., Shin, S. J., Fy, Spiro, O. b., Vembu, No, S., Wintersinger, Ns, J. A., Fl, T. -P., Nh, Nt, K., Nu, H., Spellman, Nv, P. T., Nw, Weinstein, J. N., Ee, Chen, Ef, Fujita, Cb, M., Han, Kq, L., Hasegawa, Al, T., Komura, Al, M., Ae, J., Mizuno, Nx, S., Shimizu, Al, E., Ny, Xu, Nz, Y., Yamaguchi, Al, R., No, F., Kq, Y., Yoon, C. J., Jf, Yuan, Liang, Ae, H., Alawi, Oa, M., Borozan, Ob, Brewer, I. k., D. S., Oc, Cooper, Od, C. S., Od, Oe, Of, Desai, N. n., Grundhoff, Oa, A., Iskar, Og, Oh, M., Oi, X., Zapatka, Lichter, Eq, P., Alsop, Oh, Jj, K., Bruxner, T. J. C., Jh, Christ, A. N., Jh, Cordner, S. M., Oj, Cowin, P. A., Ok, Drapkin, Ol, R., Fereday, Ok, S., George, Gb, J., Ok, A., Holmes, Ma, O., Hung, Mb, J. A., Om, Kassahn, On, K. S., Jh, Kazakoff, Oo, S. H., Ma, Kennedy, Mb, C. J., Op, Leonard, Oq, C. R., Ma, Mileshkin, Mb, Jj, L., Miller, D. K., Jh, Mp, Or, Arnau, G. M., Ok, Mitchell, Ok, C., Newell, Ma, F., Nones, Mb, Ma, K., Patch, Mb, A. -M., Ma, Quinn, Mb, M. C., Ma, Taylor, Mb, D. F., Jh, Thorne, Ok, H., Traficante, Ok, N., Vedururu, Ok, R., N. M., Mb, Waring, P. M., Os, Wood, Ma, S., Mb, Xu, Ma, Q., Defazio, Mb, Ot, A., Ou, Ov, Anderson, M. J., Jh, Antonello, Ow, D., Barbour, A. P., Ox, Bassi, Oy, Ow, C., Bersani, Oz, S., Cataldo, Oz, I., Chantrill, Pa, L. A., Mp, Chiew, Pb, Y. -E., Ot, Chou, Mp, A., Cingarlini, Pc, Ht, S., Cloonan, Pd, N., Corbo, Pa, V., Davi, Pe, M. V., Pf, Duthie, F. R., Gc, Gill, Pg, A. J., Mp, Graham, Pc, J. S., Gc, Harliwong, Ph, Jh, I., Jamieson, N. B., Gc, Nb, Pi, Johns, A. L., Mp, Kench, Or, J. G., Mp, Pc, Pj, Landoni, Ow, L., Lawlor, R. T., Pa, Mafficini, Pa, A., Merrett, N. D., Ow, Miotto, Pk, Ow, M., Musgrove, E. A., Gc, Nagrial, A. M., Mp, Oien, K. A., Os, Pajic, Pl, Mp, M., Pinese, Pm, M., Robertson, A. J., Jh, Rooman, Mp, I., Rusev, B. C., Pa, Samra, J. S., Ow, Scardoni, Pc, Oz, M., Scarlett, C. J., Mp, Scarpa, Pn, Sereni, Ow, E., Sikora, K. O., Pa, Simbolo, Pe, M., Taschuk, M. L. n., Toon, C. W., Mp, Vicentini, Pa, C., Mp, J., Zeps, Po, N., Behren, Pp, Pq, A., Burke, Pr, H., Cebon, Pq, J., Dagg, R. A., Ps, Paoli-Iseppi, De, Pt, R., Dutton-Regester, Field, M. A., Pu, Fitzgerald, Pv, A., Hersey, Pr, P., Jakrot, Pr, V., Johansson, P. A., Ma, Kakavand, Pt, H., Kefford, R. F., Pw, Lau, L. M. S., Px, Long, G. V., Py, Pickett, H. A., Px, Pritchard, A. L., Ma, Pupo, G. M., Pz, Saw, R. P. M., Py, Schramm, S. -J., Qa, Shang, C. A., Pv, Py, P., Spillane, A. J., Py, Stretch, J. R., Py, Tembe, Ot, V., Thompson, Qa, J. F., Py, Vilain, R. E., Qb, Wilmott, J. S., Py, J. Y., Qc, Hayward, N. K., Ma, Mann, Pr, G. J., Ot, Scolyer, Qd, R. A., Ou, Py, Qb, Bartlett, Qe, Qf, J., Bavi, Qg, Qh, P., Chadwick, D. E., Qi, Chan-Seng-Yue, Qh, M., Cleary, Qh, S., Connor, Qj, A. A., Qj, Czajka, Qk, If, K., Denroche, R. E., Qh, Dhani, N. C., Ql, Eagles, If, J., Gallinger, Qj, Qk, Grant, R. C., Qh, Hedley, Qk, Ql, D., Hollingsworth, M. A., Qm, Jang, G. H., Qh, Kalimuthu, S. -B., Qn, Lungu, Qh, I., Luo, Qo, Mbabaali, X. k., If, F., T. A., Qk, J. K., If, Moore, M. J., Ql, Notta, Qh, F., Pasternack, Qp, If, D., Petersen, G. M., Qq, Roehrl, M. H. A. q., Qh, Qr, Qs, Qt, Sam, If, M., Selander, Qk, I., Serra, Os, S., Shahabi, Qn, S., Thayer, S. P., Qm, Timms, L. E., If, Wilson, G. W. k., Wilson, Qh, J. M., Qh, Wouters, B. G., Qu, J. D., If, Qh, Qv, Beck, T. A. n., Bhandari, Qw, Collins, V. k., C. C., Eo, Fleshner, N. E., Qx, Fox, N. S. k., Fraser, M. k., Heisler, L. E., Qy, Lalonde, E. k., Livingstone, J. k., Meng, Qz, A., Sabelnykova, V. Y. k., Shiah, Y. -J. k., Van der Kwast, Ra, T., Bristow, R. G. q., Rb, Rc, Rd, Re, Ding, Rf, S., Rg, D., Fv, L., Nie, Rg, Y., Xiao, Rh, Xing, Hm, R., Yang, Ri, Rj, Y., Banks, R. E., Rk, Bourque, Rl, G., Brennan, Rm, Rn, P., Letourneau, Ro, L., Riazalhosseini, Rm, Y., Scelo, Rn, G., Vasudev, Rk, N., Viksna, Rp, Rq, J., Lathrop, Rm, M., Tost, Rr, J., Ahn, S. -M., Rs, Aparicio, Rt, S., Arnould, Ru, L., Aure, M. R., Rv, Bhosle, Abp, S. G., Birney, E. f., Borg, Rw, A., Boyault, Rx, S., Brinkman, A. B., Ry, Brock, J. E., Rz, Broeks, Sa, A., Børresen-Dale, A. -L., Rv, Caldas, Sb, C., Chin, Sc, S. -F., Sb, Davies, Sc, Mu, H., Abp, Mv, Desmedt, Sd, C., Dirix, Se, Sf, L., Dronov, Ehinger, Sg, A., Eyfjord, J. E., Sh, Fatima, Gt, A., Foekens, J. A., Si, Futreal, P. A., Sj, Garred, Sk, Ø., Giri, Sl, D. D., Sm, Glodzik, Abp, D., Grabau, Sn, D., Hilmarsdottir, Sh, H., Hooijer, G. K., So, Jacquemier, Sp, J., S. J., Sq, Jonasson, J. G., Sh, Jonkers, Sr, J., H. -Y., Sp, King, T. A., Ss, Knappskog, St, Su, S., Abp, Kong, Sp, G., Krishnamurthy, Sv, S., Lakhani, S. R., Sw, Langerød, Rv, A., Larsimont, Sx, D., H. J., Sq, J. -Y., Sy, M. T. M., Sj, Lingjærde, O. C., Sz, Macgrogan, Ta, G., Martens, J. W. M., Si, O’Meara, Pauporté, He, I., Pinder, Tb, S., Pivot, Tc, X., Provenzano, Td, E., Purdie, C. A., Te, Ramakrishna, Abp, M., Ramakrishnan, Abp, K., Reis-Filho, Sm, J., Richardson, A. L., Gt, Ringnér, Rw, M., Rodriguez, J. B., Am, Rodríguez-González, F. G., Iz, Romieu, Tf, G., Salgado, Os, R., Sauer, Sz, T., Shepherd, Abp, R., Sieuwerts, A. M., Si, Simpson, P. T., Sw, Smid, Si, M., Sotiriou, Span, P. N., Tg, Stefánsson, Ó. A., Th, Stenhouse, Ti, A., Stunnenberg, H. G., Fw, Sweep, Tj, Tk, F., Tan, B. K. T., Tl, Thomas, Tm, G., Thompson, A. M., Ti, Tommasi, Tn, S., Treilleux, To, I., Tutt, Tp, Ueno, N. T., Nv, Van, Laere, Sf, S., Van den Eynden, G. G., Sf, Vermeulen, Sf, P., Viari, Vincent-Salomon, Tj, A., Wong, B. H., Tq, Yates, Abp, X., Van, Deurzen, C. H. M., Tr, van de Vijver, M. J., Os, Van’T, Veer, Ts, L., Ammerpohl, Tt, O., Tu, Tv, Aukema, Tu, S., Tv, Tw, Bergmann, A. K., Tx, Bernhart, S. H., Kx, Ky, Lb, Borkhardt, Ty, A., Borst, Tz, C., Burkhardt, Ua, B., Claviez, Ub, A., Goebler, M. E., Uc, Haake, Tt, A., Haas, Tz, S., Hansmann, Ud, M., Hoell, J. I., Ty, Hummel, Ue, M., Karsch, Uf, D., Klapper, Tw, W., Kneba, Uf, M., Kreuz, Ug, M., Kube, Uh, D., Küppers, Ui, R., Lenze, Ue, D., Loeffler, López, Ca, C., Mantovani-Löffler, Tt, Uj, L., Möller, Uk, P., Ott, Ul, G., Radlwimmer, Oh, B., Richter, Tt, J., Rohde, Tw, Um, M., Rosenstiel, P. C., Un, Rosenwald, Uo, A., Schilhabel, M. B., Un, Schreiber, Up, S., Stadler, P. F., Kx, Staib, Uq, P., Stilgenbauer, Ur, S., Sungalee, S. g., Szczepanowski, Tw, M., Toprak, U. H., Ac, Trümper, Us, L. H. P., Uh, Wagener, Ca, R., Zenz, Tt, Er, T., Hovestadt, Oh, V., Von, Kalle, Do, C., Kool, Korshunov, Lr, Ik, A., Landgraf, Ut, P., Lehrach, Uu, Uv, H., Northcott, P. A., Uw, Pfister, S. M., Ik, Lr, Ux, Reifenberger, Uu, G., Warnatz, H. -J., Uv, Wolf, Uy, S., Yaspo, M. -L., Uv, Assenov, Uz, Y., Gerhauser, Minner, Va, S., Schlomm, Ct, T., Simon, Vb, Vc, R., Sauter, Vc, G., Sültmann, Er, H., Biswas, Vd, N. K., Ve, Maitra, Ve, A., Majumder, P. P., Ve, Sarin, Vf, R., Barbi, Pe, S., Bonizzato, Pa, G., Cantù, Dei, Tos, A. P., Vg, Fassan, Vh, M., Grimaldi, Pa, S., Luchini, Oz, C., Malleo, Ow, G., Marchegiani, Milella, Michele, Ht, M., Paiella, Ow, S., Pea, Ow, A., Pederzoli, Ow, P., Ruzzenente, Salvia, Ow, R., Sperandio, Pa, N., Arai, Hq, Y., Hama, Hq, N., Hiraoka, Vi, N., Hosoda, Hq, F., Nakamura, Hq, H., Ojima, Vj, H., Okusaka, Vk, T., Totoki, Urushidate, Hr, T., Fukayama, Vl, M., Ishikawa, Vm, S., Katai, Vn, H., Katoh, Vm, H., Vm, D., Rokutan, Ms, H., Saito-Adachi, Suzuki, Kw, A., Taniguchi, Vo, Vp, H., Tatsuno, Kw, K., Ushiku, Vl, T., Yachida, Hq, S., Yamamoto, Vq, Kw, S., Aikata, Vr, H., Arihiro, Vr, K., Ariizumi, S. -I., Vs, Chayama, Furuta, Gotoh, Vt, K., Hayami, Vu, S., Hirano, Vv, S., Kawakami, Vr, Y., Maejima, Cb, K., Vv, T., Nakano, Ohdan, Sasaki-Oku, Tanaka, Al, H., Vu, M., Yamamoto, Vs, M., Yamaue, Vu, H., Choo, S. P., Vw, Cutcutache, Gl, I., Khuntikeo, Mg, Ow, N., Ong, Vx, C. K., Vy, Pairojkul, Os, C., Popescu, Vz, I., K. S., Wa, Aymerich, Wb, M., Lopez-Guillermo, Wc, A., López-Otín, Wd, C., Puente, X. S., Wd, Campo, We, E., Amary, Wf, Wg, F., Baumhoer, Wh, D., Behjati, Bjerkehagen, Wh, B., Futreal, Wi, Myklebost, Su, O., Pillay, Wj, N., Tarpey, Wk, P., Tirabosco, Wl, R., Zaikova, Wm, O., Flanagan, A. M., Wn, Boultwood, Wo, J., Bowen, Abp, D. T., Cazzola, Wp, M., A. R., Lp, Hellstrom-Lindberg, Wq, E., Malcovati, Wp, L., Nangalia, Wr, J., Papaemmanuil, Vyas, Ma, P., Ang, Ws, Wt, Y., Barr, Wu, H., Beardsmore, Wv, D., Eldridge, Lo, M., Gossage, Ww, J., Grehan, Mv, N., Hanna, G. B., Wx, Hayes, S. J., Wy, Hupp, Wz, T. R., Xa, Khoo, Xb, D., Lagergren, Wq, J., Lovat, Xc, L. B., Ge, Macrae, Ee, S., O’Donovan, Mv, M., O’Neill, J. R., Xd, Parsons, S. L., Xe, Preston, S. R., Xf, Puig, Xg, S., Roques, Xh, T., Sanders, G. w., Sothi, Xi, S., Tavaré, Lo, S., Tucker, Xj, O., Turkington, Xk, R., Underwood, T. J., Xl, Welch, Xm, I., R. C., Mv, Berney, D. M., Xn, Bono, De, J. S., Oe, Cahill, Xo, D., Camacho, Oe, N., Dennis, N. M., Xo, Dudderidge, Xo, T., Edwards, Xp, S. E., Oe, Fisher, Xo, C., Foster, C. S., Xq, Ghori, Xr, Gill, Ws, P., Gnanapragasam, V. J., Nn, Gundem, Xs, Jq, G., Hamdy, F. C., Xt, Hawkins, Hazell, Xo, S., Howat, Nn, W., Isaacs, W. B., Xu, Karaszi, Ws, K., Kay, J. D., Ge, Xo, V., Kote-Jarai, Oe, Z., Kremeyer, Abp, B., Xo, P., Lambert, Ws, A., Leongamornlert, D. A., Oe, Abp, Livni, Xo, N., Y. -J., Xn, Luxton, Xv, H. J., Ge, Marsden, Ws, L., Massie, C. E., Lo, Matthews, Oe, L., Mayer, Xo, E., Mcdermott, Xw, Abp, U., Merson, Oe, S., Neal, D. E., Lo, Nn, Ng, Xx, A., Nicol, Ogden, Rowe, E. W., Xo, Shah, N. C., Nn, Xo, A., Verrill, Ws, C., Visakorpi, Xy, Du, T., Warren, A. Y., Nn, Whitaker, Xz, H. C., Ge, Xv, H., Van, As, Eeles, R. A., Oe, Abeshouse, Xo, Jq, A., Agrawal, Fe, N., Akbani, Mv, R., Al-Ahmadie, Ya, Jq, H., Albert, Qg, M., Aldape, Oi, K., Ally, Yb, Yc, A., Appelbaum, E. L. z., Armenia, Ge, Yd, J., Asa, Xe, S., Auman, Ye, J. T., Yf, Balasundaram, Yc, M., Balu, S. w., Barnholtz-Sloan, Yg, J., Bathe, Yh, O. F., Yi, Baylin, Yj, S. B., Dr, Benz, Xp, Yk, C., Berchuck, Yl, A., Berrios, Ym, M., Bigner, Yn, D., Birrer, M. r., Bodenheimer, T. w., Boice, Xg, L., Bootwalla, M. S., Ym, Bosenberg, Yo, M., Bowlby, Yc, R., Boyd, Yp, J., Broaddus, R. R., Oi, Yq, M., Brooks, Yc, D., Bullman, S. b., Caesar-Johnson, Fj, S. J., Hv, Carey, T. E., Yr, Carlsen, Cerfolio, Ys, R., Chandan, V. S., Yt, H. -W., Wt, Cherniack, Yd, A. D. b., Ey, Chien, Fj, Yu, J., Cho, J. b., Chuah, Yc, E., Cibulskis, C. b., Cope, Yv, L., Cordes, M. G. z., Curley, Xh, Yw, E., Czerniak, Oi, B., Danilova, Xb, Davis, I. J., Yx, Defreitas, T. b., Demchok, J. A., Hv, Dhalla, Yc, N., Dhir, Yy, R., Doddapaneni, H. V., Ag, El-Naggar, Oi, A., Felau, Xb, Hv, I., Ferguson, M. L., Yz, Finocchiaro, Za, G., Fong, K. M., Zb, Frazer, S. b., Friedman, Zc, W., Fronick, C. C. z., Fulton, Xh, Gabriel, L. A. z., Gao, S. B. b., Gehlenborg, N. b., Gershenwald, Zd, J. E., Ze, Ghossein, Zf, Sm, R., Giama, N. H., Zg, Gibbs, R. A., Ag, Gomez, Zh, C., Govindan, R. y., Hayes, D. N. w., Zi, Zj, Hegde, A. M., Ee, Heiman, Ef, Heins, D. I. b., Jq, Z., Hepperla, A. J. w., Holbrook, Ym, A., Holt, R. A., Yc, Hoyle, A. P. w., Hruban, R. H., Yv, Ag, J., Xg, M., Huntsman, Zk, D., Huse, Jq, J., Iacobuzio-Donahue, C. A., Sm, Ittmann, Zl, M., Jayaseelan, Zm, J. C., Ag, Jefferys, S. R. w., C. D., Zn, S. J. M., Zo, Juhl, Zp, H., Kang, K. J., Zq, Karlan, Zr, B., Kasaian, Zo, K., Kebebew, Zs, E., Kim, Zt, H. K., Zu, Korchina, Ag, V., Kundra, Wt, R., Lai, Yd, P. H., Ym, Lander, E. b., Zv, X., Levine, D. A., Jq, Lewis, Zw, Ag, L., Ley, Zx, T., H. I., Yc, Lin, P. b., Linehan, W. M., Zy, F. F., No, Ef, Y., Lype, Zz, L., Yc, Y., Maglinte, D. T., Ym, Aaa, Mardis, E. R. z., Yp, Aab, Marks, Ow, J., Aac, Marra, M. A., Yc, Matthew, T. J., Aj, Mayo, Mccune, Aad, K., Meier, S. R. b., Meng, S. w., Mieczkowski, P. A. v., Mikkelsen, Aae, T., Miller, C. A. z., Mills, Aaf, G. B., Morrison, Aag, Mose, Moser, L. E. w., C. D., Zg, Mungall, A. J., Yc, Yc, K., Mutch, Aah, D., Muzny, Aai, D. M., Myers, Aaj, J., Newton, Aj, Y., Noble, M. S. b., O’Donnell, Aak, P., Aal, B. P., Ochoa, Aam, J. -W., Parker, Aan, J. S., Pass, Aao, H., Pastore, Pennell, Aap, N. A., Perou, Aaq, C. M., Petrelli, Aar, N., Potapova, Aas, O., Rader, Aat, J. S., Ramalingam, Aau, S., Rathmell, Aav, W. K., Reuter, Sm, V., Reynolds, S. M., Zz, Ringel, Aaw, M., Roach, Aax, J., L. R., Zg, A. G., Yc, Sadeghi, Yc, S., Saller, Aay, C., Sanchez-Vega, Wt, F., Schadendorf, Yd, Eq, D., Aaz, Schein, J. E., Yc, Schmidt, H. K. z., Schultz, Yd, N., Seethala, Aba, R., Senbabaoglu, Dg, Y., Shelton, Yw, T., Shi, Y. w., Shih, J. b., Shmulevich, Fj, Zz, I., Shriver, Abb, C., Signoretti, Fj, S., Abc, Jb, Simons, J. V. w., Singer, Abd, Sipahimalani, Yc, P., Skelly, T. J. v., Smith-McCune, Socci, N. D., Dg, Soloway, Aan, M. G., Sood, Abe, A. K., Tam, Tan, D. v., Tarnuzzer, Hv, R., Thiessen, Abf, R. H., L. B., Xg, Tsao, Xe, M., Umbricht, Ye, Lk, C., Abg, Wv, Van Den Berg, D. J., Ym, Van, Meir, Abh, E. G., Veluvolu, U. v., Voet, D. b., Weinberger, Abi, P., Weisenberger, Wigle, Abj, D., Wilkerson, M. D. v., Wilson, R. K. z., Abk, Winterhoff, Abl, B., Wiznerowicz, Abm, M., Abn, Wong, T. z., Yc, Abo, W., Yau, Zhang, H. b., Yd, H., Hv, J., The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)

المساهمون: Medical Oncology, Pathology, IBM, Pharmacyclics, Novartis, Celgene, AstraZeneca, Bayer, Janssen Biotech, University of Chicago, Ipsen, Pfizer, Ono Pharmaceutical, Ariad Pharmaceuticals, Gilead Sciences, Bristol-Myers Squibb, University of St Andrews. School of Medicine, University of St Andrews. Statistics, University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis, University of St Andrews. Cellular Medicine Division, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Metamedica, Háskóli Íslands, University of Iceland, Faculty of Medicine, University of Helsinki, Department of Medical and Clinical Genetics, Research Programs Unit, Lauri Antti Aaltonen / Principal Investigator, ATG - Applied Tumor Genomics, Helsinki Institute of Life Science HiLIFE, Organismal and Evolutionary Biology Research Programme, Helsinki Institute for Information Technology, Institute of Biotechnology, Bioinformatics, Department of Computer Science, STEMM - Stem Cells and Metabolism Research Program, Centre of Excellence in Stem Cell Metabolism, Genome-Scale Biology (GSB) Research Program, Department of Physics, HUS Helsinki and Uusimaa Hospital District, University of Zurich, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Apollo - University of Cambridge Repository, Graduate School, Laboratory Genetic Metabolic Diseases, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, CCA - Cancer biology and immunology, Campbell, P, Getz, G, Korbel, J, Stuart, J, Jennings, J, Stein, L, Perry, M, Nahal-Bose, H, Ouellette, B, Li, C, Rheinbay, E, Nielsen, G, Sgroi, D, Wu, C, Faquin, W, Deshpande, V, Boutros, P, Lazar, A, Hoadley, K, Louis, D, Dursi, L, Yung, C, Bailey, M, Saksena, G, Raine, K, Buchhalter, I, Kleinheinz, K, Schlesner, M, Zhang, J, Wang, W, Wheeler, D, Ding, L, Simpson, J, O'Connor, B, Yakneen, S, Ellrott, K, Miyoshi, N, Butler, A, Royo, R, Shorser, S, Vazquez, M, Rausch, T, Tiao, G, Waszak, S, Rodriguez-Martin, B, Shringarpure, S, Wu, D, Demidov, G, Delaneau, O, Hayashi, S, Imoto, S, Habermann, N, Segre, A, Garrison, E, Cafferkey, A, Alvarez, E, Heredia-Genestar, J, Muyas, F, Drechsel, O, Bruzos, A, Temes, J, Zamora, J, Baez-Ortega, A, Kim, H, Mashl, R, Ye, K, Dibiase, A, Huang, K, Letunic, I, Mclellan, M, Newhouse, S, Shmaya, T, Kumar, S, Wedge, D, Wright, M, Yellapantula, V, Gerstein, M, Khurana, E, Marques-Bonet, T, Navarro, A, Bustamante, C, Siebert, R, Nakagawa, H, Easton, D, Ossowski, S, Tubio, J, De La Vega, F, Estivill, X, Yuen, D, Mihaiescu, G, Omberg, L, Ferretti, V, Sabarinathan, R, Pich, O, Gonzalez-Perez, A, Taylor-Weiner, A, Fittall, M, Demeulemeester, J, Tarabichi, M, Roberts, N, Van Loo, P, Cortes-Ciriano, I, Urban, L, Park, P, Zhu, B, Pitkanen, E, Li, Y, Saini, N, Klimczak, L, Weischenfeldt, J, Sidiropoulos, N, Alexandrov, L, Rabionet, R, Escaramis, G, Bosio, M, Holik, A, Susak, H, Prasad, A, Erkek, S, Calabrese, C, Raeder, B, Harrington, E, Mayes, S, Turner, D, Juul, S, Roberts, S, Song, L, Koster, R, Mirabello, L, Hua, X, Tanskanen, T, Tojo, M, Chen, J, Aaltonen, L, Ratsch, G, Schwarz, R, Butte, A, Brazma, A, Chanock, S, Chatterjee, N, Stegle, O, Harismendy, O, Bova, G, Gordenin, D, Haan, D, Sieverling, L, Feuerbach, L, Chalmers, D, Joly, Y, Knoppers, B, Molnar-Gabor, F, Phillips, M, Thorogood, A, Townend, D, Goldman, M, Fonseca, N, Xiang, Q, Craft, B, Pineiro-Yanez, E, Munoz, A, Petryszak, R, Fullgrabe, A, Al-Shahrour, F, Keays, M, Haussler, D, Weinstein, J, Huber, W, Valencia, A, Papatheodorou, I, Zhu, J, Fan, Y, Torrents, D, Bieg, M, Chen, K, Chong, Z, Cibulskis, K, Eils, R, Fulton, R, Gelpi, J, Gonzalez, S, Gut, I, Hach, F, Heinold, M, Hu, T, Huang, V, Hutter, B, Jager, N, Jung, J, Kumar, Y, Lalansingh, C, Leshchiner, I, Livitz, D, Ma, E, Maruvka, Y, Milovanovic, A, Nielsen, M, Paramasivam, N, Pedersen, J, Puiggros, M, Sahinalp, S, Sarrafi, I, Stewart, C, Stobbe, M, Wala, J, Wang, J, Wendl, M, Werner, J, Wu, Z, Xue, H, Yamaguchi, T, Davis-Dusenbery, B, Grossman, R, Kim, Y, Hinton, J, Jones, D, Menzies, A, Stebbings, L, Hess, J, Rosenberg, M, Dunford, A, Gupta, M, Imielinski, M, Meyerson, M, Beroukhim, R, Reimand, J, Dhingra, P, Favero, F, Dentro, S, Wintersinger, J, Rudneva, V, Park, J, Hong, E, Heo, S, Kahles, A, Lehmann, K, Soulette, C, Shiraishi, Y, Liu, F, He, Y, Demircioglu, D, Davidson, N, Greger, L, Li, S, Liu, D, Stark, S, Zhang, F, Amin, S, Bailey, P, Chateigner, A, Frenkel-Morgenstern, M, Hou, Y, Huska, M, Kilpinen, H, Lamaze, F, Li, X, Liu, X, Marin, M, Markowski, J, Nandi, T, Ojesina, A, Pan-Hammarstrom, Q, Pedamallu, C, Su, H, Tan, P, Teh, B, Xiong, H, Ye, C, Zhang, X, Zheng, L, Zhu, S, Awadalla, P, Creighton, C, Wu, K, Yang, H, Goke, J, Zhang, Z, Brooks, A, Martincorena, I, Rubio-Perez, C, Juul, M, Schumacher, S, Shapira, O, Tamborero, D, Mularoni, L, Hornshoj, H, Deu-Pons, J, Muinos, F, Bertl, J, Guo, Q, Bazant, W, Barrera, E, Al-Sedairy, S, Aretz, A, Bell, C, Betancourt, M, Buchholz, C, Calvo, F, Chomienne, C, Dunn, M, Edmonds, S, Green, E, Gupta, S, Hutter, C, Jegalian, K, Jones, N, Lu, Y, Nakagama, H, Nettekoven, G, Planko, L, Scott, D, Shibata, T, Shimizu, K, Stratton, M, Yugawa, T, Tortora, G, Vijayraghavan, K, Zenklusen, J, Aminou, B, Bartolome, J, Boroevich, K, Boyce, R, Buchanan, A, Byrne, N, Chen, Z, Cho, S, Choi, W, Clapham, P, Dow, M, Eils, J, Farcas, C, Fayzullaev, N, Flicek, P, Heath, A, Hofmann, O, Hong, J, Hudson, T, Hubschmann, D, Ivkovic, S, Jeon, S, Jiao, W, Kabbe, R, Kerssemakers, J, Kim, J, Koscher, M, Koures, A, Kovacevic, M, Lawerenz, C, Liu, J, Mijalkovic, S, Mijalkovic-Lazic, A, Miyano, S, Nastic, M, Nicholson, J, Ocana, D, Ohi, K, Ohno-Machado, L, Pihl, T, Prinz, M, Radovic, P, Short, C, Sofia, H, Spring, J, Struck, A, Tijanic, N, Vicente, D, Wang, Z, Williams, A, Woo, Y, Wright, A, Yang, L, Hamilton, M, Johnson, T, Kahraman, A, Kellis, M, Polak, P, Sallari, R, Sinnott-Armstrong, N, von Mering, C, Beltran, S, Gerhard, D, Gut, M, Trotta, J, Whalley, J, Niu, B, Espiritu, S, Gao, S, Huang, Y, Teague, J, Abascal, F, Bader, G, Bandopadhayay, P, Barenboim, J, Brunak, S, Carlevaro-Fita, J, Chakravarty, D, Chan, C, Choi, J, Diamanti, K, Fink, J, Frigola, J, Gambacorti Passerini, C, Garsed, D, Haradhvala, N, Harmanci, A, Helmy, M, Herrmann, C, Hobolth, A, Hodzic, E, Hong, C, Isaev, K, Izarzugaza, J, Johnson, R, Juul, R, Jan, K, Lanzos, A, Larsson, E, Lee, D, Lin, Z, Liu, E, Lochovsky, L, Lou, S, Madsen, T, Marchal, K, Martinez-Fundichely, A, Mcgillivray, P, Meyerson, W, Paczkowska, M, Park, K, Pons, T, Pulido-Tamayo, S, Reyes-Salazar, I, Reyna, M, Rubin, M, Salichos, L, Sander, C, Shackleton, M, Shen, C, Shrestha, R, Shuai, S, Tsunoda, T, Umer, H, Uuskula-Reimand, L, Verbeke, L, Wadelius, C, Wadi, L, Warrell, J, Wu, G, Yu, J, Zhang, Y, Zhao, Z, Zou, L, Lawrence, M, Raphael, B, Craft, D, Aburatani, H, Binder, H, Dinh, H, Heath, S, Hoffmann, S, Imbusch, C, Kretzmer, H, Laird, P, Martin-Subero, J, Nagae, G, Shen, H, Wang, Q, Weichenhan, D, Zhou, W, Berman, B, Brors, B, Plass, C, Akdemir, K, Bowtell, D, Burns, K, Busanovich, J, Chan, K, Dueso-Barroso, A, Edwards, P, Etemadmoghadam, D, Haber, J, Ju, Y, Kazanov, M, Koh, Y, Kumar, K, Lee, E, Lee, J, Lynch, A, Macintyre, G, Markowetz, F, Navarro, F, Pearson, J, Rippe, K, Scully, R, Villasante, I, Waddell, N, Yao, X, Yoon, S, Zhang, C, Bergstrom, E, Boot, A, Covington, K, Fujimoto, A, Huang, M, Islam, S, Mcpherson, J, Morganella, S, Mustonen, V, Ng, A, Prokopec, S, Vazquez-Garcia, I, Wu, Y, Yousif, F, Yu, W, Rozen, S, Xia, T, Atwal, G, Chang, D, Cooke, S, Faltas, B, Haider, S, Kaiser, V, Karlic, R, Kato, M, Kubler, K, Margolin, A, Martin, S, Nik-Zainal, S, P'Ng, C, Semple, C, Smith, J, Sun, R, Thai, K, Wright, D, Yuan, K, Biankin, A, Garraway, L, Grimmond, S, Adams, D, Anur, P, Cao, S, Christie, E, Cmero, M, Cun, Y, Dawson, K, Deshwar, A, Donmez, N, Drews, R, Gerstung, M, Ha, G, Haase, K, Jerman, L, Ji, Y, Jolly, C, Lee-Six, H, Malikic, S, Mitchell, T, Morris, Q, Oesper, L, Peifer, M, Peto, M, Rosebrock, D, Rubanova, Y, Salcedo, A, Sengupta, S, Shi, R, Shin, S, Spiro, O, Vembu, S, Yang, T, Yu, K, Zhu, H, Spellman, P, Chen, Y, Fujita, M, Han, L, Hasegawa, T, Komura, M, Li, J, Mizuno, S, Shimizu, E, Wang, Y, Xu, Y, Yamaguchi, R, Yang, F, Yang, Y, Yoon, C, Yuan, Y, Liang, H, Alawi, M, Borozan, I, Brewer, D, Cooper, C, Desai, N, Grundhoff, A, Iskar, M, Su, X, Zapatka, M, Lichter, P, Alsop, K, Bruxner, T, Christ, A, Cordner, S, Cowin, P, Drapkin, R, Fereday, S, George, J, Hamilton, A, Holmes, O, Hung, J, Kassahn, K, Kazakoff, S, Kennedy, C, Leonard, C, Mileshkin, L, Miller, D, Arnau, G, Mitchell, C, Newell, F, Nones, K, Patch, A, Quinn, M, Taylor, D, Thorne, H, Traficante, N, Vedururu, R, Waring, P, Wood, S, Xu, Q, Defazio, A, Anderson, M, Antonello, D, Barbour, A, Bassi, C, Bersani, S, Cataldo, I, Chantrill, L, Chiew, Y, Chou, A, Cingarlini, S, Cloonan, N, Corbo, V, Davi, M, Duthie, F, Gill, A, Graham, J, Harliwong, I, Jamieson, N, Johns, A, Kench, J, Landoni, L, Lawlor, R, Mafficini, A, Merrett, N, Miotto, M, Musgrove, E, Nagrial, A, Oien, K, Pajic, M, Pinese, M, Robertson, A, Rooman, I, Rusev, B, Samra, J, Scardoni, M, Scarlett, C, Scarpa, A, Sereni, E, Sikora, K, Simbolo, M, Taschuk, M, Toon, C, Vicentini, C, Wu, J, Zeps, N, Behren, A, Burke, H, Cebon, J, Dagg, R, De Paoli-Iseppi, R, Dutton-Regester, K, Field, M, Fitzgerald, A, Hersey, P, Jakrot, V, Johansson, P, Kakavand, H, Kefford, R, Lau, L, Long, G, Pickett, H, Pritchard, A, Pupo, G, Saw, R, Schramm, S, Shang, C, Shang, P, Spillane, A, Stretch, J, Tembe, V, Thompson, J, Vilain, R, Wilmott, J, Yang, J, Hayward, N, Mann, G, Scolyer, R, Bartlett, J, Bavi, P, Chadwick, D, Chan-Seng-Yue, M, Cleary, S, Connor, A, Czajka, K, Denroche, R, Dhani, N, Eagles, J, Gallinger, S, Grant, R, Hedley, D, Hollingsworth, M, Jang, G, Johns, J, Kalimuthu, S, Liang, S, Lungu, I, Luo, X, Mbabaali, F, Mcpherson, T, Miller, J, Moore, M, Notta, F, Pasternack, D, Petersen, G, Roehrl, M, Sam, M, Selander, I, Serra, S, Shahabi, S, Thayer, S, Timms, L, Wilson, G, Wilson, J, Wouters, B, Beck, T, Bhandari, V, Collins, C, Fleshner, N, Fox, N, Fraser, M, Heisler, L, Lalonde, E, Livingstone, J, Meng, A, Sabelnykova, V, Shiah, Y, Van der Kwast, T, Bristow, R, Ding, S, Fan, D, Li, L, Nie, Y, Xiao, X, Xing, R, Yang, S, Yu, Y, Zhou, Y, Banks, R, Bourque, G, Brennan, P, Letourneau, L, Riazalhosseini, Y, Scelo, G, Vasudev, N, Viksna, J, Lathrop, M, Tost, J, Ahn, S, Aparicio, S, Arnould, L, Aure, M, Bhosle, S, Birney, E, Borg, A, Boyault, S, Brinkman, A, Brock, J, Broeks, A, Borresen-Dale, A, Caldas, C, Chin, S, Davies, H, Desmedt, C, Dirix, L, Dronov, S, Ehinger, A, Eyfjord, J, Fatima, A, Foekens, J, Futreal, P, Garred, O, Giri, D, Glodzik, D, Grabau, D, Hilmarsdottir, H, Hooijer, G, Jacquemier, J, Jang, S, Jonasson, J, Jonkers, J, King, T, Knappskog, S, Kong, G, Krishnamurthy, S, Lakhani, S, Langerod, A, Larsimont, D, Lee, H, Lee, M, Lingjaerde, O, Macgrogan, G, Martens, J, O'Meara, S, Pauporte, I, Pinder, S, Pivot, X, Provenzano, E, Purdie, C, Ramakrishna, M, Ramakrishnan, K, Reis-Filho, J, Richardson, A, Ringner, M, Rodriguez, J, Rodriguez-Gonzalez, F, Romieu, G, Salgado, R, Sauer, T, Shepherd, R, Sieuwerts, A, Simpson, P, Smid, M, Sotiriou, C, Span, P, Stefansson, O, Stenhouse, A, Stunnenberg, H, Sweep, F, Tan, B, Thomas, G, Thompson, A, Tommasi, S, Treilleux, I, Tutt, A, Ueno, N, Van Laere, S, Van den Eynden, G, Vermeulen, P, Viari, A, Vincent-Salomon, A, Wong, B, Yates, L, Zou, X, van Deurzen, C, van de Vijver, M, van't Veer, L, Ammerpohl, O, Aukema, S, Bergmann, A, Bernhart, S, Borkhardt, A, Borst, C, Burkhardt, B, Claviez, A, Goebler, M, Haake, A, Haas, S, Hansmann, M, Hoell, J, Hummel, M, Karsch, D, Klapper, W, Kneba, M, Kreuz, M, Kube, D, Kuppers, R, Lenze, D, Loeffler, M, Lopez, C, Mantovani-Loffler, L, Moller, P, Ott, G, Radlwimmer, B, Richter, J, Rohde, M, Rosenstiel, P, Rosenwald, A, Schilhabel, M, Schreiber, S, Stadler, P, Staib, P, Stilgenbauer, S, Sungalee, S, Szczepanowski, M, Toprak, U, Trumper, L, Wagener, R, Zenz, T, Hovestadt, V, von Kalle, C, Kool, M, Korshunov, A, Landgraf, P, Lehrach, H, Northcott, P, Pfister, S, Reifenberger, G, Warnatz, H, Wolf, S, Yaspo, M, Assenov, Y, Gerhauser, C, Minner, S, Schlomm, T, Simon, R, Sauter, G, Sultmann, H, Biswas, N, Maitra, A, Majumder, P, Sarin, R, Barbi, S, Bonizzato, G, Cantu, C, Dei Tos, A, Fassan, M, Grimaldi, S, Luchini, C, Malleo, G, Marchegiani, G, Milella, M, Paiella, S, Pea, A, Pederzoli, P, Ruzzenente, A, Salvia, R, Sperandio, N, Arai, Y, Hama, N, Hiraoka, N, Hosoda, F, Nakamura, H, Ojima, H, Okusaka, T, Totoki, Y, Urushidate, T, Fukayama, M, Ishikawa, S, Katai, H, Katoh, H, Komura, D, Rokutan, H, Saito-Adachi, M, Suzuki, A, Taniguchi, H, Tatsuno, K, Ushiku, T, Yachida, S, Yamamoto, S, Aikata, H, Arihiro, K, Ariizumi, S, Chayama, K, Furuta, M, Gotoh, K, Hayami, S, Hirano, S, Kawakami, Y, Maejima, K, Nakamura, T, Nakano, K, Ohdan, H, Sasaki-Oku, A, Tanaka, H, Ueno, M, Yamamoto, M, Yamaue, H, Choo, S, Cutcutache, I, Khuntikeo, N, Ong, C, Pairojkul, C, Popescu, I, Ahn, K, Aymerich, M, Lopez-Guillermo, A, Lopez-Otin, C, Puente, X, Campo, E, Amary, F, Baumhoer, D, Behjati, S, Bjerkehagen, B, Myklebost, O, Pillay, N, Tarpey, P, Tirabosco, R, Zaikova, O, Flanagan, A, Boultwood, J, Bowen, D, Cazzola, M, Green, A, Hellstrom-Lindberg, E, Malcovati, L, Nangalia, J, Papaemmanuil, E, Vyas, P, Ang, Y, Barr, H, Beardsmore, D, Eldridge, M, Gossage, J, Grehan, N, Hanna, G, Hayes, S, Hupp, T, Khoo, D, Lagergren, J, Lovat, L, Macrae, S, O'Donovan, M, O'Neill, J, Parsons, S, Preston, S, Puig, S, Roques, T, Sanders, G, Sothi, S, Tavare, S, Tucker, O, Turkington, R, Underwood, T, Welch, I, Fitzgerald, R, Berney, D, De Bono, J, Cahill, D, Camacho, N, Dennis, N, Dudderidge, T, Edwards, S, Fisher, C, Foster, C, Ghori, M, Gill, P, Gnanapragasam, V, Gundem, G, Hamdy, F, Hawkins, S, Hazell, S, Howat, W, Isaacs, W, Karaszi, K, Kay, J, Khoo, V, Kote-Jarai, Z, Kremeyer, B, Kumar, P, Lambert, A, Leongamornlert, D, Livni, N, Luxton, H, Marsden, L, Massie, C, Matthews, L, Mayer, E, Mcdermott, U, Merson, S, Neal, D, Nicol, D, Ogden, C, Rowe, E, Shah, N, Thomas, S, Verrill, C, Visakorpi, T, Warren, A, Whitaker, H, Zhang, H, van As, N, Eeles, R, Abeshouse, A, Agrawal, N, Akbani, R, Al-Ahmadie, H, Albert, M, Aldape, K, Ally, A, Appelbaum, E, Armenia, J, Asa, S, Auman, J, Balasundaram, M, Balu, S, Barnholtz-Sloan, J, Bathe, O, Baylin, S, Benz, C, Berchuck, A, Berrios, M, Bigner, D, Birrer, M, Bodenheimer, T, Boice, L, Bootwalla, M, Bosenberg, M, Bowlby, R, Boyd, J, Broaddus, R, Brock, M, Brooks, D, Bullman, S, Caesar-Johnson, S, Carey, T, Carlsen, R, Cerfolio, R, Chandan, V, Chen, H, Cherniack, A, Chien, J, Cho, J, Chuah, E, Cibulskis, C, Cope, L, Cordes, M, Curley, E, Czerniak, B, Danilova, L, Davis, I, Defreitas, T, Demchok, J, Dhalla, N, Dhir, R, Doddapaneni, H, El-Naggar, A, Felau, I, Ferguson, M, Finocchiaro, G, Fong, K, Frazer, S, Friedman, W, Fronick, C, Fulton, L, Gabriel, S, Gao, J, Gehlenborg, N, Gershenwald, J, Ghossein, R, Giama, N, Gibbs, R, Gomez, C, Govindan, R, Hayes, D, Hegde, A, Heiman, D, Heins, Z, Hepperla, A, Holbrook, A, Holt, R, Hoyle, A, Hruban, R, Hu, J, Huntsman, D, Huse, J, Iacobuzio-Donahue, C, Ittmann, M, Jayaseelan, J, Jefferys, S, Jones, C, Jones, S, Juhl, H, Kang, K, Karlan, B, Kasaian, K, Kebebew, E, Korchina, V, Kundra, R, Lai, P, Lander, E, Le, X, Levine, D, Lewis, L, Ley, T, Li, H, Lin, P, Linehan, W, Lype, L, Ma, Y, Maglinte, D, Mardis, E, Marks, J, Marra, M, Matthew, T, Mayo, M, Mccune, K, Meier, S, Meng, S, Mieczkowski, P, Mikkelsen, T, Miller, C, Mills, G, Moore, R, Morrison, C, Mose, L, Moser, C, Mungall, A, Mungall, K, Mutch, D, Muzny, D, Myers, J, Newton, Y, Noble, M, O'Donnell, P, O'Neill, B, Ochoa, A, Parker, J, Pass, H, Pastore, A, Pennell, N, Perou, C, Petrelli, N, Potapova, O, Rader, J, Ramalingam, S, Rathmell, W, Reuter, V, Reynolds, S, Ringel, M, Roach, J, Roberts, L, Sadeghi, S, Saller, C, Sanchez-Vega, F, Schadendorf, D, Schein, J, Schmidt, H, Schultz, N, Seethala, R, Senbabaoglu, Y, Shelton, T, Shi, Y, Shih, J, Shmulevich, I, Shriver, C, Signoretti, S, Simons, J, Singer, S, Sipahimalani, P, Skelly, T, Smith-McCune, K, Socci, N, Soloway, M, Sood, A, Tam, A, Tan, D, Tarnuzzer, R, Thiessen, N, Thompson, R, Thorne, L, Tsao, M, Umbricht, C, Van Den Berg, D, Van Meir, E, Veluvolu, U, Voet, D, Wang, L, Weinberger, P, Weisenberger, D, Wigle, D, Wilkerson, M, Wilson, R, Winterhoff, B, Wiznerowicz, M, Wong, T, Wong, W, Xi, L, Yau, C, Consortium, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes, Demeulemeester, Jonas, Desmedt, Christine, Van Loo, Peter, Barcelona Supercomputing Center, Imperial College Healthcare NHS Trust- BRC Funding, Cancer Research UK, Basic (bio-) Medical Sciences, Laboratory for Medical and Molecular Oncology

المصدر: Nature, vol 578, iss 7793
Semple, C 2020, ' Pan-cancer analysis of whole genomes ', Nature, vol. 578, no. 7793, pp. 82-93 . https://doi.org/10.1038/s41586-020-1969-6Test
Nature, 578, 82-93. Nature Publishing Group
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Bristow, R, Hayes, S, Wedge, D & et al. 2020, ' Pan-cancer analysis of whole genomes ', Nature. https://doi.org/10.1038/s41586-020-1969-6Test
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Weischenfeldt, J L, Sidiropoulos, N, Brunak, S & Rodriguez Gonzalez, F G 2020, ' Pan-cancer analysis of whole genomes ', Nature, vol. 578, no. 7793, pp. 82-93 . https://doi.org/10.1038/s41586-020-1969-6Test
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The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium 2020, ' Pan-cancer analysis of whole genomes ', Nature, vol. 578, no. 7793, pp. 82-93 . https://doi.org/10.1038/s41586-020-1969-6Test
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مصطلحات موضوعية: Male, tert promoter mutations, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], DNA Mutational Analysis, Normal tissue, systematic analysis, Germline, Transcriptome, 0302 clinical medicine, Aetiology, Càncer, Cellular Senescence, Cancer, 0303 health sciences, dna-damage, Massive parallel sequencing, Pan cancer, REARRANGEMENTS, High-Throughput Nucleotide Sequencing, Genomics, Sciences bio-médicales et agricoles, Telomere, COMPREHENSIVE, 3. Good health, TERT PROMOTER MUTATIONS, signatures, 030220 oncology & carcinogenesis, Science & Technology - Other Topics, Erfðarannsóknir, Human, Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], Evolution, RNA Splicing, Article, Evolution, Molecular, Structural variation, RC0254, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Genetic, genomics, SYSTEMATIC ANALYSIS, Genetics, Genomics--Databases, Humans, Genetic Testing, Molecular Biology, SIGNATURES, Whole genome sequencing, 1000 Multidisciplinary, Chromothripsis, Science & Technology, RC0254 Neoplasms. Tumors. Oncology (including Cancer), Information Dissemination, ResearchInstitutes_Networks_Beacons/mcrc, Prevention, Biology and Life Sciences, Molecular, Oncogenes, Cloud Computing, medicine.disease, Genòmica, Compute clouds, Mutation, 570 Life sciences, biology, COMPREHENSIVE CHARACTERIZATION, Genètica, Whole Genome Sequencing--methods, Background information, Genetic / genetics, Genome, Germ-Line Mutation / genetics, Human / genetics, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Medizin, Whole-genome, Genome mapping, Neoplasms, 2.1 Biological and endogenous factors, Promoter Regions, Genetic, Càncer -- Aspectes genètics, Telomerase, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], Multidisciplinary, Manchester Cancer Research Centre, genomics, cancer, profiling, 3rd-DAS, 10124 Institute of Molecular Life Sciences, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Multidisciplinary Sciences, Parallel sequencing, Female, profiling, Medical Genetics, Engineering sciences. Technology, Biotechnology, General Science & Technology, The Cancer Genome Atlas, 610 Medicine & health, Computational biology, QH426 Genetics, Biology, Consortium of the International Cancer Genome Consortium, Promoter Regions, Germline mutation, Pan-cancer analysis, Krabbameinsrannsóknir, medicine, cancer, ddc:610, QH426, Germ-Line Mutation, Medicinsk genetik, Krabbamein, 030304 developmental biology, Cell Proliferation, LANDSCAPE, Genome, Human, comprehensive characterization, Pan-cancer analysis of whole genomes, Point mutation, Human Genome, Reproducibility of Results, SOMATIC MUTATIONS, EVOLUTION, Cancer, sequencing, Chromothripsis, telomere, DNA-DAMAGE, Mutagenesis, PATTERNS, 3111 Biomedicine, CHARACTERIZATION

الوصف: Publisher's version (útgefin grein)
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1,2,3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10,11,12,13,14,15,16,17,18.
Competing interests Gad Getz receives research funds from IBM and Pharmacyclics and is an inventor on patent applications related to MuTect, ABSOLUTE, MutSig, MSMuTect, MSMutSig and POLYSOLVER. Hikmat Al-Ahmadie is consultant for AstraZeneca and Bristol-Myers Squibb. Samuel Aparicio is a founder and shareholder of Contextual Genomics. Pratiti Bandopadhayay receives grant funding from Novartis for an unrelated project. Rameen Beroukhim owns equity in Ampressa Therapeutics. Andrew Biankin receives grant funding from Celgene, AstraZeneca and is a consultant for or on advisory boards of AstraZeneca, Celgene, Elstar Therapeutics, Clovis Oncology and Roche. Ewan Birney is a consultant for Oxford Nanopore, Dovetail and GSK. Marcus Bosenberg is a consultant for Eli Lilly. Atul Butte is a cofounder of and consultant for Personalis, NuMedii, a consultant for Samsung, Geisinger Health, Mango Tree Corporation, Regenstrief Institute and in the recent past a consultant for 10x Genomics and Helix, a shareholder in Personalis, a minor shareholder in Apple, Twitter, Facebook, Google, Microsoft, Sarepta, 10x Genomics, Amazon, Biogen, CVS, Illumina, Snap and Sutro and has received honoraria and travel reimbursement for invited talks from Genentech, Roche, Pfizer, Optum, AbbVie and many academic institutions and health systems. Carlos Caldas has served on the Scientific Advisory Board of Illumina. Lorraine Chantrill acted on an advisory board for AMGEN Australia in the past 2 years. Andrew D. Cherniack receives research funding from Bayer. Helen Davies is an inventor on a number of patent applications that encompass the use of mutational signatures. Francisco De La Vega was employed at Annai Systems during part of the project. Ronny Drapkin serves on the scientific advisory board of Repare Therapeutics and Siamab Therapeutics. Rosalind Eeles has received an honorarium for the GU-ASCO meeting in San Francisco in January 2016 as a speaker, a honorarium and support from Janssen for the RMH FR meeting in November 2017 as a speaker (title: genetics and prostate cancer), a honorarium for an University of Chicago invited talk in May 2018 as speaker and an educational honorarium paid by Bayer & Ipsen to attend GU Connect ‘Treatment sequencing for mCRPC patients within the changing landscape of mHSPC’ at a venue at ESMO, Barcelona, on 28 September 2019. Paul Flicek is a member of the scientific advisory boards of Fabric Genomics and Eagle Genomics. Ronald Ghossein is a consultant for Veracyte. Dominik Glodzik is an inventor on a number of patent applications that encompass the use of mutational signatures. Eoghan Harrington is a full-time employee of Oxford Nanopore Technologies and is a stock holder. Yann Joly is responsible for the Data Access Compliance Office (DACO) of ICGC 2009-2018. Sissel Juul is a full-time employee of Oxford Nanopore Technologies and is a stock holder. Vincent Khoo has received personal fees and non-financial support from Accuray, Astellas, Bayer, Boston Scientific and Janssen. Stian Knappskog is a coprincipal investigator on a clinical trial that receives research funding from AstraZeneca and Pfizer. Ignaty Leshchiner is a consultant for PACT Pharma. Carlos López-Otín has ownership interest (including stock and patents) in DREAMgenics. Matthew Meyerson is a scientific advisory board chair of, and consultant for, OrigiMed, has obtained research funding from Bayer and Ono Pharma and receives patent royalties from LabCorp. Serena Nik-Zainal is an inventor on a number of patent applications that encompass the use of mutational signatures. Nathan Pennell has done consulting work with Merck, Astrazeneca, Eli Lilly and Bristol-Myers Squibb. Xose S. Puente has ownership interest (including stock and patents in DREAMgenics. Benjamin J. Raphael is a consultant for and has ownership interest (including stock and patents) in Medley Genomics. Jorge Reis-Filho is a consultant for Goldman Sachs and REPARE Therapeutics, member of the scientific advisory board of Volition RX and Paige.AI and an ad hoc member of the scientific advisory board of Ventana Medical Systems, Roche Tissue Diagnostics, InVicro, Roche, Genentech and Novartis. Lewis R. Roberts has received grant support from ARIAD Pharmaceuticals, Bayer, BTG International, Exact Sciences, Gilead Sciences, Glycotest, RedHill Biopharma, Target PharmaSolutions and Wako Diagnostics and has provided advisory services to Bayer, Exact Sciences, Gilead Sciences, GRAIL, QED Therapeutics and TAVEC Pharmaceuticals. Richard A. Scolyer has received fees for professional services from Merck Sharp & Dohme, GlaxoSmithKline Australia, Bristol-Myers Squibb, Dermpedia, Novartis Pharmaceuticals Australia, Myriad, NeraCare GmbH and Amgen. Tal Shmaya is employed at Annai Systems. Reiner Siebert has received speaker honoraria from Roche and AstraZeneca. Sabina Signoretti is a consultant for Bristol-Myers Squibb, AstraZeneca, Merck, AACR and NCI and has received funding from Bristol-Myers Squibb, AstraZeneca, Exelixis and royalties from Biogenex. Jared Simpson has received research funding and travel support from Oxford Nanopore Technologies. Anil K. Sood is a consultant for Merck and Kiyatec, has received research funding from M-Trap and is a shareholder in BioPath. Simon Tavaré is on the scientific advisory board of Ipsen and a consultant for Kallyope. John F. Thompson has received honoraria and travel support for attending advisory board meetings of GlaxoSmithKline and Provectus and has received honoraria for participation in advisory boards for MSD Australia and BMS Australia. Daniel Turner is a full-time employee of Oxford Nanopore Technologies and is a stock holder. Naveen Vasudev has received speaker honoraria and/or consultancy fees from Bristol-Myers Squibb, Pfizer, EUSA pharma, MSD and Novartis. Jeremiah A. Wala is a consultant for Nference. Daniel J. Weisenberger is a consultant for Zymo Research. Dai-Ying Wu is employed at Annai Systems. Cheng-Zhong Zhang is a cofounder and equity holder of Pillar Biosciences, a for-profit company that specializes in the development of targeted sequencing assays. The other authors declare no competing interests.

وصف الملف: text; application/pdf; 1 full-text file(s): application/pdf; application/application/pdf; 41586_2020_Article_1969.pdf - application/pdf; application/zip; text/xml; Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd8e0932de92879d87f512023f5ccd1Test
https://eprints.soton.ac.uk/437979Test/

المؤلفون: J. A. J. Alford, G. A. Younes, Z. Wadiasingh, M. Abdelmaguid, H. An, M. Bachetti, M. G. Baring, A. Beloborodov, A. Y. Chen, T. Enoto, J. A. García, J. D. Gelfand, E. V. Gotthelf, A. K. Harding, C-P. Hu, A. D. Jaodand, V. Kaspi, C. Kim, C. Kouveliotou, L. Kuiper, K. Mori, M. Nynka, J. Park, D. Stern, J. Valverde, D. J. Walton

المصدر: Frontiers in Astronomy and Space Sciences, Vol 10 (2024)

مصطلحات موضوعية: X-ray sources, HEX-P, pulsars, magnetars, neutron stars, spectra Frontiers, Astronomy, QB1-991, Geophysics. Cosmic physics, QC801-809

الوصف: The hard X-ray emission from magnetars and other isolated neutron stars remains under-explored. An instrument with higher sensitivity to hard X-rays is critical to understanding the physics of neutron star magnetospheres and also the relationship between magnetars and Fast Radio Bursts (FRBs). High sensitivity to hard X-rays is required to determine the number of magnetars with hard X-ray tails, and to track transient non-thermal emission from these sources for years post-outburst. This sensitivity would also enable previously impossible studies of the faint non-thermal emission from middle-aged rotation-powered pulsars (RPPs), and detailed phase-resolved spectroscopic studies of younger, bright RPPs. The High Energy X-ray Probe (HEX-P) is a probe-class mission concept that will combine high spatial resolution X-ray imaging (

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fspas.2023.1294449/fullTest; https://doaj.org/toc/2296-987XTest

الوصول الحر: https://doaj.org/article/0d5033e0213f452d803560def776d0feTest

المؤلفون: I. Pope, K. Mori, M. Abdelmaguid, J. D. Gelfand, S. P. Reynolds, S. Safi-Harb, C. J. Hailey, H. An, NuSTAR Collaboration, P. Bangale, P. Batista, W. Benbow, J. H. Buckley, M. Capasso, J. L. Christiansen, A. J. Chromey, A. Falcone, Q. Feng, J. P. Finley, G. M Foote, G. Gallagher, W. F Hanlon, D. Hanna, O. Hervet, J. Holder, T. B. Humensky, W. Jin, P. Kaaret, M. Kertzman, D. Kieda, T. K. Kleiner, N. Korzoun, F. Krennrich, S. Kumar, M. J. Lang, G. Maier, C. E McGrath, C. L. Mooney, P. Moriarty, R. Mukherjee, S. O’Brien, R. A. Ong, N. Park, S. R. Patel, K. Pfrang, M. Pohl, E. Pueschel, J. Quinn, K. Ragan, P. T. Reynolds, E. Roache, I. Sadeh, L. Saha, G. H. Sembroski, D. Tak, J. V. Tucci, A. Weinstein, D. A. Williams, J. Woo, VERITAS Collaboration

المصدر: The Astrophysical Journal, Vol 960, Iss 1, p 75 (2023)

مصطلحات موضوعية: Pulsar wind nebulae, X-ray astronomy, Gamma-ray astronomy, Astrophysics, QB460-466

الوصف: G106.3+2.7, commonly considered to be a composite supernova remnant (SNR), is characterized by a boomerang-shaped pulsar wind nebula (PWN) and two distinct (“head” and “tail”) regions in the radio band. A discovery of very-high-energy gamma-ray emission ( E _γ > 100 GeV) followed by the recent detection of ultrahigh-energy gamma-ray emission ( E _γ > 100 TeV) from the tail region suggests that G106.3+2.7 is a PeVatron candidate. We present a comprehensive multiwavelength study of the Boomerang PWN (100″ around PSR J2229+6114) using archival radio and Chandra data obtained two decades ago, a new NuSTAR X-ray observation from 2020, and upper limits on gamma-ray fluxes obtained by Fermi-LAT and VERITAS observatories. The NuSTAR observation allowed us to detect a 51.67 ms spin period from the pulsar PSR J2229+6114 and the PWN emission characterized by a power-law model with Γ = 1.52 ± 0.06 up to 20 keV. Contrary to the previous radio study by Kothes et al., we prefer a much lower PWN B -field ( B ∼ 3 μ G) and larger distance ( d ∼ 8 kpc) based on (1) the nonvarying X-ray flux over the last two decades, (2) the energy-dependent X-ray size of the PWN resulting from synchrotron burn-off, and (3) the multiwavelength spectral energy distribution (SED) data. Our SED model suggests that the PWN is currently re-expanding after being compressed by the SNR reverse shock ∼1000 yr ago. In this case, the head region should be formed by GeV–TeV electrons injected earlier by the pulsar propagating into the low-density environment.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1538-4357Test

الوصول الحر: https://doaj.org/article/60c94a125c72449ab4b3d75f182f0e0bTest

المؤلفون: J. D. Gerken, T. Fritzsche, C. Denke, M. Schäfer, S. Tafelski

المصدر: Pain Research and Management, Vol 2020 (2020)

مصطلحات موضوعية: Medicine (General), R5-920

الوصف: Objective. Current recommendations controversially discuss local infiltration techniques as specific treatment for refractory pain syndromes. Evidence of effectiveness remains inconclusive and local infiltration series are discussed as a therapeutic option in patients not responding to standard therapy. The aim of this study was to investigate the effectiveness of infiltration series with techniques such as sphenopalatine ganglion (SPG) block and ganglionic local opioid analgesia (GLOA) for the treatment of neuropathic pain in the head and neck area in a selected patient group. Methods. In a retrospective clinical study, 4960 cases presenting to our university hospital outpatient pain clinic between 2009 and 2016 were screened. Altogether, 83 patients with neuropathic pain syndromes receiving local infiltration series were included. Numeric rating scale (NRS) scores before, during, and after infiltration series, comorbidity, and psychological assessment were evaluated. Results. Maximum NRS before infiltration series was median 9 (IQR 8–10). During infiltration series, maximum NRS was reduced by mean 3.2 points (SD 3.3, p

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1203-6765Test; https://doaj.org/toc/1918-1523Test

الوصول الحر: https://doaj.org/article/15b093d893f048928668bf953b09dae7Test

المؤلفون: L. D. Ciesiolka, T. Hwin, J. D. Gearlds, G. V. Minsavage, R. Saenz, M. Bravo, V. Handley, S. M. Conover, H. Zhang, J. Caporgno, N. B. Phengrasamy, A. O. Toms, R. E. Stall, M. C. Whalen

المصدر: Molecular Plant-Microbe Interactions, Vol 12, Iss 1, Pp 35-44 (1999)

مصطلحات موضوعية: sequence overlap extension, sitedirected mutagenesis, Microbiology, QR1-502, Botany, QK1-989

الوصف: Resistance in tomato line Hawaii 7998 as well as in several nonhost plants to Xanthomonas campestris pv. vesicatoria tomato strain (XcvT) is mediated in part by the avirulence gene avrRxv. Analysis of growth of wild-type and avrRxv deletion strains indicates that avrRxv plays a crucial role in the ability of XcvT 92–14 to induce resistance on Hawaii 7998. We used avrRxv reporter gene fusions and Northern (RNA) blot analysis to test several growth environments for inductive potential. We found that avrRxv is constitutively expressed at high levels and that growth in planta, in tobacco conditioned medium, and in hrp-inductive medium XVM2 did not affect the high levels of expression. In addition, hrp structural and regulatory mutant backgrounds had no effect. We mutated the bipartite plant inducible promoter (PIP)-box sequence and found that avrRxv activity appears to be independent of an intact PIP-box element. We present the sequence of the avrRxv homologue called avrBsT and align the six AvrRxv host interaction factor family members including mammalian pathogen virulence factors YopJ and YopP from Yersinia spp. and AvrA from Salmonella typhimurium, and open reading frame Y4LO with unknown function from the symbiont Rhizobium sp.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/0894-0282Test; https://doaj.org/toc/1943-7706Test

الوصول الحر: https://doaj.org/article/6fc4ba896e2b4965a627c886d677fa7cTest

المؤلفون: A. Uchida, Akira Suda, Akito Sagisaka, C. Fabre, E. Takahashi, F. Kannari, F. Kuwashima, Fumihiko Nakano, G. Jiangrui, H. Fukuti, H. Horinaka, H. Imajo, H. Iwasawa, H. Kobune, H. Nishioka, H. Sawada, H. Takada, Hirokazu Taniguchi, Hiroyuki ISII, Hiroyuki Nagai, I. Kitazima, I. Matsushima, I. Okuda, J. D. Geiser, Juniti Higuti, K. Fujii, K. Hayasaka, K. Kanou, K. Kasai, K. Kusakabe, K. Kuwahara, K. Matsubara, K. Motomura, K. Nukihara, K. Togawa, K. Torizuka, K. Ueda, K. Wada, Katsumi Midorikawa, Kazuo Yamane, Kenshi Takahashi, Kiyotaka Kawai, Koichi Yamakawa, Koichi Yoshioka, Kotyayev Oleg, M. Fujimoto, M. Hosoda, M. Kakehata, M. Matsuoka, M. Mukai, M. Obara, M. Shinozuka, M. Watanabe, Makoto Aoyama, Masakazu Mori, Masaru Nakamura, Min-Kyu KIM, Mitsuo MAEDA, N. Kon, N. Sokabe, Nguyen Hong Shon, Nilesh J. Vasa, Nori Taniguchi, Norihiko Nishizawa, Oleg G. Kotyayev, P. L. Houston, Parhat Husayin, Penggian Wang, R. Ohmukai, R. Ueda, S. Aoshima, S. M. Dylewski, S. Okumi, S. Oonaru, S. Uchida, S. Urabe, Shigenobu Okutani, Sin-ichi Matsuoka, T. Baba, T. Ishizaka, T. Matsuyama, T. Nakanishi, T. Nakayama, T. Ogawa, T. Yamamoto, Takayuki TAKAO, Tatsuo Okada, Toshio Goto, U. Tanaka, Y. Matsumoto, Y. Owadano, Y. Takagi, Y. Tsuchiya, Yoshio Cho, Yuji OKI, Yutaka Akahane, Yutaka Matsumi, コチャエフ オレッグ, バサ ニレシ, フセイン パルハット, 上田 朗可, 中山 斌義, 中村 優, 中西 彊, 中野 文彦, 今 望武, 今城 秀司, 内田 成明, 内田 淳史, 前田 三男, 匂坂 明人, 北嶋 巌, 占部 伸二, 叶 浩司, 吉岡 孝一, 向井 将泰, 和田 健司, 土屋 裕, 堀中 博道, 大向 隆三, 大和田野 芳郎, 大成 真一, 奥田 功, 奥見 正治, 奥谷 重伸, 小原 實, 小川 武史, 小船 秀明, 山川 考一, 山本 俊, 山根 一雄, 岡田 龍雄, 岩澤 宏, 張 吉夫, 後藤 俊夫, 日下部 和人, 早坂 和弘, 曽我部 伸, 本村 幸治, 松原 健祐, 松山 哲也, 松岡 伸一, 松岡 正浩, 松嶋 功, 松本 裕治, 松見 豊, 桑原 研爾, 桑島 史欣, 森 正和, 植田 憲一, 樋口 淳一, 欠端 雅之, 永井 裕之, 河井 清貴, 渡川 和晃, 渡辺 昌良, 澤田 寛, 田中 歌子, 石井 啓之, 石坂 隆典, 神成 文彦, 福地 治之, 笠井 克幸, 篠塚 昌彦, 細田 誠, 興 雄司, 藤井 和也, 藤本 正俊, 西岡 一, 西澤 典彦, 谷口 のり, 谷口 浩一, 貫原 謙一, 赤羽 温, 金 民圭, 青山 誠, 青島 紳一郎, 馬場 寿夫, 高尾 隆之, 高木 芳弘, 高橋 けんし, 高橋 栄一, 高田 英行, 鳥塚 健二

المصدر: レーザー研究 / The Review of Laser Engineering. 2000, 28(Supplement):1

المؤلفون: J. D. Gerstenberg, Johann Kaspar Philipp Elwert

الوصول الحر: https://www.europeana.eu/item/92004/NKCR___NKCR__1F000059BAND2UQ32I1_cs?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCaTest