المؤلفون: Iván Godoy-Flores, Alessandro Soares da Silva, Elias Pizarro Pizarro

المصدر: Athenea Digital, Vol 22, Iss 3 (2022)

مصطلحات موضوعية: Balmaceda, Biografía, Historia, Psicología, Política, History of scholarship and learning. The humanities, AZ20-999, Social sciences (General), H1-99

الوصف: Estudios anteriores sugieren que el origen de la psicología política en Chile se habría generado con la obra Balmaceda y el Parlamentarismo en Chile, Un estudio de psicología política chilena, del político e historiador Ricardo Salas Edwards, a inicios del siglo XX, desplazando hacia atrás la línea histórica desde la psicología clínica y social como consecuencia de los trastornos psicológicos provocados por la dictadura militar a mediados de la década del 1970. Pero, además, mediante un análisis de contenido, sostenemos que la Psicología Política debió su origen al carácter psicohistórico de esta narrativa. Así, en el presente trabajo analizamos las contribuciones de Salas Edwards para la emergencia de la Psicología Política a partir de su comprensión de los hechos políticos de 1891.

وصف الملف: electronic resource

العلاقة: https://atheneadigital.net/article/view/3043Test; https://doaj.org/toc/2014-4539Test; https://doaj.org/toc/1578-8946Test

الوصول الحر: https://doaj.org/article/f6362e1cc9834c0ea0460c95d67b1dd1Test

المؤلفون: Maria Paz Ocaranza, Patricio Valderas, Jackeline Moya, Luigi Gabrielli, Iván Godoy, Samuel Córdova, Paul Mac Nab, Lorena García, Luis Farías, Jorge E. Jalil

المصدر: Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-12 (2020)

مصطلحات موضوعية: Diabetes, Metabolic syndrome, Rho kinase, ROCK, MYPT-1, ERM, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Background The intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes, ROCK activation has also a role in abnormal glucose metabolism as well as in subsequent vascular and myocardial dysfunction. In humans, there are a few data assessing ROCK activation in patients with type 2 diabetes mellitus (T2D) and no studies assessing upstream/downstream components of the ROCK pathway. We assessed here levels of ROCK activation and some of the RhoA/ROCK cascade molecules in peripheral blood mononuclear cells (PBMCs) in T2D patients under current treatment. Methods Cross-sectional observational study comparing 28 T2D patients under current antidiabetic treatment with 31 consecutive healthy subjects, matched by age and gender. Circulating levels of malondialdehyde, angiotensin II and inflammatory cytokines IL-6 and IL-8 were determined in all subjects. ROCK activation in PMBCs, upstream and downstream cascade proteins, and levels of the proinflammatory molecules VCAM, ICAM-1 and IL-8 were determined in their PMBCs by Western blot. Results Compared to healthy controls, ROCK activation in T2D patients measured by 2 direct ROCK targets in PBMCs was increased by 420 and 570% (p

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12933-020-01027-2Test; https://doaj.org/toc/1475-2840Test

الوصول الحر: https://doaj.org/article/4e2bcc6c0810436993c1b1ce3b0fda7cTest

المؤلفون: Iván Godoy

المصدر: Ideas y Valores, Vol 66, Iss 165, Pp 111-132 (2017)

مصطلحات موضوعية: van gogh, pauer, togay, arte, verdad, zapatos, Philosophy. Psychology. Religion, Philosophy (General), B1-5802

الوصف: Los zapatos nos sirven y nos acompañan, testimonian diferentes verdades, dependiendo de su utilidad y su dueño. Pueden ser de vagabundos o de prisioneros, de militares, artistas o campesinos, de adultos o de niños, de asesinos o de asesinados. Muchos guardan un misterio, todos tienen una historia. El arte los ha acogido desde sus comienzos, vinculándolos a diferentes sucesos, como en las obras de Vincent Van Gogh, Can Togay y Gyula Pauer. A partir del trabajo de estos artistas se busca vincular el vacío y el horror en el arte con el tema de la verdad, entendida como alétheia o desocultación, rememoración y acontecimiento, e indagar por la historia que se oculta tras ciertas obras artísticas.

وصف الملف: electronic resource

العلاقة: http://www.redalyc.org/articulo.oa?id=80955136005Test; https://doaj.org/toc/0120-0062Test; https://doaj.org/toc/2011-3668Test

الوصول الحر: https://doaj.org/article/a22628665afd4accb3c072630971e2b5Test

المؤلفون: Pilar Arnaiz, Salesa Barja, Luis Villarroel, Angélica Domínguez, Iván Godoy, Oscar Castillo, Marcelo Farías, Francisco Mardones

المصدر: Nutrición Hospitalaria, Vol 28, Iss 5, Pp 1587-1593 (2013)

مصطلحات موضوعية: Síndrome metabólico X, Resistencia insulínica, Grosor de la íntima-media carotídea, Pediatría, Nutritional diseases. Deficiency diseases, RC620-627

الوصف: Introducción: El síndrome metabólico (SM) en niños se ha vinculado al desarrollo de ateroesclerosis subclínica, estimada por el grosor intimo-medial carotideo (CIMT). Objetivos: Estudiar la asociación del CIMT con los componentes del SM, la resistencia insulínica (RI) y el estado nutricional en escolares, además de explorar puntos de corte asociados a riesgo. Métodos: Estudio transversal de 447 niños asistentes a escuelas públicas de Santiago, Chile (2009-2011), seleccionados por presentar uno o más componentes del SM y RI. Se realizó antropometría y toma estandarizada de presión de arteria braquial, además de muestras de sangre para determinar lípidos glicemia e insulinemia. Se midió el CIMT por ultrasonografía de alta resolución. Se utilizó correlación de Pearson, t de Student, chi cuadrado y regresión logística. Resultados: Edad 11,5 ± 1,0 años (rango 10-14); 59% mujeres; 93% púberes; 72% con exceso de peso; 24% con SM y 15% con RI. Los promedios de los componentes del SM en los niños con CIMT ≥ percentil 75 vs < percentil 75 tuvieron diferencias para presión arterial sistólica o diastólica ≥ percentil 90 (PA) y colesterol unido a lipoproteínas de alta densidad ≤ 40 mg/dL (CHDL). En la regresión logística para CIMT ≥ percentil 75 fueron seleccionadas PA y CHDL. En la regresión logística para CIMT ≥ percentil 90 no hubo variables seleccionadas. Conclusiones: En este grupo de niños los niveles de PA y CHDL se asocian con CIMT ≥ percentil 75. No se encontró asociación con estado nutricional y RI posiblemente por ser una muestra seleccionada.

وصف الملف: electronic resource

العلاقة: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112013000500033&lng=en&tlng=enTest; https://doaj.org/toc/0212-1611Test

الوصول الحر: https://doaj.org/article/36215082c8b6409498ec565136d7e70cTest

المؤلفون: Carlos Benítez, Marco Arrese, Jorge Jorquera, Iván Godoy, Andrea Conteras, Soledad Loyola, Pilar Domínguez P, Nicolás Jarufe, Jorge Martínez, Rosa María Pérez-Ayuso, M.D.

المصدر: Annals of Hepatology, Vol 8, Iss 1, Pp 71-74 (2009)

مصطلحات موضوعية: Cirrhosis, respiratory failure, liver transplantation, Specialties of internal medicine, RC581-951

الوصف: Hepatopulmonary syndrome (HPS) is a complication of portal hypertension (PH) defined by the presence of liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations (IPVD) producing a right to left intrapulmonary shunt. Liver transplantation (LT) is the treatment of choice; however, severe hypoxemia may contraindi-cate LT. The use of transjugular intrahepatic porto-systemic shunts (TIPS) could be effective in HPS, although available data is limited. Aim: To report a clinical case of severe HPS treated sequentially with TIPS and LT. Case report: A 46 year old female cir-rhotic patient presented with rapidly progressive dyspnea, hypoxemia (PaO2 60 mmHg, SaO2 92%) and increased alveolar-arterial oxygen gradient (A-a) (46 mmHg). She also had orthodeoxia (SaO2 87% in sitting position, but 91% in a prone position). A CT scan and pulmonary angiography were normal. Spirometric assessment showed a mild restrictive pattern and a desaturation was observed in a six-minute walking test. Contrast-enhanced echocardiography (CEE) showed intrapulmonary shunting. A HPS was diagnosed and liver transplantation was disregarded due to severe hypoxemia. The patient underwent TIPS placement. After four weeks, a significant improvement of dyspnea and a complete remission of orthodeoxia were seen. One year later, the patient was successfully transplanted. Interestingly, six months after LT, and in the absence of dyspnea, a new CEE showed persistent passing of bubbles to the left cavities. Comments/Conclusion: Persistent right-to-left shunt after TIPS placement and liver transplantation in spite of the improvement of pulmonary function tests suggests long-term persistence of structural changes in the pulmonary vascular tree after liver transplantation. Because of lack of data, it is not possible to recommend the routine use of TIPS as a part of the conventional management of HPS. However, in patients with severe hypoxemia TIPS placement can reasonably be used as a bridge towards transplantation.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1665268119318162Test; https://doaj.org/toc/1665-2681Test

الوصول الحر: https://doaj.org/article/921cda98f28e454094f0ceb9d1516f52Test

المؤلفون: Flores, Iván Godoy, Romero, Juan Carlos Romero

المصدر: Interciencia

مصطلحات موضوعية: Multidisciplinary

الوصف: © 2018 Interciencia Association. All rights reserved. Political psychology is a field of multidisciplinary and trans-disciplinary studies of the social sciences, born in Europe at the beginning of the 20th century. Today, political psychology encompasses subjects of study ranging from the leadership of politicians, public policies, corruption, conflicts, political violence and terrorism, among others. In Chile, several authors identify the birth of political psychology in the late 1970s as a result of clinical psychology interventions in disorders caused by military dictatorship. The present paper reviews and discusses these statements, postulating that one of its possible beginnings is in the work Balmaceda y el Parlamentarismo en Chile, a psycho-political and historical text of 1914, written by the politician and historian Ricardo Salas Edwards, who reports the Political-Military Conflict of 1891. In our work we present qualitative analyzes and evidences that support our assertion, m

وصف الملف: application/pdf

العلاقة: Interciencia, Volumen 43, Issue 6, 2018, Pages 455-460; https://repositorio.uchile.cl/handle/2250/167502Test

الإتاحة: https://repositorio.uchile.cl/handle/2250/167502Test

المؤلفون: Ivan Godoy Contreras

المصدر: Co-herencia: Revista de Humanidades, Vol 14, Iss 26, Pp 59-86 (2017)

مصطلحات موضوعية: Mal, violencia, crueldad, horror, terrorismo, History America, E-F, Language and Literature, Philosophy. Psychology. Religion

الوصف: Será la guerra, justamente, el escenario propicio para el abuso de cadáveres con fines políticos, en el que confluyen dos elementos consustanciales al Mal. El primero apunta a la negación del Otro como ser humano y sujeto de derecho, lo cual habilita al agresor para proceder con crueldad sobre su víctima. El segundo remite a la gradual “espectacularización” del cadáver, cuyas imágenes develan el ensañamiento con el Otro. Del arte a las imágenes digitales, las escenografías del Mal se despliegan de modo polisémico. El drama, por lo tanto, acontece en la puesta en escena del sufrimiento del otro, reside no solo en el rostro de dolor y el grito de muerte del derrotado -o en el placer, coraje o valentía de su verdugo-, sino también en un más allá, en el uso y abuso del cadáver enemigo para prolongar el daño y el dolor -directa o indirectamente- en el deudo y su comunidad.

العلاقة: http://publicaciones.eafit.edu.co/index.php/co-herencia/article/view/2917/3916Test; https://doaj.org/toc/1794-5887Test; https://doaj.org/article/1dbea636f32b45c6bd039c039102d229Test

الإتاحة: https://doi.org/10.17230/co-herencia.14.26.3Test
https://doaj.org/article/1dbea636f32b45c6bd039c039102d229Test

المؤلفون: Ulises Novoa, Luigi Gabrielli, Claudio Cantin, Juan F Bulnes, Samuel Córdova, María Paz Ocaranza, Paul MacNab, Jorge E. Jalil, Iván Godoy

المصدر: Current Vascular Pharmacology. 18:87-91

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Angiotensin receptor, Time Factors, Diastole, Down-Regulation, Tetrazoles, Blood Pressure, Pilot Projects, 030204 cardiovascular system & hematology, Essential hypertension, Peripheral blood mononuclear cell, Myosin-Light-Chain Phosphatase, 03 medical and health sciences, 0302 clinical medicine, Hydrochlorothiazide, Internal medicine, medicine, Humans, Prospective Studies, Phosphorylation, Antihypertensive Agents, Pharmacology, rho-Associated Kinases, business.industry, Imidazoles, Middle Aged, medicine.disease, Angiotensin II, Treatment Outcome, 030104 developmental biology, Blood pressure, Endocrinology, Leukocytes, Mononuclear, Female, Essential Hypertension, Cardiology and Cardiovascular Medicine, Olmesartan, business, Angiotensin II Type 1 Receptor Blockers, medicine.drug

الوصف: Background: Angiotensin II is a potent activator of the Rho-kinase (ROCK) pathway, through which it exerts some of its adverse vasoconstrictor effects. Clinical evidence on the effects of blocking the angiotensin II receptor 1 on ROCK activity in hypertensive patients is scarce. Objective: To demonstrate that ROCK activity in peripheral blood mononuclear cells (PMBCs) in patients with essential hypertension is reduced earlier than previously observed, along with blood pressure (BP) lowering on treatment with olmesartan. Methods: Prospective pilot open study; 17 hypertensive patients were treated with progressive olmesartan doses starting with 20 mg qd. BP was measured at 3, 6 and 9 weeks after treatment initiation. If treatment failed to normalize BP after 3 weeks, olmesartan dose was increased to 40 mg qd, and if still hypertensive after 6 weeks, 12.5 mg of hydrochlorothiazide qd was added. ROCK activity was measured at baseline and 9 weeks after treatment as myosin phosphatase target subunit 1 phosphorylation (MYPT1-p/T ratio) in PBMC. Results: Mean baseline BP was 162 ± 4.9/101 ± 2.4 mmHg. After 9 weeks of treatment, both systolic and diastolic BP were reduced by 41 and 22 mmHg, respectively (p Conclusion: Normotension achieved after 9 weeks in 82% of the patients treated with olmesartan was associated with a significant reduction of ROCK activity in PBMC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac7ee76ed6c893125bff1c6ee6da193Test
https://doi.org/10.2174/1570161117666190121103116Test

المؤلفون: Cristián Mancilla, Cristián Molina, María Paz Ocaranza, Sergio Lavandero, Paul Mac Nab, Pablo Castro, Iván Godoy, Lorena García, Luis Farías, Javier González, Víctor Rossel, Jorge E. Jalil, Luigi Gabrielli, Camila Fierro, Jackeline Moya, Samuel Córdova, Alexis M. Kalergis

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: 0301 basic medicine, Male, heart failure, Apoptosis, MYPT1, Rho‐kinase, Myosin-Light-Chain Phosphatase, 0302 clinical medicine, Catecholamines, Myosin, Natriuretic Peptide, Brain, remodelling, Phosphorylation, Rho-associated protein kinase, rho-Associated Kinases, Ventricular Remodeling, Chemistry, Microfilament Proteins, Middle Aged, ERM, 030220 oncology & carcinogenesis, Molecular Medicine, Cytokines, Original Article, Female, Myosin-light-chain phosphatase, Signal Transduction, medicine.medical_specialty, Angiotensins, Systole, macromolecular substances, Peripheral blood mononuclear cell, 03 medical and health sciences, Antigens, CD, Internal medicine, medicine, Animals, Humans, Myocardium, Membrane Proteins, Stroke Volume, Cell Biology, Original Articles, Janus Kinase 2, medicine.disease, Angiotensin II, Rats, Enzyme Activation, Cytoskeletal Proteins, Disease Models, Animal, 030104 developmental biology, Endocrinology, Heart failure, Leukocytes, Mononuclear

الوصف: Background Increased Rho‐kinase activity in circulating leucocytes is observed in heart failure with reduced ejection fraction (HFrEF). However, there is little information in HFrEF regarding other Rho‐kinase pathway components an on the relationship between Rho‐kinase and apoptosis. Here, Rho‐kinase activation levels and phosphorylation of major downstream molecules and apoptosis levels were measured for the first time both in HFrEF patients and healthy individuals. Methods Cross‐sectional study comparing HFrEF patients (n = 20) and healthy controls (n = 19). Rho‐kinase activity in circulating leucocytes (peripheral blood mononuclear cells, PBMCs) was determined by myosin light chain phosphatase 1 (MYPT1) and ezrin‐radixin‐moesin (ERM) phosphorylation. Rho‐kinase cascade proteins phosphorylation p38‐MAPK, myosin light chain‐2, JAK and JNK were also analysed along with apoptosis. Results MYPT1 and ERM phosphorylation were significantly elevated in HFrEF patients, (3.9‐ and 4.8‐fold higher than in controls, respectively). JAK phosphorylation was significantly increased by 300% over controls. Phosphorylation of downstream molecules p38‐MAPK and myosin light chain‐2 was significantly higher by 360% and 490%, respectively, while JNK phosphorylation was reduced by 60%. Catecholamine and angiotensin II levels were significantly higher in HFrEF patients, while angiotensin‐(1‐9) levels were lower. Apoptosis in circulating leucocytes was significantly increased in HFrEF patients by 2.8‐fold compared with controls and significantly correlated with Rho‐kinase activation. Conclusion Rho‐kinase pathway is activated in PMBCs from HFrEF patients despite optimal treatment, and it is closely associated with neurohormonal activation and with apoptosis. ROCK cascade inhibition might induce clinical benefits in HFrEF patients, and its assessment in PMBCs could be useful to evaluate reverse remodelling and disease regression.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c7785c6ec2d55a5df536dd50a99a3dTest
http://europepmc.org/articles/PMC6991691Test

المؤلفون: Ivan Godoy C.

المصدر: Arbor: Ciencia, Pensamiento y Cultura, Vol 189, Iss 764, Pp a087-a087 (2013)

مصطلحات موضوعية: picasso, casagemas, gargallo, suicidio, duelo, melancolía, periodo azul, General Works

الوصف: París 1901: por el amor de una mujer, se suicida de un balazo en la cabeza Carles Casagemas, amigo íntimo de juventud de Pablo Picasso. Este trágico suceso producirá un gran dolor en el artista, el cual, lo hará internarse en el tema de la muerte y elaborar su “duelo” apoyado en su pintura. El “hoyo a bala” en la sien de su amigo se desplazará simbólicamente a varios espacios de la vida del joven Picasso y devendrá en “vacío profundo” y “melancolía”, permeando diferentes ámbitos dentro de la pintura de Picasso, dando comienzo a su mentado período azul.

العلاقة: http://arbor.revistas.csic.es/index.php/arbor/article/view/1889Test; https://doaj.org/toc/0210-1963Test; https://doaj.org/toc/1988-303XTest; https://doaj.org/article/d5119411e9954833963ef97c9fd9d9cfTest

الإتاحة: https://doi.org/10.3989/arbor.2013.764n6010Test
https://doaj.org/article/d5119411e9954833963ef97c9fd9d9cfTest