المؤلفون: Hsu, Y., Pintacuda, G., Liu, R., Nacu, E., Kim, A., Tsafou, K., Petrossian, N., Crotty, W., Suh, J., Riseman, J., Martin, J., Biagini, J., Mena, D., Ching, J., Malolepsza, E., Li, T., Singh, T., Ge, T., Egri, S., Tanenbaum, B., Stanclift, C., Apffel, A., Ripke, S., Neale, B., Corvin, A., Walters, J., Farh, K., Holmans, P., Lee, P., Bulik-Sullivan, B., Collier, D., Huang, H., Pers, T., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S., Begemann, M., Belliveau, R., Bene, J., Bergen, S., Bevilacqua, E., Bigdeli, T., Black, D., Bruggeman, R., Buccola, N., Buckner, R., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R., Carr, V., Carrera, N., Catts, S., Chambert, K., Chan, R., Chen, E., Cheng, W., Cheung, E., Chong, S., Cloninger, C., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J., Curtis, D., Davidson, M., Davis, K., Degenhardt, F., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A., Farrell, M., Frank, J., Franke, L., Freedman, R., Freimer, N., Friedl, M., Friedman, J., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J., Golimbet, V., Gopal, S., Gratten, J., de Haan, L., Hammer, C., Hamshere, M., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A., Henskens, F., Herms, S., Hirschhorn, J., Hoffmann, P., Hofman, A., Hollegaard, M., Hougaard, D., Ikeda, M., Joa, I., Julià, A., Kahn, R., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M., Kennedy, J., Khrunin, A., Kim, Y., Klovins, J., Knowles, J., Konte, B., Kucinskas, V., Kucinskiene, Z., Kuzelova-Ptackova, H., Kähler, A., Laurent, C., Lee, J., Lee, S., Legge, S., Lerer, B., Li, M., Liang, K., Lieberman, J., Limborska, S., Loughland, C., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P., Maher, B., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R., McDonald, C., McIntosh, A., Meier, S., Meijer, C., Melegh, B., Melle, I., Mesholam-Gately, R., Metspalu, A., Michie, P., Milani, L., Milanova, V., Mokrab, Y., Morris, D., Mors, O., Murphy, K., Murray, R., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D., Nestadt, G., Nicodemus, K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., O'Neill, F., Oh, S., Olincy, A., Olsen, L., Van Os, J., Pantelis, C., Papadimitriou, G., Papiol, S., Parkhomenko, E., Pato, M., Paunio, T., Pejovic-Milovancevic, M., Perkins, D., Pietiläinen, O., Pimm, J., Pocklington, A., Powell, J., Price, A., Pulver, A., Purcell, S., Quested, D., Rasmussen, H., Reichenberg, A., Reimers, M., Richards, A., Roffman, J., Roussos, P., Ruderfer, D., Salomaa, V., Sanders, A., Schall, U., Schubert, C., Schulze, T., Schwab, S., Scolnick, E., Scott, R., Seidman, L., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J., Sim, K., Slominsky, P., Smoller, J., So, H., Spencer, C., Stahl, E., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R., Strengman, E., Strohmaier, J., Stroup, T., Subramaniam, M., Suvisaari, J., Svrakic, D., Szatkiewicz, J., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B., Weiser, M., Wildenauer, D., Williams, N., Williams, S., Witt, S., Wolen, A., Wong, E., Wormley, B., Xi, H., Zai, C., Zheng, X., Zimprich, F., Wray, N., Stefansson, K., Visscher, P., Adolfsson, R., Andreassen, O., Blackwood, D., Bramon, E., Buxbaum, J., Børglum, A., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P., Gill, M., Gurling, H., Hultman, C., Iwata, N., Jablensky, A., Jönsson, E., Kendler, K., Kirov, G., Knight, J., Lencz, T., Levinson, D., Li, Q., Liu, J., Malhotra, A., McCarroll, S., McQuillin, A., Moran, J., Mortensen, P., Mowry, B., Nöthen, M., Ophoff, R., Owen, M., Palotie, A., Pato, C., Petryshen, T., Posthuma, D., Rietschel, M., Riley, B., Rujescu, D., Sham, P., Sklar, P., St Clair, D., Weinberger, D., Wendland, J., Werge, T., Daly, M., Sullivan, P., O'Donovan, M., Qin, S., Sawa, A., Hong, K., Shi, W., Tsuang, M., Itokawa, M., Feng, G., Glatt, S., Ma, X., Tang, J., Ruan, Y., Zhu, F., Horiuchi, Y., Lee, B., Joo, E., Myung, W., Ha, K., Won, H., Baek, J., Chung, Y., Kim, S., Kusumawardhani, A., Chen, W., Hwu, H., Hishimoto, A., Otsuka, I., Sora, I., Toyota, T., Yoshikawa, T., Kunugi, H., Hattori, K., Ishiwata, S., Numata, S., Ohmori, T., Arai, M., Ozeki, Y., Fujii, K., Lee, H., Ahn, Y., Akiyama, K., Shimoda, K., Kinoshita, M., Carr, S., Schenone, M., Jaffe, J., Fornelos, N., Eggan, K., Lage, K.

المصدر: iScience

الوصف: Genetics have nominated many schizophrenia risk genes and identified convergent signals between schizophrenia and neurodevelopmental disorders. However, functional interpretation of the nominated genes in the relevant brain cell types is often lacking. We executed interaction proteomics for six schizophrenia risk genes that have also been implicated in neurodevelopment in human induced cortical neurons. The resulting protein network is enriched for common variant risk of schizophrenia in Europeans and East Asians, is down-regulated in layer 5/6 cortical neurons of individuals affected by schizophrenia, and can complement fine-mapping and eQTL data to prioritize additional genes in GWAS loci. A sub-network centered on HCN1 is enriched for common variant risk and contains proteins (HCN4 and AKAP11) enriched for rare protein-truncating mutations in individuals with schizophrenia and bipolar disorder. Our findings showcase brain cell-type-specific interactomes as an organizing framework to facilitate interpretation of genetic and transcriptomic data in schizophrenia and its related disorders.

وصف الملف: application/pdf

العلاقة: http://hdl.handle.net/21.11116/0000-000D-7A3C-8Test; http://hdl.handle.net/21.11116/0000-000D-7A3E-6Test

الإتاحة: https://doi.org/10.1016/j.isci.2023.106701Test
http://hdl.handle.net/21.11116/0000-000D-7A3C-8Test
http://hdl.handle.net/21.11116/0000-000D-7A3E-6Test

المؤلفون: Ikeda, M, Takahashi, A, Kamatani, Y, Okahisa, Y, Kunugi, H, Mori, N, Sasaki, T, Ohmori, Tetsuro, Okamoto, Y, Kawasaki, H, Shimodera, S, Kato, T, Yoneda, H, Yoshimura, R, Iyo, M, Matsuda, K, Akiyama, M, Ashikawa, K, Kashiwase, K, Tokunaga, K, Kondo, K, Saito, T, Shimasaki, A, Kawase, K, Kitajima, T, Matsuo, K, Itokawa, M, Someya, T, Inada, T, Hashimoto, R, Inoue, T, Akiyama, K, Tanii, H, Arai, H, Kanba, S, Ozaki, N, Kusumi, I, Yoshikawa, T, Kubo, M, Iwata, N

الوصف: Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In the present GWAS (Phase I/II), which included 2964 BD and 61 887 control subjects from the Japanese population, we detected a novel susceptibility locus at 11q12.2 (rs28456, P=6.4 × 10−9), a region known to contain regulatory genes for plasma lipid levels (FADS1/2/3). A subsequent meta-analysis of Phase I/II and the Psychiatric GWAS Consortium for BD (PGC-BD) identified another novel BD gene, NFIX (P best=5.8 × 10−10), and supported three regions previously implicated in BD susceptibility: MAD1L1 (P best=1.9 × 10−9), TRANK1 (P best=2.1 × 10−9) and ODZ4 (P best=3.3 × 10−9). Polygenicity of BD within Japanese and trans-European-Japanese populations was assessed with risk profile score analysis. We detected higher scores in BD cases both within (Phase I/II) and across populations (Phase I/II and PGC-BD). These were defined by (1) Phase II as discovery and Phase I as target, or vice versa (for ‘within Japanese comparisons’, Pbest~10−29, R2~2%), and (2) European PGC-BD as discovery and Japanese BD (Phase I/II) as target (for ‘trans-European-Japanese comparison,’ Pbest~10−13, R2~0.27%). This ‘trans population’ effect was supported by estimation of the genetic correlation using the effect size based on each population (liability estimates~0.7). These results indicate that (1) two novel and three previously implicated loci are significantly associated with BD and that (2) BD ‘risk’ effect are shared between Japanese and European populations.

العلاقة: http://repo.lib.tokushima-u.ac.jp/files/public/11/115603/20210121170342347629/mp_23_3_639.pdfTest; AA11164978; AA12909982; http://repo.lib.tokushima-u.ac.jp/115603Test

الإتاحة: http://repo.lib.tokushima-u.ac.jp/115603Test

المؤلفون: Ide, M, Ohnishi, T, Toyoshima, M, Balan, S, Maekawa, M, Shimamoto-Mitsuyama, C, Iwayama, Y, Ohba, H, Watanabe, A, Ishii, T, Shibuya, N, Kimura, Y, Hisano, Y, Murata, Y, Hara, T, Morikawa, M, Hashimoto, K, Nozaki, Y, Toyota, T, Wada, Y, Tanaka, Y, Kato, T, Nishi, A, Fujisawa, S, Okano, H, Itokawa, M, Hirokawa, N, Kunii, Y, Kakita, A, Yabe, H, Iwamoto, K, Meno, K, Katagiri, T, Dean, B, Uchida, K, Kimura, H, Yoshikawa, T

الوصف: Mice with the C3H background show greater behavioral propensity for schizophrenia, including lower prepulse inhibition (PPI), than C57BL/6 (B6) mice. To characterize as-yet-unknown pathophysiologies of schizophrenia, we undertook proteomics analysis of the brain in these strains, and detected elevated levels of Mpst, a hydrogen sulfide (H2 S)/polysulfide-producing enzyme, and greater sulfide deposition in C3H than B6 mice. Mpst-deficient mice exhibited improved PPI with reduced storage sulfide levels, while Mpst-transgenic (Tg) mice showed deteriorated PPI, suggesting that "sulfide stress" may be linked to PPI impairment. Analysis of human samples demonstrated that the H2 S/polysulfides production system is upregulated in schizophrenia. Mechanistically, the Mpst-Tg brain revealed dampened energy metabolism, while maternal immune activation model mice showed upregulation of genes for H2 S/polysulfides production along with typical antioxidative genes, partly via epigenetic modifications. These results suggest that inflammatory/oxidative insults in early brain development result in upregulated H2 S/polysulfides production as an antioxidative response, which in turn cause deficits in bioenergetic processes. Collectively, this study presents a novel aspect of the neurodevelopmental theory for schizophrenia, unraveling a role of excess H2 S/polysulfides production.

العلاقة: Ide, M., Ohnishi, T., Toyoshima, M., Balan, S., Maekawa, M., Shimamoto-Mitsuyama, C., Iwayama, Y., Ohba, H., Watanabe, A., Ishii, T., Shibuya, N., Kimura, Y., Hisano, Y., Murata, Y., Hara, T., Morikawa, M., Hashimoto, K., Nozaki, Y., Toyota, T. ,. Yoshikawa, T. (2019). Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology. EMBO MOLECULAR MEDICINE, 11 (12), https://doi.org/10.15252/emmm.201910695Test.; http://hdl.handle.net/11343/247092Test

الإتاحة: https://doi.org/10.15252/emmm.201910695Test
http://hdl.handle.net/11343/247092Test

المؤلفون: Ikeda, M, Takahashi, A, Kamatani, Y, Okahisa, Y, Kunugi, H, Mori, N, Sasaki, T, Ohmori, T, Okamoto, Y, Kawasaki, H, Shimodera, S, Kato, T, Yoneda, H, Yoshimura, R, Iyo, M, Matsuda, K, Akiyama, M, Ashikawa, K, Kashiwase, K, Tokunaga, K, Kondo, K, Saito, T, Shimasaki, A, Kawase, K, Kitajima, T, Matsuo, K, Itokawa, M, Someya, T, Inada, T, Hashimoto, R, Inoue, T, Akiyama, K, Tanii, H, Arai, H, Kanba, S, Ozaki, N, Kusumi, I, Yoshikawa, T, Kubo, M, Iwata, N

المصدر: Molecular Psychiatry ; volume 23, issue 3, page 639-647 ; ISSN 1359-4184 1476-5578

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Psychiatry and Mental health, Molecular Biology

الإتاحة: https://doi.org/10.1038/mp.2016.259Test
http://www.nature.com/articles/mp2016259.pdfTest
http://www.nature.com/articles/mp2016259Test

المؤلفون: Mizutani, R, Saiga, R, Takekoshi, S, Inomoto, C, Nakamura, N, Arai, M, Oshima, K, Itokawa, M, Takeuchi, A, Uesugi, K, Terada, Y, Suzuki, Y

المصدر: Journal of Physics: Conference Series ; volume 849, page 012042 ; ISSN 1742-6588 1742-6596

الإتاحة: https://doi.org/10.1088/1742-6596/849/1/012042Test
http://stacks.iop.org/1742-6596/849/i=1/a=012042?key=crossref.4fd0f20ad88515a9027be365cfea34afTest
http://stacks.iop.org/1742-6596/849/i=1/a=012042/pdfTest

المؤلفون: Nishizawa, D, Fukuda, K, Kasai, S, Hasegawa, J, Aoki, Y, Nishi, A, Saita, N, Koukita, Y, Nagashima, M, Katoh, R, Satoh, Y, Tagami, M, Higuchi, S, Ujike, H, Ozaki, N, Inada, T, Iwata, N, Sora, I, Iyo, M, Kondo, N, Won, M-J, Naruse, N, Uehara-Aoyama, K, Itokawa, M, Koga, M, Arinami, T, Kaneko, Y, Hayashida, M, Ikeda, K

المصدر: Molecular Psychiatry ; volume 19, issue 1, page 55-62 ; ISSN 1359-4184 1476-5578

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Psychiatry and Mental health, Molecular Biology

الإتاحة: https://doi.org/10.1038/mp.2012.164Test
http://www.nature.com/articles/mp2012164.pdfTest
http://www.nature.com/articles/mp2012164Test

المؤلفون: Nishida, A., Sasaki, T., Nishimura, Y., Tanii, H., Hara, N., Inoue, K., Yamada, T., Takami, T., Shimodera, S., Itokawa, M., Asukai, N., Okazaki, Y.

المصدر: Acta Psychiatrica Scandinavica ; volume 121, issue 4, page 301-307 ; ISSN 0001-690X 1600-0447

الوصف: Nishida A, Sasaki T, Nishimura Y, Tanii H, Hara N, Inoue K, Yamada T, Takami T, Shimodera S, Itokawa M, Asukai N, Okazaki Y. Psychotic‐like experiences are associated with suicidal feelings and deliberate self‐harm behaviors in adolescents aged 12–15 years. Objective: Psychotic disorders are a significant risk factor for suicide, especially among young people. Psychotic‐like experiences (PLEs) in the general population may share an etiological background with psychotic disorders. Therefore, the present study examined the association between PLEs and risk of suicide in a community sample of adolescents. Method: Psychotic‐like experiences, suicidal feelings, and self‐harm behaviors were studied using a self‐report questionnaire administered to 5073 Japanese adolescents. Depression and anxiety were evaluated using the 12‐item General Health Questionnaire (GHQ). Results: The presence of PLEs was significantly associated with suicidal feelings (OR = 3.1, 95% CI = 2.2–4.5) and deliberate self‐harm behaviors (OR = 3.1, 95% CI = 2.0–4.8) after controlling for the effects of age, gender, GHQ‐12 score, victimization, and substance use. Suicidal feelings and behaviors were more prevalent in subjects with a greater number of PLEs. Conclusion: Psychotic‐like experiences may increase the risk of suicidal problems among adolescents.

الإتاحة: https://doi.org/10.1111/j.1600-0447.2009.01439.xTest

المؤلفون: Ide, S, Kobayashi, H, Ujike, H, Ozaki, N, Sekine, Y, Inada, T, Harano, M, Komiyama, T, Yamada, M, Iyo, M, Iwata, N, Tanaka, K, Shen, H, Iwahashi, K, Itokawa, M, Minami, M, Satoh, M, Ikeda, K, Sora, I

المصدر: The Pharmacogenomics Journal ; volume 6, issue 3, page 179-188 ; ISSN 1470-269X 1473-1150

مصطلحات موضوعية: Pharmacology, Genetics, Molecular Medicine

الإتاحة: https://doi.org/10.1038/sj.tpj.6500355Test
https://www.nature.com/articles/6500355.pdfTest
https://www.nature.com/articles/6500355Test

المؤلفون: Kikuchi, M, Yamada, K, Toyota, T, Itokawa, M, Hattori, E, Yoshitsugu, K, Shimizu, H, Yoshikawa, T

المصدر: Molecular Psychiatry ; volume 8, issue 5, page 467-469 ; ISSN 1359-4184 1476-5578

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Psychiatry and Mental health, Molecular Biology

الإتاحة: https://doi.org/10.1038/sj.mp.4001280Test
https://www.nature.com/articles/4001280.pdfTest
https://www.nature.com/articles/4001280Test

المؤلفون: Ishida, Y.I., Kayama, T., Kibune, Y., Nishimoto, S., Koike, S., Suzuki, T., Horiuchi, Y., Miyashita, M., Itokawa, M., Arai, M., Ogasawara, Y.

المساهمون: JSPS KAKENHI

المصدر: Biochemical and Biophysical Research Communications ; volume 493, issue 1, page 573-577 ; ISSN 0006-291X

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry, Biophysics

الإتاحة: https://doi.org/10.1016/j.bbrc.2017.08.150Test
https://api.elsevier.com/content/article/PII:S0006291X17316819?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0006291X17316819?httpAccept=text/plainTest