المؤلفون: Gerussi, Valentina, Peghin, Maddalena, Palese, Alvisa, De Martino, Maria, Graziano, Elena, Chiappinotto, Stefania, Fonda, Federico, Bontempo, Giulia, Semenzin, Tosca, Martini, Luca, Isola, Miriam, Tascini, Carlo

المساهمون: PRIN 2017 n

المصدر: Human Vaccines & Immunotherapeutics ; volume 20, issue 1 ; ISSN 2164-5515 2164-554X

الإتاحة: https://doi.org/10.1080/21645515.2024.2358565Test

المؤلفون: Collini, Valentino, De Martino, Maria, Andreis, Alessandro, De Biasio, Marzia, Gaspard, Francesca, Paneva, Elena, Tomat, Mariacristina, Deferrari, Gaetano Maria, Isola, Miriam, Imazio, Massimo

مصطلحات موضوعية: Special populations

الوصف: Objective Clinical trials have evaluated the efficacy and safety of colchicine only in simple pericarditis, excluding cases of concomitant myocarditis. The aim of this paper is to evaluate the efficacy and safety of colchicine for the treatment of the first attack of acute pericarditis with concomitant myocardial involvement. Methods Double-centre retrospective cohort study analysing consecutive patients admitted for first attack of pericarditis with myocarditis and treated with or without colchicine. The primary efficacy end point was the time to the first recurrence. Propensity score matching was used to generate two groups of patients with similar baseline characteristics. Colchicine-associated side effects were analysed as safety end-point. Results A total of 175 patients (mean age 46.2±20.1 years, 25.1% females, 88.6% with idiopathic/viral aetiology) were included. Seventy-nine (45.1%) patients were treated with colchicine. After a median follow-up of 25.3 (IQR 8.3–45.6) months, 58 (33.1%) patients had recurrences. The propensity score generated two groups of 73 patients with similar baseline characteristics but the use of colchicine. Patients treated with colchicine had a lower incidence of recurrences (respectively, 19.2% vs 43.8%; p=0.001) and a longer event-free survival (p=0.005). In multivariable analysis, women (HR 1.97, 95% CI 1.04 to 3.73; p=0.037) and corticosteroid use (HR 2.27, 95% CI 1.15 to 4.47; p=0.018) were independent risk factors for recurrences. Colchicine-associated side effects were mild and occurred in 3 (1.7%) patients. Conclusion In patients with first attack of pericarditis associated with myocardial involvement, colchicine was safe and efficacious for the reduction of recurrences.

وصف الملف: text/html

العلاقة: http://heart.bmj.com/cgi/content/short/110/10/735Test; http://dx.doi.org/10.1136/heartjnl-2023-323484Test

الإتاحة: https://doi.org/10.1136/heartjnl-2023-323484Test
http://heart.bmj.com/cgi/content/short/110/10/735Test

المؤلفون: Collini, Valentino, Andreis, Alessandro, De Biasio, Marzia, De Martino, Maria, Isola, Miriam, Croatto, Nicole, Lepre, Veronica, Cantarini, Luca, Merlo, Marco, Sinagra, Gianfranco, Abbate, Antonio, Lazaros, George, Brucato, Antonio, Klein, Allan L, Imazio, Massimo

المصدر: Open Heart ; volume 11, issue 1, page e002599 ; ISSN 2053-3624

الوصف: Aim Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies. However, it is unclear if the combination with colchicine, a non-specific inhibitor of the inflammasome targeting the same inflammatory pathway of IL-1, could provide additional benefit to prevent further recurrences. The aim of the present observational study is to assess whether the addition of colchicine on top of anakinra could prolong the time to first recurrence and prevent recurrences better than anakinra alone. Methods International, all-comers, multicentre, retrospective observational cohort study analysing all consecutive patients treated with anakinra for corticosteroid-dependent and colchicine-resistant recurrent pericarditis. The efficacy endpoint was recurrence rate and the time to the first recurrence. Results A total of 256 patients (mean age 45.0±15.4 years, 65.6% females, 80.9% with idiopathic/viral aetiology) were included. 64 (25.0%) were treated with anakinra as monotherapy while 192 (75.0%) with both anakinra and colchicine. After a follow-up of 12 months, 56 (21.9%) patients had recurrences. Patients treated with colchicine added to anakinra had a lower incidence of recurrences (respectively, 18.8% vs 31.3%; p=0.036) and a longer event-free survival (p=0.025). In multivariable analysis, colchicine use prevented recurrences (HR 0.52, 95% CI 0.29 to 0.91; p=0.021). Conclusions The addition of colchicine on top of anakinra treatment could be helpful to reduce recurrences and prolong the recurrence-free survival.

الإتاحة: https://doi.org/10.1136/openhrt-2023-002599Test

المؤلفون: Peghin, Maddalena, De Martino, Maria, Palese, Alvisa, Chiappinotto, Stefania, Fonda, Federico, Gerussi, Valentina, Sartor, Assunta, Curcio, Francesco, Grossi, Paolo Antonio, Isola, Miriam, Tascini, Carlo

المصدر: Clinical Microbiology and Infection ; volume 30, issue 4, page 522-530 ; ISSN 1198-743X

مصطلحات موضوعية: Infectious Diseases, Microbiology (medical), General Medicine

الإتاحة: https://doi.org/10.1016/j.cmi.2023.12.017Test
https://api.elsevier.com/content/article/PII:S1198743X23006250?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1198743X23006250?httpAccept=text/plainTest

المؤلفون: Colizzi, Marco, Comacchio, Carla, De Martino, Maria, Peghin, Maddalena, Bontempo, Giulia, Chiappinotto, Stefania, Fonda, Federico, Isola, Miriam, Tascini, Carlo, Balestrieri, Matteo, Palese, Alvisa

المصدر: Irish Journal of Psychological Medicine ; page 1-8 ; ISSN 0790-9667 2051-6967

الوصف: Objectives: To assess the prevalence of neuropsychiatric symptoms 2 years after the COVID-19 acute phase and to identify biobehavioral risk factors. Methods: This 2-year prospective study assessed adult individuals with COVID-19 via face-to-face interview and laboratory testing at onset, and via telephone interview at 2-year follow-up. Data collected included COVID-19 severity and management at onset, as well as depression, anxiety, insomnia, cognitive failure, and fatigue at follow-up using standardized assessment tools. Results: Out of 1,067 screened COVID-19 patients, 230 completed the 2-year follow-up (female, 53.5%; aged>40, 80.9%; native Italian, 94.9%; medical comorbidity, 53.5%; chronic medication, 46.3%; moderate to severe COVID-19, 24.9%; hospital admission, 28.7%; ICU, 5.2%). At follow-up, 9.1% had anxiety, 11.3% depression, 9.1% insomnia, 18.3% cognitive failure, and 39.1% fatigue, of clinical relevance. Headache (OR = 2.49, 95% CI = 1.01–6.16, p = 0.048), dyspnea (OR = 2.55, 95% CI = 1.03–6.31, p = 0.043), and number of symptoms (OR = 1.23, 95% CI = 1.01–1.51, p = 0.047) at onset were associated with anxiety at follow-up; dyspnea at onset was associated with depression at follow-up (OR = 2.80, 95% CI = 1.22–6.41, p = 0.015); number of comorbidities at onset was associated with insomnia at follow-up (OR = 1.48, 95% CI = 1.06–2.08, p = 0.022); female gender (OR = 2.39, 95% CI = 1.14–5.00, p = 0.020) and number of symptoms (OR = 1.20, 95% CI = 1.02–1.42, p = 0.026) at onset was associated with cognitive failure at follow-up; number of comorbidities (OR = 1.33, 95% CI = 1.03–1.73, p = 0.029) and symptoms (OR = 1.19, 95% CI = 1.04-1.37, p = 0.013) and raised interleukin 6 levels ( OR = 4.02, 95% CI = 1.42–11.36, p = 0.009) at onset was associated with fatigue at follow-up. Conclusions: COVID-19 survivors, especially if female, with preexisting health problems, and with a more severe acute phase, may present with long-lasting neuropsychiatric sequalae, urging interventions to sustain recovery ...

الإتاحة: https://doi.org/10.1017/ipm.2023.53Test
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0790966723000538Test

المؤلفون: Peghin, Maddalena, De Martino, Maria, Palese, Alvisa, Chiappinotto, Stefania, Fonda, Federico, Gerussi, Valentina, Sartor, Assunta, Curcio, Francesco, Grossi, Paolo Antonio, Isola, Miriam, Tascini, Carlo

المساهمون: Peghin, Maddalena, De Martino, Maria, Palese, Alvisa, Chiappinotto, Stefania, Fonda, Federico, Gerussi, Valentina, Sartor, Assunta, Curcio, Francesco, Grossi, Paolo Antonio, Isola, Miriam, Tascini, Carlo

مصطلحات موضوعية: COVID-19, long COVID, post-COVID-19 syndrome, SARS-CoV-2 antibodies

الوصف: Background The aim of this study was to describe the long-term evolution of post-COVID-19 syndrome over 2 years after the onset of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) in survivors of the first wave. Methods This prospective study was based on interviews and investigated post-COVID-19 syndrome 6, 12, and 24 months after the disease onset in all adult in- and outpatients with COVID-19 followed at Udine Hospital (Italy) during the first wave (March–May 2020). Humoral response, vaccination status, and reinfection were assessed. Results Overall, 230 patients (53.5% female; mean age 54.7 years) were interviewed 2.3 years (standard deviation = 0.11) after acute onset. Post-COVID-19 syndrome was observed in 36.1% of patients (n = 83) at 2 years. The most common persistent symptoms were fatigue (14.4%), rheumatological (14.4%), and psychiatric symptoms (9.6%). Overall, 55.4% (46 of 83) of long haulers searched for healthcare system support and 21 (45.7%) were visited by a specialist. Female gender (odds ratio [OR] = 2.50, P = .005), a proportional increase in the number of symptoms during acute COVID-19 (OR = 1.40, P = .001), and the presence of comorbidities (OR = 1.57, P = .004) were all independent risk factors for post-COVID-19 syndrome. Vaccination and reinfection had no impact on post-COVID-19 syndrome dynamics. The presence of receptor-binding domain (RBD) SARS-CoV-2 immunoglobulin G (IgG) and non-RBD SARS-CoV-2 IgG titers were not associated with the occurrence of post-COVID-19 syndrome. Conclusions Two years after COVID-19, the burden of persistent symptoms remains high among in- and outpatients’ population infected during the first wave. Post-COVID-19 dynamic does not seem to be influenced by SARS-CoV-2 immunization status and reinfection.

العلاقة: volume:10; issue:7; journal:OPEN FORUM INFECTIOUS DISEASES; https://hdl.handle.net/11390/1253704Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85168106028

الإتاحة: https://doi.org/10.1093/ofid/ofad364Test
https://hdl.handle.net/11390/1253704Test

المؤلفون: De Vita, Salvatore, Isola, Miriam, Baldini, Chiara, Goules, Andreas V, Chatzis, Loukas G, Quartuccio, Luca, Zabotti, Alen, Giovannini, Ivan, Donati, Valentina, Ferro, Francesco, Rizzo, Maria Teresa, Manfrè, Valeria, Pegolo, Enrico, Voulgarelis, Michael, Zaja, Francesco, Fanin, Renato, Masaoutis, Christos, Rontogianni, Dimitra, Fotiadis, Dimitrios I, Ponzoni, Maurilio, Tzioufas, Athanasios G

المساهمون: De Vita, Salvatore, Isola, Miriam, Baldini, Chiara, Goules, Andreas V, Chatzis, Loukas G, Quartuccio, Luca, Zabotti, Alen, Giovannini, Ivan, Donati, Valentina, Ferro, Francesco, Rizzo, Maria Teresa, Manfrè, Valeria, Pegolo, Enrico, Voulgarelis, Michael, Zaja, Francesco, Fanin, Renato, Masaoutis, Christo, Rontogianni, Dimitra, Fotiadis, Dimitrios I, Ponzoni, Maurilio, Tzioufas, Athanasios G

مصطلحات موضوعية: Sjögren’s syndrome, lymphoma, parotid gland, salivary swelling

الوصف: Objective: Parotid swelling (PSW) is a major predictor of non-Hodgkin lymphoma (NHL) in primary Sjögren's syndrome (pSS). However, since detailed information on the time of onset and duration of PSW is scarce, this was investigated to verify whether it may lead to further improved prediction. NHL localisation was concomitantly studied to evaluate the role of the parotid gland microenvironment in pSS-related lymphomagenesis. Methods: A multicentre study was conducted among patients with pSS who developed B cell NHL during follow-up and matched controls that did not develop NHL. The study focused on the history of salivary gland and lachrymal gland swelling, evaluated in detail at different times and for different durations, and on the localisation of NHL at onset. Results: PSW was significantly more frequent among the cases: at the time of first referred pSS symptoms before diagnosis, at diagnosis, and from pSS diagnosis to NHL. The duration of PSW was evaluated starting from pSS diagnosis, and the NHL risk increased from PSW of 2-12 months to > 12 months. NHL was prevalently localised in the parotid glands of the cases. Conclusion: A more precise clinical recording of PSW can improve lymphoma prediction in pSS. PSW as a very early symptom is a predictor, and a longer duration of PSW is associated with a higher risk of NHL. Since lymphoma usually localises in the parotid glands, and not in the other salivary or lachrymal glands, the parotid microenvironment appears to be involved in the whole history of pSS and related lymphomagenesis.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36063040; info:eu-repo/semantics/altIdentifier/wos/WOS:000852755500001; volume:62; issue:4; firstpage:1586; lastpage:1593; numberofpages:8; journal:RHEUMATOLOGY; https://hdl.handle.net/11368/3039746Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85145387814; https://academic.oup.com/rheumatology/article/62/4/1586/6692297Test

الإتاحة: https://doi.org/10.1093/rheumatology/keac470Test
https://hdl.handle.net/11368/3039746Test
https://academic.oup.com/rheumatology/article/62/4/1586/6692297Test

المؤلفون: Palese, Alvisa, Chiappinotto, Stefania, Fonda, Federico, Visintini, Erica, Peghin, Maddalena, Colizzi, Marco, Balestrieri, Matteo, De Martino, Maria, Isola, Miriam, Tascini, Carlo

المساهمون: Palese, Alvisa, Chiappinotto, Stefania, Fonda, Federico, Visintini, Erica, Peghin, Maddalena, Colizzi, Marco, Balestrieri, Matteo, De Martino, Maria, Isola, Miriam, Tascini, Carlo

مصطلحات موضوعية: COVID-19, Lessons learned, Longitudinal study, Research design

الوصف: Background: Several scientific contributions have summarized the “lessons learnt” during the coronavirus disease 2019 (COVID-19) pandemic, but only a few authors have discussed what we have learnt on how to design and conduct research during a pandemic. The main intent of this study was to summarize the lessons learnt by an Italian multidisciplinary research group that developed and conducted a longitudinal study on COVID-19 patients infected during the first wave in March 2020 and followed-up for 3years. Methods: A qualitative research approach embedded into the primary CORonavirus MOnitoRing study (CORMOR) study was developed, according to the the consolidated criteria for reporting qualitative research. Multiple data collection strategies were performed: each member was invited to report the main lessons learnt according to his/her perspective and experience from the study design throughout its conduction. The narratives collected were summarized and discussed in face-to-face rounds. The narratives were then thematically analysed according to their main topic in a list that was resent to all members to check the content and their organization. The list of the final “lessons learnt” has been agreed by all members, as described in a detailed fashion. Results: Several lessons were learnt while designing and conducting a longitudinal study during the COVID-19 pandemic and summarised into ten main themes: some are methodological, while others concern how to conduct research in pandemics/epidemics/infectious disease emergencies. Conclusions: The multidisciplinary approach, which also included patients’ perspective, helped us to protect the consistency and quality of the research provided in pandemic times. The lesson learnt suggest that our research approach may benefit from changes in education, clinical practice and policies.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:001090780200003; volume:21; issue:1; firstpage:111; journal:HEALTH RESEARCH POLICY AND SYSTEMS; https://hdl.handle.net/11390/1265226Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85175678494

الإتاحة: https://doi.org/10.1186/s12961-023-01055-wTest
https://hdl.handle.net/11390/1265226Test

المؤلفون: Deana, Cristian, Vetrugno, Luigi, Cortegiani, Andrea, Mongodi, Silvia, Salve, Giulia, Mangiagalli, Matteo, Boscolo, Annalisa, Pettenuzzo, Tommaso, Miori, Sara, Sanna, Andrea, Lassola, Sergio, Magnoni, Sandra, Ferrari, Elena, Biagioni, Emanuela, Bassi, Flavio, Castaldo, Nadia, Fantin, Alberto, Longhini, Federico, Corradi, Francesco, Forfori, Francesco, Cammarota, Gianmaria, De Robertis, Edoardo, Buonsenso, Danilo, Spadaro, Savino, Grieco, Domenico Luca, Martino, Maria De, Isola, Miriam, Mojoli, Francesco, Girardis, Massimo, Giarratano, Antonino, Bignami, Elena Giovanna, Navalesi, Paolo, Cecconi, Maurizio, Maggiore, Salvatore Maurizio, On Behalf Of The Italian Odissea Group, null

المساهمون: Deana, Cristian, Vetrugno, Luigi, Cortegiani, Andrea, Mongodi, Silvia, Salve, Giulia, Mangiagalli, Matteo, Boscolo, Annalisa, Pettenuzzo, Tommaso, Miori, Sara, Sanna, Andrea, Lassola, Sergio, Magnoni, Sandra, Ferrari, Elena, Biagioni, Emanuela, Bassi, Flavio, Castaldo, Nadia, Fantin, Alberto, Longhini, Federico, Corradi, Francesco, Forfori, Francesco, Cammarota, Gianmaria, De Robertis, Edoardo, Buonsenso, Danilo, Spadaro, Savino, Grieco, Domenico Luca, Martino, Maria De, Isola, Miriam, Mojoli, Francesco, Girardis, Massimo, Giarratano, Antonino, Bignami, Elena Giovanna, Navalesi, Paolo, Cecconi, Maurizio, Maggiore, Salvatore Maurizio, On Behalf Of The Italian Odissea Group, Null

مصطلحات موضوعية: ARDS, COVID-19, ICU, SF-36, health related quality of life, impact of event scale-revised, post-traumatic stress disorder

الوصف: Background: Investigating the health-related quality of life (HRQoL) after intensive care unit (ICU) discharge is necessary to identify possible modifiable risk factors. The primary aim of this study was to investigate the HRQoL in COVID-19 critically ill patients one year after ICU discharge. Methods: In this multicenter prospective observational study, COVID-19 patients admitted to nine ICUs from 1 March 2020 to 28 February 2021 in Italy were enrolled. One year after ICU discharge, patients were required to fill in short-form health survey 36 (SF-36) and impact of event-revised (IES-R) questionnaire. A multivariate linear or logistic regression analysis to search for factors associated with a lower HRQoL and post-traumatic stress disorded (PTSD) were carried out, respectively. Results: Among 1003 patients screened, 343 (median age 63 years [57-70]) were enrolled. Mechanical ventilation lasted for a median of 10 days [2-20]. Physical functioning (PF 85 [60-95]), physical role (PR 75 [0-100]), emotional role (RE 100 [33-100]), bodily pain (BP 77.5 [45-100]), social functioning (SF 75 [50-100]), general health (GH 55 [35-72]), vitality (VT 55 [40-70]), mental health (MH 68 [52-84]) and health change (HC 50 [25-75]) describe the SF-36 items. A median physical component summary (PCS) and mental component summary (MCS) scores were 45.9 (36.5-53.5) and 51.7 (48.8-54.3), respectively, considering 50 as the normal value of the healthy general population. In all, 109 patients (31.8%) tested positive for post-traumatic stress disorder, also reporting a significantly worse HRQoL in all SF-36 domains. The female gender, history of cardiovascular disease, liver disease and length of hospital stay negatively affected the HRQoL. Weight at follow-up was a risk factor for PTSD (OR 1.02, p = 0.03). Conclusions: The HRQoL in COVID-19 ARDS (C-ARDS) patients was reduced regarding the PCS, while the median MCS value was slightly above normal. Some risk factors for a lower HRQoL have been identified, the presence of PTSD is one of ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36769705; info:eu-repo/semantics/altIdentifier/wos/WOS:000932571200001; volume:12; issue:3; firstpage:1058; journal:JOURNAL OF CLINICAL MEDICINE; https://hdl.handle.net/11577/3468069Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147955953

الإتاحة: https://doi.org/10.3390/jcm12031058Test
https://hdl.handle.net/11577/3468069Test

المؤلفون: Colizzi, Marco, Peghin, Maddalena, De Martino, Maria, Bontempo, Giulia, Gerussi, Valentina, Palese, Alvisa, Isola, Miriam, Tascini, Carlo, Balestrieri, Matteo

المساهمون: Colizzi, Marco, Peghin, Maddalena, De Martino, Maria, Bontempo, Giulia, Gerussi, Valentina, Palese, Alvisa, Isola, Miriam, Tascini, Carlo, Balestrieri, Matteo

مصطلحات موضوعية: Anxiety, Cognition, Depression, Fatigue, Insomnia Depresión, Ansiedad, Insomnio, Cognición, Fatiga

الوصف: Introduction: Emerging evidence suggests that mental health symptoms in COVID-19 survivors are higher than expected, possibly indicating that such symptoms are more likely to develop post-infection than just persist as a residual component of the acute phase. It is thus imperative to investigate the potential development of a post-COVID mental health syndrome in the longerterm and identify its risk factors. Material and methods: A prospective study investigated mental health symptoms associated with COVID-19 and its determinants over a 12-month period following the disease onset in all consecutive adult inpatients and outpatients with COVID-19 attending a tertiary referral hospital from March to May 2020. Results: A total of 479 patients (female, 52.6%) were followed-up for 12 months after COVID-19 onset. Of them, 47.2% were still presenting with at least one symptom. While most symptoms subsided as compared to COVID-19 onset (all p < 0.001), a significant increase was observed only for symptoms of psychiatric disorders (10.2%) and lack of concentration and focus (20%; all p < 0.001). Patients presenting with symptoms related to multiple body systems 12 months after contracting COVID-19 (all p ≤ 0.034) were more likely to suffer from mental health domainrelated symptoms at follow-up. Also, a higher risk of presenting with lack of concentration and focus 12 months post infection was found in those suffering of psychiatric symptoms at COVID-19 onset (p = 0.005). Conclusions: Findings of this study may have important public health implications, as they underlie the increased need for mental health support in COVID-19 survivors. ; Introducción: Nuevas evidencias sugieren que los síntomas de salud mental en los supervivientes de COVID-19 son mayores de lo esperado, lo que posiblemente indica que es más probable que dichos síntomas se desarrollen después de la infección en vez de sólo persistir como componente residual de la fase aguda. Por lo tanto, es imperativo investigar el posible desarrollo de un ...

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35755492; info:eu-repo/semantics/altIdentifier/wos/WOS:001087128500004; volume:Vol. 16; firstpage:38; lastpage:46; numberofpages:9; journal:REVISTA DE PSIQUIATRÍA Y SALUD MENTAL; https://hdl.handle.net/11383/2140733Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85133686562

الإتاحة: https://doi.org/10.1016/j.rpsm.2022.05.008Test
https://hdl.handle.net/11383/2140733Test