المؤلفون: Isaac Allen, Hend Hassan, Walburga Yvonne Joko-Fru, Catherine Huntley, Lucy Loong, Tameera Rahman, Bethany Torr, Andrew Bacon, Craig Knott, Sophie Jose, Sally Vernon, Margreet Lüchtenborg, Joanna Pethick, Katrina Lavelle, Fiona McRonald, Diana Eccles, Eva J.A Morris, Steven Hardy, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C. Antoniou

المصدر: The Lancet Regional Health. Europe, Vol 40, Iss , Pp 100903- (2024)

مصطلحات موضوعية: Breast cancer, Second primary cancer, Risk, Incidence, Treatment, Pathology, Public aspects of medicine, RA1-1270

الوصف: Summary: Background: Second primary cancers (SPCs) after breast cancer (BC) present an increasing public health burden, with little existing research on socio-demographic, tumour, and treatment effects. We addressed this in the largest BC survivor cohort to date, using a novel linkage of National Disease Registration Service datasets. Methods: The cohort included 581,403 female and 3562 male BC survivors diagnosed between 1995 and 2019. We estimated standardized incidence ratios (SIRs) for combined and site-specific SPCs using incidences for England, overall and by age at BC and socioeconomic status. We estimated incidences and Kaplan–Meier cumulative risks stratified by age at BC, and assessed risk variation by socio-demographic, tumour, and treatment characteristics using Cox regression. Findings: Both genders were at elevated contralateral breast (SIR: 2.02 (95% CI: 1.99–2.06) females; 55.4 (35.5–82.4) males) and non-breast (1.10 (1.09–1.11) females, 1.10 (1.00–1.20) males) SPC risks. Non-breast SPC risks were higher for females younger at BC diagnosis (SIR: 1.34 (1.31–1.38)

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666776224000693Test; https://doaj.org/toc/2666-7762Test

الوصول الحر: https://doaj.org/article/2bb76f742aa448a4bbc11bef987cfb06Test

المؤلفون: Isaac Allen, Hend Hassan, Eleni Sofianopoulou, Diana Eccles, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C. Antoniou

المصدر: Breast Cancer Research, Vol 25, Iss 1, Pp 1-29 (2023)

مصطلحات موضوعية: Breast neoplasms, Second primary, Second cancer, Multiple primary, Multiple cancer, Risk, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Second primary cancer incidence is rising among breast cancer survivors. We examined the risks of non-breast second primaries, in combination and at specific cancer sites, through a systematic review and meta-analysis. Methods We conducted a systematic search of PubMed, Embase, and Web of Science, seeking studies published by March 2022. We included studies that reported standardized incidence ratios (SIRs), with associated standard errors, assessing the combined risk of second non-breast primaries following breast cancer. We performed meta-analyses of combined second primary risks, stratifying by age, follow-up duration, and geographic region. We also assessed second primary risks at several specific sites, stratifying by age. The inverse variance method with DerSimonian–Laird estimators was used in all meta-analyses, assuming a random-effects model. Associated biases and study quality were evaluated using the Newcastle–Ottawa scale. Results One prospective and twenty-seven retrospective cohort studies were identified. SIRs for second non-breast primaries combined ranged from 0.84 to 1.84. The summary SIR estimate was 1.24 (95% CI 1.14–1.36, I 2: 99%). This varied by age: the estimate was 1.59 (95% CI 1.36–1.85) when breast cancer was diagnosed before age 50, which was significantly higher than in women first diagnosed at 50 or over (SIR: 1.13, 95% CI 1.01–1.36, p for difference:

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1465-542XTest

الوصول الحر: https://doaj.org/article/c8c7e7ad2ce145f49e687362afde36d7Test

المؤلفون: Isaac Allen, Hend Hassan, Eleni Sofianopoulou, Diana Eccles, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C. Antoniou

المساهمون: Allen, Isaac [0000-0003-4640-3617], Tischkowitz, Marc [0000-0002-7880-0628], Pharoah, Paul [0000-0001-8494-732X], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Male, Cancer Research, Oncology, Risk Factors, Incidence, Humans, Neoplasms, Second Primary, Survivors, Middle Aged, Colorectal Neoplasms, Retrospective Studies, Breast Neoplasms, Male

الوصف: BACKGROUND: With increasing survival after cancer diagnoses, second primary cancers (SPCs) are becoming more prevalent. We investigated the incidence and site of non-breast SPC risks following male breast cancer (BC). METHODS: PubMed, Embase and Web of Science were systematically searched for studies reporting standardised incidence ratios (SIRs) for SPCs published by March 2022. Meta-analyses used the generic inverse-variance method, assuming a random-effects model. We evaluated SIRs for overall SPCs, site-specific risks, by age at BC onset, time since BC onset and geographic region. We assessed study quality using routine techniques. RESULTS: Eight population-based retrospective cohort studies were identified. SIRs ranged from 1.05 to 2.17. The summary SIR estimate was 1.27 (95% CI: 1.03-1.56, I2: 86%), and there were increased colorectal (SIR: 1.29, 95% CI: 1.03-1.61), pancreatic (SIR: 1.64, 95% CI: 1.05-2.55) and thyroid (SIR: 5.58, 95% CI: 1.04-30.05) SPC risks. When an outlying study was excluded, the summary SIR for men diagnosed with BC before age 50 was 1.50 (95% CI: 1.21-1.85), significantly higher than men diagnosed at older ages (SIR: 1.14, 95% CI: 0.98-1.33). CONCLUSIONS: Male BC survivors are at elevated risks of developing second primary colorectal, pancreatic and thyroid cancers. The estimates may assist their clinical management and guide decisions on genetic testing.
CRUK Catalyst Award CanGene-CanVar (C61296/A27223).

وصف الملف: application/pdf; application/zip; text/xml; text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cced7d7ac4e78bf07abdcba7be7b1d2bTest

المؤلفون: Hend Hassan, Tameera Rahman, Andrew Bacon, Craig Knott, Isaac Allen, Catherine Huntley, Lucy Loong, Yvonne Walburga, Katrina Lavelle, Eva Morris, Steven Hardy, Bethany Torr, Diana M Eccles, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C. Antoniou

المصدر: Cancer Research. 83:988-988

مصطلحات موضوعية: Cancer Research, Oncology

الوصف: Introduction: Breast cancer is the most common cancer in women. Women with personal history of breast cancer are at increased risk of second primary cancers including ovarian cancer. Bilateral salpingo-oophorectomy (BSO) is a well-established option for ovarian cancer risk reduction. However, the benefit of ovarian cancer risk reduction should be balanced against the health sequelae caused by the premature estrogen loss. We examined the associations between BSO after breast cancer diagnosis and long-term health outcomes, using large-scale linked electronic health records. Methods: We selected women diagnosed with invasive breast cancer before the age of 75 between 1995 and 2019 using data from the National Cancer Registration Dataset (NCRD), which describes all cancers registered in England. These women were linked to the Hospital Episode Statistics (HES) Admitted Patient Care (APC) dataset to identify the delivery of BSO, while the use of hormonal replacement therapy (HRT) was identified from the community dispensed prescriptions dataset. Long-term outcomes (e.g., ischemic heart disease) were selected from HES, and the NCRD provided data on second cancer diagnosis and all-cause mortality. Multiple imputation was used to impute missing data on stage, grade, hormonal receptor status and ethnicity. Women were followed from the date of breast cancer diagnosis to development of an outcome of interest or censoring or end of data collection. Multivariable Cox regression was used to examine the associations, with BSO modeled as a time-dependent covariate. The analysis was stratified by patient age at BSO ( Results: The study included 566,731 women, with median follow up time 8.40 (IQR: 4.4-14.5) years. Of those, 23,881 women had BSO after their breast cancer diagnosis. BSO before the age of 55 was not associated with all-cause mortality (hazard ratio (HR):1.03, 95%CI:0.98-1.08), while BSO after the age of 55 was associated with a small reduction in the risk of all-cause mortality (HR:0.93, 95%CI:0.89-0.99). BSO before and after the age of 55 was associated with increased risk of ischemic heart disease with HRs of 1.23(95%CI:1.07-1.41) and 1.13(95%CI:1.02-1.25), respectively. There was no association between BSO and cerebrovascular events (HR:0.97, 95%CI:0.82-1.15, for BSO under age 55, HR:0.96, 95%CI:0.87-1.07, for BSO after age 55). Ongoing analyses are investigating the associations stratified by the severity of cardiovascular outcome (fatal/non-fatal) and the use of HRT, and the associations with second cancers and neuropsychiatric outcomes. Conclusion: BSO after 55 does not appear to be associated with detrimental health effects in women diagnosed with breast cancer. Further examination of the associations between BSO and other long-term health outcomes and the influence of HRT in younger women is needed. Citation Format: Hend Hassan, Tameera Rahman, Andrew Bacon, Craig Knott, Isaac Allen, Catherine Huntley, Lucy Loong, Yvonne Walburga, Katrina Lavelle, Eva Morris, Steven Hardy, Bethany Torr, Diana M Eccles, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C. Antoniou. Long-term health outcomes of bilateral salpingo-oophorectomy in women with personal history of breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 988.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fdb518795c0b4f13ecf7669e3c1131cdTest
https://doi.org/10.1158/1538-7445.am2023-988Test

المؤلفون: Isaac Allen, Tameera Rahman, Andrew Bacon, Craig Knott, Sophie Jose, Sally Vernon, Hend Hassan, Catherine Huntley, Lucy Loong, Yvonne Walburga, Katrina Lavelle, Eva Morris, Steven Hardy, Beth Torr, Diana Eccles, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C. Antoniou

المصدر: Cancer Research. 83:3057-3057

مصطلحات موضوعية: Cancer Research, Oncology

الوصف: Background: Second primary cancer (SPC) incidence is rising among breast cancer (BC) survivors, but these risks remain unclear. We estimated SPC risks for male and female BC survivors using large-scale electronic health record data from a linkage of National Cancer Registration and Analysis Service data and Hospital Episode Statistics surgical records in England. Material and Methods: We used a retrospective cohort study design comprising 763,578 female and 4,795 male BC survivors first diagnosed with BC between 1995-2018. We calculated overall and site-specific SPC standardized incidence ratios (SIRs) by comparing observed and expected SPC counts for 19 cancer sites. Study participants were followed from one year after the first BC diagnosis until either a SPC diagnosis (excluding ipsilateral breast and non-melanoma skin cancers), death, migration, relevant surgical procedures, or the end of 2019. Expected SPC counts were calculated using year-, age- and sex-specific cancer incidence rates in the general English population. We stratified the SIRs by age group, sex, and cancer site. We estimated Kaplan-Meier absolute risks of site-specific SPCs and assessed the influence of age at first BC diagnosis using Cox proportional hazards models. Results: There were 68,550 and 720 incident SPCs among female and male BC survivors, respectively. There was a significant increased risk of all SPCs combined for female BC survivors (SIR: 1.19, 95%CI: 1.18-1.20). There were significant increased risks for SPC at all sites combined, all non-breast sites combined, and at 12 further specific sites for females and at 2 specific sites for males. Among females, the increase was greatest for contralateral breast (SIR: 1.82, 95%CI: 1.79-1.85) and uterine cancers (SIR: 1.80, 95%CI: 1.76-1.85). The risk at all sites combined was higher for women first diagnosed with BC before age 50 (SIR: 1.89, 95%CI: 1.85-1.92) compared to women diagnosed with BC at age 50 or over (SIR: 1.11, 95%CI: 1.10-1.12). The largest associations were observed for contralateral breast (SIR: 3.19, 95%CI: 3.11-3.29) and uterine (SIR: 1.77, 95%CI: 1.73-1.82) SPCs in the younger and older age groups, respectively. Increasing age at first female BC diagnosis was associated with decreasing CBC absolute risks, but significantly increased absolute risks of all other SPCs. Male BC survivors were at increased risk of contralateral breast (SIR: 42.39, 95%CI: 28.39-60.89) and prostate (SIR: 1.29, 95%CI: 1.13-1.46) SPCs. Conclusions: This is the largest study to date to assess SPC risks following BC in either men or women. SPC risks were significantly increased, both in combination and at specific sites. These findings could help guide clinical management, such as screening recommendations, for BC survivors. Further analysis is underway to investigate the effects of chemotherapy, radiotherapy, hormonal therapy, comorbidities, or germline BC susceptibility. Citation Format: Isaac Allen, Tameera Rahman, Andrew Bacon, Craig Knott, Sophie Jose, Sally Vernon, Hend Hassan, Catherine Huntley, Lucy Loong, Yvonne Walburga, Katrina Lavelle, Eva Morris, Steven Hardy, Beth Torr, Diana Eccles, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C. Antoniou. Second primary cancer risks for female and male breast cancer survivors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3057.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::441c034d89dd5d6d9e47a1422aa8844aTest
https://doi.org/10.1158/1538-7445.am2023-3057Test

المؤلفون: Isaac Allen, Susan Robertson, Michael Friend, John Broster

المصدر: Small Ruminant Research. 202:106463

مصطلحات موضوعية: geography, geography.geographical_feature_category, biology, Perennial plant, business.industry, biology.organism_classification, Endophyte, Pasture, Plant use of endophytic fungi in defense, Ergovaline, Food Animals, Agronomy, Productivity (ecology), Animal Science and Zoology, Livestock, Cultivar, business

الوصف: Tall fescue (Lolium arundinaceum (Schreb.) Darbysh) is a valuable perennial pasture species, the productivity of which is increased by infection with endophytic fungi. However, toxins produced by the endophyte can cause fescue toxicoses, which are potentially detrimental to animal growth and health. It is desirable therefore, to develop non-ergot alkaloid producing endophytes which are not harmful to livestock. The purpose of this study was to compare cultivars of tall fescue with or without novel endophytes for their effect on lamb growth and productivity. Five tall fescue cultivar or endophyte treatments were sown into a randomised block design including three replicates. The treatments were Martin 2 (Mart; no endophyte, acting as a positive control), Kentucky-31 (KY-31; containing wild endophyte and acting as a negative control), Martin 2 with novel endophyte Protek™ (Mart Protek™), Tower with endophyte Protek™ (TowerProtek™) and DuraMax fescue with endophyte Series 9 (DuraMax 9). When established, composite lambs were allocated to the 15 plots and grazed the irrigated pastures in two successive periods of 42 (n = 150 lambs; summer) or 65 days (n = 150 lambs; autumn) between January and May 2012. Herbage quality was similar between treatments. Ergovaline was detected at low levels (

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::427462c0ae1a9b3f49ddff7a998b8ed3Test
https://doi.org/10.1016/j.smallrumres.2021.106463Test

المؤلفون: Jack, I. Allen (Isaac Allen), 1843-1903

المساهمون: Queen's University, W.D. Jordan Special Collections & Music Library (archive.org)

مصطلحات موضوعية: Botany, New Brunswick

الوصول الحر: http://www.biodiversitylibrary.org/bibliography/64081Test

المؤلفون: Jack, I. Allen (Isaac Allen), 1843-1903

المساهمون: Canadiana.org (archive.org)

مصطلحات موضوعية: Botany, New Brunswick

الوصول الحر: http://www.biodiversitylibrary.org/bibliography/38816Test

المؤلفون: MOORE, ISAAC Allen

المساهمون: Caricato, Marco, Laird, Brian B, Elles, Christopher

مصطلحات موضوعية: Computational chemistry, Physical chemistry, Chemistry, benzyl alcohol, catalysis, density functional theory, hydrodeoxygenation, palladium, terpyridine

الوصف: Lignin is a readily available renewable carbon polymer consisting of aromatic monomers, which can be used in the generation of alternative fuels. However, many of these monomers contain oxygen, reducing their usability and overall value. Therefore, catalytic hydrodeoxygenation that allows for the removal of oxygen atoms while preserving the aromaticity of these monomers is desirable. The Vannucci group at the University of South Carolina has developed a catalyst for this purpose, chloro(2,2’:6’,2’’-terpyridine-4’-carboxylic acid) palladium(II) chloride. Their catalyst has shown high conversion and selectivity with model lignin monomers at low temperatures when attached to the surface of amorphous silica to generate a molecular/heterogeneous catalyst motif. The two mechanisms investigated include one where the Pd center is reduced and one where an intermediate Pd-hydride species appears. In this thesis, we use density functional theory to determine the structures for the intermediate and transition state species, and their corresponding energies. With these energies, we ascertain which of the proposed reaction mechanisms is energetically favored. Understanding this mechanism and determining what leads to the high conversion and selectivity of this catalyst will help in the future development of similar catalysts with increased efficiency, conversion, and selectivity, potentially leading to a wider availability of these fuels.

وصف الملف: 47 pages; application/pdf

العلاقة: http://dissertations.umi.com/ku:18369Test; https://hdl.handle.net/1808/35391Test

الإتاحة: https://hdl.handle.net/1808/35391Test
http://dissertations.umi.com/ku:18369Test

المؤلفون: Jack, I. Allen (Isaac Allen), 1843-1903

مصطلحات موضوعية: Botany New Brunswick

العلاقة: Cover title.; Reprinted from a series of papers published in the "Daily Sun."; http://hdl.handle.net/1974/9308Test

الإتاحة: http://hdl.handle.net/1974/9308Test