المؤلفون: Miguel German Borda, Gustavo Duque, Mario Ulises Pérez‐Zepeda, Jonathan Patricio Baldera, Eric Westman, Anna Zettergren, Jessica Samuelsson, Silke Kern, Lina Rydén, Ingmar Skoog, Dag Aarsland

المصدر: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 189-197 (2024)

مصطلحات موضوعية: dementia, diagnosis, geriatrics, H70, neurodegenerative disorders, sarcopenia, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695

الوصف: Abstract Background Sarcopenia is associated with multiple adverse outcomes. Traditional methods to determine low muscle mass for the diagnosis of sarcopenia are mainly based on dual‐energy X‐ray absorptiometry (DXA), whole‐body magnetic resonance imaging (MRI) and bioelectrical impedance analysis. These tests are not always available and are rather time consuming and expensive. However, many brain and head diseases require a head MRI. In this study, we aim to provide a more accessible way to detect sarcopenia by comparing the traditional method of DXA lean mass estimation versus the tongue and masseter muscle mass assessed in a standard brain MRI. Methods The H70 study is a longitudinal study of older people living in Gothenburg, Sweden. In this cross‐sectional analysis, from 1203 participants aged 70 years at baseline, we included 495 with clinical data and MRI images available. We used the appendicular lean soft tissue index (ALSTI) in DXA images as our reference measure of lean mass. Images from the masseter and tongue were analysed and segmented using 3D Slicer. For the statistical analysis, the Spearman correlation coefficient was used, and concordance was estimated with the Kappa coefficient. Results The final sample consisted of 495 participants, of which 52.3% were females. We found a significant correlation coefficient between both tongue (0.26) and masseter (0.33) with ALSTI (P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2190-5991Test; https://doaj.org/toc/2190-6009Test

الوصول الحر: https://doaj.org/article/3b35f1923d0545b0b67f648f437727a7Test

المؤلفون: Wolf Wonneberger, Bertil Sterner, Ulrika MacLean, Margareta Claesson, Lena Havstam Johansson, Ingmar Skoog, Madeleine Zetterberg, Anna Zettergren

المصدر: BMC Ophthalmology, Vol 24, Iss 1, Pp 1-6 (2024)

مصطلحات موضوعية: Sporadic keratoconus, FOXO1 gene, ZNF469 gene, Single-nucleotide polymorphism, Ophthalmology, RE1-994

الوصف: Abstract Background Keratoconus (KC) is characterized by pathological thinning and bulging of the cornea that may lead to visual impairment. The etiology of sporadic KC remains enigmatic despite intensive research in recent decades. The purpose of this study was to examine the relationship between previously highlighted genetic variants associated with KC and sporadic KC in a Swedish cohort. Methods A total of 176 patients (age 16–70 years) with sporadic KC diagnosed by Scheimpflug-topography (Pentacam) were included. The control group (n = 418; age 70 years) was a subsample originating from the Gothenburg H70 Birth Cohort Studies of ageing. Extraction of DNA from blood samples was performed according to standard procedures, and genotyping was performed using competitive allele specific PCR (KASP) technology. A total of 11 single nucleotide polymorphisms (SNPs) were selected for analysis. Results Statistically significant associations (p = 0.005) were found between the SNPs rs2721051 and rs9938149 and sporadic KC. These results replicate earlier research that found associations between genetic variants in the FOXO1 and BANP-ZNF469 genes and sporadic KC in other populations. Conclusion Genetic variations in the FOXO1 and BANP-ZNF469 genes may be involved in the pathogenesis of sporadic KC.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2415Test

الوصول الحر: https://doaj.org/article/55f9b8816a37468aa68c81391f607ee2Test

المؤلفون: Masuma Novak, Margda Waern, Lena Johansson, Anna Zettergren, Lina Ryden, Hanna Wetterberg, Therese Rydberg Sterner, Madeleine Mellqvist Fässberg, Pia Gudmundsson, Ingmar Skoog

المصدر: BMC Geriatrics, Vol 23, Iss 1, Pp 1-10 (2023)

مصطلحات موضوعية: Living alone, Loneliness, Mortality, Gender, Sweden, Epidemiology, Geriatrics, RC952-954.6

الوصف: Abstract Background This study examined how living alone and loneliness associate with all-cause mortality in older men and women. Methods Baseline data from the Gothenburg H70 Birth Cohort Studies, including 70-year-olds interviewed in 2000 and 75-year-olds (new recruits) interviewed in 2005 were used for analyses (N = 778, 353 men, 425 women). Six-year mortality was based on national register data. Results At baseline, 36.6% lived alone and 31.9% reported feelings of loneliness. A total of 72 (9.3%) participants died during the 6-year follow-up period. Cumulative mortality rates per 1000 person-years were 23.9 for men and 9.6 for women. Mortality was increased more than twofold among men who lived alone compared to men living with someone (HR 2.40, 95% CI 1.34–4.30). Elevated risk remained after multivariable adjustment including loneliness and depression (HR 2.56, 95% CI 1.27–5.16). Stratification revealed that mortality risk in the group of men who lived alone and felt lonely was twice that of their peers who lived with someone and did not experience loneliness (HR 2.52, 95% CI 1.26–5.05). In women, a more than fourfold increased risk of mortality was observed in those who experienced loneliness despite living with others (HR 4.52, 95% CI 1.43–14.23). Conclusions Living alone was an independent risk factor for death in men but not in women. Mortality was doubled in men who lived alone and felt lonely. In contrast, mortality was particularly elevated in women who felt lonely despite living with others. In the multivariable adjusted models these associations were attenuated and were no longer significant after adjusting for mainly depression in men and physical inactivity in women. Gender needs to be taken into account when considering the health consequences of living situation and loneliness.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2318Test

الوصول الحر: https://doaj.org/article/86b8029cbe3244c2ac1c763d12b15641Test

المؤلفون: Felicia Ahlner, Hanna Falk Erhag, Lena Johansson, Jessica Samuelsson, Hanna Wetterberg, Madeleine Mellqvist Fässberg, Margda Waern, Ingmar Skoog

المصدر: BMC Geriatrics, Vol 23, Iss 1, Pp 1-14 (2023)

مصطلحات موضوعية: Alcohol, 70-year-olds, Septuagenarians, Risk factors, Unhealthy behaviors, Mortality, Geriatrics, RC952-954.6

الوصف: Abstract Background In this study, we examined the effect of alcohol, as well as the combined effect of seven lifestyle factors, on all-cause mortality in older adults (baseline age 70 years). Methods Data was derived from the population-based Gothenburg H70 Birth Cohort study, including 1124 participants from the 2014–16 examination. Risk consumption was defined as > 98 g alcohol per week, and hazardous drinking was based on the Alcohol Use Disorders Identification Test-Consumption questionnaire (AUDIT-C). Cox regression models were used to examine the individual effect of alcohol consumption, as well as the combined effect of seven lifestyle risk factors (high alcohol consumption, lifetime smoking, unhealthy Body Mass Index, insufficient physical activity, sedentary behavior, insufficient/prolonged sleep, unhealthy dietary pattern) on all-cause mortality. Results During a mean follow-up of 7.7 years, 81 (7.2%) participants died. Neither risk consumption nor hazardous drinking were associated with elevated mortality, but hazardous drinking was associated with an increased risk of mortality in those with insufficient physical activity. Those with at least five lifestyle risk factors had an increased all-cause mortality compared to those fulfilling criteria for a maximum of one lifestyle risk factor. High alcohol consumption showed a relatively minor impact on this risk, while physical activity and unhealthy dietary pattern had an independent effect on mortality. Conclusions In this particular sample, there was no independent effect of alcohol on the risk of 8-year all-cause mortality. However, an interaction effect of physical activity was observed. It may be that high alcohol consumption per se is less important for mortality among older adults. However, a combination of several unhealthy lifestyle behaviors was linked to a substantial increase in the risk of mortality in Swedish older adults. Also, it has to be emphasized that high alcohol consumption may have other adverse health effects apart from mortality among older adults.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2318Test

الوصول الحر: https://doaj.org/article/a496c8a38ae34695bfc9bd62f0ef88b2Test

المؤلفون: Atef Badji, Joana Pereira, Sara Shams, Johan Skoog, Anna Marseglia, Konstantinos Poulakis, lina Ryden, Kaj Blennow, Henrik Zetterberg, Silke Kern, Anna Wahlund, Lars-Olof Wahlund, Hélène Girouard, Ingmar Skoog, Eric Westman

المصدر: Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100048- (2024)

مصطلحات موضوعية: Specialties of internal medicine, RC581-951, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666245022000137Test; https://doaj.org/toc/2666-2450Test

الوصول الحر: https://doaj.org/article/a756af7b1a0a42d19dd41ffbf9d2ed69Test

المؤلفون: Anna Marseglia, Alexander Darin-Mattsson, Johan Skoog, Lina Rydén, Timothy Hadarsson-Bodin, Silke Kern, Therese Rydberg Sterner, Ying Shang, Anna Zettergren, Eric Westman, Ingmar Skoog

المصدر: Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100095- (2024)

مصطلحات موضوعية: Specialties of internal medicine, RC581-951, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666245022000605Test; https://doaj.org/toc/2666-2450Test

الوصول الحر: https://doaj.org/article/3f48026d8a5642ef90683e8f3086fb4aTest

المؤلفون: Nazib M Seidu, Silke Kern, Simona Sacuiu, Therese Rydberg Sterner, Kaj Blennow, Henrik Zetterberg, Olof Lindberg, Daniel Ferreira, Eric Westman, Anna Zettergren, Ingmar Skoog

المصدر: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)

مصطلحات موضوعية: Alzheimer's disease, amygdala, amyloid beta 1‐42, cognitively healthy, cerebrospinal fluid biomarkers, cortical Alzheimer's disease signature score, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

الوصف: Abstract The relation between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures is poorly understood in cognitively healthy individuals from the general population. Participants’ (n = 226) mean age was 70.9 years (SD = 0.4). CSF concentrations of amyloid beta (Aβ)1‐42, total tau (t‐tau), phosphorylated tau (p‐tau), neurogranin, and neurofilament light, and volumes of hippocampus, amygdala, total basal forebrain (TBF), and cortical thickness were measured. Linear associations between CSF biomarkers and MRI measures were investigated. In Aβ1‐42 positives, higher t‐tau and p‐tau were associated with smaller hippocampus (P = 0.001 and P = 0.003) and amygdala (P = 0.005 and P = 0.01). In Aβ1‐42 negatives, higher t‐tau, p‐tau, and neurogranin were associated with larger TBF volume (P = 0.001, P = 0.001, and P = 0.01). No associations were observed between the CSF biomarkers and an AD signature score of cortical thickness. AD‐specific biomarkers in cognitively healthy 70‐year‐olds may be related to TBF, hippocampus, and amygdala. Lack of association with cortical thickness might be due to early stage of disease.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2352-8729Test

الوصول الحر: https://doaj.org/article/5e86e5af78234c3a820b99d07d4c5f5bTest

المؤلفون: Keshuo Lin, Wei Wen, Darren M. Lipnicki, Louise Mewton, Rory Chen, Jing Du, Dadong Wang, Ingmar Skoog, Therese Rydberg Sterner, Jenna Najar, Ki Woong Kim, Ji Won Han, Jun Sung Kim, Tze Pin Ng, Roger Ho, Denise Qian Ling Chua, Kaarin J. Anstey, Nicolas Cherbuin, Moyra E. Mortby, Henry Brodaty, Nicole Kochan, Perminder S. Sachdev, Jiyang Jiang, for the Cohort Studies of Memory in an International Consortium (COSMIC)

المصدر: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)

مصطلحات موضوعية: cognition, ethnic differences, population‐based studies, vascular risk factors, white matter hyperintensities, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

الوصف: Abstract INTRODUCTION White matter hyperintensities (WMHs) are an important imaging marker for cerebral small vessel diseases, but their risk factors and cognitive associations have not been well documented in populations of different ethnicities and/or from different geographical regions. METHODS We investigated how WMHs were associated with vascular risk factors and cognition in both Whites and Asians, using data from five population‐based cohorts of non‐demented older individuals from Australia, Singapore, South Korea, and Sweden (N = 1946). WMH volumes (whole brain, periventricular, and deep) were quantified with UBO Detector and harmonized using the ComBat model. We also harmonized various vascular risk factors and scores for global cognition and individual cognitive domains. RESULTS Factors associated with larger whole brain WMH volumes included diabetes, hypertension, stroke, current smoking, body mass index, higher alcohol intake, and insufficient physical activity. Hypertension and stroke had stronger associations with WMH volumes in Whites than in Asians. No associations between WMH volumes and cognitive performance were found after correction for multiple testing. CONCLUSION The current study highlights ethnic differences in the contributions of vascular risk factors to WMHs.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2352-8729Test

الوصول الحر: https://doaj.org/article/dcc854f6f0b244749f16da5322b64e8dTest

المؤلفون: Jenna Najar, Valgeir Thorvaldsson, Silke Kern, Johan Skoog, Margda Waern, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Anna Zettergren

المصدر: Neurobiology of Disease, Vol 189, Iss , Pp 106357- (2023)

مصطلحات موضوعية: Cognition, Polygenic risk scores, Cognitive decline, APOE genotype, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: Background: Polygenic risk scores for Alzheimer's disease (AD-PRSs) have been associated with cognition. However, few studies have examined the effect of AD-PRS beyond the APOE gene, and the influence of genetic variants related to level of cognitive ability (COG-PRS) on cognitive performance over time in the general older population. Method: A population-based sample of 965 individuals born in 1930, with genetic and standardized cognitive data on six psychometric tests (Thurstone's picture memory, immediate recall of 10 words, Block design, word fluency, figure identification, delayed recall of 12 items), were examined at age 70, 75, 79, and 85 years. Non-APOE AD-PRSs and COG-PRSs (P

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S096999612300373XTest; https://doaj.org/toc/1095-953XTest

الوصول الحر: https://doaj.org/article/1d6f3371074c4d0896cd0e15861ae4d1Test

المؤلفون: Miguel Germán Borda, Jessica Samuelsson, Tommy Cederholm, Jonathan Patricio Baldera, Mario Ulises Pérez-Zepeda, George E. Barreto, Anna Zettergren, Silke Kern, Lina Rydén, Mariana Gonzalez-Lara, Salomón Salazar-Londoño, Gustavo Duque, Ingmar Skoog, Dag Aarsland

المصدر: Nutrients, Vol 16, Iss 4, p 568 (2024)

مصطلحات موضوعية: sarcopenia, body composition, aging, diet, walking speed, muscle strength, Nutrition. Foods and food supply, TX341-641

الوصف: Treatment options for sarcopenia are currently limited, and primarily rely on two main therapeutic approaches: resistance-based physical activity and dietary interventions. However, details about specific nutrients in the diet or supplementation are unclear. We aim to investigate the relationship between nutrient intake and lean mass, function, and strength. Data were derived from the Gothenburg H70 birth cohort study in Sweden, including 719,70-year-olds born in 1944 (54.1% females). For independent variables, the diet history method (face-to-face interviews) was used to estimate habitual food intake during the preceding three months. Dependent variables were gait speed (muscle performance), hand grip strength (muscle strength), and the appendicular lean soft tissue index (ALSTI). Linear regression analyses were performed to analyze the relationship between the dependent variables and each of the covariates. Several nutrients were positively associated with ALSTI, such as polyunsaturated fatty acids (DHA, EPA), selenium, zinc, riboflavin, niacin equivalent, vitamin B12, vitamin D, iron, and protein. After correction for multiple comparisons, there were no remaining correlations with handgrip and gait speed. Findings of positive correlations for some nutrients with lean mass suggest a role for these nutrients in maintaining muscle volume. These results can be used to inform clinical trials to expand the preventive strategies and treatment options for individuals at risk of muscle loss and sarcopenia.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6643/16/4/568Test; https://doaj.org/toc/2072-6643Test

الوصول الحر: https://doaj.org/article/b88caeea67964e469be8ec86b87804ecTest