المؤلفون: Walus-Miarka, M., Kurdziel, J., Fedak, A., Kawalec, E., Idzior-Waluś, B.

المصدر: Atherosclerosis ; volume 379, page S95 ; ISSN 0021-9150

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.atherosclerosis.2023.06.347Test
https://api.elsevier.com/content/article/PII:S0021915023044398?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021915023044398?httpAccept=text/plainTest

المؤلفون: Peeters S. A., Engelen L., Buijs J., Chaturvedi N., Fuller J. H., Schalkwijk C. G., Stehouwer C. D., Karamanos B., Kofinis A., Petrou K., Giorgino F., Picca G., Angarano A., de Pergola. G., Laviola L., Giorgino R., Ionescu-Tirgoviste C., Coszma A., Guja C., Songini M., Casu A., Pedron M., Pintus S., Fossarello M., Ferriss J. B., Grealy G., O'Keefe D., Toeller M., Arden C., Rottiers R., Tuyttens C., Priem H., Ebeling P., Kylliainen M., Koivisto V. A., Idzior-Walus B., Sieradzki J., Cyganek K., Solnica B., Lemkes H. H. P. J., Lemkes-Stuffken J. C., Nunes-Correa J., Rogado M. C., Gardete-Correia L., Cardoso M. C., Silva A., Boavida J., Machado Sa Marques M., Michel G., Wirion R., Cardillo S., Pozza G., Mangili R., Asnaghi V., Standl E., Schaffler B., Brand H., Harms A., Ben Soussan M., Verier-Mine O., Fallas P., Fallas M. C., Holloway J., Asbury L., Betteridge D. J., Cathelineau G., Bouallouche A., Villatte Cathelineau B., Santeusanio F., Rosi G., D'Alessandro V., Cagini C., Bottini P., Reboldi G. P., Navalesi R., Penno G., Bandinelli S., Miccoli R., Nannipieri M., Ghirlanda G., Saponara C., Cotroneo P., Manto A., Minnella A., Ward J. D., Tesfaye S., Eaton S., Mody C., Borra M., Cavallo Perin P., Giunti S., Grassi G., Pagano G. F., Porta M., Sivieri R., Vitelli F., Veglio M., Papazoglou N., Manes G., Muggeo M., Iagulli M., Cacciatori V., Cattedra di Malattie del Metabolismo V., Irsigler K., Abrahamian H., Walford S., Sinclair J., Hughes S., McLelland V., Ward J., Roglic G., Metelko Z., Pepeonik Z. R.

المساهمون: Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., Stehouwer, C. D., Karamanos, B., Kofinis, A., Petrou, K., Giorgino, F., Picca, G., Angarano, A., Pergola. G., De, Laviola, L., Giorgino, R., Ionescu-Tirgoviste, C., Coszma, A., Guja, C., Songini, M., Casu, A., Pedron, M., Pintus, S., Fossarello, M., Ferriss, J. B., Grealy, G., O'Keefe, D., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Koivisto, V. A., Idzior-Walus, B., Sieradzki, J., Cyganek, K., Solnica, B., Lemkes, H. H. P. J., Lemkes-Stuffken, J. C., Nunes-Correa, J., Rogado, M. C., Gardete-Correia, L., Cardoso, M. C., Silva, A., Boavida, J., Machado Sa Marques, M., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, M., Verier-Mine, O., Fallas, P., Fallas, M. C., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D'Alessandro, V., Cagini, C., Bottini, P., Reboldi, G. P., Navalesi, R., Penno, G., Bandinelli, S., Miccoli, R., Nannipieri, M., Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Borra, M., Cavallo Perin, P., Giunti, S., Grassi, G., Pagano, G. F., Porta, M., Sivieri, R., Vitelli, F., Veglio, M., Papazoglou, N., Manes, G.

مصطلحات موضوعية: Albuminuria, Cardiovascular disease, Matrix metalloproteinase, Retinopathy, Tissue inhibitor of metalloproteinase, Type 1 diabete, Adult, Biomarker, Cohort Studie, Cross-Sectional Studie, Diabetes Complication, Diabetes Mellitus, Type 1, Europe, Female, Human, Male, Matrix Metalloproteinase 10, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, Middle Aged, Prospective Studie, Tissue Inhibitor of Metalloproteinase-1, Vascular Diseases

الوصف: Impaired regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in patients with type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 and TIMP-1, and cardiovascular disease (CVD) or microvascular complications in type 1 diabetic patients. We also evaluated to which extent these associations could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: 493 type 1 diabetes patients (39.5 ± 9.9 years old, 51% men) from the EURODIAB Prospective Complications Study were included. Linear regression analysis was applied to investigate differences in plasma levels of MMP-1, -2, -3, -9, -10, and TIMP-1 between patients with and without CVD, albuminuria or retinopathy. All analyses were adjusted for age, sex, duration of diabetes, Hba1c and additionally for other cardiovascular risk factors including LGI and ED. Results: Patients with CVD (n = 118) showed significantly higher levels of TIMP-1 [β = 0.32 SD (95%CI: 0.12; 0.52)], but not of MMPs, than patients without CVD (n = 375). Higher plasma levels of MMP-2, MMP-3, MMP-10 and TIMP-1 were associated with higher levels of albuminuria (p-trends were 0.028, 0.004, 0.005 and 0.001, respectively). Severity of retinopathy was significantly associated with higher levels of MMP-2 (p-trend = 0.017). These associations remained significant after further adjustment for markers of LGI and ED. Conclusions: These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25848912; info:eu-repo/semantics/altIdentifier/wos/WOS:000350726000001; volume:14; issue:1; firstpage:31; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11586/353539Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925234995

الإتاحة: https://doi.org/10.1186/s12933-015-0195-2Test
http://hdl.handle.net/11586/353539Test

المؤلفون: Waluś-Miarka, M., Idzior-Waluś, B., Kawalec, E., Woźniak, A., Kapusta, M.

المصدر: Atherosclerosis ; volume 355, page 153-154 ; ISSN 0021-9150

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.atherosclerosis.2022.06.668Test
https://api.elsevier.com/content/article/PII:S0021915022009558?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021915022009558?httpAccept=text/plainTest

المؤلفون: Sharifi, M, Walus-Miarka, M, Idzior-Waluś, B, Malecki, MT, Sanak, M, Whittall, R, Li, KW, Futema, M, Humphries, SE

المصدر: Metabolism , 65 (3) pp. 48-53. (2016)

مصطلحات موضوعية: Familial hypercholesterolemia, LDL-C gene score, LDLR mutation

الوصف: BACKGROUND: Familial hypercholesterolemia (FH) is a common autosomal dominant disorder with a frequency of 1 in 200 to 500 in most European populations. Mutations in LDLR, APOB and PCSK9 genes are known to cause FH. In this study, we analyzed the genetic spectrum of the disease in the understudied Polish population. MATERIALS AND METHODS: 161 unrelated subjects with a clinical diagnosis of FH from the south-eastern region of Poland were recruited. High resolution melt and direct sequencing of PCR products were used to screen 18 exons of LDLR, a region of exon 26 in the APOB gene and exon 7 of PCSK9. Multiplex ligation-dependent probe amplification (MLPA) was performed to detect gross deletions and insertions in LDLR. Genotypes of six LDL-C raising SNPs were used for a polygenic gene score calculation. RESULTS: We found 39 different pathogenic mutations in the LDLR gene with 10 of them being novel. 13 (8%) individuals carried the p.Arg3527Gln mutation in APOB, and overall the detection rate was 43.4%. Of the patients where no mutation could be found, 53 (84.1%) had a gene score in the top three quartiles of the healthy comparison group suggesting that they have a polygenic cause for their high cholesterol. CONCLUSIONS: These results confirm the genetic heterogeneity of FH in Poland, which should be considered when designing a diagnostic strategy in the country. As in the UK, in the majority of patients where no mutation can be found, there is likely to be a polygenic cause of their high cholesterol level.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/1476435/1/1-s2.0-S0026049515003108-main.pdfTest; https://discovery.ucl.ac.uk/id/eprint/1476435Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/1476435/1/1-s2.0-S0026049515003108-main.pdfTest
https://discovery.ucl.ac.uk/id/eprint/1476435Test/

المؤلفون: Walus-Miarka, M., Kawalec, E., Idzior-Walus, B., Kapusta, M., Miarka, P.

المصدر: Atherosclerosis ; volume 331, page e144 ; ISSN 0021-9150

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.atherosclerosis.2021.06.429Test
https://api.elsevier.com/content/article/PII:S0021915021007012?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021915021007012?httpAccept=text/plainTest

المؤلفون: Walus-Miarka, M., Kapusta, M., Idzior-Walus, B., Kawalec, E.

المصدر: Atherosclerosis ; volume 315, page e180-e181 ; ISSN 0021-9150

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.atherosclerosis.2020.10.562Test
https://api.elsevier.com/content/article/PII:S0021915020311448?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021915020311448?httpAccept=text/plainTest

المؤلفون: Soedamah-Muthu, S.S., Chaturvedi, N., Teerlink, T., Idzior-Walus, B., Fuller, J.H., Stehouwer, C.D.A.

المصدر: Soedamah-Muthu , S S , Chaturvedi , N , Teerlink , T , Idzior-Walus , B , Fuller , J H & Stehouwer , C D A 2005 , ' Plasma homocysteine and microvascular and macrovascular complications in type 1 diabetes: a cross-sectional nested case-control study ' , Journal of Internal Medicine , vol. 258 , no. 5 , pp. 450-459 . https://doi.org/10.1111/j.1365-2796.2005.01560.xTest

العلاقة: https://research.vumc.nl/en/publications/346b203a-40ad-45f9-ace5-36918494c6b5Test

الإتاحة: https://doi.org/10.1111/j.1365-2796.2005.01560.xTest
https://research.vumc.nl/en/publications/346b203a-40ad-45f9-ace5-36918494c6b5Test

المؤلفون: Walus-Miarka, M., Toton-Zuranska, J., Wolkow, P., Kapusta, P., Idzior-Walus, B., Malecki, M.

المصدر: Atherosclerosis ; volume 287, page e70 ; ISSN 0021-9150

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.atherosclerosis.2019.06.200Test
https://api.elsevier.com/content/article/PII:S0021915019306574?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021915019306574?httpAccept=text/plainTest

المؤلفون: Soedamah-Muthu, S. S., Colhoun, H. M., Taskinen, M.-R., Idzior-Walus, B., Fuller, J. H.

المصدر: Diabetologia ; volume 43, issue 11, page 1353-1359 ; ISSN 0012-186X 1432-0428

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Internal Medicine

الإتاحة: https://doi.org/10.1007/s001250051538Test

المؤلفون: Walus-miarka, M., Idzior-Walus, B., Kapusta, M., Trojak, A., Miarka, P., Malecki, M.T.

المصدر: Atherosclerosis ; volume 275, page e151 ; ISSN 0021-9150

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.atherosclerosis.2018.06.449Test
https://api.elsevier.com/content/article/PII:S0021915018307615?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021915018307615?httpAccept=text/plainTest