المؤلفون: Peeters S. A., Engelen L., Buijs J., Chaturvedi N., Fuller J. H., Schalkwijk C. G., Stehouwer C. D., Karamanos B., Kofinis A., Petrou K., Giorgino F., Picca G., Angarano A., de Pergola. G., Laviola L., Giorgino R., Ionescu-Tirgoviste C., Coszma A., Guja C., Songini M., Casu A., Pedron M., Pintus S., Fossarello M., Ferriss J. B., Grealy G., O'Keefe D., Toeller M., Arden C., Rottiers R., Tuyttens C., Priem H., Ebeling P., Kylliainen M., Koivisto V. A., Idzior-Walus B., Sieradzki J., Cyganek K., Solnica B., Lemkes H. H. P. J., Lemkes-Stuffken J. C., Nunes-Correa J., Rogado M. C., Gardete-Correia L., Cardoso M. C., Silva A., Boavida J., Machado Sa Marques M., Michel G., Wirion R., Cardillo S., Pozza G., Mangili R., Asnaghi V., Standl E., Schaffler B., Brand H., Harms A., Ben Soussan M., Verier-Mine O., Fallas P., Fallas M. C., Holloway J., Asbury L., Betteridge D. J., Cathelineau G., Bouallouche A., Villatte Cathelineau B., Santeusanio F., Rosi G., D'Alessandro V., Cagini C., Bottini P., Reboldi G. P., Navalesi R., Penno G., Bandinelli S., Miccoli R., Nannipieri M., Ghirlanda G., Saponara C., Cotroneo P., Manto A., Minnella A., Ward J. D., Tesfaye S., Eaton S., Mody C., Borra M., Cavallo Perin P., Giunti S., Grassi G., Pagano G. F., Porta M., Sivieri R., Vitelli F., Veglio M., Papazoglou N., Manes G., Muggeo M., Iagulli M., Cacciatori V., Cattedra di Malattie del Metabolismo V., Irsigler K., Abrahamian H., Walford S., Sinclair J., Hughes S., McLelland V., Ward J., Roglic G., Metelko Z., Pepeonik Z. R.

المساهمون: Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., Stehouwer, C. D., Karamanos, B., Kofinis, A., Petrou, K., Giorgino, F., Picca, G., Angarano, A., Pergola. G., De, Laviola, L., Giorgino, R., Ionescu-Tirgoviste, C., Coszma, A., Guja, C., Songini, M., Casu, A., Pedron, M., Pintus, S., Fossarello, M., Ferriss, J. B., Grealy, G., O'Keefe, D., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Koivisto, V. A., Idzior-Walus, B., Sieradzki, J., Cyganek, K., Solnica, B., Lemkes, H. H. P. J., Lemkes-Stuffken, J. C., Nunes-Correa, J., Rogado, M. C., Gardete-Correia, L., Cardoso, M. C., Silva, A., Boavida, J., Machado Sa Marques, M., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, M., Verier-Mine, O., Fallas, P., Fallas, M. C., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D'Alessandro, V., Cagini, C., Bottini, P., Reboldi, G. P., Navalesi, R., Penno, G., Bandinelli, S., Miccoli, R., Nannipieri, M., Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Borra, M., Cavallo Perin, P., Giunti, S., Grassi, G., Pagano, G. F., Porta, M., Sivieri, R., Vitelli, F., Veglio, M., Papazoglou, N., Manes, G.

مصطلحات موضوعية: Albuminuria, Cardiovascular disease, Matrix metalloproteinase, Retinopathy, Tissue inhibitor of metalloproteinase, Type 1 diabete, Adult, Biomarker, Cohort Studie, Cross-Sectional Studie, Diabetes Complication, Diabetes Mellitus, Type 1, Europe, Female, Human, Male, Matrix Metalloproteinase 10, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, Middle Aged, Prospective Studie, Tissue Inhibitor of Metalloproteinase-1, Vascular Diseases

الوصف: Impaired regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in patients with type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 and TIMP-1, and cardiovascular disease (CVD) or microvascular complications in type 1 diabetic patients. We also evaluated to which extent these associations could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: 493 type 1 diabetes patients (39.5 ± 9.9 years old, 51% men) from the EURODIAB Prospective Complications Study were included. Linear regression analysis was applied to investigate differences in plasma levels of MMP-1, -2, -3, -9, -10, and TIMP-1 between patients with and without CVD, albuminuria or retinopathy. All analyses were adjusted for age, sex, duration of diabetes, Hba1c and additionally for other cardiovascular risk factors including LGI and ED. Results: Patients with CVD (n = 118) showed significantly higher levels of TIMP-1 [β = 0.32 SD (95%CI: 0.12; 0.52)], but not of MMPs, than patients without CVD (n = 375). Higher plasma levels of MMP-2, MMP-3, MMP-10 and TIMP-1 were associated with higher levels of albuminuria (p-trends were 0.028, 0.004, 0.005 and 0.001, respectively). Severity of retinopathy was significantly associated with higher levels of MMP-2 (p-trend = 0.017). These associations remained significant after further adjustment for markers of LGI and ED. Conclusions: These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25848912; info:eu-repo/semantics/altIdentifier/wos/WOS:000350726000001; volume:14; issue:1; firstpage:31; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11586/353539Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925234995

الإتاحة: https://doi.org/10.1186/s12933-015-0195-2Test
http://hdl.handle.net/11586/353539Test

المؤلفون: Soedamah Muthu SS, Chaturvedi N, Fuller JH, Toeller M, Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, FOSSARELLO, MAURIZIO, Ferriss J, O'Keefe D, Grealy G, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kyllia M, Koivisto V, Idzior Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes H, Lemkes Stuffken J, Rogado M, Gardete Correia L, Cardoso M, Silva A, Boavida J, Machado Sa Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Soussan D, Verier O, Fallas P, Fallas M, Fuller J, Holloway J, Asbury L, Betteridge D, Cathelineau G, Bouallouche A, Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi G, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Ward J, Tesfaye S, Eaton S, Mody C, Borra M, Perin PC, Giunti S, Grassi G, Pagano G, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Cacciatori V, Cattedra V, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Roglic G, Metelko Z, Pepeonik Z, Ferriss B, Webb D, Viberti GC, Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook MA, Aldington S, Mortemore T, Lipinski H, Scherbaum WA, Gries F.A.

المساهمون: Soedamah Muthu, S, Chaturvedi, N, Fuller, Jh, Toeller, M, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, F, Picca, G, Angarano, A, De Pergola, G, Laviola, L, Giorgino, R, Ionescu Tirgoviste, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, Maurizio, Ferriss, J, O'Keefe, D, Grealy, G, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kyllia, M, Koivisto, V, Idzior Walus, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, H, Lemkes Stuffken, J, Rogado, M, Gardete Correia, L, Cardoso, M, Silva, A, Boavida, J, Machado Sa Marques, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Soussan, D, Verier, O, Fallas, P, Fallas, M, Fuller, J, Holloway, J, Asbury, L, Betteridge, D, Cathelineau, G, Bouallouche, A, Cathelineau, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, G, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Ward, J, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Perin, Pc, Giunti, S, Grassi, G, Pagano, G, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M, Cacciatori, V, Cattedra, V, Irsigler, K, Abrahamian, H

الوصف: BACKGROUND/OBJECTIVES: Individuals with type 1 diabetes have a high risk of developing cardiovascular diseases, and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individuals with type 1 diabetes over a period of 7 years. SUBJECTS/METHODS: We analysed data from the EURODIAB Prospective Complications Study, a European multicentre prospective cohort study. Standardized 3-day dietary records were employed in individuals with type 1 diabetes. One thousand one hundred and two patients (553 men, 549 women, baseline age 33 ± 10 years, duration 15 ± 9 years) had complete nutritional data available at baseline and after 7 years. We calculated mean differences in reported nutrients over time and adjusted these for age, gender, HbA1c and BMI with ANOVA models. RESULTS: Compared to baseline, there were minor changes in nutrients. Reported protein (-0.35% energy (en), fat (-1.07% en), saturated fat (-0.25% en) and cholesterol (-7.42 mg/1000 kcal) intakes were lower, whereas carbohydrate (+1.23% en) and fibre (+0.46 g/1000 kcal) intakes were higher at the 7-year follow-up. European recommendations for adequate nutrient intakes were followed in individuals with type 1 diabetes for protein (76% at baseline and 78% at follow-up), moderately for fat (34, 40%), carbohydrate (34, 41%) and cholesterol (39, 47%), but poorly for fibre (1.4, 2.4%) and saturated fat (11, 13%). CONCLUSION: European individuals with type 1 diabetes consume a high atherogenic diet as few patients met recommendations for dietary fibre and saturated fat. This study showed minor changes in dietary nutrients and energy intakes over a period of 7 years. Nutrition education needs particular focus on strategies to increase dietary fibre and reduce saturated fat to exploit their potential benefit

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23224030; info:eu-repo/semantics/altIdentifier/wos/WOS:000324833000002; volume:52; issue:7; firstpage:1701; lastpage:1710; numberofpages:10; journal:EUROPEAN JOURNAL OF NUTRITION; http://hdl.handle.net/11584/59760Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84885471550

الإتاحة: https://doi.org/10.1007/s00394-012-0473-7Test
http://hdl.handle.net/11584/59760Test

المؤلفون: van Bussel BC, Soedamah Muthu SS, Henry RM, Schalkwijk CG, Ferreira I, Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, FOSSARELLO, MAURIZIO, Ferriss J, Grealy G, O'Keefe D, Toeller M, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto V, Idzior Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes H, Lemkes Stuffken J, Nunes Correa J, Rogado M, Gardete Correia L, Cardoso M, Silva A, Boavida J, Machado Sa Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Ben Soussan D, Verier Mine O, Fallas P, Fallas M, Fuller J, Holloway J, Asbury L, Betteridge D, Cathelineau G, Bouallouche A, Villatte Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi G, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward J, Tesfaye S, Eaton S, Mody C, Borra M, Cavallo Perin P, Giunti S, Grassi G, Pagano G, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Cacciatori V, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Roglic G, Metelko Z, Pepeonik Z, Sjolie A., Chaturvedi N, Ferriss B, Webb D, Viberti G., Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook MA, Aldington S, Mortemore T, Lipinski H, Scherbaum WA, Gries FA

المساهمون: van Bussel, Bc, Soedamah Muthu, S, Henry, Rm, Schalkwijk, Cg, Ferreira, I, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, F, Picca, G, Angarano, A, De Pergola, G, Laviola, L, Giorgino, R, Ionescu Tirgoviste, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, Maurizio, Ferriss, J, Grealy, G, O'Keefe, D, Toeller, M, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, V, Idzior Walus, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, H, Lemkes Stuffken, J, Nunes Correa, J, Rogado, M, Gardete Correia, L, Cardoso, M, Silva, A, Boavida, J, Machado Sa Marques, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, Ben Soussan, D, Verier Mine, O, Fallas, P, Fallas, M, Fuller, J, Holloway, J, Asbury, L, Betteridge, D, Cathelineau, G, Bouallouche, A, Villatte Cathelineau, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, G, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, J, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Cavallo Perin, P, Giunti, S, Grassi, G, Pagano, G, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M

مصطلحات موضوعية: Diet, Endothelial dysfunction, Epidemiologu

الوصف: BACKGROUND AND AIMS: A healthy diet has been inversely associated with endothelial dysfunction (ED) and low-grade inflammation (LGI). We investigated the association between nutrient consumption and biomarkers of ED and LGI in type 1 diabetes. METHODS AND RESULTS: We investigated 491 individuals. Nutrient consumption and lifestyle risk factors were measured in 1989 and 1997. Biomarkers of ED (von Willebrand factor, soluble vascular cell adhesion molecule-1 and soluble endothelial selectin) and LGI (C-reactive protein, interleukin 6 and tumour necrosis factor α) were measured in 1997 and averaged into Z-scores. The nutrient residual method was used to adjust individual nutrient intake for energy intake. Data were analysed with generalised estimation equations. We report increments/decrements in nutrient consumption, averaged over time, per +1 standard deviation (SD) of 1997 ED or LGI Z-scores, after adjustment for sex, age, duration of diabetes, investigation centre, body mass index, energy intake, smoking behaviour, alcohol consumption, and each of the other nutrients. One SD elevation in ED Z-score was associated with a diet lower in fibre [β(95%CI);-0.09(-0.18;-0.004)], polyunsaturated fat [-0.18(-0.31;-0.05)] and vegetable protein [-0.10(-0.20;-0.001)]. For the LGI Z-score results showed associations with fibre [-0.09(-0.17;-0.01)], polyunsaturated fat [-0.14(-0.24;-0.03)] and cholesterol [0.10(0.01; 0.18)]. CONCLUSION: In type 1 diabetes, consumption of less fibre, polyunsaturated fat and vegetable protein, and more cholesterol over the study period was associated with more ED and LGI. Following dietary guidelines in type 1 diabetes may reduce cardiovascular disease risk by favourably affecting ED and LGI.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/22795869; info:eu-repo/semantics/altIdentifier/wos/WOS:000321551300012; volume:23; issue:8; firstpage:758; lastpage:764; numberofpages:7; journal:NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES; http://hdl.handle.net/11584/58062Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84880046493

الإتاحة: https://doi.org/10.1016/j.numecd.2012.04.005Test
http://hdl.handle.net/11584/58062Test

المؤلفون: Schoenaker DA1, Toeller M, Chaturvedi N, Fuller JH, Soedamah Muthu SS, Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, FOSSARELLO, MAURIZIO, Ferriss J, Grealy G, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto V, Idzior Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes H, Lemkes Stuffken J, Nunes Correa J, Rogado M, Gardete Correia L, Cardoso M, Silva A, Boavida J, Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Soussan D, Verier Mine O, Fallas P, Fallas M, Fuller J, Holloway J, Asbury L, Betteridge D, Cathelineau G, Bouallouche A, Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi G, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward J, Tesfaye S, Eaton S, Mody C, Borra M, Perin P, Giunti S, Grassi G, Pagano G, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Cacciatori V, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Roglic G, Metelko Z, Pepeonik Z, Ferriss B, Webb D, Viberti G., Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook MA, Aldington S, Mortemore T, Lipinski H, Scherbaum WA, Gries F.A.

المساهمون: Schoenaker, Da1, Toeller, M, Chaturvedi, N, Fuller, Jh, Soedamah Muthu, S, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, F, Picca, G, Angarano, A, De Pergola, G, Laviola, L, Giorgino, R, Ionescu Tirgoviste, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, Maurizio, Ferriss, J, Grealy, G, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, V, Idzior Walus, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, H, Lemkes Stuffken, J, Nunes Correa, J, Rogado, M, Gardete Correia, L, Cardoso, M, Silva, A, Boavida, J, Marques, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, Soussan, D, Verier Mine, O, Fallas, P, Fallas, M, Fuller, J, Holloway, J, Asbury, L, Betteridge, D, Cathelineau, G, Bouallouche, A, Cathelineau, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, G, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, J, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Perin, P, Giunti, S, Grassi, G, Pagano, G, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M, Cacciatori, V

الوصف: AIMS/HYPOTHESIS: Low adherence to recommendations for dietary saturated fatty acid (SFA) and fibre intake in patients with type 1 diabetes mellitus may heighten their increased risk of cardiovascular disease (CVD) and mortality. We examined the relationship of SFA and total, soluble and insoluble fibre with incident CVD and all-cause mortality in type 1 diabetic patients. METHODS: A prospective cohort analysis was performed in 2,108 European type 1 diabetic patients aged 15-60 years who were free of CVD at baseline and enrolled in the EURODIAB Prospective Complications Study (51% male). Diet was assessed from a standardised 3 day dietary record. HR were calculated using Cox proportional hazards models. RESULTS: During a mean follow-up of 7.3 years, 148 incident cases of fatal and non-fatal CVD and 46 all-cause deaths were documented. No statistically significant association was found between SFA and CVD and all-cause mortality. Total dietary fibre, per 5 g/day, was associated with lower all-cause mortality risk (HR 0.72; 95% CI 0.55, 0.95). This association was stronger for soluble fibre (per 5 g/day, HR 0.34; 95% CI 0.14, 0.80) compared with insoluble fibre (per 5 g/day; HR 0.66; 95% CI 0.45, 0.97). Similar results were found for the association with CVD. CONCLUSIONS/INTERPRETATION: This study suggests that reported dietary SFA is not significantly associated with CVD and all-cause mortality in type 1 diabetic patients. On the contrary, higher dietary fibre consumption, especially soluble fibre, within the range commonly consumed by type 1 diabetic patients, may contribute to the prevention of CVD and all-cause mortality in type 1 diabetic patients.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/22526612; info:eu-repo/semantics/altIdentifier/wos/WOS:000306122600008; volume:55; issue:8; firstpage:2132; lastpage:2141; numberofpages:10; journal:DIABETOLOGIA; http://hdl.handle.net/11584/58063Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84866364919

الإتاحة: https://doi.org/10.1007/s00125-012-2550-0Test
http://hdl.handle.net/11584/58063Test

المؤلفون: Soedamah Muthu, Sabita S., Chaturvedi, Nish, Witte, Daniel R., Stevens, Lynda K., Porta, Massimo, Fuller, John H. Karamanos B, Kofinis A, Petrou K, GIORGINO, Francesco, Picca G, Angarano A, De Pergola G, LAVIOLA, Luigi, Giorgino R, Songini M, Casu A, Pedron M, Pintus S, Fossarello M, Ferriss JB, Grealy G, Keefe DO, Toeller M, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto VA, Idzior Walus B, Sieradzki J, Cyganek K, Lemkes HH, Lemkes Stuffken JC, Nunes Correa J, Rogado MC, Gardete Correia L, Cardoso MC, Silva A, Boavida J, Sa Marques MM, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Soussan B, Verier Mine O, Fallas P, Fallas MC, Fuller JH, Holloway J, Asbury L, Betteridge DJ, Cathelineau G, Bouallouche A, Cathelineau BV, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi P, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward JD, Tesfaye S, Eaton S, Mody C, Borra M, Perin PC, Giunti S, Grassi G, Pagano GF, Porta M, Sivieri R, Vitelli F, Ferrari D, Papazoglou N, Manes G, Muggeo M, Iagulli M, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Ward J, Roglic G, Metelko Z, Pepeonik ZR, Babic Z, Ionescu Tirgoviste C, Coszma A, Guja C, Karamanos B, Sjolie AK, Chaturvedi B, Ferriss B, Chaturvedi N, Webb D, Shipley M, Livingstone SJ, Viberti GC, Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook M.A.

المساهمون: Soedamah Muthu, Sabita S., Chaturvedi, Nish, Witte, Daniel R., Stevens, Lynda K., Porta, Massimo, Fuller, John H., Karamanos B, Kofinis, A, Petrou, K, Giorgino, Francesco, Picca, G, Angarano, A, De Pergola, G, Laviola, Luigi, Giorgino, R, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, M, Ferriss, Jb, Grealy, G, Keefe, Do, Toeller, M, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, Va, Idzior Walus, B, Sieradzki, J, Cyganek, K, Lemkes, Hh, Lemkes Stuffken, Jc, Nunes Correa, J, Rogado, Mc, Gardete Correia, L, Cardoso, Mc, Silva, A, Boavida, J, Sa Marques, Mm, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, Soussan, B, Verier Mine, O, Fallas, P, Fallas, Mc, Fuller, Jh, Holloway, J, Asbury, L, Betteridge, Dj, Cathelineau, G, Bouallouche, A, Cathelineau, Bv, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, P, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, Jd, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Perin, Pc, Giunti, S, Grassi, G, Pagano, Gf, Porta, M, Sivieri, R, Vitelli, F, Ferrari, D, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M, Irsigler, K, Abrahamian, H, Walford, S

مصطلحات موضوعية: Adolescent, Adult, Albuminuria, Cohort Studie, Diabetes Mellitus, Type 1, Diabetic Neuropathie, Diabetic Retinopathy, Europe, Female, Human, Hypotension, Orthostatic, Male, Middle Aged, Proportional Hazards Model, Risk Factor, Internal Medicine, Endocrinology, Diabetes and Metabolism, Advanced and Specialized Nursing

الوصف: OBJECTIVE: The purpose of this study was to examine risk factors for mortality in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: Baseline risk factors were measured in the EURODIAB Prospective Cohort Study with 2,787 type 1 diabetic patients (51% men and 49% women) recruited from 16 European countries. Mortality data were collected during a 7-year follow-up. RESULTS: There was an annual mortality rate of 5 per 1,000 person-years in patients with type 1 diabetes (mean age at baseline 33 years, range 15-61 years); of the total 2,787 subjects, 102 died. The final multivariable model contained age at baseline (standardized hazard ratio 1.78 [95% CI 1.44-2.20]), A1C (1.18 [0.95-1.46]), waist-to-hip ratio (WHR) (1.32 [1.14-1.52]), pulse pressure (1.33 [1.13-1.58]), and non-HDL cholesterol (1.33 [1.12-1.60]) as risk factors for all-cause mortality. Macroalbuminuria (2.39 [1.19-4.78]) and peripheral (1.88 [1.06-3.35]) and autonomic neuropathy (2.40 [1.32-4.36]) were the most important risk markers for mortality. Similar risk factors were found for all-cause, non-cardiovascular disease (CVD), unknown-cause, and CVD mortality. CONCLUSIONS: Important risk factors for the increased total and non-CVD mortality in type 1 diabetic patients are age, WHR, pulse pressure, and non-HDL cholesterol. Microvascular complications from macroalbuminuria and peripheral and autonomic neuropathy are strong risk markers for future mortality exceeding the effect of the traditional risk factors.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000257421000017; volume:31; issue:7; firstpage:1360; lastpage:1366; numberofpages:7; journal:DIABETES CARE; http://hdl.handle.net/11586/198842Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-49649102891; http://care.diabetesjournals.org/cgi/reprint/31/7/1360Test

الإتاحة: https://doi.org/10.2337/dc08-0107Test
http://hdl.handle.net/11586/198842Test
http://care.diabetesjournals.org/cgi/reprint/31/7/1360Test

المؤلفون: Chaturvedi, Nish, Bandinelli, Simona, Mangili, Ruggero, Penno, Guiseppe, Rottiers, Raoul E., Fuller, John H., Karamanos, B., Kofinis, A., Petrou, K., Giorgino, R., Giorgino, F., Picca, G., Angarano, A., De Pergola, G., Ionescu-Tirgoviste, C., Coszma, A., Songini, M., Casu, A., Pedron, M., Fossarello, M., Ferriss, J. B., Grealy, G., Keefe, D. O., White, A., Cleary, P. E., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Kyostio-Renvall, T., Idzior-Walus, B., Sieradzki, J., Cyganek, K., Lemkes, H. H. P. J., Roest, C., Nunes-Correa, J., Rogado, M. C., Gardete-Correia, L., Cardoso, M. C., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Lattanzio, Rosangela, Galardi, G., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, D., Verier-Mine, O., Fuller, J. H., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D’ Alessandro, V., Cagini, C., Navalesi, R., Penno, G., Bandinelli, S., Miccoli, R., Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Porta, M., Perin, P. Cavallo, Borra, M., Giunti, S., Papazoglou, N., Manes, Gianfranco, Muggeo, M., Iagulli, M., Irsigler, K., Abrahamian, H., Walford, S., Wardle, E. V., Sinclair, J., Hughes, S., Roglic, G., Metelko, Z., Resman, Z., Sjolie, A. -. K., Chaturvedi, N., Ferriss, B., Webb, D., Viberti, G. -. C., Swaminathan, R., Lumb, P., Collins, A., Sankaralingham, S., Aldington, S., Mortemore, T., Lipinski, H.

المصدر: Kidney International. 60:219-227

مصطلحات موضوعية: Albuminuria, Blood sugar control, Cardiovascular disease, Insulin resistance, Renal disease, Adolescent, Adult, Blood Glucose, Body Constitution, Cohort Studies, Diabetes Mellitus, Type 1, Differential Threshold, Disease Progression, Europe, Female, Follow-Up Studies, Humans, Incidence, Insulin Resistance, Male, Middle Aged, Prospective Studies, Reference Values, Risk Factors, Triglycerides, Nephrology, endocrine system diseases, urologic and male genital diseases, Gastroenterology, Waist–hip ratio, Proteinuria, Settore MED/30 - MALATTIE APPARATO VISIVO, female genital diseases and pregnancy complications, medicine.symptom, Type 1, medicine.medical_specialty, Internal medicine, Diabetes mellitus, Diabetes Mellitus, medicine, Risk factor, Glycemic, Type 1 diabetes, business.industry, nutritional and metabolic diseases, medicine.disease, Endocrinology, Microalbuminuria, business

الوصف: Microalbuminuria in type 1 diabetes: Rates, risk factors and glycemic threshold.BackgroundThe occurrence of microalbuminuria in type 1 diabetes is strongly predictive of renal and cardiovascular disease and is still likely to occur despite improvements in glycemic control. A better understanding of microalbuminuria is required to inform new interventions. We determined the incidence and risk factors for microalbuminuria [albumin excretion rate (AER) 20 to 200 μg/min] in the EURODIAB Prospective Complications Study.MethodsThis is a seven-year follow-up (between 1988 and 1991) of 1134 normoalbuminuric men and women (aged 15 to 60) with type 1 diabetes from 31 European centers. Risk factors and AER were measured centrally.ResultsThe incidence of microalbuminuria was 12.6% over 7.3 years. Independent baseline risk factors were HbA1c (7.1 vs. 6.2%, P = 0.0001) and AER (9.6 vs. 7.8 μg/min, P = 0.0001) and, independent of these, fasting triglyceride (0.99 vs. 0.88 mmol/L, P = 0.01), low-density lipoprotein cholesterol (3.5 vs. 3.2 mmol/L, P = 0.02), body mass index (24.0 vs. 23.4 kg/m2, P = 0.01), and waist to hip ratio (WHR; 0.85 vs. 0.83, P = 0.009). Triglyceride and WHR risk factors were nearly as strong as AER in predicting microalbuminuria (standardized regression effects of 1.3 for triglyceride and WHR and 1.5 for AER). Blood pressure at follow-up, but not at baseline, was also raised in those who progressed. There was no evidence of a threshold of HbA1c on microalbuminuria risk.ConclusionsThe incidence of microalbuminuria in patients with type 1 diabetes remains high, and there is no apparent glycemic threshold for it. Markers of insulin resistance, such as triglyceride and WHR, are strong risk factors. Systemic blood pressure is not raised prior to the onset of microalbuminuria.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2556bd8b447ca8ee9908bb7998f9d141Test
https://doi.org/10.1046/j.1523-1755.2001.00789.xTest

المؤلفون: Nin JW, Ferreira I, Schalkwijk CG, Prins MH, Chaturvedi N, Fuller JH, Stehouwer CD, Karamanos B, Kofinis A, Petrou K, Giorgino F, Picca G, Angarano A, De Pergola G, Laviola L, Giorgino R, Ionescu Tirgoviste C, Coszma A, Guja C, Songini M, Casu A, Pedron M, Pintus S, FOSSARELLO, MAURIZIO, Ferriss JB, Grealy G, Keefe DO, Toeller M, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto VA, Idzior Walus B, Sieradzki J, Cyganek K, Solnica B, Lemkes HH, Lemkes Stuffken JC, Nunes Correa J, Rogado MC, Gardete Correia L, Cardoso MC, Silva A, Boavida J, Machado Sa Marques M, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Ben Soussan D, Verier Mine O, Fallas P, Fallas MC, Holloway J, Asbury L, Betteridge DJ, Cathelineau G, Bouallouche A, Villatte Cathelineau B, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi GP, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward JD, Tesfaye S, Eaton S, Mody C, Borra M, Cavallo Perin P, Giunti S, Grassi G, Pagano GF, Porta M, Sivieri R, Vitelli F, Veglio M, Papazoglou N, Manes G, Muggeo M, Iagulli M, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Ward J, Roglic G, Metelko Z, Pepeonik ZR, Sjolie AK, Ferriss B, Webb D, Viberti GC, Swaminathan R, Lumb P, Collins A, Sankaralingham S, Aldington S, Mortemore T, Lipinski H.

المساهمون: Nin, Jw, Ferreira, I, Schalkwijk, Cg, Prins, Mh, Chaturvedi, N, Fuller, Jh, Stehouwer, Cd, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, F, Picca, G, Angarano, A, De Pergola, G, Laviola, L, Giorgino, R, Ionescu Tirgoviste, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, Maurizio, Ferriss, Jb, Grealy, G, Keefe, Do, Toeller, M, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, Va, Idzior Walus, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, Hh, Lemkes Stuffken, Jc, Nunes Correa, J, Rogado, Mc, Gardete Correia, L, Cardoso, Mc, Silva, A, Boavida, J, Machado Sa Marques, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, Ben Soussan, D, Verier Mine, O, Fallas, P, Fallas, Mc, Holloway, J, Asbury, L, Betteridge, Dj, Cathelineau, G, Bouallouche, A, Villatte Cathelineau, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, Gp, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, Jd, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Cavallo Perin, P, Giunti, S, Grassi, G, Pagano, Gf, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G

الوصف: CONTEXT AND OBJECTIVE: High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction (ED) and pulse pressure (PP, a marker of arterial stiffness); ii) prevalent nephropathy, retinopathy and cardiovascular disease (CVD) in type 1 diabetes; and iii) the potential mediating roles of LGI, ED and PP therein. DESIGN AND METHODS: This was a cross-sectional nested case-control study of 463 patients (226 women; mean age 40±10 years) with type 1 diabetes from the EURODIAB Prospective Complications Study. We used linear and binary or multinomial logistic regression analyses adjusted for traditional risk factors. RESULTS: Serum Ln-HMGB1 levels were positively associated with LGI and ED (standardised β=0.07 (95% confidence interval (CI): 0.02-0.12) and β=0.08 (95% CI: 0.02-0.14) respectively), but not with PP. Higher Ln-HMGB1 (per unit) was associated with greater odds of micro- and macroalbuminuria: odds ratio (OR)=1.24 (95% CI: 0.90-1.71) and OR=1.61 (95% CI: 1.15-2.25) respectively, P for trend=0.004. Further adjustments for LGI or ED did not attenuate these associations. No such associations were found between Ln-HMGB1 and estimated glomerular filtration rate (eGFR), retinopathy or CVD, however. CONCLUSIONS: In type 1 diabetes, higher serum HMGB1 levels are associated with greater prevalence and severity of albuminuria, though not with eGFR, retinopathy and CVD. Prospective studies are needed to clarify the causal role of HMGB1, if any, in the pathogenesis of vascular complications in type 1 diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/22127490; info:eu-repo/semantics/altIdentifier/wos/WOS:000300295000023; volume:166; issue:2; firstpage:325; lastpage:332; numberofpages:8; journal:EUROPEAN JOURNAL OF ENDOCRINOLOGY; http://hdl.handle.net/11584/58104Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84856078195

الإتاحة: https://doi.org/10.1530/EJE-11-0662Test
http://hdl.handle.net/11584/58104Test

المؤلفون: Zaccheroni, V, Iagulli, M P, Vescini, F, Bianchi, G P, Menini, S, Vacirca, A, Vallese, M, Lodi, A

المساهمون: Zaccheroni, V, Iagulli, M P, Vescini, F, Bianchi, G P, Menini, S, Vacirca, A, Vallese, M, Lodi, A

مصطلحات موضوعية: Adult, Aged Aged, 80 and over Calcinosis Female Goiter, Endemic Thyroglobulin Thyroid Gland, Thyroid Neoplasms Ultrasonography

الوصف: Intrathyroid calcifications represent a common finding within simple or nodular goiters, but, as far as they can be found also inside papillary and medullary thyroid carcinomas, an ultrasonographic detection of intrathyroid calcifications stands as a different diagnosis problem. We have been looking for the presence of parameters associated with thyroid calcifications in patients affected by simple or nodular goiter, either sporadic or endemic. We studied 284 euthyroid subjects, 250 females, ageing from 24 to 90 years, affected by a simple goiter, in the 9.51% of the cases, and by a nodular goiter in the remaining part. 69.37% of the patients came from an endemic goiter area, while the others were affected by sporadic goiter. We tested fT3, fT4, TSH, hTG, Ab-TG, Ab-TPO and performed an ultrasonography in all the subjects, 57.75% of patients shown intrathyroid calcifications in the 57.75% of them. We applied a multistep discriminant analysis taking for the presence/absence of calcifications as dependent variable and we tried to find which variable, by itself or in combination with others, could foretell its presence. We also created a new variable (TG1) to differentiate normal from supraphysiologic concentrations of hTG (< 60 ng/ml). The variable with the highest significance F originated from endemic goiter area (F = 96.36), followed by TG1 (F = 24.46) and age (F = 10.61). On the contrary hTG did not relate to calcifications, due to non-proportionally direct relationship between these two parameters, afterwards we used the multistep logistic regression that gave overlapping significances. This means that supraphysiologic hTG rates are sufficient to predict the possible presence of intrathyroid calcifications. In conclusion, as far as a follicular hyperstimulation can be assumed, especially if long-lasting, the presence of intrathyroid calcifications should rise a clinical suspect toward an old goiter rather than a neoplastic lesion.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/10464709; info:eu-repo/semantics/altIdentifier/wos/WOS:000081617000013; volume:18; issue:2; firstpage:213; lastpage:217; numberofpages:5; journal:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH; https://hdl.handle.net/11585/793319Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0032795007

الإتاحة: https://hdl.handle.net/11585/793319Test

المؤلفون: SOEDAMAH MUTHU, S. S., Chaturvedi, N, Teerlink, T, IDZIOR WALUS, B, Fuller, J. H., EURODIAB PROSPECTIVE COMPLICATIONS STUDY GROUP, STEHOUWER C. D. A., Muggeo, Michele, Iagulli, M., Cacciatori, V.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______1943::2d3f607b6828448e13671deea10c0139Test
http://hdl.handle.net/11562/231363Test

المؤلفون: Peeters, Stijn A., Engelen, Lian, Buijs, Jacqueline, Chaturvedi, Nish, Fuller, John H., Schalkwijk, Casper G., Stehouwer, Coen D, Karamanos, B., Kofinis, A., Petrou, K., Giorgino, F., Picca, G., Angarano, A., Null, de P. e. r. g. o. l. a. G., Laviola, L., Giorgino, R., Ionescu Tirgoviste, C., Coszma, A., Guja, C., Songini, M., Casu, A., Pedron, M., Pintus, S., Fossarello, M., Ferriss, J. B., Grealy, G., O'Keefe, D., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Koivisto, V. A., Idzior Walus, B., Sieradzki, J., Cyganek, K., Solnica, B., Lemkes, H. H. P. J., Lemkes Stuffken, J. C., Nunes Correa, J., Rogado, M. C., Gardete Correia, L., Cardoso, M. C., Silva, A., Boavida, J., Machado Sa Marques, M., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, M., Verier Mine, O., Fallas, P., Fallas, M. C., Fuller, J. H., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D'Alessandro, V., Cagini, C., Bottini, P., Reboldi, G. P., Navalesi, R., Penno, Giuseppe, Bandinelli, S., Miccoli, Roberto, Nannipieri, Monica, Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Borra, M., Cavallo Perin, P., Giunti, S., Grassi, G., Pagano, G. F., Porta, M., Sivieri, R., Vitelli, F., Veglio, M., Papazoglou, N., Manes, G., Muggeo, M., Iagulli, M., Cacciatori, V., Cattedra di Malattie del Metabolismo, V., Irsigler, K., Abrahamian, H., Walford, S., Sinclair, J., Hughes, S., Mclelland, V., Ward, J., Roglic, G., Metelko, Z., Pepeonik, Z. R.

المساهمون: Clinicum, Department of Medicine, Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), RS: CARIM - R3 - Vascular biology

المصدر: Cardiovascular Diabetology
Cardiovascular Diabetology, 14:31. BioMed Central Ltd

مصطلحات موضوعية: Male, Endocrinology, Diabetes and Metabolism, Matrix metalloproteinase, Gastroenterology, Cohort Studies, Endocrinology, Prospective Studies, Endothelial dysfunction, Original Investigation, Settore MED/30 - MALATTIE APPARATO VISIVO, Middle Aged, Cardiovascular disease, 3. Good health, Europe, Diabetes and Metabolism, Albuminuria, Retinopathy, Tissue inhibitor of metalloproteinase, Type 1 diabetes, Adult, Biomarkers, Cross-Sectional Studies, Diabetes Complications, Diabetes Mellitus, Type 1, Female, Humans, Matrix Metalloproteinase 10, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, Tissue Inhibitor of Metalloproteinase-1, Vascular Diseases, Cardiology and Cardiovascular Medicine, medicine.symptom, Type 1, medicine.medical_specialty, education, Inflammation, Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, business.industry, Settore MED/09 - MEDICINA INTERNA, medicine.disease, 3121 General medicine, internal medicine and other clinical medicine, business

الوصف: Background Impaired regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in patients with type 1 diabetes. We investigated associations between plasma MMP-1, −2, −3, −9, −10 and TIMP-1, and cardiovascular disease (CVD) or microvascular complications in type 1 diabetic patients. We also evaluated to which extent these associations could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods 493 type 1 diabetes patients (39.5 ± 9.9 years old, 51% men) from the EURODIAB Prospective Complications Study were included. Linear regression analysis was applied to investigate differences in plasma levels of MMP-1, −2, −3, −9, −10, and TIMP-1 between patients with and without CVD, albuminuria or retinopathy. All analyses were adjusted for age, sex, duration of diabetes, Hba1c and additionally for other cardiovascular risk factors including LGI and ED. Results Patients with CVD (n = 118) showed significantly higher levels of TIMP-1 [β = 0.32 SD (95%CI: 0.12; 0.52)], but not of MMPs, than patients without CVD (n = 375). Higher plasma levels of MMP-2, MMP-3, MMP-10 and TIMP-1 were associated with higher levels of albuminuria (p-trends were 0.028, 0.004, 0.005 and 0.001, respectively). Severity of retinopathy was significantly associated with higher levels of MMP-2 (p-trend = 0.017). These associations remained significant after further adjustment for markers of LGI and ED. Conclusions These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes. Electronic supplementary material The online version of this article (doi:10.1186/s12933-015-0195-2) contains supplementary material, which is available to authorized users.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78226d7d86ee0e00241b8f5e4f5f1456Test