المؤلفون: Bauwens, Grégory, Purcaro, Giorgia

المصدر: Analytica Chimica Acta, 1312, 342788 (2024-07-11)

مصطلحات موضوعية: Fats and oils, LC-GC-FID, Mineral oil aromatic hydrocarbon (MOAH), Saponification, Hydrocarbons, Aromatic, Mineral Oil, Hydrocarbons, Aromatic/analysis, Mineral Oil/analysis, Mineral Oil/chemistry, Microwaves, Analytical challenge, Fats and oil, Hydrocarbon analysis, Internal standards, Methyl naphthalene, Microwave-assisted, Mineral oil aromatic hydrocarbon, Sources of uncertainty, Uncertainty, Analytical Chemistry, Environmental Chemistry, Biochemistry, Spectroscopy, Physical, chemical, mathematical & earth Sciences, Chemistry, Life sciences, Food science, Physique, chimie, mathématiques & sciences de la terre, Chimie, Sciences du vivant, Sciences des denrées alimentaires

الوصف: [en] BACKGROUND: Mineral oil aromatic hydrocarbon (MOAH) analysis in foods is a major analytical challenge. Quantification is associated with a high uncertainty. The sources of uncertainty are multiple, but the major one is related to data interpretation and integration, which is partially derived from insufficiently efficient sample preparation. Recently, an updated ISO method for the analysis of mineral oil in fats and oils and a standard operating procedure for infant formula analysis have been published. Both methods reported significantly different (up to 1.25) distributions of the internal standards used for quantification (i.e., tri-tert-butyl benzene (TBB) and 2-methyl naphthalene (2-MN)) over the different solvent phases used in the saponification step.RESULTS: In this work, a microwave-assisted saponification and extraction method was optimized for MOAH analysis to solve the problem related to the MOAH internal standards partition. The paper examines the impact of the solvent mixture used, the concentration of KOH on the partition of TBB and 2-MN, and the effect of the matrix and the washing step to extract the unsaponifiable fraction containing the mineral oils.SIGNIFICANCE: The optimized procedure achieved a TBB/2-MN ratio of 1.05 ± 0.01 tested in five different fats and oils, namely, sunflower, rapeseed, coconut, palm, and extra virgin olive oils. The method can significantly contribute to reducing the uncertainty of the MOAH quantification when saponification is applied.

العلاقة: https://api.elsevier.com/content/article/PII:S0003267024005890?httpAccept=text/xmlTest; urn:issn:0003-2670; urn:issn:1873-4324

الوصول الحر: https://orbi.uliege.be/handle/2268/319578Test

المؤلفون: Mariussen, Espen, Alexander, Jan, Bukhvalova, Barbara Alexandra, Dahl, Lisbeth Jane, Kvalem, Helen Engelstad, Olsen, Ann-Karin Hardie, Schlabach, Martin, Amlund, Heidi, Hannisdal, Rita, Ruus, Anders, Samdal, Ingunn Anita, Knutsen, Helle Katrine

الإتاحة: https://hdl.handle.net/11250/3131706Test

المؤلفون: Tallandier, Valentin, Chalansonnet, M, Merlen, L, Boucard, S, Thomas, A, Campo, P, Pouyatos, B

المصدر: NeuroToxicology, 84, 105 - 113 (2021-05)

مصطلحات موضوعية: Aromatic solvents, Endolymph, Potassium, Vestibular explants, Hydrocarbons, Aromatic, Solvents, Xylenes, Toluene, Styrene, Animals, Animals, Newborn, Cells, Cultured, Cochlea/drug effects, Cochlea/metabolism, Cochlea/pathology, Dose-Response Relationship, Drug, Female, Hydrocarbons, Aromatic/toxicity, Pregnancy, Rats, Rats, Long-Evans, Saccule and Utricle/drug effects, Saccule and Utricle/metabolism, Saccule and Utricle/pathology, Solvents/toxicity, Styrene/toxicity, Toluene/toxicity, Vestibule, Labyrinth/drug effects, Vestibule, Labyrinth/metabolism, Vestibule, Labyrinth/pathology, Xylenes/toxicity, Cochlea, Saccule and Utricle, Vestibule, Labyrinth, Neuroscience (all), Toxicology, General Neuroscience, Life sciences, Anatomy (cytology, histology, embryology...) & physiology, Sciences du vivant, Anatomie (cytologie, histologie, embryologie...) & physiologie

الوصف: Epidemiological and experimental studies indicate that a number of aromatic solvents widely used in the industry can affect hearing and balance following chronic exposure. Animal studies demonstrated that long-term exposure to aromatic solvents directly damages the auditory receptor within the inner ear: the cochlea. However, no information is available on their effect on the vestibular receptor, which shares many structural features with the cochlea and is also localized in inner ear. The aim of this study was to use an in vitro approach to assess and compare the vestibular toxicity of different aromatic solvents (toluene, ethylbenzene, styrene and ortho-, meta-, para-xylene), all of which have well known cochleotoxic properties. We used a three-dimensional culture model of rat utricles ("cysts") with preserved functional sensory and secretory epithelia, and containing a potassium-rich (K+) endolymph-like fluid for this study. Variations in K+ concentrations in this model were considered as biomarkers of toxicity of the substances tested. After 72 h exposure, o-xylene, ethylbenzene and styrene decreased the K+ concentration by 78 %, 37 % and 28 %, respectively. O- xylene and styrene both caused histopathological alterations in secretory and sensory epithelial areas after 72 h exposure, whereas no anomalies were observed in ethylbenzene-exposed samples. These in vitro results suggest that some widely used aromatic solvents might have vestibulotoxic properties (o-xylene, styrene and ethylbenzene), whereas others may not (p-xylene, m-xylene, toluene). Our results also indicate that variations in endolymphatic K+ concentration may be a more sensitive marker of vestibular toxicity than histopathological events. Finally, this study suggests that cochleotoxic solvents might not be necessarily vestibulotoxic, and vice versa.

العلاقة: https://api.elsevier.com/content/article/PII:S0161813X21000255?httpAccept=text/xmlTest; urn:issn:0161-813X

الوصول الحر: https://orbi.uliege.be/handle/2268/302882Test

المؤلفون: Andrea Hochegger, Reinhard Wagenhofer, Sanja Savić, Elisa Mayrhofer, Michael Washüttl, Erich Leitner

المصدر: Journal of Agricultural and Food Chemistry. 70:16401-16409

مصطلحات موضوعية: Flame Ionization, Mineral Oil, Food Contamination, General Chemistry, General Agricultural and Biological Sciences, Hydrocarbons, Aromatic, Gas Chromatography-Mass Spectrometry

الوصف: Mineral oil aromatic hydrocarbons (MOAHs) include mutagenic and carcinogenic substances and are considered a potential health risk. Current methods address the total MOAH content but cannot address the actual toxicological hazard of individual components. This work presents a combined methodology closing those gaps: high-performance liquid chromatography (HPLC) coupled to gas chromatography with flame ionization detection was used to determine the MOAH content. To characterize present substance classes, comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry was applied. Preparative HPLC separated MOAHs into subgroups, which were tested with a miniaturized Ames test evaluating DNA reactivity of isolated fractions. Combining these methods allowed a correlation between present subgroups and DNA reactivity. The developed approach was applied to a mineral oil and distinguished between not DNA-reactive mono- and diaromatics and DNA-reactive tri- and polyaromatics, providing a proof of concept. Hereinafter, it will be applied to diverse sample matrices including mineral oils, food, and food contact materials.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3c6c4b8d568575db1aed2d6809aa09Test
https://doi.org/10.1021/acs.jafc.2c05970Test

المؤلفون: Hak, Claudia

العلاقة: NILU - Norsk institutt for luftforskning: 119080

الإتاحة: https://hdl.handle.net/11250/2761503Test

المؤلفون: Christian Erker, Thomas Basché

المصدر: Journal of the American Chemical Society. 144:14053-14056

مصطلحات موضوعية: Colloid and Surface Chemistry, Solvents, General Chemistry, Hydrocarbons, Aromatic, Biochemistry, Fluorescence, Catalysis

الوصف: Internal conversion (IC) often is the dominating relaxation pathway in NIR emitters, lowering their fluorescence quantum yield. Here, we investigate dibenzoterrylene (DBT) by bulk and single molecule spectroscopy. With increasing solvent polarity, the S

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cf61df89d2c5d692447c44811fd7cdTest
https://doi.org/10.1021/jacs.2c07188Test

المؤلفون: Ruus, Anders, Ranneklev, Sissel Brit, Golmen, Lars Gunder, Grung, Merete, Allan, Ian, Øxnevad, Sigurd

الإتاحة: https://hdl.handle.net/11250/2731706Test

المؤلفون: Tao Yue, Lei Xia, Jia Tian, Baoxuan Huang, Chao Chen, Hongliang Cao, Weian Zhang

المصدر: Chemical Communications. 58:2991-2994

مصطلحات موضوعية: Staphylococcus aureus, Photosensitizing Agents, Metals and Alloys, Microbial Sensitivity Tests, macromolecular substances, General Chemistry, Hydrocarbons, Aromatic, Catalysis, Anti-Bacterial Agents, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Spectrometry, Fluorescence, Escherichia coli, Materials Chemistry, Ceramics and Composites, Spectrophotometry, Ultraviolet

الوصف: A pH-triggering supramolecular antibacterial photosensitizer was constructed by host-guest interaction between a water-soluble porphyrin photosensitizer and carboxylatopillar[5]arene (P[5]). The formation of the supramolecular complex not only improves the biocompatibility of the photosensitizer, but also enhances antibacterial efficacy by pH-triggering dissociation under the low pH bacterial microenvironment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d022c454da96f5ff54aee37d73d7fbTest
https://doi.org/10.1039/d1cc06116jTest

المؤلفون: Ryota Sato, Tomoki Iida, Takaki Kanbara, Junpei Kuwabara

المصدر: Chemical Communications. 58:11511-11514

مصطلحات موضوعية: Materials Chemistry, Metals and Alloys, Ceramics and Composites, General Chemistry, Hydrocarbons, Aromatic, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials

الوصف: A Pd-catalysed cross-dehydrogenative coupling reaction introduced two polyfluoroarenes into simple polyaromatic hydrocarbons at sterically favourable positions. An investigation of the reaction mechanism revealed that the unique regioselectivity was determined by the reductive elimination step rather than the C-H bond cleavage step.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2ef72abbc84e86a1ae7e01ed0f001eTest
https://doi.org/10.1039/d2cc04655eTest

المؤلفون: Araceli de Aquino, Francisco J. Caparrós, Gabriel Aullón, Khai-Nghi Truong, Kari Rissanen, João Carlos Lima, Laura Rodríguez

المصدر: Dalton Transactions. 51:16282-16291

مصطلحات موضوعية: Inorganic Chemistry, Luminescence, Spectrometry, Fluorescence, Polymers, Gold, Hydrocarbons, Aromatic

الوصف: The gold(i) alkynyl-fluorene compound 2 has been synthesized and used in molecular recogniton of PAHs and PFCs thanks to changes on the luminescent properties of the host. DFT theoretical calculations support the obtained data.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c1720fab187c9233d86ad7b46d5d09Test
https://doi.org/10.1039/d2dt02515aTest