المؤلفون: David Kryza, Jennifer Wischhusen, Mathieu Richaud, Maëva Hervieu, Jacqueline Sidi Boumedine, Jean‐Guy Delcros, Sophie Besse, Thomas Baudier, Pierre‐Alexandre Laval, Silvia Breusa, Erwan Boutault, Hugo Clermidy, Nicolas Rama, Benjamin Ducarouge, Mojgan Devouassoux‐Shisheboran, Jean‐Michel Chezal, Anne‐Laure Giraudet, Thomas Walter, Patrick Mehlen, David Sarrut, Benjamin Gibert

المصدر: EMBO Molecular Medicine, Vol 15, Iss 4, Pp n/a-n/a (2023)

مصطلحات موضوعية: cancer, extracellular matrix, netrin, radioimmunotherapy, targeted therapy, Medicine (General), R5-920, Genetics, QH426-470

الوصف: Abstract Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on the use of vectors to deliver radionuclides to tumor cells, targeting membrane‐bound cancer‐specific moieties. Here, we report the embryonic navigation cue netrin‐1 as an unanticipated target for vectorized radiotherapy. While netrin‐1, known to be re‐expressed in tumoral cells to promote cancer progression, is usually characterized as a diffusible ligand, we demonstrate here that netrin‐1 is actually poorly diffusible and bound to the extracellular matrix. A therapeutic anti‐netrin‐1 monoclonal antibody (NP137) has been preclinically developed and was tested in various clinical trials showing an excellent safety profile. In order to provide a companion test detecting netrin‐1 in solid tumors and allowing the selection of therapy‐eligible patients, we used the clinical‐grade NP137 agent and developed an indium‐111‐NODAGA‐NP137 single photon emission computed tomography (SPECT) contrast agent. NP137‐111In provided specific detection of netrin‐1‐positive tumors with an excellent signal‐to‐noise ratio using SPECT/CT imaging in different mouse models. The high specificity and strong affinity of NP137 paved the way for the generation of lutetium‐177‐DOTA‐NP137, a novel vectorized radiotherapy, which specifically accumulated in netrin‐1‐positive tumors. We demonstrate here, using tumor cell‐engrafted mouse models and a genetically engineered mouse model, that a single systemic injection of NP137‐177Lu provides important antitumor effects and prolonged mouse survival. Together, these data support the view that NP137‐111In and NP137‐177Lu may represent original and unexplored imaging and therapeutic tools against advanced solid cancers.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1757-4676Test; https://doaj.org/toc/1757-4684Test

الوصول الحر: https://doaj.org/article/d9f5252ceab344fca27e6ed88f83c690Test

المؤلفون: Hugo Clermidy, Guillaume Fadel, Alexandra De Lemos, Pauline Pradere, Delphine Mitilian, Antoine Girault, Jean-Baptiste Menager, Dominique Fabre, Sacha Mussot, Nicolas Leymarie, Elie Fadel, Olaf Mercier

المصدر: Frontiers in Surgery, Vol 9 (2022)

مصطلحات موضوعية: chest wall resection, titanium bars, infection, fracture, long term, Surgery, RD1-811

الوصف: ObjectivesEn-bloc complete resection remains the treatment of choice for localized chest wall (CW) tumors. Titanium bars reconstruction demonstrated encouraging results with satisfactory early outcomes. However, long-term outcomes remain under-reported. The purpose of this study is to evaluate long-term outcomes after CW resection and repair with titanium devices.MethodsFrom June 2012 to December 2018, we retrospectively reviewed all patients with CW tumors who underwent surgical resection and repair using titanium. Long-term outcomes were assessed.ResultsWe identified 87 patients who underwent CW tumor resections and titanium reconstruction. Sixty-eight patients were included in the study (excluding benign tumors, Pancoast tumors, palliative surgeries, or clavicle reconstruction). There were 29 sarcomas, 20 isolated CW metastases, eight lung cancers, four breast cancers, three thymic malignancies, two sarcomatoid mesothelioma, and one desmoid tumor. Complete resection was achieved in 64 patients (94%), while R1 resection in four patients (6%). Resection involved one rib in two patients, two ribs in thirteen, three ribs in eighteen, four ribs in nine, five ribs in two, seven ribs in one, partial sternum in fifteen, and full sternum in sixteen patients. No patient experienced flail chest. The 1-year, 3-year, and 5-year overall survival rates and disease-free survivals were 82.3%, 61.4%,57.3%, and 67.6%,57.3%,52.6%, respectively. Surgical site infection occurred in 18% (n = 12) of cases. Eleven of twelve patients had an early infection (

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fsurg.2022.950177/fullTest; https://doaj.org/toc/2296-875XTest

الوصول الحر: https://doaj.org/article/5fada1a9748b4e8699db42d543677cccTest

المؤلفون: Benjamin Chappuy, Gabrielle Drevet, Hugo Clermidy, Pascal Rosamel, Mickael Duruisseaux, Sebastien Couraud, Renaud Grima, Valentin Soldea, Lara Chalabreysse, François Tronc, Nicolas Girard, Jean-Michel Maury

المصدر: Cancers, Vol 14, Iss 20, p 5035 (2022)

مصطلحات موضوعية: IVa Masaoka, thymomas, pleural involvement, thymic surgery, HITHOC, subtotal pleurectomy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Introduction: Stage IVa thymoma is a rare disease without a standard of care. Subtotal pleurectomy and HITHOC introduced in highly selected patients may provide interesting oncologic results. The purpose of this study was to distinguish de novo stage IVa tumors (DNT) from distant relapse (DR) with respect to post-operative and long-term outcomes to provide the procedure efficacy. Methods: From July 1997–December 2021, 40 patients with IVa pleural involvement were retrospectively analyzed. The surgical procedure was subtotal pleurectomy and HITHOC (cisplatin 50 mg/m2, mitomycin 25 mg/m2, 42 °C, 90 min). The post-operative outcome, disease-free interval (DFI) and overall survival (OS) were analyzed. Results: Mean age was 52 ± 12 years. B2 and B3 thymomas were preponderant (27; 67.5%). The median number of pleural nodes were nine (4–81) vs. five (1–36); p = 0.004 * in DNT and DR, respectively. Hospital mortality rate was 2.5%. There were four specific HITHOC complications (10%). DFI were 49 and 85 months (p = 0.02 *), OS were 94 and 118 months (NS), in DNT and DR, respectively. Conclusions: Subtotal pleurectomy with HITHOC in IVa offers satisfying results in highly selected patients, for both DNT and DR. Due to the disease rarity, multicentric studies are needed to define HITHOC as a standard of care.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6694/14/20/5035Test; https://doaj.org/toc/2072-6694Test

الوصول الحر: https://doaj.org/article/58ff8734274a4b609e16e839199fcc7aTest

المؤلفون: David Kryza, Jennifer Wischhusen, Mathieu Richaud, Maëva Hervieu, Jacqueline Sidi Boumedine, Jean‐Guy Delcros, Sophie Besse, Thomas Baudier, Pierre‐Alexandre Laval, Silvia Breusa, Erwan Boutault, Hugo Clermidy, Nicolas Rama, Benjamin Ducarouge, Mojgan Devouassoux‐Shisheboran, Jean‐Michel Chezal, Anne‐Laure Giraudet, Thomas Walter, Patrick Mehlen, David Sarrut, Benjamin Gibert

المساهمون: Laboratoire d'automatique, de génie des procédés et de génie pharmaceutique (LAGEPP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Clermont Auvergne (UCA), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Netris Pharma, Partenaires INRAE, Hospices Civils de Lyon (HCL)

المصدر: EMBO Molecular Medicine
EMBO Molecular Medicine, 2023, 15, ⟨10.15252/emmm.202216732⟩

مصطلحات موضوعية: netrin, cancer extracellular matrix netrin radioimmunotherapy targeted therapy Subject Categories Cancer Pharmacology & Drug Discovery, extracellular matrix, radioimmunotherapy, Molecular Medicine, cancer, [SDV.CAN]Life Sciences [q-bio]/Cancer, Pharmacology & Drug Discovery, targeted therapy

الوصف: International audience; Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on the use of vectors to deliver radionuclides to tumor cells, targeting membrane-bound cancer-specific moieties. Here, we report the embryonic navigation cue netrin-1 as an unanticipated target for vectorized radiotherapy. While netrin-1, known to be reexpressed in tumoral cells to promote cancer progression, is usually characterized as a diffusible ligand, we demonstrate here that netrin-1 is actually poorly diffusible and bound to the extracellular matrix. A therapeutic anti-netrin-1 monoclonal antibody (NP137) has been preclinically developed and was tested in various clinical trials showing an excellent safety profile. In order to provide a companion test detecting netrin-1 in solid tumors and allowing the selection of therapy-eligible patients, we used the clinical-grade NP137 agent and developed an indium-111-NODAGA-NP137 single photon emission computed tomography (SPECT) contrast agent. NP137-111 In provided specific detection of netrin-1-positive tumors with an excellent signal-to-noise ratio using SPECT/CT imaging in different mouse models. The high specificity and strong affinity of NP137 paved the way for the generation of lutetium-177-DOTA-NP137, a novel vectorized radiotherapy, which specifically accumulated in netrin-1-positive tumors. We demonstrate here, using tumor cell-engrafted mouse models and a genetically engineered mouse model, that a single systemic injection of NP137-177 Lu provides important antitumor effects and prolonged mouse survival. Together, these data support the view that NP137-111 In and NP137-177 Lu may represent original and unexplored imaging and therapeutic tools against advanced solid cancers.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9bcbf1f2752c2a6e92c99edabd903cTest
https://cnrs.hal.science/hal-04107206Test

المؤلفون: Hugo Clermidy, Dominique Fabre, Jean Noel Hugues, Carlos Garcia Alonso, Delphine Mitilian, Olaf Mercier, Philippe Brenot, Philippe Charbonneau, Elie Fadel

المصدر: Contraception. 113

مصطلحات موضوعية: Drug Implants, Desogestrel, Reproductive Medicine, Databases, Factual, Obstetrics and Gynecology, Humans, Pulmonary Artery

الوصف: To evaluate the relationship between time since contraceptive implant placement and retrieval outcomes in patients with implant migration into the pulmonary artery.We reviewed all cases of pulmonary artery implant migration referred to the Marie Lannelongue hospital from 2015 through 2020. Using our hospital database, we collected patients' clinical data and removal information to assess the success of therapeutic management according to the delay between implant insertion and removal.We identified 8 cases. Physicians located 2 in the upper and 6 in the lower lobe. Five patients had associated pulmonary symptoms, most commonly, chest pain and dyspnea. Physicians attempted an endovascular procedure in all cases with successful removal in 3 patients. In the 5 failures, angiography displayed arterial thrombosis distal to the implant. These patients had successful removal with an open mini-thoracotomy (5 cm). None of the 8 patients had serious post-operative complications. For the 3 patients with successful endovascular retrieval, 2 had early diagnosis (≤ 3 months).Endovascular approach with angiography should be performed as a first line treatment modality. Endothelialization and fibrosis within the vessel represent the principal limitations of endovascular strategy, but a retrieval could be attempted anyway with caution. In case of failure, an open approach is required.When a migration into the pulmonary artery is diagnosed, health care professionals should refer patients as soon as possible to a tertiary center with a vascular surgery and/or interventional radiology and thoracic surgery departments.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc364a15920f3eba11597cae3ce7c93Test
https://pubmed.ncbi.nlm.nih.gov/35351447Test

المؤلفون: Marie Christine Herault, Benjamin Chappuy, Gil Frey, Pierre-Yves Brichon, Hugo Clermidy, Alexandre Nerot

المصدر: The Annals of Thoracic Surgery. 110:e55-e57

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Flail chest, business.industry, medicine.medical_treatment, technology, industry, and agriculture, 030204 cardiovascular system & hematology, medicine.disease, Polytrauma, Surgery, body regions, Conservative treatment, stomatognathic diseases, 03 medical and health sciences, 0302 clinical medicine, Deep breath, 030228 respiratory system, Anterior chest, Pectus excavatum, medicine, Haller index, Continuous positive airway pressure, Cardiology and Cardiovascular Medicine, business

الوصف: We describe a patient with polytrauma that included anterior chest flail caused by a fall while climbing. As the situation was similar to a pectus excavatum, we attempted to stabilize the depressed chest wall by using a vacuum bell. Deep breath, peak flow, and pectus index were increased when the patient used the vacuum bell. Conservative treatment with a vacuum bell during the day and continuous positive airway pressure during the night was undertaken for 6 weeks. This report documents stabilization of an anterior flail chest using a vacuum bell.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::743991b9c8982f863e017eff9168f256Test
https://doi.org/10.1016/j.athoracsur.2019.10.065Test

المؤلفون: Nicolas Girard, Jean-Michel Maury, Gabrielle Drevet, Stéphane Collaud, Hugo Clermidy, François Tronc, Marylise Ginoux, Lara Chalabreysse, Françoise Mornex

المساهمون: Centre Hospitalier Louis Pradel, Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Infections Virales et Pathologie Comparée - UMR 754 (IVPC), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universität Duisburg-Essen [Essen], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Institut Curie [Paris]

المصدر: Lung Cancer
Lung Cancer, Elsevier, 2021, 157, pp.156-162. ⟨10.1016/j.lungcan.2021.05.022⟩

مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Thymoma, medicine.medical_treatment, Population, Medizin, Malignancy, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, education, Lymph node, Neoplasm Staging, Retrospective Studies, Lymph node metastasis, education.field_of_study, business.industry, Lymphadenectomy, Thymus Neoplasms, medicine.disease, 3. Good health, Dissection, 030104 developmental biology, medicine.anatomical_structure, Nodal metastases, Oncology, 030220 oncology & carcinogenesis, Cohort, Lymph Node Dissection, Lymph Node Excision, Radiology, Lymph, Lymph Nodes, business, Cohort study

الوصف: International audience; Objectives: Lymph node dissection (LND) and nodal metastases in thymomas remain controversial and understudied. The aim of our study was to evaluate the incidence of nodal metastasis and the short term outcomes of systematic LND in thymomas. Material and methods: From December 2017 to September 2020, we performed 54 LND conducted according to the International Thymic Malignancy Interest Group (ITMIG) lymph node map. This group was compared to a historical control group of 55 patients who underwent surgery in our center from January 2015 to November 2017. Results: LND was performed in 72 % and in 5 % of the cases in the study cohort group and historical control group, respectively. The number of lymph nodes retrieved was significantly higher in the study cohort group (3.89 per patient vs. 1.62, p = 0.0021). In the whole population studied, nodal metastases were found in 3 patients (2.8 % of all patients) with 5.6 % in the cohort study group vs. 0 % in the control group (p = 0.12). Patients with nodal metastasis had larger tumors (> 7 cm), and a higher histology grade (B2 and B3). There was a trend towards higher risk of laryngeal nerve palsy in the cohort study group (9.3 % vs. 1.8 %, p = 0.11). Conclusion: Systematic LND increases the number of lymph node harvested and detects more lymph node metastases, which remains infrequent in thymomas. The impact of LND and the true prognostic significance of lymph node metastases remains controversial. Given the potential complications, LND or sampling should not be perfomed in small, encapsulated and low grade thymomas.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9935cc0f9020dfc50fcb2183ae14846Test
https://www.ncbi.nlm.nih.gov/pubmed/34053783Test

المؤلفون: Hugo Clermidy, Patrick Feugier

المصدر: European Journal of Vascular and Endovascular Surgery. 62:917

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Superior vena cava, medicine, Surgery, Behcet's disease, Cardiology and Cardiovascular Medicine, medicine.disease, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4043240b69cfb0bfc78ced264b4c385fTest
https://doi.org/10.1016/j.ejvs.2021.08.031Test

المؤلفون: Mayeul Tabutin, François Tronc, Hugo Clermidy, Catherine Lombard-Bohas

المصدر: General thoracic and cardiovascular surgery. 69(1)

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, 030209 endocrinology & metabolism, Carcinoid Tumor, 030204 cardiovascular system & hematology, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, medicine, Carcinoid Heart Disease, Ventricular outflow tract, Humans, Aged, biology, business.industry, Chromogranin A, General Medicine, medicine.disease, Cardiac surgery, Neuroendocrine Tumors, Cardiothoracic surgery, Positron-Emission Tomography, biology.protein, Surgery, Radiology, Neoplasm Recurrence, Local, Cardiology and Cardiovascular Medicine, business, Carcinoid syndrome

الوصف: We present the case of a 70-year-old man with intramyocardial solitary metastasis from a carcinoid bowel tumor. One year previously, he had undergone distal ileum resection for a neuroendocrine tumor. Asymptomatic recurrence was diagnosed with the combination of elevated chromogranin A serum level and somatostatin receptor scintigraphy. The tumor was located on the right ventricle free wall, without obstruction of the right ventricular outflow tract and absence of carcinoid syndrome or liver involvement. Complete resection was obtained under cardiopulmonary bypass. The patient is currently alive without disease 2 years after surgery. Oncologists should be aware of the heart as a possible site of neuroendocrine metastatic disease. This case highlights the value of positron emission tomography with somatostatin analogs for earlier and more frequent metastasis detection. Persistent remission can be obtained with complete surgical resection when the metastatic tumor is localized in the right ventricle without evidence of carcinoid heart disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ee2004391976ce2af761225344ac4dTest
https://pubmed.ncbi.nlm.nih.gov/32556900Test

المؤلفون: Stanislas Bruley des Varannes, Sabine Roman, Hugo Clermidy, Lucille Quénéhervé, François Mion, Frank Zerbib

المصدر: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 44(12)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Manometry, Achalasia, Chest pain, Gastroenterology, Esophageal Sphincter, Lower, Cohort Studies, Young Adult, Age Distribution, Internal medicine, otorhinolaryngologic diseases, medicine, Humans, Young adult, Child, High resolution manometry, Aged, Retrospective Studies, Aged, 80 and over, Hepatology, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Dysphagia, digestive system diseases, Esophageal Achalasia, Cohort, Gastroesophageal Reflux, Female, Esophagogastric Junction, France, medicine.symptom, business, Deglutition Disorders, Cohort study

الوصف: Background Achalasia is divided into 3 subtypes using the Chicago classification for high-resolution manometry. Aim of this study was to apply this classification to a multicentric French cohort of achalasia and to compare clinical and manometric characteristics between the 3 subtypes. Methods Oesophageal symptoms were collected in a retrospective study of patients diagnosed with achalasia on high-resolution manometry. Manometry data were analyzed with oesophago–gastric junction resting and relaxation pressures, and upper oesophageal sphincter resting pressure. Achalasia was classified according to the Chicago classification. Results From 2007 to August 2011, achalasia was diagnosed in 169 patients, 14% classified as type I, 70% as type II and 16% as type III. Type III patients were older than types I and II (62 years vs. 52, p = 0.03). Ninety five percent of patients complained of dysphagia, 16% of chest pain (no difference between the 3 subtypes); 50% of type I patients presented regurgitations compared to 33% of type II and 22% of type III (p = 0.10). Oesophago–gastric junction and upper oesophageal sphincter pressures did not differ between the 3 groups. Conclusion Type II was the more prevalent subtype of achalasia in this French multicentre cohort. The older age of patients with type III achalasia suggests a different pathophysiology.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b114aeda394dd83947843b5a4a6ee068Test
https://pubmed.ncbi.nlm.nih.gov/22938702Test