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1دورية أكاديمية
المؤلفون: Durstenfeld, Matthew S, Thakkar, Anjali, Ma, Yifei, Zier, Lucas S, Davis, Jonathan D, Hsue, Priscilla Y
المصدر: Circulation Cardiovascular Quality and Outcomes. 17(6)
مصطلحات موضوعية: Public Health, Health Sciences, Prevention, Aging, Clinical Research, Women's Health, Heart Disease - Coronary Heart Disease, Heart Disease, Cardiovascular, Patient Safety, Clinical Trials and Supportive Activities, Atherosclerosis, Health Services, Good Health and Well Being, Humans, Female, Male, Middle Aged, Heart Failure, Aged, San Francisco, Time Factors, Risk Factors, Coronary Angiography, Risk Assessment, Safety-net Providers, Electronic Health Records, Predictive Value of Tests, Cause of Death, Coronary Artery Disease, Prognosis, Comparative Effectiveness Research, angiography, coronary artery disease, disparities, heart failure, mortality, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Public health
الوصف: BackgroundIschemic cardiomyopathy is the leading cause of heart failure (HF). Most patients do not undergo coronary assessment after HF diagnosis. There are no randomized clinical trials of coronary assessment after HF diagnosis.MethodsUsing an electronic health record cohort of all individuals with HF within the San Francisco Health Network from 2001 to 2019, we identified factors associated with coronary assessment. Then, we studied the association of coronary assessment within 30 days of HF diagnosis with all-cause mortality and a composite of mortality and emergent angiography using a target trial emulation observational comparative-effectiveness approach. Target trial emulation is an approach to causal inference based on creating a hypothetical randomized clinical trial protocol and using observational data to emulate the protocol. We used propensity scores for covariate adjustment. We used national death records to improve the ascertainment of mortality and included falsification end points for the cause of death.ResultsAmong 14 829 individuals with HF (median, 62 years old; 5855 [40%] women), 3987 (26.9%) ever completed coronary assessment, with 2467/13 301 (18.5%) with unknown coronary artery disease status at HF diagnosis assessed. Women, older individuals, and people without stable housing were less likely to complete coronary assessment. Among 5972 eligible persons of whom 627 underwent early elective coronary assessment, coronary assessment was associated with lower mortality (hazard ratio, 0.84 [95% CI, 0.72-0.97]; P=0.025), reduced risk of the composite outcome (hazard ratio, 0.86 [95% CI, 0.73-1.00]), higher rates of revascularization (odds ratio, 7.6 [95% CI, 5.4-10.6]), and higher use of medical therapy (odds ratio, 2.5 [95% CI, 1.7-3.6]), but not the falsification end points.ConclusionsIn a safety-net population, disparities in coronary assessment after HF diagnosis are not fully explained by coronary artery disease risk factors. Early coronary assessment is associated with improved HF outcomes possibly related to higher rates of revascularization and guideline-directed medical therapy but with low certainty that this finding is not attributable to unmeasured confounding.
وصف الملف: application/pdf
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2دورية أكاديمية
المصدر: Cardiovascular Digital Health Journal. 4(6)
مصطلحات موضوعية: Health Services and Systems, Biomedical and Clinical Sciences, Public Health, Health Sciences, Heart Disease, Behavioral and Social Science, HIV/AIDS, Prevention, Clinical Research, Cardiovascular, Good Health and Well Being, Atherosclerotic cardiovascular disease, Pri-mary prevention, Digital health, Mobile health, Text messages, Hu-man immunodeficiency virus, Human immunodeficiency virus, Primary prevention
الوصف: ObjectivePersons with HIV (PWH) have increased risk for atherosclerotic cardiovascular disease (CVD). Despite this increased risk, perceived cardiovascular risk among PWH is low, and interventions that are known to be beneficial in the general population, such as statins, have low uptake in this population. We sought to develop a bank of text messages about (1) the association between HIV and CVD and (2) advice on reducing cardiovascular risk.MethodsWe developed an initial bank of 162 messages. We solicited feedback from 29 PWH recruited from outpatient clinics providing HIV care at a large urban tertiary medical center and a public hospital in San Francisco, California. Participants reviewed 7-10 messages each and rated message usefulness, readability, and potential impact on behavior on a scale from 1 (least) to 5 (most). We also collected open-ended feedback on the messages and data on preferences about message timing.ResultsThe average score for the messages was 4.4/5 for usefulness, 4.4/5 for readability, and 4.0/5 for potential impact on behavior. The text messages were iteratively revised based on participant feedback, and lowest-rated messages were removed from the message bank. The final message bank included 116 messages on diet (30.2%), physical activity (24.8%), tobacco (11.2%), the association between HIV and cardiovascular disease (9.5%), general heart health (6.9%), cholesterol (5.2%), blood pressure (4.3%), blood sugar (2.6%), sleep (2.6%), and weight (2.6%).ConclusionWe describe an approach for developing educational text messages on primary prevention of cardiovascular disease among PWH.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/8s9150dgTest
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3دورية أكاديمية
المؤلفون: Durstenfeld, Matthew S, Peluso, Michael J, Spinelli, Matthew A, Li, Danny, Hoh, Rebecca, Chenna, Ahmed, Yee, Brandon, Winslow, John, Petropoulos, Christos, Gandhi, Monica, Henrich, Timothy J, Aras, Mandar A, Long, Carlin S, Deeks, Steven G, Hsue, Priscilla Y
المصدر: Journal of the American Heart Association. 12(20)
مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Sexually Transmitted Infections, Coronaviruses, Emerging Infectious Diseases, Physical Activity, Infectious Diseases, Cardiovascular, HIV/AIDS, Infection, Good Health and Well Being, Humans, Female, Middle Aged, Male, Post-Acute COVID-19 Syndrome, Exercise Tolerance, Cross-Sectional Studies, COVID-19, SARS-CoV-2, HIV Infections, cardiopulmonary exercise testing, cardiorespiratory fitness, chronotropic incompetence, exercise, HIV, long COVID, postacute sequelae of SARS-CoV-2, postacute sequelae of SARS‐CoV‐2, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
الوصف: Background Postacute sequelae of COVID-19 (PASC) and HIV are both associated with reduced exercise capacity, but whether SARS-CoV-2 or PASC are associated with exercise capacity among people with HIV (PWH) is unknown. We hypothesized that PWH with PASC would have reduced exercise capacity from chronotropic incompetence. Methods and Results We conducted cross-sectional cardiopulmonary exercise testing within a COVID recovery cohort that included PWH with and without prior SARS-CoV-2 infection and people without HIV with prior SARS-CoV-2 infection (controls). We evaluated associations of HIV, SARS-CoV-2, and PASC with exercise capacity (peak oxygen consumption) and chronotropy (adjusted heart rate reserve). We included 83 participants (median age, 54 years; 35% women; 37 PWH): 23 out of 37 (62%) PWH and all 46 controls had prior SARS-CoV-2 infection, and 11 out of 23 (48%) PWH and 28 out of 46 (61%) without HIV had PASC. Peak oxygen consumption was reduced among PWH versus controls (80% predicted versus 99%, P=0.005), a difference of 5.5 mL/kg per minute (95% CI, 2.7-8.2; P
وصف الملف: application/pdf
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4دورية أكاديمية
المؤلفون: Durstenfeld, Matthew S, Peluso, Michael J, Kaveti, Punita, Hill, Christopher, Li, Danny, Sander, Erica, Swaminathan, Shreya, Arechiga, Victor M, Lu, Scott, Goldberg, Sarah A, Hoh, Rebecca, Chenna, Ahmed, Yee, Brandon C, Winslow, John W, Petropoulos, Christos J, Kelly, J Daniel, Glidden, David V, Henrich, Timothy J, Martin, Jeffrey N, Lee, Yoo Jin, Aras, Mandar A, Long, Carlin S, Grandis, Donald J, Deeks, Steven G, Hsue, Priscilla Y
المصدر: The Journal of Infectious Diseases. 228(5)
مصطلحات موضوعية: Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Coronaviruses, Clinical Research, Physical Activity, Heart Disease, Infectious Diseases, Cardiovascular, Emerging Infectious Diseases, Good Health and Well Being, Female, Male, Humans, Exercise Tolerance, Contrast Media, Heart Rate, COVID-19, SARS-CoV-2, Gadolinium, Inflammation, Phenotype, cardiac magnetic resonance imaging, cardiopulmonary exercise testing, chronotropic incompetence, postacute sequelae of COVID-19, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
الوصف: BackgroundMechanisms underlying persistent cardiopulmonary symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (postacute sequelae of coronavirus disease 2019 [COVID-19; PASC] or "long COVID") remain unclear. This study sought to elucidate mechanisms of cardiopulmonary symptoms and reduced exercise capacity.MethodsWe conducted cardiopulmonary exercise testing (CPET), cardiac magnetic resonance imaging (CMR) and ambulatory rhythm monitoring among adults >1 year after SARS-CoV-2 infection, compared those with and those without symptoms, and correlated findings with previously measured biomarkers.ResultsSixty participants (median age, 53 years; 42% female; 87% nonhospitalized; median 17.6 months after infection) were studied. At CPET, 18/37 (49%) with symptoms had reduced exercise capacity (1 year after COVID-19 were associated with reduced exercise capacity, which was associated with earlier inflammatory markers. Chronotropic incompetence may explain exercise intolerance among some with "long COVID."
وصف الملف: application/pdf
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5دورية أكاديمية
المؤلفون: Bertero, Thomas, Oldham, William M, Cottrill, Katherine A, Pisano, Sabrina, Vanderpool, Rebecca R, Yu, Qiujun, Zhao, Jingsi, Tai, Yiyin, Tang, Ying, Zhang, Ying-Yi, Rehman, Sofiya, Sugahara, Masataka, Qi, Zhi, Gorcsan, John, Vargas, Sara O, Saggar, Rajan, Saggar, Rajeev, Wallace, W Dean, Ross, David J, Haley, Kathleen J, Waxman, Aaron B, Parikh, Victoria N, De Marco, Teresa, Hsue, Priscilla Y, Morris, Alison, Simon, Marc A, Norris, Karen A, Gaggioli, Cedric, Loscalzo, Joseph, Fessel, Joshua, Chan, Stephen Y
مرشدي الرسالة: Univ Arizona, Dept Med
الوصف: Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary hypertension (PH). However, the mechanisms by which biophysical properties of the vascular extracellular matrix (ECM) relate to metabolic processes important in PH remain undefined. In this work, we examined cultured pulmonary vascular cells and various types of PH-diseased lung tissue and determined that ECM stiffening resulted in mechanoactivation of the transcriptional coactivators YAP and TAZ (WWTR1). YAP/TAZ activation modulated metabolic enzymes, including glutaminase (GLS1), to coordinate glutaminolysis and glycolysis. Glutaminolysis, an anaplerotic pathway, replenished aspartate for anabolic biosynthesis, which was critical for sustaining proliferation and migration within stiff ECM. In vitro, GLS1 inhibition blocked aspartate production and reprogrammed cellular proliferation pathways, while application of aspartate restored proliferation. In the monocrotaline rat model of PH, pharmacologic modulation of pulmonary vascular stiffness and YAP-dependent mechanotransduction altered glutaminolysis, pulmonary vascular proliferation, and manifestations of PH. Additionally, pharmacologic targeting of GLS1 in this model ameliorated disease progression. Notably, evaluation of simian immunodeficiency virus-infected nonhuman primates and HIV-infected subjects revealed a correlation between YAP/TAZ-GLS activation and PH. These results indicate that ECM stiffening sustains vascular cell growth and migration through YAP/TAZ-dependent glutaminolysis and anaplerosis, and thereby link mechanical stimuli to dysregulated vascular metabolism. Furthermore, this study identifies potential metabolic drug targets for therapeutic development in PH.
الإتاحة: http://hdl.handle.net/10150/621320Test
http://arizona.openrepository.com/arizona/handle/10150/621320Test -
6دورية أكاديمية
المؤلفون: Hastie, Elizabeth, Moser, Carlee, Sun, Xin, Lennox, Jeffrey, Hsue, Priscilla Y, Bosch, Ronald J, Deeks, Steven, Meneses, Milenka V, Lederman, Michael M, Hunt, Peter, Henrich, Timothy J, Marconi, Vincent C, Gianella, Sara
المصدر: The Journal of Infectious Diseases. 228(1)
مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Clinical Research, Infectious Diseases, HIV/AIDS, Prevention, Sexually Transmitted Infections, Clinical Trials and Supportive Activities, 2.1 Biological and endogenous factors, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Aetiology, Infection, Good Health and Well Being, Male, Humans, Female, Cytomegalovirus, Cytomegalovirus Infections, DNA, Viral, HIV Infections, HIV, Inflammation, Virus Shedding, CMV, immune modulators, ruxolitinib, sirolimus, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
الوصف: Long-term consequences of human immunodeficiency virus (HIV) are likely the result of persistent inflammation and immune dysfunction of which cytomegalovirus (CMV) is a known contributor. We leveraged 2 AIDS Clinical Trials Group clinical trials exploring the effects of immune modulators (ruxolitinib and sirolimus) on inflammation in people with HIV on antiretroviral therapy to determine whether these interventions affected CMV shedding at various mucosal sites. Analyzing 635 mucosal samples collected, we found no significant difference in CMV levels across study arms or time points. Men had more CMV shedding than women. We did confirm an association between higher CMV DNA and immune markers associated with HIV persistence and HIV-associated mortality rates.
وصف الملف: application/pdf
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7دورية أكاديمية
المؤلفون: Horwitz, Leora I, Thaweethai, Tanayott, Brosnahan, Shari B, Cicek, Mine S, Fitzgerald, Megan L, Goldman, Jason D, Hess, Rachel, Hodder, SL, Jacoby, Vanessa L, Jordan, Michael R, Krishnan, Jerry A, Laiyemo, Adeyinka O, Metz, Torri D, Nichols, Lauren, Patzer, Rachel E, Sekar, Anisha, Singer, Nora G, Stiles, Lauren E, Taylor, Barbara S, Ahmed, Shifa, Algren, Heather A, Anglin, Khamal, Aponte-Soto, Lisa, Ashktorab, Hassan, Bassett, Ingrid V, Bedi, Brahmchetna, Bhadelia, Nahid, Bime, Christian, Bind, Marie-Abele C, Black, Lora J, Blomkalns, Andra L, Brim, Hassan, Castro, Mario, Chan, James, Charney, Alexander W, Chen, Benjamin K, Chen, Li Qing, Chen, Peter, Chestek, David, Chibnik, Lori B, Chow, Dominic C, Chu, Helen Y, Clifton, Rebecca G, Collins, Shelby, Costantine, Maged M, Cribbs, Sushma K, Deeks, Steven G, Dickinson, John D, Donohue, Sarah E, Durstenfeld, Matthew S, Emery, Ivette F, Erlandson, Kristine M, Facelli, Julio C, Farah-Abraham, Rachael, Finn, Aloke V, Fischer, Melinda S, Flaherman, Valerie J, Fleurimont, Judes, Fonseca, Vivian, Gallagher, Emily J, Gander, Jennifer C, Gennaro, Maria Laura, Gibson, Kelly S, Go, Minjoung, Goodman, Steven N, Granger, Joey P, Greenway, Frank L, Hafner, John W, Han, Jenny E, Harkins, Michelle S, Hauser, Kristine SP, Heath, James R, Hernandez, Carla R, Ho, On, Hoffman, Matthew K, Hoover, Susan E, Horowitz, Carol R, Hsu, Harvey, Hsue, Priscilla Y, Hughes, Brenna L, Jagannathan, Prasanna, James, Judith A, John, Janice, Jolley, Sarah, Judd, SE, Juskowich, Joy J, Kanjilal, Diane G, Karlson, Elizabeth W, Katz, Stuart D, Kelly, J Daniel, Kelly, Sara W, Kim, Arthur Y, Kirwan, John P, Knox, Kenneth S, Kumar, Andre, Lamendola-Essel, Michelle F, Lanca, Margaret, Lee-lannotti, Joyce K, Lefebvre, R Craig, Levy, Bruce D
مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Clinical Research, Emerging Infectious Diseases, Infectious Diseases, Infection, Good Health and Well Being
الوصف: Abstract: Importance: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis. Methods: RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility– and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross– validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms. Discussion: RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options.
الوصول الحر: https://escholarship.org/uc/item/7kg2z0szTest
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8دورية أكاديمية
المؤلفون: Peluso, Michael J, Deveau, Tyler-Marie, Munter, Sadie E, Ryder, Dylan M, Buck, Amanda M, Beck-Engeser, Gabriele, Chan, Fay, Lu, Scott, Goldberg, Sarah A, Hoh, Rebecca, Tai, Viva, Torres, Leonel, Iyer, Nikita S, Deswal, Monika, Ngo, Lynn H, Buitrago, Melissa, Rodriguez, Antonio E, Chen, Jessica Y, Yee, Brandon C, Chenna, Ahmed, Winslow, John W, Petropoulos, Christos J, Deitchman, Amelia N, Hellmuth, Joanna, Spinelli, Matthew A, Durstenfeld, Matthew S, Hsue, Priscilla Y, Kelly, John Daniel, Martin, Jeffrey N, Deeks, Steven G, Hunt, Peter W, Henrich, Timothy J
المصدر: Journal of Clinical Investigation. 133(3)
مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Immunology, HIV/AIDS, Sexually Transmitted Infections, Infectious Diseases, Coronaviruses, Clinical Research, Emerging Infectious Diseases, Infection, Good Health and Well Being, Adult, Humans, COVID-19, SARS-CoV-2, Post-Acute COVID-19 Syndrome, HIV Infections, Coinfection, Fatigue, Cytomegalovirus Infections, Immunoglobulin G, Antibodies, Viral, Adaptive immunity, Cytokines, Medical and Health Sciences, Biological sciences, Biomedical and clinical sciences, Health sciences
الوصف: BACKGROUNDThe presence and reactivation of chronic viral infections, such as EBV, CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but studies in well-characterized postacute cohorts of individuals with COVID-19 over a longer time course consistent with current case definitions of LC are limited.METHODSIn a cohort of 280 adults with prior SARS-CoV-2 infection, we assessed the presence and types of LC symptoms and prior medical history (including COVID-19 history and HIV status) and performed serological testing for EBV and CMV using a commercial laboratory. We used covariate-adjusted binary logistic regression models to identify independent associations between variables and LC symptoms.RESULTSWe observed that LC symptoms, such as fatigue and neurocognitive dysfunction, at a median of 4 months following initial diagnosis were independently associated with serological evidence suggesting recent EBV reactivation (early antigen-diffuse IgG positivity) or high nuclear antigen (EBNA) IgG levels but not with ongoing EBV viremia. Serological evidence suggesting recent EBV reactivation (early antigen-diffuse IgG positivity) was most strongly associated with fatigue (OR = 2.12). Underlying HIV infection was also independently associated with neurocognitive LC (OR = 2.5). Interestingly, participants who had serologic evidence of prior CMV infection were less likely to develop neurocognitive LC (OR = 0.52).CONCLUSIONOverall, these findings suggest differential effects of chronic viral coinfections on the likelihood of developing LC and association with distinct syndromic patterns. Further assessment during the acute phase of COVID-19 is warranted.TRIAL REGISTRATIONLong-term Impact of Infection with Novel Coronavirus; ClinicalTrials.gov NCT04362150.FUNDINGThis work was supported by NIH/National Institute of Allergy and Infectious Diseases grants (3R01AI141003-03S1, R01AI158013, and K24AI145806); the Zuckerberg San Francisco General Hospital Department of Medicine and Division of HIV, Infectious Diseases, and Global Medicine; and the UCSF-Bay Area Center for AIDS Research (P30-AI027763).
وصف الملف: application/pdf
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9دورية أكاديمية
المؤلفون: Peluso, Michael J, Mitchell, Anthea, Wang, Chung Yu, Takahashi, Saki, Hoh, Rebecca, Tai, Viva, Durstenfeld, Matthew S, Hsue, Priscilla Y, Kelly, J Daniel, Martin, Jeffrey N, Wilson, Michael R, Greenhouse, Bryan, Deeks, Steven G, DeRisi, Joseph L, Henrich, Timothy J
المصدر: The Journal of infectious diseases. 227(2)
مصطلحات موضوعية: Humans, Interferon-alpha, Autoantibodies, Prevalence, COVID-19, SARS-CoV-2, Post-Acute COVID-19 Syndrome, autoimmunity, long COVID, post-COVID conditions, postacute sequalae of SARS-CoV-2 infection, Emerging Infectious Diseases, Infectious Diseases, Biodefense, Prevention, Pneumonia, Lung, Vaccine Related, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Biological Sciences, Medical and Health Sciences, Microbiology
الوصف: Interferon (IFN)-specific autoantibodies have been implicated in severe coronavirus disease 2019 (COVID-19) and have been proposed as a potential driver of the persistent symptoms characterizing "long COVID," a type of postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We report that only 2 of 215 participants with convalescent SARS-CoV-2 infection tested over 394 time points, including 121 people experiencing long COVID symptoms, had detectable IFN-α2 antibodies. Both had been hospitalized during the acute phase of the infection. These data suggest that persistent anti-IFN antibodies, although a potential driver of severe COVID-19, are unlikely to contribute to long COVID symptoms in the postacute phase of the infection.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/1s37n1b2Test
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10دورية أكاديمية
المؤلفون: Peluso, Michael J, Spinelli, Matthew A, Deveau, Tyler-Marie, Forman, Carrie A, Munter, Sadie E, Mathur, Sujata, Tang, Alex F, Lu, Scott, Goldberg, Sarah A, Arreguin, Mireya I, Hoh, Rebecca, Tai, Viva, Chen, Jessica Y, Martinez, Enrique O, Yee, Brandon C, Chenna, Ahmed, Winslow, John W, Petropoulos, Christos J, Sette, Alessandro, Weiskopf, Daniella, Kumar, Nitasha, Lynch, Kara L, Hunt, Peter W, Durstenfeld, Matthew S, Hsue, Priscilla Y, Kelly, J Daniel, Martin, Jeffrey N, Glidden, David V, Gandhi, Monica, Deeks, Steven G, Rutishauser, Rachel L, Henrich, Timothy J
المصدر: AIDS. 36(12)
مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Emerging Infectious Diseases, Clinical Research, Coronaviruses, Infectious Diseases, Sexually Transmitted Infections, HIV/AIDS, Infection, Inflammatory and immune system, Good Health and Well Being, Humans, Antibodies, Viral, CD4-Positive T-Lymphocytes, COVID-19, HIV Infections, Immunologic Memory, Programmed Cell Death 1 Receptor, SARS-CoV-2, Post-Acute COVID-19 Syndrome, coronavirus disease 2019, HIV, immune response, long coronavirus disease, postacute sequelae of SARS-CoV-2, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Virology, Biomedical and clinical sciences, Health sciences
الوصف: BackgroundLimited data are available on the long-term clinical and immunologic consequences of SARS-CoV-2 infection in people with HIV (PWH).MethodsWe measured SARS-CoV-2-specific humoral and cellular responses in people with and without HIV recovering from COVID-19 ( n = 39 and n = 43, respectively) using binding antibody, surrogate virus neutralization, intracellular cytokine staining, and inflammatory marker assays. We identified individuals experiencing postacute sequelae of SARS-CoV-2 infection (PASC) and evaluated immunologic parameters. We used linear regression and generalized linear models to examine differences by HIV status in the magnitude of inflammatory and virus-specific antibody and T-cell responses, as well as differences in the prevalence of PASC.ResultsAmong PWH, we found broadly similar SARS-CoV-2-specific antibody and T-cell responses as compared with a well matched group of HIV-negative individuals. PWH had 70% lower relative levels of SARS-CoV-2-specific memory CD8 + T cells ( P = 0.007) and 53% higher relative levels of PD-1+ SARS-CoV-2-specific CD4 + T cells ( P = 0.007). Higher CD4 + /CD8 + ratio was associated with lower PD-1 expression on SARS-CoV-2-specific CD8 + T cells (0.34-fold effect, P = 0.02). HIV status was strongly associated with PASC (odds ratio 4.01, P = 0.008), and levels of certain inflammatory markers (IL-6, TNF-alpha, and IP-10) were associated with persistent symptoms.ConclusionWe identified potentially important differences in SARS-CoV-2-specific CD4 + and CD8 + T cells in PWH and HIV-negative participants that might have implications for long-term immunity conferred by natural infection. HIV status strongly predicted the presence of PASC. Larger and more detailed studies of PASC in PWH are urgently needed.
وصف الملف: application/pdf
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