المؤلفون: Ko, Po-Jen, Yu, Sheng-Yueh, Chang, John Chien-Hwa, Hsieh, Ming-Ju, Chu, Sung-Yu, Tan, Jimmy Wei-Hwa, Cheng, Wan-Ling, Ho, Pei

المصدر: JMIR Medical Education, Vol 7, Iss 2, p e23980 (2021)

مصطلحات موضوعية: Special aspects of education, LC8-6691, Medicine (General), R5-920

الوصف: BackgroundThe COVID-19 pandemic has stunted medical education activities, resulting in most conferences being cancelled or postponed. To continue professional education during this crisis, web-based conferences can be conducted via livestream and an audience interaction platform as an alternative. ObjectiveThe unprecedented COVID-19 pandemic has affected human connections worldwide. Conventional conferences have been replaced by web-based conferences. However, web-based conferencing has its challenges and limitations. This paper reports the logistics and preparations required for converting an international, on-site, multidisciplinary conference into a completely web-based conference within 3 weeks during the pandemic. MethodsThe program was revised, and a teleconference system, live recording system, director system setup, and broadcasting platform were arranged to conduct the web-based conference. ResultsWe used YouTube (Alphabet Inc) and WeChat (Tencent Holdings Limited) for the web-based conference. Of the 24 hours of the conventional conference, 21.5 hours (90%) were retained in the web-based conference via live broadcasting. The conference was attended by 71% (37/52) of the original international faculties and 71% (27/38) of the overall faculties. In total, 61 out of 66 presentations (92%) were delivered. A special session—“Dialysis access management under the impact of viral epidemics”—was added to replace precongress workshops and competitions. The conference received 1810, 1452, and 1008 visits on YouTube and 6777, 4623, and 3100 visits on WeChat on conference days 1, 2, and 3, respectively. ConclusionsSwitching from a conventional on-site conference to a completely web-based format within a short period is a feasible method for maintaining professional education in a socially responsible manner during a pandemic.

وصف الملف: electronic resource

العلاقة: https://mededu.jmir.org/2021/2/e23980Test; https://doaj.org/toc/2369-3762Test

الوصول الحر: https://doaj.org/article/5d9b720283fa41119050f9aed115eca8Test

المؤلفون: Berg, Katherine M, Bray, Janet E, Ng, Kee-Chong, Liley, Helen G, Greif, Robert, Carlson, Jestin N, Morley, Peter T, Drennan, Ian R, Smyth, Michael, Scholefield, Barnaby R, Weiner, Gary M, Cheng, Adam, Djärv, Therese, Abelairas-Gómez, Cristian, Acworth, Jason, Andersen, Lars W, Atkins, Dianne L, Berry, David C, Bhanji, Farhan, Bierens, Joost, Bittencourt Couto, Thomaz, Borra, Vere, Böttiger, Bernd W, Bradley, Richard N, Breckwoldt, Jan, Cassan, Pascal, Chang, Wei-Tien, Charlton, Nathan P, Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T, Couper, Keith, Dainty, Katie N, Dassanayake, Vihara, Davis, Peter G, Dawson, Jennifer A, Fernanda de Almeida, Maria, De Caen, Allan R, Deakin, Charles D, Dicker, Bridget, Douma, Matthew J, Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G, Fawke, Joe, Fijacko, Nino, Finn, Judith C, Flores, Gustavo E, Foglia, Elizabeth E, Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A, Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hatanaka, Tetsuo, Hirsch, Karen G, Holmberg, Mathias J, Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H, Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J, Kapadia, Vishal S, Daripa Kawakami, Mandira, Kim, Han-Suk, Kleinman, Monica E, Kloeck, David A, Kudenchuk, Peter, Kule, Amy, Kurosawa, Hiroshi, Lagina, Anthony T, Lauridsen, Kasper G, Lavonas, Eric J, Lee, Henry C, Lin, Yiqun, Lockey, Andrew S, Macneil, Finlay, Maconochie, Ian K, John Madar, R, Malta Hansen, Carolina, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher JD, Meyran, Daniel, Monnelly, Vix, Nadkarni, Vinay, Nakwa, Firdose L, Nation, Kevin J, Nehme, Ziad, Nemeth, Michael, Neumar, Robert W, Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A, Ohshimo, Shinchiro, Olasveengen, Theresa M, Gene Ong, Yong-Kwang, Orkin, Aaron M, Parr, Michael J, Patocka, Catherine, Perkins, Gavin D, Perlman, Jeffrey M, Rabi, Yacov, Raitt, James, Ramachandran, Shalini, Ramaswamy, Viraraghavan V, Raymond, Tia T, Reis, Amelia G, Reynolds, Joshua C, Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C, Rüdiger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L, Schexnayder, Steve M, Schmölzer, Georg M, Schnaubelt, Sebastian, Semeraro, Federico, Singletary, Eunice M, Skrifvars, Markus B, Smith, Christopher M, Soar, Jasmeet, Stassen, Willem, Sugiura, Takahiro, Tijssen, Janice A, Topjian, Alexis A, Trevisanuto, Daniele, Vaillancourt, Christian, Wyckoff, Myra H, Wyllie, Jonathan P, Yang, Chih-Wei, Yeung, Joyce, Zelop, Carolyn M, Zideman, David A, Nolan, Jerry P, and Collaborators

مصطلحات موضوعية: and Collaborators, Humans, Premature Birth, First Aid, Cardiopulmonary Resuscitation, Consensus, Adult, Child, Infant, Newborn, Emergency Medical Services, Female, Out-of-Hospital Cardiac Arrest, AHA Scientific Statements, Advanced life support, Cardiac arrest, Pediatrics, 32 Biomedical and Clinical Sciences, 3202 Clinical Sciences, 42 Health Sciences, Physical Injury - Accidents and Adverse Effects, Cardiovascular, Pediatric, Heart Disease, Science & Technology, Life Sciences & Biomedicine, Critical Care Medicine, Emergency Medicine, General & Internal Medicine, HOSPITAL CARDIAC-ARREST

جغرافية الموضوع: Ireland

الوصف: The International Liaison Committee on Resuscitation engages in a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation and first aid science. Draft Consensus on Science With Treatment Recommendations are posted online throughout the year, and this annual summary provides more concise versions of the final Consensus on Science With Treatment Recommendations from all task forces for the year. Topics addressed by systematic reviews this year include resuscitation of cardiac arrest from drowning, extracorporeal cardiopulmonary resuscitation for adults and children, calcium during cardiac arrest, double sequential defibrillation, neuroprognostication after cardiac arrest for adults and children, maintaining normal temperature after preterm birth, heart rate monitoring methods for diagnostics in neonates, detection of exhaled carbon dioxide in neonates, family presence during resuscitation of adults, and a stepwise approach to resuscitation skills training. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the quality of the evidence, using Grading of Recommendations Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence-to-Decision Framework Highlights sections. In addition, the task forces list priority knowledge gaps for further research. Additional topics are addressed with scoping reviews and evidence updates.

وصف الملف: Print-Electronic; application/pdf

العلاقة: Resuscitation; (2024). Resuscitation, 195, 109992-.; https://hdl.handle.net/2292/68615Test; 37937881 (pubmed); S0300-9572(23)00306-4

الإتاحة: https://doi.org/10.1016/j.resuscitation.2023.109992Test
https://hdl.handle.net/2292/68615Test

المؤلفون: Hsieh, Ming-Ju, Lin, Chung-Jung, Lin, Yen-Heng, Kung, Ling-Chieh, Yu, Jiun-Yu, Kuo, Chia-Wei

المساهمون: National Science and Technology Council, National Taiwan University Hospital

المصدر: Journal of the Formosan Medical Association ; ISSN 0929-6646

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.jfma.2024.04.007Test
https://api.elsevier.com/content/article/PII:S0929664624002079?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0929664624002079?httpAccept=text/plainTest

المؤلفون: Hsu, Wen-Chi, Chen, Kuei-An, Pan, Kuang-Tse, Chang, Po-Chun, Wu, Ching-Feng, Fu, Jui-Ying, Hsieh, Ming-Ju, Liu, Yun-Hen, Wu, Ching-Yang

المصدر: European Journal of Radiology ; volume 172, page 111322 ; ISSN 0720-048X

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, General Medicine

الإتاحة: https://doi.org/10.1016/j.ejrad.2024.111322Test
https://api.elsevier.com/content/article/PII:S0720048X2400038X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0720048X2400038X?httpAccept=text/plainTest

المؤلفون: Sheng, Wang-Huei, Lin, Pin-Hung, Cheng, Yu-Chen, Wu, Yu-Yun, Hsieh, Ming-Ju, Yang, Hung-Chih, Chang, Sui-Yuan, Chang, Shan-Chwen

المساهمون: National Taiwan University College of Medicine, College of Medicine, Catholic University of Korea, National Science and Technology Council, Ministry of Science and Technology, Taiwan, National Taiwan University

المصدر: Journal of the Formosan Medical Association ; volume 123, issue 3, page 340-346 ; ISSN 0929-6646

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.jfma.2023.10.012Test
https://api.elsevier.com/content/article/PII:S0929664623004308?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0929664623004308?httpAccept=text/plainTest

المؤلفون: Wyckoff, Myra H., Greif, Robert, Morley, Peter T., Ng, Kee-Chong, Olasveengen, Theresa M., Singletary, Eunice M., Soar, Jasmeet, Cheng, Adam, Drennan, Ian R., Liley, Helen G., Scholefield, Barnaby R., Smyth, Michael A., Welsford, Michelle, Zideman, David A., Acworth, Jason, Aickin, Richard, Andersen, Lars W., Atkins, Diane, Berry, David C., Bhanji, Farhan, Bierens, Joost, Borra, Vere, Boettiger, Bernd W., Bradley, Richard N., Bray, Janet E., Breckwoldt, Jan, Callaway, Clifton W., Carlson, Jestin N., Cassan, Pascal, Castren, Maaret, Chang, Wei-Tien, Charlton, Nathan P., Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Couto, Thomaz Bittencourt, Dainty, Katie N., Davis, Peter G., de Almeida, Maria Fernanda, de Caen, Allan R., Deakin, Charles D., Djarv, Therese, Donnino, Michael W., Douma, Matthew J., Duff, Jonathan P., Dunne, Cody L., Eastwood, Kathryn, El-Naggar, Walid, Fabres, Jorge G., Fawke, Joe, Finn, Judith, Foglia, Elizabeth E., Folke, Fredrik, Gilfoyle, Elaine, Goolsby, Craig A., Granfeldt, Asger, Guerguerian, Anne-Marie, Guinsburg, Ruth, Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Johnson, Nicholas J., Kapadia, Vishal S., Kawakami, Mandira Daripa, Kim, Han-Suk, Kleinman, Monica, Kloeck, David A., Kudenchuk, Peter J., Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lee, Henry C., Lin, Yiqun (Jeffrey), Lockey, Andrew S., Maconochie, Ian K., Madar, R. John, Hansen, Carolina Malta, Masterson, Siobhan, Matsuyama, Tasuku, McKinlay, Christopher J. D., Meyran, Daniel, Morgan, Patrick, Morrison, Laurie J., Nadkarni, Vinay, Nakwa, Firdose L., Nation, Kevin J., Nehme, Ziad, Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Nikolaou, Nikolaos, Nishiyama, Chika, Norii, Tatsuya, Nuthall, Gabrielle A., O'Neill, Brian J., Ong, Yong-Kwang Gene, Orkin, Aaron M., Paiva, Edison F., Parr, Michael J., Patocka, Catherine, Pellegrino, Jeffrey L., Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Reis, Amelia G., Reynolds, Joshua C., Ristagno, Giuseppe, Rodriguez-Nunez, Antonio, Roehr, Charles C., Ruediger, Mario, Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor L., Schexnayder, Steve M., Schmolzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Skrifvars, Markus B., Smith, Christopher M., Sugiura, Takahiro, Tijssen, Janice A., Trevisanuto, Daniele, Van de Voorde, Patrick, Wang, Tzong-Luen, Weiner, Gary M., Wyllie, Jonathan P., Yang, Chih-Wei, Yeung, Joyce, Nolan, Jerry P., Berg, Katherine M.

المساهمون: HUS Emergency Medicine and Services, Department of Diagnostics and Therapeutics, Clinicum

مصطلحات موضوعية: AHA Scientific Statements, Advanced life support, Basic life support, Cardiac arrest, First aid, Infant, Newborn, Pediatrics, Resuscitation, 3126 Surgery, anesthesiology, intensive care, radiology

الوصف: This is the sixth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. This summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. Topics covered by systematic reviews include cardiopulmonary resuscitation during transport; approach to resuscitation after drowning; passive ventilation; minimising pauses during cardiopulmonary resuscitation; temperature management after cardiac arrest; use of diagnostic point-of-care ultrasound during cardiac arrest; use of vasopressin and corticosteroids during cardiac arrest; coronary angiography after cardiac arrest; public-access defibrillation devices for children; pediatric early warning systems; maintaining normal temperature immediately after birth; suctioning of amniotic fluid at birth; tactile stimulation for resuscitation immediately after birth; use of continuous positive airway pressure for respiratory distress at term birth; respiratory and heart rate monitoring in the delivery room; supraglottic airway use in neonates; prearrest prediction of in-hospital cardiac arrest mortality; basic life support training for likely rescuers of high-risk populations; effect of resuscitation team training; blended learning for life support training; training and recertification for resuscitation instructors; and recovery position for maintenance of breathing and prevention of cardiac arrest. Members from 6 task forces have assessed, discussed, and debated the quality of the evidence using Grading of Recommendations Assessment, Development, and Evaluation criteria and generated consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence-to-Decision Framework Highlights sections, and priority knowledge gaps for future research are listed. ; Peer reviewed

وصف الملف: application/pdf

العلاقة: Wyckoff , M H , Greif , R , Morley , P T , Ng , K-C , Olasveengen , T M , Singletary , E M , Soar , J , Cheng , A , Drennan , I R , Liley , H G , Scholefield , B R , Smyth , M A , Welsford , M , Zideman , D A , Acworth , J , Aickin , R , Andersen , L W , Atkins , D , Berry , D C , Bhanji , F , Bierens , J , Borra , V , Boettiger , B W , Bradley , R N , Bray , J E , Breckwoldt , J , Callaway , C W , Carlson , J N , Cassan , P , Castren , M , Chang , W-T , Charlton , N P , Chung , S P , Considine , J , Costa-Nobre , D T , Couper , K , Couto , T B , Dainty , K N , Davis , P G , de Almeida , M F , de Caen , A R , Deakin , C D , Djarv , T , Donnino , M W , Douma , M J , Duff , J P , Dunne , C L , Eastwood , K , El-Naggar , W , Fabres , J G , Fawke , J , Finn , J , Foglia , E E , Folke , F , Gilfoyle , E , Goolsby , C A , Granfeldt , A , Guerguerian , A-M , Guinsburg , R , Hirsch , K G , Holmberg , M J , Hosono , S , Hsieh , M-J , Hsu , C H , Ikeyama , T , Isayama , T , Johnson , N J , Kapadia , V S , Kawakami , M D , Kim , H-S , Kleinman , M , Kloeck , D A , Kudenchuk , P J , Lagina , A T , Lauridsen , K G , Lavonas , E J , Lee , H C , Lin , Y , Lockey , A S , Maconochie , I K , Madar , R J , Hansen , C M , Masterson , S , Matsuyama , T , McKinlay , C J D , Meyran , D , Morgan , P , Morrison , L J , Nadkarni , V , Nakwa , F L , Nation , K J , Nehme , Z , Nemeth , M , Neumar , R W , Nicholson , T , Nikolaou , N , Nishiyama , C , Norii , T , Nuthall , G A , O'Neill , B J , Ong , Y-K G , Orkin , A M , Paiva , E F , Parr , M J , Patocka , C , Pellegrino , J L , Perkins , G D , Perlman , J M , Rabi , Y , Reis , A G , Reynolds , J C , Ristagno , G , Rodriguez-Nunez , A , Roehr , C C , Ruediger , M , Sakamoto , T , Sandroni , C , Sawyer , T L , Schexnayder , S M , Schmolzer , G M , Schnaubelt , S , Semeraro , F , Skrifvars , M B , Smith , C M , Sugiura , T , Tijssen , J A , Trevisanuto , D , Van de Voorde , P , Wang , T-L , Weiner , G M , Wyllie , J P , Yang , C-W , Yeung , J , Nolan , J P & Berg , K M 2022 , ' 2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations : Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces ' , Resuscitation , vol. 181 , pp. 208-288 . https://doi.org/10.1016/j.resuscitation.2022.10.005Test; 1079f422-51b2-48fe-b660-43e11f5bc2f8; http://hdl.handle.net/10138/568259Test; 001072601200001

الإتاحة: http://hdl.handle.net/10138/568259Test

المؤلفون: Wyckoff, Myra H., Singletary, Eunice M., Soar, Jasmeet, Olasveengen, Theresa M., Greif, Robert, Liley, Helen G., Zideman, David, Bhanji, Farhan, Andersen, Lars W., Avis, Suzanne R., Aziz, Khalid, Bendall, Jason C., Berry, David C., Borra, Vere, Bottiger, Bernd W., Bradley, Richard, Bray, Janet E., Breckwoldt, Jan, Carlson, Jestin N., Cassan, Pascal, Castren, Maaret, Chang, Wei-Tien, Charlton, Nathan P., Cheng, Adam, Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Dainty, Katie N., Davis, Peter G., Almeida, Maria Fernanda de, Caen, Allan R. de, Paiva, Edison F. de, Deakin, Charles D., Djarv, Therese, Douma, Matthew J., Drennan, Ian R., Duff, Jonathan P., Eastwood, Kathryn J., El-Naggar, Walid, Epstein, Jonathan L., Escalante, Raffo, Fabres, Jorge G., Fawke, Joe, Finn, Judith C., Foglia, Elizabeth E., Folke, Fredrik, Freeman, Karoline, Gilfoyle, Elaine, Goolsby, Craig A., Grove, Amy, Guinsburg, Ruth, Hatanaka, Tetsuo, Hazinski, Mary Fran, Heriot, George S., Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hung, Kevin K. C., Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Kapadia, Vishal S., Kawakami, Mandira Daripa, Kim, Han-Suk, Kloeck, David A., Kudenchuk, Peter J., Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lockey, Andrew S., Hansen, Carolina Malta, Markenson, David, Matsuyama, Tasuku, McKinlay, Christopher J. D., Mehrabian, Amin, Merchant, Raina M., Meyran, Daniel, Morley, Peter T., Morrison, Laurie J., Nation, Kevin J., Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Niermeyer, Susan, Nikolaou, Nikolaos, Nishiyama, Chika, O'Neil, Brian J., Orkin, Aaron M., Osemeke, Osokogu, Parr, Michael J., Patocka, Catherine, Pellegrino, Jeffrey L., Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Reynolds, Joshua C., Ristagno, Giuseppe, Roehr, Charles C., Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor, Schmolzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Skrifvars, Markus B., Smith, Christopher M., Smyth, Michael A., Soll, Roger F., Sugiura, Takahiro, Taylor-Phillips, Sian, Trevisanuto, Daniele, Vaillancourt, Christian, Wang, Tzong-Luen, Weiner, Gary M., Welsford, Michelle, Wigginton, Jane, Wyllie, Jonathan P., Yeung, Joyce, Nolan, Jerry P., Berg, Katherine M.

المساهمون: University of Helsinki, Clinicum, Department of Diagnostics and Therapeutics, HUS Emergency Medicine and Services

مصطلحات موضوعية: AHA Scientific Statements, Advanced cardiac life support, Cardiopulmonary resuscitation, First aid, Health plan implemen-tation, Infant, Newborn, 3126 Surgery, anesthesiology, intensive care, radiology, 3121 General medicine, internal medicine and other clinical medicine

الوصف: Peer reviewed

وصف الملف: application/pdf

العلاقة: Wyckoff , M H , Singletary , E M , Soar , J , Olasveengen , T M , Greif , R , Liley , H G , Zideman , D , Bhanji , F , Andersen , L W , Avis , S R , Aziz , K , Bendall , J C , Berry , D C , Borra , V , Bottiger , B W , Bradley , R , Bray , J E , Breckwoldt , J , Carlson , J N , Cassan , P , Castren , M , Chang , W-T , Charlton , N P , Cheng , A , Chung , S P , Considine , J , Costa-Nobre , D T , Couper , K , Dainty , K N , Davis , P G , Almeida , M F D , Caen , A R D , Paiva , E F D , Deakin , C D , Djarv , T , Douma , M J , Drennan , I R , Duff , J P , Eastwood , K J , El-Naggar , W , Epstein , J L , Escalante , R , Fabres , J G , Fawke , J , Finn , J C , Foglia , E E , Folke , F , Freeman , K , Gilfoyle , E , Goolsby , C A , Grove , A , Guinsburg , R , Hatanaka , T , Hazinski , M F , Heriot , G S , Hirsch , K G , Holmberg , M J , Hosono , S , Hsieh , M-J , Hung , K K C , Hsu , C H , Ikeyama , T , Isayama , T , Kapadia , V S , Kawakami , M D , Kim , H-S , Kloeck , D A , Kudenchuk , P J , Lagina , A T , Lauridsen , K G , Lavonas , E J , Lockey , A S , Hansen , C M , Markenson , D , Matsuyama , T , McKinlay , C J D , Mehrabian , A , Merchant , R M , Meyran , D , Morley , P T , Morrison , L J , Nation , K J , Nemeth , M , Neumar , R W , Nicholson , T , Niermeyer , S , Nikolaou , N , Nishiyama , C , O'Neil , B J , Orkin , A M , Osemeke , O , Parr , M J , Patocka , C , Pellegrino , J L , Perkins , G D , Perlman , J M , Rabi , Y , Reynolds , J C , Ristagno , G , Roehr , C C , Sakamoto , T , Sandroni , C , Sawyer , T , Schmolzer , G M , Schnaubelt , S , Semeraro , F , Skrifvars , M B , Smith , C M , Smyth , M A , Soll , R F , Sugiura , T , Taylor-Phillips , S , Trevisanuto , D , Vaillancourt , C , Wang , T-L , Weiner , G M , Welsford , M , Wigginton , J , Wyllie , J P , Yeung , J , Nolan , J P & Berg , K M 2021 , ' 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group ' , Resuscitation , vol. 169 , 34774963 , pp. 229-311 . https://doi.org/10.1016/j.resuscitation.2021.10.040Test; RIS: urn:D26893C0C618FA4B09D87B69C5CA2629; 65a5def2-cbb0-4248-9bda-22c6ab7cf9c9; http://hdl.handle.net/10138/567819Test; 000778827400019

الإتاحة: http://hdl.handle.net/10138/567819Test

المؤلفون: Hsieh, Ming‐Ju, Lin, Chia‐Chieh, Lo, Yu‐Sheng, Ho, Hsin‐Yu, Chuang, Yi‐Ching, Chen, Mu‐Kuan

المساهمون: National Science Council

المصدر: Journal of Cellular and Molecular Medicine ; volume 28, issue 2 ; ISSN 1582-1838 1582-4934

الوصف: Oral squamous cell carcinoma (OSCC), which accounts for 90% of all oral cancers, has become a public health crisis worldwide. despite advances in therapeutic interventions, the prognosis remains poor for advanced‐stage OSCC. In this study, we investigate the anticancer activity and the mode of action of hellebrigenin in human OSCC. The findings demonstrated that hellebrigenin exerted cytotoxic effects in OSCC cells through cell cycle arrest at the G2/M phase and downregulation of cell cycle‐related proteins (cyclins A2, B1 and D3, Cdc2, CDK4 and CDK6). Moreover, hellebrigenin caused activation of PARP and caspase 3, 8 and 9, followed by downregulation of antiapoptotic proteins (Bcl‐2 and Bcl‐xL) and upregulation of pro‐apoptotic proteins (Bax and Bak). The hellebrigenin treatment also increased Fas, DR5, DcR2 and DcR3 expressions in oral cancer cells, indicating the compound causes oral cancer cell apoptosis through both intrinsic and extrinsic pathways. Regarding upstream signalling, hellebrigenin was found to reduce the phosphorylation of ERK, p38, and JNK, indicating that hellebrigenin triggers caspase‐mediated apoptosis by downregulating MAPK signalling pathway. Finally, the human apoptosis array findings revealed that hellebrigenin specifically suppressed the expression of XIAP to execute its pro‐apoptotic activities. Taken together, the study suggests that hellebrigenin can act as a potent anticancer compound in human OSCC.

الإتاحة: https://doi.org/10.1111/jcmm.18071Test

المؤلفون: Ho, Hsin‐Yu, Chen, Mu‐Kuan, Lin, Chia‐Chieh, Lo, Yu‐Sheng, Chuang, Yi‐Ching, Hsieh, Ming‐Ju

المساهمون: National Science Council, Changhua Christian Hospital

المصدر: Journal of Cellular and Molecular Medicine ; volume 27, issue 23, page 3796-3804 ; ISSN 1582-1838 1582-4934

الوصف: Head and neck squamous cell carcinoma (HNSCC) is one of the most common histological types of head and neck cancer. Epiberberine is a potent antitumour agent for several types of cancer. This study is aimed at investigating the regulatory and molecular mechanism of epiberberine on HNSSC cell metastasis. The results showed that epiberberine inhibited the motility of Ca9‐22 and FaDu cell lines at nontoxicity doses. Moreover, the epithelial‐mesenchymal transition (EMT)‐related proteins, vimentin, snail and slug, were found suppressing after epiberberine treatments. In addition, the JNK signalling cascade and the metalloproteinase 13 (MMP‐13) expression were also found downregulated by epiberberine. In conclusion, the present study demonstrates that epiberberine suppresses cell migration and invasion by regulating the JNK pathway and MMP‐13. These results suggest that epiberberine could be a potential antimetastatic agent in HNSCC cells.

الإتاحة: https://doi.org/10.1111/jcmm.17954Test

المؤلفون: Hsieh, Ming-Ju, Lo, Yu-Sheng, Tsai, Yun-Jung, Ho, Hsin-Yu, Lin, Chia-Chieh, Chuang, Yi-Ching, Lin, Shu-Hui, Chen, Mu-Kuan

المصدر: BMC Cancer ; volume 23, issue 1 ; ISSN 1471-2407

مصطلحات موضوعية: Cancer Research, Genetics, Oncology

الوصف: Background Single nucleotide polymorphism (SNP) is a genetic variation that occurs when a single nucleotide base in the DNA sequence varies between individuals and is present in at least 1% of the population. Genetic variants in FAM13A are associated with different types of chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and lung cancer. However, there is little literature on the association of FAM13A genotypes with oral cancer. Therefore, this project will explore the correlation between the FAM13A genotype and the formation of oral cancer. Methods In this project, we will examine the presence of gene polymorphisms gene polymorphisms of rs1059122, rs3017895, rs3756050, and rs7657817 in the FAM13A gene exon, and combine the expression of these genes to try to clarify the impact of the FAM13A gene polymorphism on oral cancer. First, four loci (rs1059122, rs3017895, rs3756050, and rs7657817) of the FAM13A SNP were genotyped using TaqMan allelic discrimination. Results By estimating OR and AOR, FAM13A exhibited different genotypic variables in four SNPs that were not statistically significant between controls and patients with oral cancer. The results of the general analysis showed that different distributions of allelic types did not affect clinical stage, tumour size, lymph node invasion, distant metastasis, and pathological differentiation status. However, in the alcohol drinking group specifically, patients with the rs3017895 SNP G genotype had a 3.17-fold (95% CI, 1.102–9.116; p = 0.032) increase in the well differentiated state of cells compared to patients with the A allele. Conclusions Our results suggested that the SNP rs3017895 FAM13A could contribute to oral cancer. More sample studies are needed in the future to confirm our results and more functional studies are needed to investigate their relevant roles in the development of oral cancer.

الإتاحة: https://doi.org/10.1186/s12885-023-11052-5Test