المؤلفون: Yale, Jf, Bakris, G, Cariou, B, Nieto, J, David Neto, E, Yue, D, Wajs, E, Figueroa, K, Jiang, J, Law, G, Usiskin, K, Meininger, G, DIA3004 Study Group, Ansari, A, Arnouts, P, Assefi, A, Barreto, A, Barysheva, O, Bavanandam, S, Blaze, K, Bochenek, A, Bononi, P, Booth, W, Boyarkin, M, Burgess, L, Busch, K, Buse, J, Carranza, J, Cha, B, Chang, A, Clavel, S, Cockrell, Rc, Conway, J, Cook, W, Dande, A, De Los Rios MO, Deshmukh, V, Dobjanschi, C, Dotta, Francesco, Elliott, T, Ellis, G, Ferraro, R, Fishman, N, Fomin, V, Fraige Filho, F, Gagiu, R, Goh, Bl, Goldenberg, R, Gorriz, Jl, Gottschlich, G, Gouet, D, Grenfell, R, Griffin, C, Guarisco, M, Guerci, B, Henkel, E, Hramiak, I, Ison, R, Jadoul, M, Jang, H, Januszewicz, A, Kale, S, Karpova, I, Kaye, W, Kerstein, H, Kijanska, J, Kobalava, Z, Kong, N, Krasilnikova, E, Krebs, J, Kuczerowski, R, Kuzin, A, Kuzmenko, A, Laurens, W, Lim, Sk, Marasaev, V, Castelao, Am, Merker, L, Michlin, B, Morales, E, Motylev, I, Muse, D, Mutha, A, Neto, Ed, Nicholls, K, Niemetz, I, Iglesias, Jn, Ong, Lm, Onor, G, Packham, D, Petit, C, Piatti, M, Pirags, V, Poch, E, Ramirez, G, Riser, J, Roger, S, Ross, S, Rudolph, L, Sangumani, J, Schollum, J, Scott, R, Sebopa, B, Serafinceanu, C, Serusclat, P, Seufert, J, Siegmund, T, Silva, A, Skokowska, E, Smith, D, Sokolova, J, Solovyov, O, Steindorf, J, Stringam, S, Teterovska, D, Thivolet, C, Tytus, R, Vally, T, Van Vlem, B, Vercammen, C, Volkova, N, Warling, X, Winkler, L, Young, S, Zanella, Mt, Zimmerer, M.

المصدر: Diabetes, Obesity and Metabolism. 16:1016-1027

مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Urinary system, Urology, Renal function, Blood Pressure, Thiophenes, Placebo, Drug Administration Schedule, Diabetic nephropathy, chemistry.chemical_compound, Endocrinology, Double-Blind Method, Glucosides, Sodium-Glucose Transporter 2, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Diabetic Nephropathies, Canagliflozin, Renal Insufficiency, Chronic, Sodium-Glucose Transporter 2 Inhibitors, Aged, Creatinine, business.industry, Body Weight, medicine.disease, Treatment Outcome, Blood pressure, Diabetes Mellitus, Type 2, chemistry, Disease Progression, Female, business, Glomerular Filtration Rate, Kidney disease, medicine.drug

الوصف: Aim This study evaluated the efficacy and safety of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus (T2DM) and within a subset of Stage 3 chronic kidney disease (CKD; estimated glomerular filtration rate [eGFR] ≥30 and

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae750653397d536ccc4fe947ed11e42Test
https://doi.org/10.1111/dom.12348Test

المؤلفون: Yale JF, Bakris G, Cariou B, Nieto J, David Neto E, Yue D, Wajs E, Figueroa K, Jiang J, Law G, Usiskin K, Meininger G, DIA3004 Study Group, Ansari A, Arnouts P, Assefi A, Barreto A, Barysheva O, Bavanandam S, Blaze K, Bochenek A, Bononi P, Booth W, Boyarkin M, Burgess L, Busch K, Buse J, Carranza J, Cha B, Chang A, Clavel S, Cockrell RC, Conway J, Cook W, Dande A, De Los Rios MO, Deshmukh V, Dobjanschi C, DOTTA, FRANCESCO, Elliott T, Ellis G, Ferraro R, Fishman N, Fomin V, Fraige Filho F, Gagiu R, Goh BL, Goldenberg R, Gorriz JL, Gottschlich G, Gouet D, Grenfell R, Griffin C, Guarisco M, Guerci B, Henkel E, Hramiak I, Ison R, Jadoul M, Jang H, Januszewicz A, Kale S, Karpova I, Kaye W, Kerstein H, Kijanska J, Kobalava Z, Kong N, Krasilnikova E, Krebs J, Kuczerowski R, Kuzin A, Kuzmenko A, Laurens W, Lim SK, Marasaev V, Castelao AM, Merker L, Michlin B, Morales E, Motylev I, Muse D, Mutha A, Neto ED, Nicholls K, Niemetz I, Iglesias JN, Ong LM, Onor G, Packham D, Petit C, Piatti M, Pirags V, Poch E, Ramirez G, Riser J, Roger S, Ross S, Rudolph L, Sangumani J, Schollum J, Scott R, Sebopa B, Serafinceanu C, Serusclat P, Seufert J, Siegmund T, Silva A, Skokowska E, Smith D, Sokolova J, Solovyov O, Steindorf J, Stringam S, Teterovska D, Thivolet C, Tytus R, Vally T, Van Vlem B, Vercammen C, Volkova N, Warling X, Winkler L, Young S, Zanella MT, Zimmerer M.

المساهمون: Yale, Jf, Bakris, G, Cariou, B, Nieto, J, David Neto, E, Yue, D, Wajs, E, Figueroa, K, Jiang, J, Law, G, Usiskin, K, Meininger, G, DIA3004 Study, Group, Ansari, A, Arnouts, P, Assefi, A, Barreto, A, Barysheva, O, Bavanandam, S, Blaze, K, Bochenek, A, Bononi, P, Booth, W, Boyarkin, M, Burgess, L, Busch, K, Buse, J, Carranza, J, Cha, B, Chang, A, Clavel, S, Cockrell, Rc, Conway, J, Cook, W, Dande, A, De Los Rios, Mo, Deshmukh, V, Dobjanschi, C, Dotta, Francesco, Elliott, T, Ellis, G, Ferraro, R, Fishman, N, Fomin, V, Fraige Filho, F, Gagiu, R, Goh, Bl, Goldenberg, R, Gorriz, Jl, Gottschlich, G, Gouet, D, Grenfell, R, Griffin, C, Guarisco, M, Guerci, B, Henkel, E, Hramiak, I, Ison, R, Jadoul, M, Jang, H, Januszewicz, A, Kale, S, Karpova, I, Kaye, W, Kerstein, H, Kijanska, J, Kobalava, Z, Kong, N, Krasilnikova, E, Krebs, J, Kuczerowski, R, Kuzin, A, Kuzmenko, A, Laurens, W, Lim, Sk, Marasaev, V, Castelao, Am, Merker, L, Michlin, B, Morales, E, Motylev, I, Muse, D, Mutha, A, Neto, Ed, Nicholls, K, Niemetz, I, Iglesias, Jn, Ong, Lm, Onor, G, Packham, D, Petit, C, Piatti, M, Pirags, V, Poch, E, Ramirez, G, Riser, J, Roger, S, Ross, S, Rudolph, L

مصطلحات موضوعية: Diabetic nephropathy, Randomized trial, Sodium glucose co-transporter 2 (SGLT2) inhibitor, Type 2 diabetes mellitus

الوصف: Aim: This study evaluated the efficacy and safety of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus (T2DM) and within a subset of Stage 3 chronic kidney disease (CKD; estimated glomerular filtration rate [eGFR] ≥30 and <50 ml/min/1.73 m2). Methods: In this 52-week, randomized, double-blind, placebo-controlled study, patients (N=269; mean eGFR, 39.4 ml/min/1.73 m2) received canagliflozin 100 or 300 mg and placebo once daily. Efficacy endpoints included changes in glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), body weight and systolic blood pressure (BP); adverse events (AEs) were also recorded. Results: At week 52, canagliflozin 100 and 300 mg reduced HbA1c compared with placebo (-0.19, -0.33 and 0.07%, respectively); placebo-subtracted differences (95% confidence interval) were -0.27% (-0.53, 0.001) and -0.41% (-0.68, -0.14). Canagliflozin also lowered FPG, body weight and BP versus placebo. Overall AE incidence was 85.6, 80.9, and 86.7% with canagliflozin 100 and 300 mg and placebo, respectively. Osmotic diuresis-related AEs were more common with both canagliflozin doses, and incidences of urinary tract infections and volume depletion-related AEs were higher with canagliflozin 300 mg versus placebo. Decreases in eGFR (-2.1, -4.0 and -1.6 ml/min/1.73 m2) were seen with canagliflozin 100 and 300 mg compared with placebo. Canagliflozin 100 and 300 mg provided median percent reductions in urine albumin to creatinine ratio versus placebo (-16.4, -28.0 and 19.7%). Conclusions: Canagliflozin improved glycaemic control and was generally well tolerated in patients with T2DM and within a subset of Stage 3 CKD over 52 weeks.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/24965700; info:eu-repo/semantics/altIdentifier/wos/WOS:000342925200018; volume:16; issue:10; firstpage:1016; lastpage:1027; numberofpages:12; journal:DIABETES, OBESITY AND METABOLISM; http://hdl.handle.net/11365/49426Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84912527805

الإتاحة: https://doi.org/10.1111/dom.12348Test
http://hdl.handle.net/11365/49426Test

المؤلفون: Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I, Desai N, Abrahamsen T, Grossman M, Morin S, Im K, Hoffman E, Gabovitch D, Pricken A, Buskila A, Stahre C, Price D, Billing-Clason S, Sabel K, Monyak J, Sjostrand M, Wei C, Lu J, Miller E, Raichlen J, Fitt S, Iqbal N, Donovan M, Davidson JA, Aguilar-Salinas C, Alvarsson M, Amerena J, Ardissino D, Averkov O, Avogaro A, Barnett A, Bretzel R, Chiang CE, Codoceo V, Corbalan R, Dalby A, Darius H, Deerochanawong C, Dellborg M, Eliaschewitz F, Garcia-Castillo A, Gomis R, Henry P, Hoekstra J, Jermendy G, Kastelein J, Keech A, Kiss R, Krempf M, Laakso M, Leiter L, Leitersdorf E, Lewis B, Litwak L, Lopez-Sendon J, Ma R, McGuire D, Medina F, Moses R, Nicolau JC, Opolski G, Ophuis TO, Paolasso E, Ruda M, Kumar KMP, Shestakova M, Sheu WHH, Smahelova A, Bhupathiraju BSR, Spinar J, Sritata P, Strojeck K, Villena-Chavez JE, Jia WP, Huo Y, Lowe C, Awtry E, Berger C, Desai AS, Gelfand E, Leeman D, Link M, Ruberg F, Vita J, Rost N, Silverman S, Greenberger NJ, Lerch MM, Gersh B, Nesto R, Del Prato S, Tuomilehto J, Kelsey S, Alvarisqueta A, Cuadrado J, Rista L, Hermida S, Baccaro C, Luquez C, Lagrutta M, Maffei L, Bartolacci I, Montana O, Cutuli H, Berli M, Lorenzatti A, Frechtel G, La Greca R, Fretes O, Diaz M, Papini NR, Farias E, Issa C, Elbert A, Lehman R, Arya M, Singh B, Colquhoun D, Jayasinghe R, de Looze F, Blombery P, Ward G, Szto G, Abhayaratna W, Borges J, Russo L, Felicio J, Santos F, Guimaraes F, Castro ML, Rossi P, Armaganijan D, Leaes P, Bandeira F, Franken M, Rassi N, Rea R, Zanella M, Amodeo C, Cesar L, Betti R, Chacra A, Schmid H, Bell A, Syan G, Zadra R, Conter H, Dumas R, Borts D, Dattani I, Poirier P, Cha J, Dzongowski P, Labonte R, St Pierre B, Gaudet D, Kouz S, Lamy A, Tishler S, Chehayeb R, Bedard J, Hramiak I, Teitelbaum I, Fortin C, Woo V, Conway J, Mehta P, Robinson S, Sussex B, Chiasson J, Muirhead N, Bose S, Ouellet A, Yale J, Bhargava R, Lau D, Tobe S, Perron P, Sigalas J, Bilodeau L, Tytus R, Achyuthan G, Pearce M, Steele A, Bailey G, Ma P, St-Maurice F, Rupka D, Houlden R, Bailey A, Rewa G, Sohal P, Ting R, Prieto J, Rodriguez M, Godoy G, Larenas G, Pincetti C, Cobos L, Saavedra V, Varleta P, Lucero F, Kuzmanic O, Acevedo M, Aguirre M, Florenzano F, Ma J, Bao Y, Jiang M, Xu W, Shi Y, Zheng M, Li Y, Dong Y, Zhao W, Sun M, Lei M, Wang J, Pistek Z, Rihacek I, Kucera D, Brada M, Naplava R, Karasova J, Vlasicova H, Skopecek J, Spinarova L, Raclavska L, Sarbochova R, Okenka L, Racicka E, Urbancova K, Oznerova M, Lorenc Z, Wasserburger B, Zahumensky E, Grunfeldova H, Hradec J, Lukac M, Svacina S, Podzimek J, Hemzsky L, Mikulkova I, Pavlickova J, Brychta T, Chochola J, Couffinhal T, Elbaz M, Petit C, Faller B, Marechaud R, Moulin P, Fendri S, Nazeyrollas P, Wendisch U, Busch K, Klausmann G, Duengen H, Appel K, Toursarkissian N, Jung T, Ott P, Schenkenberger I, Kuesters D, Landers B, Nischik R, Fischer H, Tschoepe D, Paschen B, Krause K, Derwahl K, Wenzl-Bauer V, Hamann A, Strotmann H, Milek K, Mueller S, Chu D, Tan K, Kung K, Tsang C, Tomlinson B, Koranyi L, Kerenyi Z, Benczur B, Illyes L, Hidvegi T, Somogyi A, Valco J, Ferenczi S, Rapi J, Voros P, Winkler G, Sydo T, Hetey M, Simon K, Penzes J, Kempler P, Bako B, Lengyel Z, Witmann I, Dudas M, Vandorfi G, Takacs J, Matoltsy A, Ladanyi E, Gyimesi A, Sadikot S, Parikh K, Jain S, Yajnik C, Sosale A, Shamanna P, Srikanta S, Shah S, Srinivas A, Banker D, Shah P, Sharda A, Makkar B, Rais N, Mardikar H, Mishra A, Bhupati S, Menon J, Sathe S, Gupta R, Sharma V, Darawsha M, Herskovits T, Hamoud S, Nikolsky E, Adawi F, Zimlichman R, Tsalihin D, Wainstein J, Klainman E, Mosseri M, Yerushalmi Y, Karnieli E, Knobler H, Benchetrit S, Tsur A, Yagil Y, Atar S, Beberashvili I, Fuchs S, Stern N, Pollak A, Chajek-Shaul T, Rozenman Y, Biton A, Bramucci E, Fiscella A, Grassia V, 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Fares I, Mader P, Skierkowska J, Stasinska T, Pomiecko W, Skorski M, Krzyzagorska E, Polaszewska-Muszynska M, Sowinski D, Strojek K, Rosinska-Migda J, Romanczuk P, Golebiowski G, Kubica J, Mazurek T, Wojnowski L, Pasternak D, Stachlewski P, Trzepla E, Bogdanowicz G, Uzunow A, Potakowska I, Miszczyszyn Z, Waszyrowski T, Smolenskaya O, Lukyanov Y, Vorokhobina N, Khalimov Y, Orlikova O, Rebrov A, Kukharchuk V, Boldueva S, Arkhipov M, Zhelninova T, Pavlysh E, Antsiferov M, Panov A, Pavlova M, Shustov S, Demchenko E, Galyavich A, Malakhina E, Semenova O, Kobalava Z, Kotova S, Gavrisheva I, Oschepkova E, Karpov Y, Sidorenko B, Kislyak O, Ametov A, Dreval A, Grineva E, Mkrtumyan A, Tyurina T, Sazonova O, Bonnici F, Ranjith N, Burgess L, Nortje H, Distiller L, Mitha I, Moore R, Conradie M, Horak A, Pillay S, Wellmann H, Berg E, Pillai P, Padayachee T, Corbett C, Makan H, Wing J, Vawda Z, Ebrahim I, Mitha E, Bhorat A, Fernandez JC, Munoz C, Cortada JB, Conde AC, Calvo C, Extremera BG, Delgado E, Masmiquel L, Puig JG, Parreno LD, Mauricio D, Redon J, Brito M, Lopez C, de la Morera JS, Linderfalk C, Larnefeldt H, Olsson A, Lonneborg L, Ekelund M, Samad B, Borgencrantz B, Nilsson J, Berglund O, Svensson M, Mooe T, Curiac D, Albin J, Angesjo E, Lannemyr O, Chiang C, Sheu W, Chen J, Tien K, Ueng K, Lai W, Yin W, Hung Y, Shyu K, Hou J, Lam H, Laothavorn P, Kuanprasert S, Khovidhunkit W, Benjasuratwong Y, Chotinaiwattarakul C, Mamanasiri S, Suraamornkul S, Pratipanawatr T, Nitiyanant W, Heller S, Ray K, Pieters R, Strang C, Bodalia B, Middleton A, Hall T, Chapman G, Calvert J, Reed R, Tam D, Butcher G, Jones N, Takhar A, Turner W, McNally D, Corey O, Chapman J, Mohr S, Edwards S, Bhatt D, Ocampo A, Kandath D, Aude Y, Ervin W, Savin V, Anderson R, Littlefield R, Oberoi M, Platt GE, Yazdani S, Mangoo-Karim R, Walder J, Gogia H, Chandrashekhar Y, Boccalandro F, Rogers W, Bilazarian S, Zieve F, Siage Y, O'Connor T, Mudaliar S, Nikas A, Giusti R, Glover R, Chilka S, French W, Roth E, 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D, Speer J, Stegemoller R, Waxman F, Chang FY, Braun E, Eder F, Minor S, Albert M, Carr KW, Diaczok B, Gastman I, Gupta V, Longshaw K, Gonzalez-Campoy JM, Raikhel M, Thomas J, Wood K, Diab I, Furda J, Gelernt M, Halter M, House B, Kaster S, Raad G, Stamatin R, Barker B, Blonder R, Bloomberg RJ, Calderon RB, Carrol A, Comerota A, Feinglos M, Henderson D, Kastelic R, Stonesifer LD, Talano J, Lee PV, Brosseau J, Clark W, Cohen E, Fialkow J, Horton K, Kozman H, McGill J, Mihills C, Poonawala R, Shore K, Tejada L, Torres R, Wright W, Calatayud G, Chandna H, Drozdiak R, Fink R, Gill R, Glandt M, Gottlieb DW, Hack T, Kay J, Mansouri V, McKnight T, Mostel E, Schmidt L, Seide H, Sonel E, Taylor R, Velasquez M, Bretton E, Feldman R, Hartman A, Hershon K, Leach CR, Martin E, Mohiuddin F, Naygandhi Y, Riske T, Schima S, Uzoaga ER, Ward H, Weinstock R, Williams T, Altschuller A, Aoki T, Blumenthal S, Cash A, Eisner G, Gutmann J, Hagan M, Kabour A, Markus T, McKenzie W, Moursi M, Mystkowski P, Ovalle F, Perkins R, Popeil L, Saniuk R, Sierra Y, Alvarado O, Anderson J, Bajaj M, Blank R, Chu A, Levinsky L, Levy P, Osborne J, Pavon H, Sanderlin D, Schaer G, Zarich S, Atassi K, Bayron C, Casagrande M, Das D, Gimness M, Handel F, Kinstrey T, Leu S, Osei K, Nouel JS, Soltani Z, Sussman H, Chiu K, Duda R, Farnsworth K, Lano M, Lee F, Levin P, Pratt S, Richwine R, Ruiz-Rivera L, Turner J, Wood J, Zigrang WD, Baquerizo HR, Colon CB, Demattia J, Desai V, Fitz-Patrick D, Goral S, Odhav A, Prentiss A, Ruff C, Wu W, Wyne K, Abbott LG, Applegate R, Cabral J, Kotha P, Ortega P, Simmons D

المساهمون: General Internal Medicine, Vascular Medicine, Other departments, Scirica, B, Bhatt, D, Braunwald, E, Steg, P, Davidson, J, Hirshberg, B, Ohman, P, Frederich, R, Wiviott, S, Hoffman, E, Cavender, M, Udell, J, Desai, N, Mosenzon, O, Mcguire, D, Ray, K, Leiter, L, Raz, I, Abrahamsen, T, Grossman, M, Morin, S, Im, K, Gabovitch, D, Pricken, A, Buskila, A, Stahre, C, Price, D, Billing-Clason, S, Sabel, K, Monyak, J, Sjostrand, M, Wei, C, Lu, J, Miller, E, Raichlen, J, Fitt, S, Iqbal, N, Donovan, M, Aguilar-Salinas, C, Alvarsson, M, Amerena, J, Ardissino, D, Averkov, O, Avogaro, A, Barnett, A, Bretzel, R, Chiang, C, Codoceo, V, Corbalan, R, Dalby, A, Darius, H, Deerochanawong, C, Dellborg, M, Eliaschewitz, F, Garcia-Castillo, A, Gomis, R, Henry, P, Hoekstra, J, Jermendy, G, Kastelein, J, Keech, A, Kiss, R, Krempf, M, Laakso, M, Leitersdorf, E, Lewis, B, Litwak, L, Lopez-Sendon, J, Ma, R, Medina, F, Moses, R, Nicolau, J, Opolski, G, Ophuis, T, Paolasso, E, Ruda, M, Kumar, K, Shestakova, M, Sheu, W, Smahelova, A, Bhupathiraju, B, Spinar, J, Sritata, P, Strojeck, K, Villena-Chavez, J, Jia, W, Huo, Y, Lowe, C, Awtry, E, Berger, C, Desai, A, Gelfand, E, Leeman, D, Link, M, Ruberg, F, Vita, J, Rost, N, Silverman, S, Greenberger, N, Lerch, M, Gersh, B, Nesto, R, Del Prato, S, Tuomilehto, J, Kelsey, S, Alvarisqueta, A, Cuadrado, J, Rista, L, Hermida, S, Baccaro, C, Luquez, C, Lagrutta, M, Maffei, L, Bartolacci, I, Montana, O, Cutuli, H, Berli, M, Lorenzatti, A, Frechtel, G, La Greca, R, Fretes, O, Diaz, M, Papini, N, Farias, E, Issa, C, Elbert, A, Lehman, R, Arya, M, Singh, B, Colquhoun, D, Jayasinghe, R, de Looze, F, Blombery, P, Ward, G, Szto, G, Abhayaratna, W, Borges, J, Russo, L, Felicio, J, Santos, F, Guimaraes, F, Castro, M, Rossi, P, Armaganijan, D, Leaes, P, Bandeira, F, Franken, M, Rassi, N, Rea, R, Zanella, M, Amodeo, C, Cesar, L, Betti, R, Chacra, A, Schmid, H, Bell, A, Syan, G, Zadra, R, Conter, H, Dumas, R, Borts, D, Dattani, I, Poirier, P, Cha, J, Dzongowski, P, Labonte, R, St Pierre, B, Gaudet, D, Kouz, S, Lamy, A, Tishler, S, Chehayeb, R, Bedard, J, Hramiak, I, Teitelbaum, I, Fortin, C, Woo, V, Conway, J, Mehta, P, Robinson, S, Sussex, B, Chiasson, J, Muirhead, N, Bose, S, Ouellet, A, Yale, J, Bhargava, R, Lau, D, Tobe, S, Perron, P, Sigalas, J, Bilodeau, L, Tytus, R, Achyuthan, G, Pearce, M, Steele, A, Bailey, G, Ma, P, St-Maurice, F, Rupka, D, Houlden, R, Bailey, A, Rewa, G, Sohal, P, Ting, R, Prieto, J, Rodriguez, M, Godoy, G, Larenas, G, Pincetti, C, Cobos, L, Saavedra, V, Varleta, P, Lucero, F, Kuzmanic, O, Acevedo, M, Aguirre, M, Florenzano, F, Ma, J, Bao, Y, Jiang, M, Xu, W, Shi, Y, Zheng, M, Li, Y, Dong, Y, Zhao, W, Sun, M, Lei, M, Wang, J, Pistek, Z, Rihacek, I, Kucera, D, Brada, M, Naplava, R, Karasova, J, Vlasicova, H, Skopecek, J, Spinarova, L, Raclavska, L, Sarbochova, R, Okenka, L, Racicka, E, Urbancova, K, Oznerova, M, Lorenc, Z, Wasserburger, B, Zahumensky, E, Grunfeldova, H, Hradec, J, Lukac, M, Svacina, S, Podzimek, J, Hemzsky, L, Mikulkova, I, Pavlickova, J, Brychta, T, Chochola, J, Couffinhal, T, Elbaz, M, Petit, C, Faller, B, Marechaud, R, Moulin, P, Fendri, S, Nazeyrollas, P, Wendisch, U, Busch, K, Klausmann, G, Duengen, H, Appel, K, Toursarkissian, N, Jung, T, Ott, P, Schenkenberger, I, Kuesters, D, Landers, B, Nischik, R, Fischer, H, Tschoepe, D, Paschen, B, Krause, K, Derwahl, K, Wenzl-Bauer, V, Hamann, A, Strotmann, H, Milek, K, Mueller, S, Chu, D, Tan, K, Kung, K, Tsang, C, Tomlinson, B, Koranyi, L, Kerenyi, Z, Benczur, B, Illyes, L, Hidvegi, T, Somogyi, A, Valco, J, Ferenczi, S, Rapi, J, Voros, P, Winkler, G, Sydo, T, Hetey, M, Simon, K, Penzes, J, Kempler, P, Bako, B, Lengyel, Z, Witmann, I, Dudas, M, Vandorfi, G, Takacs, J, Matoltsy, A, Ladanyi, E, Gyimesi, A, Sadikot, S, Parikh, K, Jain, S, Yajnik, C, Sosale, A, Shamanna, P, Srikanta, S, Shah, S, Srinivas, A, Banker, D, Shah, P, Sharda, A, Makkar, B, Rais, N, Mardikar, H, Mishra, A, Bhupati, S, Menon, J, Sathe, S, Gupta, R, Sharma, V, Darawsha, M, Herskovits, T, Hamoud, S, Nikolsky, E, Adawi, F, Zimlichman, R, Tsalihin, D, Wainstein, J, Klainman, E, Mosseri, M, Yerushalmi, Y, Karnieli, E, Knobler, H, Benchetrit, S, Tsur, A, Yagil, Y, Atar, S, Beberashvili, I, Fuchs, S, Stern, N, Pollak, A, Chajek-Shaul, T, Rozenman, Y, Biton, A, Bramucci, E, Fiscella, A, Grassia, V, Piatti, P, De Cosmo, S, Di Lorenzo, L, Merlini, P, Mannucci, E, Frontoni, S, Trevisan, R, Zenari, L, Lambiase, C, Salvioni, A, Silvestri, O, Ambrosio, G, Di Bartolo, P, Fattore, L, Presbitero, P, Calabrese, M, Evola, R, Gamba, M, Ibarra, M, Munoz, E, Sanchez, D, Herrera, C, Rios, J, Llamas, E, Esperon, G, Cantu, E, Fragoso, J, Gonzalez, J, Martinez, G, Padilla, F, Mier, G, Marmolejo, D, Ruiz, J, Portilla, N, Rosas, E, Machado, G, Ramos, J, Briones, I, van Hessen, M, Strikwerda, S, The, S, Kooy, A, Ronner, E, Nierop, P, Remmen, J, Groenemeijer, B, Hamer, B, Basart, D, van Lennep, H, Nieuwdorp, M, van Dijk, M, Kentgens, S, van Kempen, W, Hoogendijk, J, Spiering, W, Voors-Pette, C, Kose, V, de Waard, D, Gonkel, F, Kaasjager, H, Lingan, G, Agous, I, Kruik, H, Imholz, B, Pieterse, M, Manrique, H, Villena, J, Leon, L, Kundert, K, Minchola, J, Pinto, M, Heredia, J, Rodriguez, A, Guerreros, C, Berrospi, P, Zubiate, C, Allemant, A, Arbanil, H, Ponciano, W, Calderon, J, Lisson, R, Segura, L, Sidorowicz-Bialynicka, A, Sciborski, R, Fares, I, Mader, P, Skierkowska, J, Stasinska, T, Pomiecko, W, Skorski, M, Krzyzagorska, E, Polaszewska-Muszynska, M, Sowinski, D, Strojek, K, Rosinska-Migda, J, Romanczuk, P, Golebiowski, G, Kubica, J, Mazurek, T, Wojnowski, L, Pasternak, D, Stachlewski, P, Trzepla, E, Bogdanowicz, G, Uzunow, A, Potakowska, I, Miszczyszyn, Z, Waszyrowski, T, Smolenskaya, O, Lukyanov, Y, Vorokhobina, N, Khalimov, Y, Orlikova, O, Rebrov, A, Kukharchuk, V, Boldueva, S, Arkhipov, M, Zhelninova, T, Pavlysh, E, Antsiferov, M, Panov, A, Pavlova, M, Shustov, S, Demchenko, E, Galyavich, A, Malakhina, E, Semenova, O, Kobalava, Z, Kotova, S, Gavrisheva, I, Oschepkova, E, Karpov, Y, Sidorenko, B, Kislyak, O, Ametov, A, Dreval, A, Grineva, E, Mkrtumyan, A, Tyurina, T, Sazonova, O, Bonnici, F, Ranjith, N, Burgess, L, Nortje, H, Distiller, L, Mitha, I, Moore, R, Conradie, M, Horak, A, Pillay, S, Wellmann, H, Berg, E, Pillai, P, Padayachee, T, Corbett, C, Makan, H, Wing, J, Vawda, Z, Ebrahim, I, Mitha, E, Bhorat, A, Fernandez, J, Munoz, C, Cortada, J, Conde, A, Calvo, C, Extremera, B, Delgado, E, Masmiquel, L, Puig, J, Parreno, L, Mauricio, D, Redon, J, Brito, M, Lopez, C, de la Morera, J, Linderfalk, C, Larnefeldt, H, Olsson, A, Lonneborg, L, Ekelund, M, Samad, B, Borgencrantz, B, Nilsson, J, Berglund, O, Svensson, M, Mooe, T, Curiac, D, Albin, J, Angesjo, E, Lannemyr, O, Chen, J, Tien, K, Ueng, K, Lai, W, Yin, W, Hung, Y, Shyu, K, Hou, J, Lam, H, Laothavorn, P, Kuanprasert, S, Khovidhunkit, W, Benjasuratwong, Y, Chotinaiwattarakul, C, Mamanasiri, S, Suraamornkul, S, Pratipanawatr, T, Nitiyanant, W, Heller, S, Pieters, R, Strang, C, Bodalia, B, Middleton, A, Hall, T, Chapman, G, Calvert, J, Reed, R, Tam, D, Butcher, G, Jones, N, Takhar, A, Turner, W, Mcnally, D, Corey, O, Chapman, J, Mohr, S, Edwards, S, Ocampo, A, Kandath, D, Aude, Y, Ervin, W, Savin, V, Anderson, R, Littlefield, R, Oberoi, M, Platt, G, Yazdani, S, Mangoo-Karim, R, Walder, J, Gogia, H, Chandrashekhar, Y, Boccalandro, F, Rogers, W, Bilazarian, S, Zieve, F, Siage, Y, O'Connor, T, Mudaliar, S, Nikas, A, Giusti, R, Glover, R, Chilka, S, French, W, Roth, E, Singh, N, Christofferson, R, Stich, M, Dagogo-Jack, S, Allison, J, Zengotita, G, Ison, R, Iteld, B, Sulistio, M, Gonzalez, E, Gorman, T, Hage-Korban, E, Reddy, R, Byars, W, Antonishen, M, Benjamin, S, First, B, Rosado, J, Bruschetta, H, Poling, T, Rosendorff, C, Kerstein, H, Saba, F, Willis, J, Adams, K, Vazquez, E, Ellison, H, Kahn, B, Kereiakes, D, Powell, S, Raskin, P, Smith, K, Varma, S, Whittier, F, Casanova, R, Isserman, S, Kaye, W, Mcguinn, W, Bartkowiak, A, 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Kastelic, R, Stonesifer, L, Talano, J, Lee, P, Brosseau, J, Clark, W, Cohen, E, Fialkow, J, Horton, K, Kozman, H, Mcgill, J, Mihills, C, Poonawala, R, Shore, K, Tejada, L, Torres, R, Wright, W, Calatayud, G, Chandna, H, Drozdiak, R, Fink, R, Gill, R, Glandt, M, Gottlieb, D, Hack, T, Kay, J, Mansouri, V, Mcknight, T, Mostel, E, Schmidt, L, Seide, H, Sonel, E, Taylor, R, Velasquez, M, Bretton, E, Feldman, R, Hartman, A, Hershon, K, Leach, C, Martin, E, Mohiuddin, F, Naygandhi, Y, Riske, T, Schima, S, Uzoaga, E, Ward, H, Weinstock, R, Williams, T, Altschuller, A, Aoki, T, Blumenthal, S, Cash, A, Eisner, G, Gutmann, J, Hagan, M, Kabour, A, Markus, T, Mckenzie, W, Moursi, M, Mystkowski, P, Ovalle, F, Perkins, R, Popeil, L, Saniuk, R, Sierra, Y, Alvarado, O, Anderson, J, Bajaj, M, Blank, R, Chu, A, Levinsky, L, Levy, P, Osborne, J, Pavon, H, Sanderlin, D, Schaer, G, Zarich, S, Atassi, K, Bayron, C, Casagrande, M, Das, D, Gimness, M, Handel, F, Kinstrey, T, Leu, S, Osei, K, Nouel, J, Soltani, Z, Sussman, H, Chiu, K, Duda, R, Farnsworth, K, Lano, M, Lee, F, Levin, P, Pratt, S, Richwine, R, Ruiz-Rivera, L, Turner, J, Wood, J, Zigrang, W, Baquerizo, H, Colon, C, Demattia, J, Desai, V, Fitz-Patrick, D, Goral, S, Odhav, A, Prentiss, A, Ruff, C, Wu, W, Wyne, K, Abbott, L, Applegate, R, Cabral, J, Kotha, P, Ortega, P, Simmons, D

المصدر: BASE-Bielefeld Academic Search Engine
New England journal of medicine, 369(14), 1317-1326. Massachussetts Medical Society

مصطلحات موضوعية: Male, Adamantane, Dipeptidyl peptidase-4 inhibitor, Type 2 diabetes, Kaplan-Meier Estimate, Saxagliptin, chemistry.chemical_compound, 80 and over, glucose, saxagliptin, Aged, 80 and over, Medicine (all), Hazard ratio, 11 Medical And Health Sciences, General Medicine, Dipeptides, Middle Aged, Hospitalization, Cardiovascular Diseases, Female, Aged, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors, Double-Blind Method, Heart Failure, Humans, Hypoglycemia, Hypoglycemic Agents, Pancreatitis, Alogliptin, Type 2, medicine.drug, insulin, medicine.medical_specialty, General & Internal Medicine, Internal medicine, Diabetes mellitus, medicine, Empagliflozin, Diabetes Mellitus, Intensive care medicine, glycosylated hemoglobin, business.industry, Semaglutide, SAVOR-TIMI 53 Steering Committee and Investigators, medicine.disease, chemistry, placebo, business

الوصف: BACKGROUND: The cardiovascular safety and efficacy of many current antihyperglycemic agents, including saxagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, are unclear. METHODS: We randomly assigned 16,492 patients with type 2 diabetes who had a history of, or were at risk for, cardiovascular events to receive saxagliptin or placebo and followed them for a median of 2.1 years. Physicians were permitted to adjust other medications, including antihyperglycemic agents. The primary end point was a composite of cardiovascular death, myocardial infarction, or ischemic stroke. RESULTS: A primary end-point event occurred in 613 patients in the saxagliptin group and in 609 patients in the placebo group (7.3% and 7.2%, respectively, according to 2-year Kaplan-Meier estimates; hazard ratio with saxagliptin, 1.00; 95% confidence interval [CI], 0.89 to 1.12; P=0.99 for superiority; P

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db9b1a4d32fca838cc31c06d35582e5Test
http://hdl.handle.net/11391/1387518Test

المؤلفون: Klausmann, G., Hramiak, I., Qvist, M., Mikkelsen, K. H., Guo, X.

المساهمون: Diabet Practice, Aschaffenburg, Germany., St Josephs Hlth Care, Div Endocrinol & Metab, London, ON, Canada., Novo Nordisk AS, Soborg, Denmark., Peking Univ, Dept Endocrinol, Hosp 1, Beijing 100871, Peoples R China.

المصدر: SCI

الوصف: Endocrinology & Metabolism ; SCI(E) ; 0 ; MEETING ABSTRACT ; A86-A86 ; 15

العلاقة: DIABETES TECHNOLOGY & THERAPEUTICS.2013,15,A86-A86.; 881522; http://hdl.handle.net/20.500.11897/393601Test; WOS:000315467200238

الإتاحة: https://doi.org/20.500.11897/393601Test
https://hdl.handle.net/20.500.11897/393601Test

المؤلفون: Punthakee, Zubin, Bosch, Jackie, Dagenais, Gilles R., Diaz, Rafael, Holman, Rury, Probstfield, Jeffrey L., Ramachandran, Ambady, Riddle, Matthew C., Rydén, Lars E., Zinman, Bernard, Afzal, Rizwan, Yusuf, Salim, Gerstein, Hertzel, Avezum, Alvaro, Birkeland, Kåre, Budaj, Andrzej, Cardona, E., Chaithiraphan, Suphachai, Chan, Juliana, Chazova, I., Chen, Jersey, Cobitz, Alexander, Conget, Ignacio, Dans, Antonio, Dineen, Sean, Hancu, Nicolae, Hanefeld, Markolf, Heller, Simon, Hildebrandt, Per Rossen, Jansky, Petr, Lanas, Fernando, Leiter, Lawrence A., Lopez-Jaramillo, Patricio, Maggioni, Aldo P., Malaga, Germán, Masud, F., Mellbin, Linda, Metelko, Zeljko, Murphy, K., Niskanen, Leo, O'Donnell, Martin, Pan, C. Y., Parkhomenko, Alexander, Pirags, Valdis, Raptis, Sotirios A., Raslova, Katarina, Raubenheimer, Peter, Stoel, I., Tankova, Tsvetalina, Yusoff, Khalid, McKelvie, Robert S., Anderson, N., Pfeffer, Marc A., Bennett, Peter H., Chaturvedi, Nish, DeMets, David, McMurray, John J. V., Alvarisqueta, Andrés, Calella, P., Frechtel, Gustavo Daniel, Ibanez, J., Litvak, Bruno M., Lorenzati, C., Masjoan, F., Medina, I., Aizenberg, Diego, Amuchastegui, Marcos, Bartolacci, Ines, Bustamante Labarta, Gustavo, Bustamante Labarta, M., Caccavo, A., Cantero, M., Cardona, M., Caruso, O., Cozzi Palma, Maria Sol, Cuneo, Carlos, de la Pertoza, S. 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المصدر: Diabetologia

مصطلحات موضوعية: ddc:610, Aged, cardiovascular disease, Cardiovascular diseases, CARDIOVASCULAR-DISEASE, Cholecalciferol, Combined Modality Therapy, D SUPPLEMENTATION, Diabetes Mellitus, DIABETES-MELLITUS, Dietary Supplements, Dose-Response Relationship, Double-Blind Method, Drug, Early Termination of Clinical Trials, FASTING GLUCOSE, Female, GLYBURIDE MONOTHERAPY, HEART-FAILURE, Humans, Hypoglycemic Agents, IMPAIRED GLUCOSE-TOLERANCE, Incidence, INTIMA-MEDIA THICKNESS, MACROVASCULAR EVENTS, Male, Middle aged, MYOCARDIAL-INFARCTION, Neoplasms, pioglitazone

وصف الملف: 36–45

العلاقة: urn:issn:0012-186X; urn:issn:1432-0428

الإتاحة: https://bibliographie.ub.rub.de/entry/85eafd3d-6e73-47a4-b543-9cfb24f8d81bTest

المؤلفون: BEHME, M. T., DUPRÉ, J., HARRIS, S. B., HRAMIAK, I. M., MAHON, J. L.

المصدر: Annals of the New York Academy of Sciences ; volume 1005, issue 1, page 374-377 ; ISSN 0077-8923 1749-6632

الوصف: A bstract : Insulin resistance in patients with latent autoimmune diabetes of adulthood (LADA) was determined by homeostasis model assessment (HOMA). LADA was identified by a clinical phenotype of type 2 diabetes with antibodies to GAD65 and/or IA‐2/ICA512. All patients were managed with insulin therapy. Insulin resistance in LADA was lower than in antibody‐negative type 2 diabetes, higher than in normal humans and in recent‐onset type 1 diabetes, and similar to that in long‐term type 1 diabetes. Mean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes. LADA resembles long‐term type 1 diabetes with respect to insulin resistance and BMI, but occurs at an older age.

الإتاحة: https://doi.org/10.1196/annals.1288.062Test

المؤلفون: Hramiak, I., Dupre, J., Finegood, D.

المصدر: Journal of Autoimmunity ; volume 5, page xxix ; ISSN 0896-8411

مصطلحات موضوعية: Immunology, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/0896-8411Test(92)90113-5
https://api.elsevier.com/content/article/PII:0896841192901135?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:0896841192901135?httpAccept=text/plainTest

المؤلفون: Dupre, J., Hramiak, I., Mahon, J.L., Stiller, C.R.

المصدر: Hormone Research ; volume 33, issue 2-4, page 152-158 ; ISSN 1423-0046 0301-0163

مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism

الإتاحة: https://doi.org/10.1159/000181499Test
http://www.karger.com/Article/Pdf/181499Test

المؤلفون: Dupre, John, Behme, Margaret T., Hramiak, Irene M., McFarlane, Philip, Williamson, M. Paul, Zabel, Pamela, McDonald, Thomas J., Dupre, J, Behme, M T, Hramiak, I M, McFarlane, P, Williamson, M P, Zabel, P, McDonald, T J

المصدر: Diabetes; Jun1995, Vol. 44 Issue 6, p626-630, 5p

المؤلفون: MCDONALD, T. J., TU, E., BRENNER, S., ZABEL, P., BEHME, M., PANCHAL, C., HRAMIAK, I., BARNETT, W. B., MILLER, D., DUPRÉ, J.

المصدر: American Journal of Physiology: Endocrinology & Metabolism; 1994, Vol. 29 Issue 4, pE612-E617, 6p