المؤلفون: Hoskin R. T., Grace M. H., Guiotto A., Pecorelli A., Valacchi G., Lila M. A.

المساهمون: Hoskin, R. T., Grace, M. H., Guiotto, A., Pecorelli, A., Valacchi, G., Lila, M. A.

مصطلحات موضوعية: cosmeceuticals, repurposing, skin health, sustainability, value-added

الوصف: Spray drying (SD) microencapsulation of phytochemicals from berry pomaces with Spirulina protein (SP) was incorporated into a cosmeceutical topical formulation to mitigate pollution skin damage. Initially, microparticles produced with SP and polyphenols recovered from fruit pomaces (elderberry SP-EB and muscadine grape SP-MG) were characterized regarding physicochemical and phytochemical content (polyphenol load, carotenoid and phycocyanin contents and antioxidant activity). SP had low total phenolic content (7.43 & PLUSMN; 0.23 mg GAE/g DW), but complexation with elderberry or muscadine grape pomaces polyphenols led to a substantial increase (27.63 & PLUSMN; 1.15 SP-EB and 111.0 & PLUSMN; 2.6 mg GAE/g DW SP-MG). SP-MG particles had higher anthocyanin (26.87 & PLUSMN; 1.25 mg/g) and proanthocyanidin (9.02 & PLUSMN; 0.74 mg/g) contents compared to SP-EB particles. SP-MG were prioritized to prepare a topical gel to attenuate skin oxinflammatory markers and prevent skin barrier disruption using ex vivo human biopsies exposed to diesel engine exhaust (DEE). The immunofluorescence results showed increased oxidative protein damage and inflammation associated with impaired skin barrier function after DEE exposure while topical application of gel formulated with SP-MG mitigated these effects. Overall, this study demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37507969; info:eu-repo/semantics/altIdentifier/wos/WOS:001034890100001; volume:12; issue:7; firstpage:1; lastpage:20; numberofpages:20; journal:ANTIOXIDANTS; https://hdl.handle.net/11392/2529373Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85165948189

الإتاحة: https://doi.org/10.3390/antiox12071431Test
https://hdl.handle.net/11392/2529373Test

المؤلفون: Hoskin, R, Berzuini, C, Acosta-Kane, D, El-Deredy, W, Guo, H, Talmi, D

مصطلحات موضوعية: Bayes, Expectation, Pain, Perception, Placebo effect, Uncertainty, Adult, Aged, Anticipation, Psychological, Bayes Theorem, Cues, Female, Humans, Individuality, Male, Models, Pain Perception, Young Adult

الوصف: The thoughts and feelings people have about pain (referred to as 'pain expectations') are known to alter the perception of pain. However little is known about the cognitive processes that underpin pain expectations, or what drives the differing effect that pain expectations have between individuals. This paper details the testing of a model of pain perception which formalises the response to pain in terms of a Bayesian prior-to-posterior updating process. Using data acquired from a short and deception-free predictive cue task, it was found that this Bayesian model predicted ratings of pain better than other, simpler models. At the group level, the results confirmed two core predictions of predictive coding; that expectation alters perception, and that increased uncertainty in the expectation reduces its impact on perception. The addition of parameters relating to trait differences in pain expectation improved the fit of the model, suggesting that such traits play a significant role in perception above and beyond the influence of expectations triggered by predictive cues. When the model parameters were allowed to vary by participant, the model's fit improved further. This final model produced a characterisation of each individual's sensitivity to pain expectations. This model is relevant for the understanding of the cognitive basis of pain expectations and could potentially act as a useful tool for guiding patient stratification and clinical experimentation.

وصف الملف: Print-Electronic; application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/316983Test

الإتاحة: https://doi.org/10.17863/CAM.64095Test
https://www.repository.cam.ac.uk/handle/1810/316983Test

المؤلفون: Hoskin, R., Berzuini, C., Acosta-Kane, D., El-Deredy, W., Guo, H., Talmi, D.

المصدر: Cognition ; volume 182, page 127-139 ; ISSN 0010-0277

مصطلحات موضوعية: Cognitive Neuroscience, Linguistics and Language, Developmental and Educational Psychology, Language and Linguistics, Experimental and Cognitive Psychology

الإتاحة: https://doi.org/10.1016/j.cognition.2018.08.022Test
https://api.elsevier.com/content/article/PII:S0010027718302361?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0010027718302361?httpAccept=text/plainTest

المؤلفون: Hoskin, R. E.

مصطلحات موضوعية: 333.914, Tidal power control modelling

الإتاحة: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381914Test

المؤلفون: Lee, P J, Amos, A, Robertson, L, Fitzgerald, B, Hoskin, R, Lilburn, M, Weetch, E, Murphy, G

مصطلحات موضوعية: Research papers

الوصف: Background: Although early diagnosis and treatment in phenylketonuria (PKU) leads to excellent outcomes, a population of adults born before the introduction of newborn screening exists. They can have severe intellectual disabilities and behavioural problems, and are often dependent on full-time carers. Anecdotal evidence suggests that a diet that lowers blood phenylalanine concentration can have significant benefits upon behaviour. Methods: A prospective double-blind randomised placebo-controlled crossover trial of phenylalanine-restricted diet was performed in a group of 34 adults (aged 21–61 years, median 49) with late diagnosed PKU with severe challenging behaviour. Results: Only 17 completed the 60 week study: seven withdrew before the end of the baseline period; five withdrew during the first diet period; five withdrew during the second diet period (after moving into placebo phase). The mean (SD) blood phenylalanine was 1570 (222) μmol/l during baseline, 553(158) μmol/l during the active phase and 1444 (255) μmol/l during the placebo phase. In the 22 participants exposed to both active and placebo phases, no differences were demonstrated in behaviour assessed by the Aberrant Behavior Checklist and Vineland Adaptive Behavior Scales, behaviour diaries or on video analysis of direct observations. However, 76% of carers’ comments were scored as positive during the active phase, compared with 54% during the placebo phase (χ2 = 38.06, p<0.001). Conclusions: There are significant challenges in studying people with intellectual disabilities and considerable difficulties in instituting phenylalanine-restricted diet in this population. However, if attempted, there are potential benefits to quality of life for the individuals with PKU and their carers.

وصف الملف: text/html

العلاقة: http://jnnp.bmj.com/cgi/content/short/80/6/631Test; http://dx.doi.org/10.1136/jnnp.2008.151175Test

الإتاحة: https://doi.org/10.1136/jnnp.2008.151175Test
http://jnnp.bmj.com/cgi/content/short/80/6/631Test

المؤلفون: Nazimek, J.M., Hunter, M.D., Hoskin, R., Wilkinson, I., Woodruff, P.W.

المصدر: Neuropsychologia ; volume 51, issue 11, page 2245-2250 ; ISSN 0028-3932

مصطلحات موضوعية: Behavioral Neuroscience, Cognitive Neuroscience, Experimental and Cognitive Psychology

الإتاحة: https://doi.org/10.1016/j.neuropsychologia.2013.07.019Test
https://api.elsevier.com/content/article/PII:S0028393213002480?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0028393213002480?httpAccept=text/plainTest

المؤلفون: Dennis, K., Chow, E., Roos, D., DeAngelis, C., Hartsell, W., Linden, Y. van der, Hoskin, R.

المصدر: CLINICAL ONCOLOGY

الوصف: Clinical Oncology

العلاقة: lumc-id: 4132159; https://hdl.handle.net/1887/105888Test

الإتاحة: https://doi.org/10.1016/j.clon.2011.03.011Test
https://hdl.handle.net/1887/105888Test

المؤلفون: Parker, C., Hoskin, R., Pascoe, S., Chodack, A., O'Sullivan, Joe, Germa, J.R., Lokna, A.

المصدر: Parker , C , Hoskin , R , Pascoe , S , Chodack , A , O'Sullivan , J , Germa , J R & Lokna , A 2009 , ' A double blind, randomised, dose finding, phase II, multicentre study of radium-223 for the treatment of patients with metastatic castration-refractory prostate cancer (CRPC): EudraCT number: 2005-003680-22 ' , EJC SUPPLEMENTS , vol. 7 , pp. 406-406 .

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, SDG 3 - Good Health and Well-being

الإتاحة: https://pure.qub.ac.uk/en/publications/5084578e-67c8-41c6-a679-253433d9cfbcTest

المؤلفون: Hoskin, R. D.

المصدر: New Zealand Journal of Geography ; volume 51, issue 1, page 36-36 ; ISSN 0028-8292

الإتاحة: https://doi.org/10.1111/j.0028-8292.1971.tb00501.xTest

المؤلفون: HOSKIN, R. G., SASITHARAN, T., HOWARD, R.

المصدر: Journal of Intellectual Disability Research ; volume 36, issue 2, page 183-191 ; ISSN 0964-2633 1365-2788

الوصف: If phenylketonuria is untreated in infancy, it causes irreversible brain damage. No dietary treatment can alter this brain damage. However, it has been shown that dietary treatment can reduce behaviour disturbances often associated with the condition. In this study, a subject's behaviour was monitored over 18 weeks while on a low phenylalanine diet. Results demonstrate a significant reduction in the level of her disturbed behaviour.

الإتاحة: https://doi.org/10.1111/j.1365-2788.1992.tb00494.xTest