المؤلفون: Iles-Smith, Heather, McMillan, Isobel May, Evans-Cheung, Trina, Haas Eckersley, Ruth, Russell, Margaret, Wood, Julie, McCarthy, Robyn Emelda, Rosson, Lyndsey, Doxford-Hook, Liz, Fu, Yu, McGowan, Linda

مصطلحات موضوعية: Urology

الوصف: Introduction Urinary incontinence (UI) is associated with increasing age and is more frequently experienced by women. Despite 40% prevalence in the community, little is known about the prevalence/incidence of UI in older women during hospital admission. UI during hospital admissions, within this group, has also been under-researched in terms of its relationship to specific clinical conditions and mortality rates. Given that UI has serious implications for both patient care and women’s general health and well-being on discharge, this protocol describes a planned research project which aims to determine mortality, morbidity, prevalence and incidence of UI in older women (≥55 years) during hospital admission to inform nursing practice. Additionally, it aims to explore the experience of nurses who deliver women’s care. Methods and analysis This is an explanatory mixed-methods study consisting of two phases: (1) retrospecitive analysis of electronic patient care records (EPCR) to determine prevalence/incidence of UI, clinical conditions most likely associated with UI and any associations between UI and death, (2) nurse interviews to explore views, knowledge and perceptions of performing the nursing assessment and providing care for older women (≥55 years) with UI during admission. EPCR will be gained from a National Health Service (NHS) teaching hospital. Nurse interviews will be conducted with nurses from an alternative but similar-sized NHS hospital. Ethics and dissemination Ethical approval is provided by the University of Salford Ethics Committee and regulatory approval by the NHS Health Research Authority (Integrated Research Application System project ID: 303118). Local NHS trust approval to access electronic care records for the purposes of analysis of anonymised data has been provided by one of the two collaborating NHS hospitals. Findings will be disseminated through open-access geriatric or urogynaecology journals and presented to relevant stakeholders at local, national and international meetings including ...

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العلاقة: http://bmjopen.bmj.com/cgi/content/short/13/10/e067937Test; http://dx.doi.org/10.1136/bmjopen-2022-067937Test

الإتاحة: https://doi.org/10.1136/bmjopen-2022-067937Test
http://bmjopen.bmj.com/cgi/content/short/13/10/e067937Test

المؤلفون: McMillan, Isobel, Hill, Lyndsay, McCarthy, Robyn, Haas-Eckersley, Ruth, Russell, Margaret, Wood, Julie, Doxford-Hook, Liz, Fu, Yu, McGowan, Linda, Iles-Smith, Heather

المصدر: Women's Health ; volume 19 ; ISSN 1745-5057 1745-5065

الوصف: Background: Up to 40% of older women living in the community experience urinary incontinence. In community settings, urinary incontinence impacts the quality of life, morbidity, and mortality rates. However, little is known about urinary incontinence and its impact on older women admitted to hospitals. Objectives: This scoping review aims to establish the current knowledge of urinary incontinence during hospital admission for women (⩾ 55 years of age) with three key objectives: (a) What is the prevalence/incidence of urinary incontinence? (b) What health conditions are associated with urinary incontinence? (c) Is there an association between urinary incontinence and mortality? Eligibility criteria: Empirical studies were included in assessing the incidence/prevalence of urinary incontinence during hospital admissions and its related morbidities and mortality rates. Studies which only included men or younger women (< 55 years of age) were excluded. Only articles written in English and conducted between 2015 and 2021 were included. Sources of evidence: A search strategy was developed, and CINAHL, MEDLINE, and Cochrane databases were searched. Charting methods: Data from each article meeting the criteria were pulled into a table, including study design, study population, and setting, aims, methods, outcome measures, and significant findings. A second researcher then reviewed the populated data extraction table. Results: Overall, 383 papers were found: 7 met inclusion/exclusion criteria. Prevalence rates ranged from 22% to 80% depending on the study cohort. Several conditions were associated with urinary incontinence, including frailty, orthopaedics, stroke, palliative care, neurology, and cardiology. There was a potential positive association between mortality and urinary incontinence, although only two papers reviewed reported mortality. Conclusion: A dearth of literature determined the prevalence, incidence, and mortality rates for older women admitted to hospitals. Limited consensus on associated conditions ...

الإتاحة: https://doi.org/10.1177/17455057231179061Test

المؤلفون: Oyedepo, Jadesola, Bageta, Maria, Polubothu, Maanasa, Tan, Jonathan, Gattens, Michael, Levine, Samantha, Hook, Liz

المصدر: British Journal of Dermatology ; volume 190, issue Supplement_1, page i10-i11 ; ISSN 0007-0963 1365-2133

مصطلحات موضوعية: Dermatology

الوصف: Introduction Congenital leukaemia is a rare haematologic disease presenting in the first 4-6 weeks of life. Affected children may present with systemic symptoms of fever, hepatosplenomegaly and skin infiltration in the form of leukaemia cutis. Prognosis is generally poor but some cases of spontaneous regression have been described. We report a case of a 5-week-old who had biopsy confirmed cutis leukaemia which went on to resolve spontaneously. Case A male infant developed widespread erythematous/violaceous patches and nodules in the first week of life. He remained systemically well. A skin biopsy at 5 weeks of age showed features of a malignant haematological infiltrate, favouring a myeloid/monocytic leukaemic process. Baseline bloods were normal including a blood film which did not show any evidence of blasts. Interestingly, following his biopsy, skin lesions began to improve with complete resolution of all skin lesions by six weeks of age. RNA fusion panel analysis of affected skin detected a PICALM::MLLT10 t(10;11) (p12;q14) fusion which is a rare but recurrent finding in acute lymphoblastic leukaemia . He continues monthly haematology surveillance and has remained disease free at 8 months. Conclusion Spontaneous regression of aleukaemic leukaemia cutis is a rare phenomenon. Patients require close ongoing surveillance as some may relapse with systemic disease after several years. Key to management of this case was prompt suspicion of leukaemia cutis and biopsy which enabled an accurate diagnosis despite the brief window of skin lesions and has subsequently enabled accurate genotyping and future rigorous surveillance in this child.

الإتاحة: https://doi.org/10.1093/bjd/ljad483.028Test
https://academic.oup.com/bjd/article-pdf/190/Supplement_1/i10/54898979/ljad483.028.pdfTest

المؤلفون: Urquhart, Calum, Fleming, Ben, Harper, Ines, Aloj, Luigi, Armstrong, Ruth, Hook, Liz, Long, Anna-May, Jackson, Claire, Gallagher, Ferdia A., McLean, Mary A., Tarpey, Patrick, Kosmoliaptsis, Vasilis, Nicholson, James, Hendriks, A. Emile J., Casey, Ruth T.

المصدر: Frontiers in Endocrinology ; volume 13 ; ISSN 1664-2392

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism

الوصف: There is increasing evidence to support the use of temozolomide therapy for the treatment of metastatic phaeochromocytoma/paraganglioma (PPGL) in adults, particularly in patients with SDHx mutations. In children however, very little data is available. In this report, we present the case of a 12-year-old female with a SDHB-related metastatic paraganglioma treated with surgery followed by temozolomide therapy. The patient presented with symptoms of palpitations, sweating, flushing and hypertension and was diagnosed with a paraganglioma. The primary mass was surgically resected six weeks later after appropriate alpha- and beta-blockade. During the surgery extensive nodal disease was identified that had been masked by the larger paraganglioma. Histological review confirmed a diagnosis of a metastatic SDHB-deficient paraganglioma with nodal involvement. Post-operatively, these nodal lesions demonstrated tracer uptake on 18 F-FDG PET-CT. Due to poor tumour tracer uptake on 68 Ga-DOTATATE and 123 I-MIBG functional imaging studies radionuclide therapy was not undertaken as a potential therapeutic option for this patient. Due to the low tumour burden and lack of clinical symptoms, the multi-disciplinary team opted for close surveillance for the first year, during which time the patient continued to thrive and progress through puberty. 13 months after surgery, evidence of radiological and biochemical progression prompted the decision to start systemic monotherapy using temozolomide. The patient has now completed ten cycles of therapy with limited adverse effects and has benefited from a partial radiological and biochemical response.

الإتاحة: https://doi.org/10.3389/fendo.2022.1066208Test

المؤلفون: Custers, Lars, Khabirova, Eleonora, Coorens, Tim H.H., Oliver, Thomas R.W., Calandrini, Camilla, Young, Matthew D., Vieira Braga, Felipe A., Ellis, Peter, Mamanova, Lira, Segers, Heidi, Maat, Arie, Kool, Marcel, Hoving, Eelco W., van den Heuvel-Eibrink, Marry M., Nicholson, James, Straathof, Karin, Hook, Liz, de Krijger, Ronald R., Trayers, Claire, Allinson, Kieren, Behjati, Sam, Drost, Jarno

المساهمون: PMC Medisch specialisten, Cancer, Neurochirurgen, Speerpunt, Zorg en O&O, Child Health, Pathologie Pathologen staf

مصطلحات موضوعية: General Chemistry, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy

الوصف: Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root and differentiation pathways underpinning MRT are not firmly established. Here, we study the origin of MRT by combining phylogenetic analyses and single-cell mRNA studies in patient-derived organoids. Comparison of somatic mutations shared between cancer and surrounding normal tissues places MRT in a lineage with neural crest-derived Schwann cells. Single-cell mRNA readouts of MRT differentiation, which we examine by reverting the genetic driver mutation underpinning MRT, SMARCB1 loss, suggest that cells are blocked en route to differentiating into mesenchyme. Quantitative transcriptional predictions indicate that combined HDAC and mTOR inhibition mimic MRT differentiation, which we confirm experimentally. Our study defines the developmental block of MRT and reveals potential differentiation therapies.

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/444848Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/444848Test

المؤلفون: Young, Matthew D., Mitchell, Thomas J., Custers, Lars, Margaritis, Thanasis, Morales-Rodriguez, Francisco, Kwakwa, Kwasi, Khabirova, Eleonora, Kildisiute, Gerda, Oliver, Thomas R.W., de Krijger, Ronald R., van den Heuvel-Eibrink, Marry M., Comitani, Federico, Piapi, Alice, Bugallo-Blanco, Eva, Thevanesan, Christine, Burke, Christina, Prigmore, Elena, Ambridge, Kirsty, Roberts, Kenny, Braga, Felipe A.Vieira, Coorens, Tim H.H., Del Valle, Ignacio, Wilbrey-Clark, Anna, Mamanova, Lira, Stewart, Grant D., Gnanapragasam, Vincent J., Rampling, Dyanne, Sebire, Neil, Coleman, Nicholas, Hook, Liz, Warren, Anne, Haniffa, Muzlifah, Kool, Marcel, Pfister, Stefan M., Achermann, John C., He, Xiaoling, Barker, Roger A., Shlien, Adam, Bayraktar, Omer A., Teichmann, Sarah A., Holstege, Frank C., Meyer, Kerstin B., Drost, Jarno, Straathof, Karin, Behjati, Sam

المساهمون: Groep Holstege, Pathologie Pathologen staf, Speerpunt, Zorg en O&O, Child Health, CMM Groep Burgering, Cancer

مصطلحات موضوعية: General Chemistry, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy

الوصف: Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference “cellular signals” in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of “fetalness” with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer.

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/444844Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/444844Test

المؤلفون: Young, Matthew D, Mitchell, Thomas J, Custers, Lars, Margaritis, Thanasis, Morales-Rodriguez, Francisco, Kwakwa, Kwasi, Khabirova, Eleonora, Kildisiute, Gerda, Oliver, Thomas R W, de Krijger, Ronald R, van den Heuvel-Eibrink, Marry M, Comitani, Federico, Piapi, Alice, Bugallo-Blanco, Eva, Thevanesan, Christine, Burke, Christina, Prigmore, Elena, Ambridge, Kirsty, Roberts, Kenny, Braga, Felipe A Vieira, Coorens, Tim H H, Del Valle, Ignacio, Wilbrey-Clark, Anna, Mamanova, Lira, Stewart, Grant D, Gnanapragasam, Vincent J, Rampling, Dyanne, Sebire, Neil, Coleman, Nicholas, Hook, Liz, Warren, Anne, Haniffa, Muzlifah, Kool, Marcel, Pfister, Stefan M, Achermann, John C, He, Xiaoling, Barker, Roger A, Shlien, Adam, Bayraktar, Omer A, Teichmann, Sarah A, Holstege, Frank C, Meyer, Kerstin B, Drost, Jarno, Straathof, Karin, Behjati, Sam

المصدر: essn: 2041-1723 ; nlmid: 101528555

مصطلحات موضوعية: Kidney, Fetus, Humans, Kidney Neoplasms, RNA, Messenger, Signal Transduction, Gene Expression Regulation, Developmental, Algorithms, Models, Genetic, Adult, Child, Single-Cell Analysis, Transcriptome, RNA-Seq

الوصف: Funder: Department of Health ; Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference "cellular signals" in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of "fetalness" with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer.

وصف الملف: application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/325895Test

الإتاحة: https://doi.org/10.17863/CAM.73352Test
https://www.repository.cam.ac.uk/handle/1810/325895Test

المؤلفون: McMillan, Isobel, Hill, Lyndsay, McCarthy, Robyn, Haas-Eckersley, Ruth, Russell, Margaret, Wood, Julie, Doxford-Hook, Liz, Fu, Yu, McGowan, Linda, Iles-Smith, Heather

مصطلحات موضوعية: FOS: Clinical medicine, 111402 Obstetrics and Gynaecology

الوصف: Supplemental material, sj-docx-1-whe-10.1177_17455057231179061 for Urinary incontinence in women 55 years and older: A scoping review to understand prevalence, incidence, and mortality of urinary incontinence during secondary care admission by Isobel McMillan, Lyndsay Hill, Robyn McCarthy, Ruth Haas-Eckersley, Margaret Russell, Julie Wood, Liz Doxford-Hook, Yu Fu, Linda McGowan and Heather Iles-Smith in Women’s Health

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::80785e5a118fdd0b2a65c2efcca783d0Test

المؤلفون: Stewart, Benjamin J., Fergie, Martin, Young, Matthew D., Jones, Claire, Sachdeva, Ashwin, Blain, Alex, Bacon, Chris M., Rand, Vikki, Ferdinand, John R., James, Kylie R., Mahbubani, Krishnaa T., Hook, Liz, Jonas, Nicolaas, Coleman, Nicholas, Saeb-Parsy, Kourosh, Collin, Matthew, Clatworthy, Menna R., Behjati, Sam, Carey, Christopher D.

المصدر: Blood; May 2023, Vol. 141 Issue: 19 p2343-2358, 16p

مستخلص: •Tumor-associated MNP are diverse and spatially polarized: cDC2 colocalize with malignant HRSCs; plasmacytoid and activated DCs are excluded.•DCs, monocytes, and macrophages exist in an inflammatory niche in close proximity to HRSCs, and all express inhibitory molecules.

المؤلفون: Urquhart, Calum, Fleming, Ben, Harper, Ines, Aloj, Luigi, Armstrong, Ruth, Hook, Liz, Long, Anna-May, Jackson, Claire, Gallagher, Ferdia A., McLean, Mary A., Tarpey, Patrick, Kosmoliaptsis, Vasilis, Nicholson, James, Hendriks, A. Emile J., Casey, Ruth T.

المصدر: Frontiers in Endocrinology; 11/9/2022, Vol. 13, p1-8, 8p

مصطلحات موضوعية: PARAGANGLIOMA, TEMOZOLOMIDE, LITERATURE reviews, POSITRON emission tomography computed tomography, METASTASIS, PEDIATRICS

مستخلص: There is increasing evidence to support the use of temozolomide therapy for the treatment of metastatic phaeochromocytoma/paraganglioma (PPGL) in adults, particularly in patients with SDHx mutations. In children however, very little data is available. In this report, we present the case of a 12-year-old female with a SDHB-related metastatic paraganglioma treated with surgery followed by temozolomide therapy. The patient presented with symptoms of palpitations, sweating, flushing and hypertension and was diagnosed with a paraganglioma. The primary mass was surgically resected six weeks later after appropriate alpha- and beta-blockade. During the surgery extensive nodal disease was identified that had been masked by the larger paraganglioma. Histological review confirmed a diagnosis of a metastatic SDHB-deficient paraganglioma with nodal involvement. Post-operatively, these nodal lesions demonstrated tracer uptake on ¹⁸F-FDG PET-CT. Due to poor tumour tracer uptake on ⁶⁸Ga-DOTATATE and ¹²³I-MIBG functional imaging studies radionuclide therapy was not undertaken as a potential therapeutic option for this patient. Due to the low tumour burden and lack of clinical symptoms, the multi-disciplinary team opted for close surveillance for the first year, during which time the patient continued to thrive and progress through puberty. 13 months after surgery, evidence of radiological and biochemical progression prompted the decision to start systemic monotherapy using temozolomide. The patient has now completed ten cycles of therapy with limited adverse effects and has benefited from a partial radiological and biochemical response. [ABSTRACT FROM AUTHOR]

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