المؤلفون: Simeng Sun, Ting Zhang, Hao Yu, Ting Xia, Yunan Yao, Mengting Sun, Hongmei Liang, Qiaoyu Huang, Weiwei Wang, Huafeng Yang, Xin Hong

المصدر: Frontiers in Aging Neuroscience, Vol 16 (2024)

مصطلحات موضوعية: Alzheimer’s disease, risk factors, metabolic risks, high body mass index, high fasting plasma glucose, smoking, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

الوصف: BackgroundWith the increase in the aging population worldwide, Alzheimer’s disease has become a rapidly increasing public health concern. In the Global Burden of Disease Study 2019, there are three risk factors judged to have evidence for a causal link to Alzheimer’s disease and other dementias: smoking, high body-mass index (HBMI), and high fasting plasma glucose (HFPG).ObjectiveThis study aimed to analyze trends in AD mortality and the relevant burden across China from 1990 to 2019, as well as their correlation with age, period, and birth cohort.MethodsThe data were extracted from the GBD 2019. Trends in AD mortality attributable to metabolic risks (HFPG and HBMI) and smoking were analyzed using Joinpoint regression. The age-period-cohort (APC) model was used to evaluate cohort and period effects.ResultsFrom 1990 to 2019, the overall age-standardized mortality rate of AD increased, especially in women. There was an increase in AD mortality due to smoking in the net drift, and it was more significant in women (0.46, 95%CI = [0.09, 0.82]) than men (−0.03, 95%CI = [−0.11, 0.05]). For the cause of HFPG, the net drift values for men and women were 0.82% and 0.43%. For HBMI, the values were 3.14% and 2.76%, respectively, reflecting substantial increases in AD mortality.ConclusionTime trends in AD mortality caused by metabolic risks and smoking in China from 1990 to 2019 have consistently increased. Therefore, it is necessary to prevent excessive weight gain and obesity during the later stages of life, especially for females.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fnagi.2024.1425577/fullTest; https://doaj.org/toc/1663-4365Test

الوصول الحر: https://doaj.org/article/acf273ae1cc949fb88a1209485a89e5eTest

المؤلفون: Hongmei Liang

المصدر: SAGE Open, Vol 14 (2024)

مصطلحات موضوعية: History of scholarship and learning. The humanities, AZ20-999, Social Sciences

الوصف: The purpose of this study was to reveal features of instructors’ explanations in online EMI lectures in China. Through a mixed methods case study, the researcher examined the distribution and linguistic realizations of different types of explanations in the lectures of two online EMI courses and how the instructors and students perceived the explanations. The results showed that instructors’ explanations were prevalent in the lectures of both courses with expositions being the most dominant type regardless of subject contents whereas the other explanation types such as comparisons, clarifications, additions, justifications, solutions and generalizations being subject-specific. Moreover, both instructors were capable of using various linguistic devices for different types of explanations despite some linguistic mistakes in explanations. The results also showed that instructors chose particular types of explanations mainly because of the specific teaching aims and methods of the course, and that students were positive about instructors’ use of different types of explanations in the lectures except for the suggestions that one of the instructors’ pronunciation be improved and more visual means be used to aid explanations. The study has implications for future research on enhancing EMI instructors’ explanatory capacity and addressing students’ linguistic discomfort with EMI lectures in a broader sense.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2158-2440Test

الوصول الحر: https://doaj.org/article/93fa1e8302dc423db5202d255fcce3a6Test

المؤلفون: Hongmei Liang, Li Wang, Aiping Wang, Youzhi Song, Yanzhou Wu, Yang Yang, Xiangming He

المصدر: Nano-Micro Letters, Vol 15, Iss 1, Pp 1-32 (2023)

مصطلحات موضوعية: Polymer, Inorganic composite electrolytes, All-solid-state lithium metal batteries, Fillers, Ionic conductivity, High voltage, Technology

الوصف: Highlights The current issues and recent advances in polymer/inorganic composite electrolytes are reviewed. The molecular interaction between different components in the composite environment is highlighted for designing high-performance polymer/inorganic composite electrolytes. Inorganic filler properties that affect polymer/inorganic composite electrolyte performance are pointed out. Future research directions for polymer/inorganic composite electrolytes compatible with high-voltage lithium metal batteries are outlined. Abstract Solid-state electrolytes (SSEs) are widely considered the essential components for upcoming rechargeable lithium-ion batteries owing to the potential for great safety and energy density. Among them, polymer solid-state electrolytes (PSEs) are competitive candidates for replacing commercial liquid electrolytes due to their flexibility, shape versatility and easy machinability. Despite the rapid development of PSEs, their practical application still faces obstacles including poor ionic conductivity, narrow electrochemical stable window and inferior mechanical strength. Polymer/inorganic composite electrolytes (PIEs) formed by adding ceramic fillers in PSEs merge the benefits of PSEs and inorganic solid-state electrolytes (ISEs), exhibiting appreciable comprehensive properties due to the abundant interfaces with unique characteristics. Some PIEs are highly compatible with high-voltage cathode and lithium metal anode, which offer desirable access to obtaining lithium metal batteries with high energy density. This review elucidates the current issues and recent advances in PIEs. The performance of PIEs was remarkably influenced by the characteristics of the fillers including type, content, morphology, arrangement and surface groups. We focus on the molecular interaction between different components in the composite environment for designing high-performance PIEs. Finally, the obstacles and opportunities for creating high-performance PIEs are outlined. This review aims to provide some theoretical guidance and direction for the development of PIEs.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2311-6706Test; https://doaj.org/toc/2150-5551Test

الوصول الحر: https://doaj.org/article/bd7625bc10934d8a80d25c27f7580c90Test

المؤلفون: Yin Yang, Fei Chen, Hongmei Liang, Yun Bai, Zhen Wang, Lei Zhao, Sai Ma, Qinghua Niu, Fan Li, Tianwu Xie, Yingyu Cai

المصدر: Frontiers in Oncology, Vol 13 (2023)

مصطلحات موضوعية: automatic segmentation, contrast-enhanced ultrasound, renal tumors, deep learning, UNet, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: ObjectiveTo investigate the feasibility and efficiency of automatic segmentation of contrast-enhanced ultrasound (CEUS) images in renal tumors by convolutional neural network (CNN) based models and their further application in radiomic analysis.Materials and methodsFrom 94 pathologically confirmed renal tumor cases, 3355 CEUS images were extracted and randomly divided into training set (3020 images) and test set (335 images). According to the histological subtypes of renal cell carcinoma, the test set was further split into clear cell renal cell carcinoma (ccRCC) set (225 images), renal angiomyolipoma (AML) set (77 images) and set of other subtypes (33 images). Manual segmentation was the gold standard and serves as ground truth. Seven CNN-based models including DeepLabV3+, UNet, UNet++, UNet3+, SegNet, MultilResUNet and Attention UNet were used for automatic segmentation. Python 3.7.0 and Pyradiomics package 3.0.1 were used for radiomic feature extraction. Performance of all approaches was evaluated by the metrics of mean intersection over union (mIOU), dice similarity coefficient (DSC), precision, and recall. Reliability and reproducibility of radiomics features were evaluated by the Pearson coefficient and the intraclass correlation coefficient (ICC).ResultsAll seven CNN-based models achieved good performance with the mIOU, DSC, precision and recall ranging between 81.97%-93.04%, 78.67%-92.70%, 93.92%-97.56%, and 85.29%-95.17%, respectively. The average Pearson coefficients ranged from 0.81 to 0.95, and the average ICCs ranged from 0.77 to 0.92. The UNet++ model showed the best performance with the mIOU, DSC, precision and recall of 93.04%, 92.70%, 97.43% and 95.17%, respectively. For ccRCC, AML and other subtypes, the reliability and reproducibility of radiomic analysis derived from automatically segmented CEUS images were excellent, with the average Pearson coefficients of 0.95, 0.96 and 0.96, and the average ICCs for different subtypes were 0.91, 0.93 and 0.94, respectively.ConclusionThis retrospective single-center study showed that the CNN-based models had good performance on automatic segmentation of CEUS images for renal tumors, especially the UNet++ model. The radiomics features extracted from automatically segmented CEUS images were feasible and reliable, and further validation by multi-center research is necessary.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fonc.2023.1166988/fullTest; https://doaj.org/toc/2234-943XTest

الوصول الحر: https://doaj.org/article/ff3aa800550b411c908c0a907f3d08e4Test

المؤلفون: Hongmei Liang, Weichen Wang, Yueyang Sun, Haiying Wang

المصدر: Frontiers in Psychology, Vol 13 (2022)

مصطلحات موضوعية: township teachers, teachers’ professional well-being, job-related stress, teachers’ professional identity, perceived organizational support, Psychology, BF1-990

الوصف: This study aimed to explore the relationship between job-related stress and township teachers’ professional well-being. Based on Job Demand-Resource Model, this study examined the mediating role of teachers’ professional identity and the moderating role of perceived organizational support in this relationship. A total of 24,276 township teachers in China responded to the Teacher Stress Scale, the Teachers’ Professional Identity Scale, the Teachers’ Professional Well-Being Structure Questionnaire, and the Perceived Organizational Support Scale. Results showed that: (1) the professional well-being of township teachers differed significantly in terms of school type and demographic characteristics like age and gender; (2) job-related stress negatively predicted township teachers’ professional well-being, with teachers’ professional identity playing a mediating role; (3) the relation between job-related stress and teachers’ professional identity was moderated by perceived organizational support; and (4) in the moderated mediation analysis, job-related stress positively predicted township teachers’ professional well-being. These findings indicated that township teachers’ professional well-being was influenced by both organizational and individual factors, which provided a theoretical basis and intervention pathways for improving township teachers’ professional well-being.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1000441/fullTest; https://doaj.org/toc/1664-1078Test

الوصول الحر: https://doaj.org/article/2364bf95d19049d4991e825b943a5a70Test

المؤلفون: Yaqin Xu, Yingying Dong, Yunhua Deng, Qianrong Qi, Mi Wu, Hongmei Liang, Qiuyun She, Qing Guo

المصدر: Biology, Vol 10, Iss 5, p 432 (2021)

مصطلحات موضوعية: competing endogenous RNAs network, long non-coding RNAs, microRNAs, cutaneous squamous cell carcinoma, Biology (General), QH301-705.5

الوصف: A cutaneous squamous cell carcinoma (cSCC) derived from keratinocytes is the second most common cause of non-melanoma skin cancer. The accumulation of the mutational burden of genes and cellular DNA damage caused by the risk factors (e.g., exposure to ultraviolet radiation) contribute to the aberrant proliferation of keratinocytes and the formation of a cSCC. A cSCC encompasses a spectrum of diseases that range from recursor actinic keratosis (AK) and squamous cell carcinoma (SCC) in situ (SCCIS) to invasive cSCCs and further metastatic SCCs. Emerging evidence has revealed that lncRNAs are involved in the biological process of a cSCC. According to the ceRNA regulatory theory, lncRNAs act as natural miRNA sponges and interact with miRNA response elements, thereby regulating the mRNA expression of their down-stream targets. This study was designed to search for the potential lncRNAs that may become potential therapeutic targets or biomarkers of a cSCC. Considering the spirit of the study to be adequately justified, we collected microarray-based datasets of 19 cSCC tissues and 12 normal skin samples from the GEO database (GSE42677 and GSE45164). After screening the differentially expressed genes via a limma package, we identified 24 differentially expressed lncRNAs (DElncRNAs) and 3221 differentially expressed mRNAs (DEmRNAs). The miRcode, miRTarBase, miRDB and TargetScan databases were used to predict miRNAs that could interact with DElncRNAs and DEmRNAs. A total of 137 miRNA-lncRNA and 221 miRNA-mRNA pairs were retained in the ceRNA network, consisting of 31 miRNAs, 11 DElncRNAs and 155 DEmRNAs. For the functional analysis, the top enriched biological process was enhancer sequence-specific DNA binding in Gene Ontology (GO) terms. The FoxO signaling pathway, autophagy and cellular senescence were the top enrichment terms based on a Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. The combination of a STRING tool and Cytoscape software (plug-in MCODE) identified five core mRNAs and built a core mRNA-associated ceRNA network. The expression for five identified core mRNAs and their related nine lncRNAs was validated using the external dataset GSE7553. Finally, one lncRNA HLA-F-AS1 and three mRNAs named AGO4, E2F1 and CCND1 were validated with the same expression patterns. We speculate that lncRNA HLA-F-AS1 may sponge miR-17-5p or miR-20b-5p to regulate the expression of CCND1 and E2F1 in the cSCC. The present study may provide potential diagnostic and therapeutic targets for cSCC patients.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2079-7737/10/5/432Test; https://doaj.org/toc/2079-7737Test

الوصول الحر: https://doaj.org/article/d09d680cfda745ebb37c660c6449384aTest

المؤلفون: Si ZHANG, Zhaolian LU, Hongmei LIANG, Ximei FU, Yan ZHANG, Xin LIU, Genshu BAO, Tao JING, Xuan WANG, Meng WANG, Julong WU, Gen CHEN

المصدر: Iranian Journal of Public Health, Vol 44, Iss 8 (2015)

مصطلحات موضوعية: Caenorhabditis elegans, 5-Fluorouracil, Digital gene expression, Public aspects of medicine, RA1-1270

الوصف: Background: 5-Fluorouracil could lead to a decline in fertility in Caenorhabditis elegans. The aim of this study was to describe the mechanisms underlying such an altered fertility phenotype and to illustrate the specific genes and path-ways that are involved in the related phenotypic changes in C. elegans. Methods: We isolated total RNA from the samples and used a new method called Digital Gene Expression (DGE), which can rapidly identify genes with altered transcript levels. The random genes were confirmed by real-time RT-PCR. Results: We analyzed the results of two methods to draw conclusions based on a comparison between C. elegans and other harmful parasites. Compared with controls, 1147 genes were up-regulated, and 1067 were down-regulated. Overall, 101 up-regulated genes had a log2 ratio higher than 8, whereas the log2 ratio of 141 down-regulated genes was higher than 8. After mapping to the reference database, 4 pathways were confirmed to be involved in this phe-nomenon, with statistically significant participation from 19 genes. Conclusion: For the first time, the transcript sequence of 5-Fu-treated worms and controls was detected. We found that 4 possible pathways, i.e., ECM-receptor interaction pathway, TGF-beta signaling pathway, Focal adhesion and Hypertrophic cardiomyopathy, may be involved in the number decline in the embryos of C. elegans. Specifically, the ECM-receptor interaction pathway and Focal adhesion may be very important pathways that alter the reproduction of C. elegans.

وصف الملف: electronic resource

العلاقة: https://ijph.tums.ac.ir/index.php/ijph/article/view/3356Test; https://doaj.org/toc/2251-6085Test; https://doaj.org/toc/2251-6093Test

الوصول الحر: https://doaj.org/article/83a90c6650494ad89bb8d92bd5f2ce4eTest

المؤلفون: Lin Zhou, Wei Liang, Yuxiu He, Yanping Duan, Ryan E. Rhodes, Hao Liu, Hongmei Liang, Xiaowei Shi, Jun Zhang, Yingzhe Cheng

المصدر: International Journal of Environmental Research and Public Health; Volume 19; Issue 14; Pages: 8586

مصطلحات موضوعية: physical activity, sedentary time, sleep, obesity, body fat percent, fat-free mass, skeletal muscle mass, children

جغرافية الموضوع: agris

الوصف: 24 h movement behaviors, specifically physical activity (PA), sedentary behavior, and sleep, play a crucial role in the prevention and intervention of childhood obesity. This study aimed to examine the association of 24 h movement behaviors with weight status and body composition among Chinese primary school children. Using a random stratified sampling, 978 eligible participants (9.1 ± 1.4 years, 53.2% boys) were recruited from 1 May to 15 July 2021. Demographics included children’s age, gender, grade, parents’ education level, and household income. Movement behaviors were measured by validated self-reported scales. Weight status and body composition (percent of body fat, PBF; fat-free mass, FFM; skeletal muscle mass, SMM) were measured objectively. Results indicated that participants who were younger, boys, and at lower grade showed higher guidelines adherence. PA was inversely associated with PBF, while screen time (ST) was positively associated with overweight/obesity risk and FFM. Sleep showed no association with any health indicators. Meeting the behavioral guidelines was associated with better weight status and lower PBF, yet not with FFM and SMM. Interventions to improve the Children’s weight status and PBF should involve enhancing their overall movement behaviors and considering their demographic differences. More research on examining the association of movement guidelines adherence with body composition indicators is needed.

وصف الملف: application/pdf

العلاقة: Health Behavior, Chronic Disease and Health Promotion; https://dx.doi.org/10.3390/ijerph19148586Test

الإتاحة: https://doi.org/10.3390/ijerph19148586Test

المؤلفون: Mengshi Wang, Youzhi Song, Wenjuan Wei, Hongmei Liang, Yanyan Yi, Xiaolin Wang, Dongsheng Ren, Li Wang, Jianlong Wang, Yen Wei, Xiangming He, Yang Yang

المصدر: Matter. 6:873-886

مصطلحات موضوعية: General Materials Science

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2aec27d3deb1a803766a17891739bfe7Test
https://doi.org/10.1016/j.matt.2022.12.014Test

المؤلفون: Youzhi Song, Li Wang, Li Sheng, Dongsheng Ren, Hongmei Liang, Yiding Li, Aiping Wang, Hao Zhang, Hong Xu, Xiangming He

المصدر: Energy & Environmental Science. 16:1943-1963

مصطلحات موضوعية: Nuclear Energy and Engineering, Renewable Energy, Sustainability and the Environment, Environmental Chemistry, Pollution

الوصف: Crosstalk phenomenon between the cathode and anode, that is, the diffusion of parasitic products across separator to counter electrode, is receiving intensive attention because of its significant effect on high-energy battery life and safety.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fd11f0b1b073b765137c8c889653f37fTest
https://doi.org/10.1039/d3ee00441dTest