المؤلفون: Ki-Ho Park, Ye Ji Jung, Hyun Jung Lee, Hong Jun Kim, Chi Hoon Maeng, Sun Kyung Baek, Jae Joon Han, Woojae Jeon, Dong Youn Kim, Yu-Mi Lee, Mi Suk Lee

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

مصطلحات موضوعية: Hematological cancer, Bloodstream infection, Multidrug-resistant organisms, Outcome, Mortality, Medicine, Science

الوصف: Abstract Despite the improved outcomes in patients with hematological malignancies, infections caused by multidrug-resistant organisms (MDROs) pose a new threat to these patients. We retrospectively reviewed the patients with hematological cancer and bacterial bloodstream infections (BSIs) at a tertiary hospital between 2003 and 2022 to assess the impact of MDROs on outcomes. Among 328 BSIs, 81 (24.7%) were caused by MDROs. MDRO rates increased from 10.3% (2003–2007) to 39.7% (2018–2022) (P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-2322Test

الوصول الحر: https://doaj.org/article/3d608b21897e447d82ee253e662fda5aTest

المؤلفون: Hong Jun Kim, Xing Hao Jin, Sun Woo Kang, Yoo Yong Kim

المصدر: Animal Bioscience, Vol 36, Iss 12, Pp 1860-1868 (2023)

مصطلحات موضوعية: blood profiles, gestating sow, piglets, trace mineral level, Zoology, QL1-991

الوصف: Objective This study was conducted to evaluate the effects of optimal trace mineral levels on the physiological responses, reproductive performance, litter performance, blood profiles and milk composition in gestating sows. Methods A total of 59 multiparous sows (Yorkshire×Landrace) with similar body weight (BW), backfat thickness (BF), and parity were assigned to one of four treatments with 14 or 15 sows per treatment using a completely randomized design. The treatments were 100% (M1), 300% (M3), 600% (M6), and 900% (M9) of the National Research Council (NRC) Nutrient Requirements of Swine. During lactation period, all the sows were fed the same commercial lactation diet. Results No significant differences were observed in the BW, BF, reproductive performance, milk composition, or growth performance of the piglets. On day 70 of gestation, the serum zinc concentration showed a quadratic response to M6 treatment (quadratic, p

وصف الملف: electronic resource

العلاقة: http://www.animbiosci.org/upload/pdf/ab-23-0193.pdfTest; https://doaj.org/toc/2765-0189Test; https://doaj.org/toc/2765-0235Test

الوصول الحر: https://doaj.org/article/4c104127891a49a7b48f0cfa455cbe6fTest

المؤلفون: Xing Hao Jin, Hong Jun Kim, Cheon Soo Kim, Yoo Yong Kim

المصدر: Animal Bioscience, Vol 36, Iss 7, Pp 1083-1090 (2023)

مصطلحات موضوعية: lactating sows, litter performance, milk composition, selenium, Zoology, QL1-991

الوصف: Objective This study was conducted to evaluate the short-term effects of dietary selenium supplementation on lactating sows on the physiological response, litter performance, milk composition, and tissue selenium retention in piglets when selenium was provided by different sources and at different levels in a lactation diet. Methods A total of 48 multiparous sows (Yorkshire×Landrace) with average body weight, backfat thickness, and parity were assigned to one of the four treatments with 12 sows per treatment using a 2×2 factorial arrangement in a completely randomized design. Inorganic or organic Se sources were added to the diet at 0.30 ppm and 0.50 ppm Se. Treatments were as follows: i) IS30, basal diet + inorganic Se 0.30 ppm; ii) IS50, basal diet + inorganic Se 0.50 ppm; iii) OS30, basal diet + organic Se 0.30 ppm; and iv) OS50: basal diet + organic Se 0.50 ppm. Results At Day 21 of lactation, a high tendency of litter weight (p = 0.08) and litter weight gain (p = 0.09) were observed when sows were fed an organic Se source. The milk Se concentration in the organic Se treatment was higher than that in the inorganic Se treatment at Day 21 of lactation (p

وصف الملف: electronic resource

العلاقة: http://www.animbiosci.org/upload/pdf/ab-22-0425.pdfTest; https://doaj.org/toc/2765-0189Test; https://doaj.org/toc/2765-0235Test

الوصول الحر: https://doaj.org/article/cf57a30aad084773b15843911ecdd63fTest

المؤلفون: Tae Wook Goh, Hong Jun Kim, Kunyong Moon, Yoo Yong Kim

المصدر: Animal Bioscience, Vol 36, Iss 6, Pp 929-942 (2023)

مصطلحات موضوعية: β-glucan, economic benefit, growing and finishing pig, growth performance, vitamin e, Zoology, QL1-991

الوصف: Objective This study was conducted to evaluate the effects of β-glucan with vitamin E supplementation on the growth performance, blood profiles, immune response, pork quality, pork flavor, and economic benefit in growing and finishing pigs. Methods A total of 140 growing pigs ([Yorkshire×Landrace]×Duroc) were assigned to five treatments considering sex and initial body weight (BW) in 4 replications with 7 pigs per pen in a randomized complete block design. The experimental diets included a corn-soybean meal-based basal diet with or without 0.05% or 0.1% β-glucan and 0.02% vitamin E. The pigs were fed the diets for 12 weeks (phase I, 0 to 3; phase II, 3 to 6; phase III, 6 to 9; phase IV, 9 to 12). The BW and feed intake were measured at the end of each phase. Blood samples were collected at the end of each phase. Four pigs from each treatment were selected and slaughtered for meat quality. Economic benefit was calculated considering the total feed intake and feed price. Pork flavor was analyzed through inosine monophosphate analysis. Results The average daily gain and feed efficiency were improved compared to the control when β-glucan or vitamin E was added. Supplementing 0.05% β-glucan significantly increased the lymphocyte concentration compared to the addition of 0.1% β-glucan and the content of vitamin E in the blood increased when 0.02% vitamin E was added. The treatment with 0.1% β-glucan and 0.02% vitamin E showed the most economic effect because it had the shortest days to market weight and the lowest total feed cost. The addition of β-glucan or vitamin E had a positive role in improving the flavor of pork when considering that the content of inosine monophosphate was increased. However, carcass traits and meat quality were not affected by β-glucan or vitamin E. Conclusion The addition of 0.1% β-glucan with 0.02% vitamin E in growing and finishing pig diets showed great growth performance and economic effects by supplying vitamin E efficiently and by improving the health condition of pigs due to β-glucan.

وصف الملف: electronic resource

العلاقة: http://www.animbiosci.org/upload/pdf/ab-22-0433.pdfTest; https://doaj.org/toc/2765-0189Test; https://doaj.org/toc/2765-0235Test

الوصول الحر: https://doaj.org/article/f0a6ed1a019f4402801ed078c83b058cTest

المؤلفون: Tae Wook Goh, Hong Jun Kim, Kunyong Moon, Cheon Soo Kim, Yoo Yong Kim

المصدر: Animal Bioscience, Vol 36, Iss 4, Pp 642-653 (2023)

مصطلحات موضوعية: fecal score, β-glucan, growth performance, intestinal microbiota, vitamin e, weaning pigs, Zoology, QL1-991

الوصف: Objective This study was conducted to evaluate effects of β-glucan with vitamin E supplementation on the growth performance, blood profiles, immune response, fecal microbiota, fecal score, and nutrient digestibility in weaning pigs. Methods A total of 200 weaning pigs with an average body weight (BW) of 7.64±0.741 kg were allotted to five treatment groups and were divided based on sex and initial BW in four replicates with ten pigs per pen in a randomized complete block design. The experimental diets included a corn-soybean meal-based basal diet with or without 0.1% or 0.2% β-glucan and 0.02% vitamin E. The pigs were fed the diets for 6 weeks. A total of 15 barrows were used to evaluate the nutrient digestibility by the total collection method. The BW and feed intake were measured at the end of each phase. Blood samples were collected at the end of each phase, and fecal samples were collected at the end of the experiment. Results The addition of β-glucan with vitamin E to weaning pig feed increased BW, average daily gain, and average daily feed intake. A significant decrease in yeast and mold and Proteobacteria and a tendency for Lactobacillus to increase compared to the control was shown when 0.1% β-glucan and 0.02% vitamin E were added. The fecal score in weaning pigs was lower in the treatments supplemented with 0.1% or 0.2% β-glucan and 0.02% vitamin E compared to the control. In addition, vitamin E was better supplied to weaning pigs by increasing the concentration of α-tocopherol in the blood of weaning pigs when 0.02% vitamin E was supplemented. However, there was no significant difference in either the immune response or nutrient digestibility. Conclusion Inclusion of 0.1% β-Glucan with 0.02% vitamin E in a weaning pig’s diet were beneficial to the growth performance of weaning pigs by improving intestinal microbiota and reducing the incidence of diarrhea.

وصف الملف: electronic resource

العلاقة: http://www.animbiosci.org/upload/pdf/ab-22-0311.pdfTest; https://doaj.org/toc/2765-0189Test; https://doaj.org/toc/2765-0235Test

الوصول الحر: https://doaj.org/article/a7074b54945f409b83428d7d52689bedTest

المؤلفون: Tae Wook Goh, Jinsu Hong, Hong Jun Kim, Sun Woo Kang, Yoo Yong Kim

المصدر: Animal Bioscience, Vol 36, Iss 2, Pp 264-274 (2023)

مصطلحات موضوعية: β-glucan, lactating sow, piglet, piglet growth performance, vitamin e, Zoology, QL1-991

الوصف: Objective This study was conducted to evaluate the effects of β-glucan with vitamin E supplementation on the physiological response, litter performance, blood profiles, immune response, and milk composition of lactating sows. Methods A total of 50 multiparous F1 sows (Yorkshire×Landrace) with an average body weight (BW) of 233.6±4.30 kg and an average parity of 4.00±0.307 and their litters were used in this experiment. All sows were allotted to one of five treatments, taking into consideration BW, backfat thickness, and parity in a completely randomized design with 10 replicates. The experimental diets included a corn–soybean meal-based basal diet with or without 0.1% or 0.2% β-glucan and 110 IU vitamin E/kg diet. Results All treatments added with β-glucan or vitamin E were statistically higher in the average daily feed intake (ADFI) of lactating sows compared to those of the control (Diet, p

وصف الملف: electronic resource

العلاقة: http://www.animbiosci.org/upload/pdf/ab-22-0204.pdfTest; https://doaj.org/toc/2765-0189Test; https://doaj.org/toc/2765-0235Test

الوصول الحر: https://doaj.org/article/d238e3b668ca4b97b08cb9fcc889971bTest

المؤلفون: Jung Seok Lee, Hong Jun Kim, Joong-Goo Kim

المصدر: Journal of Neurocritical Care, Vol 15, Iss 2, Pp 131-135 (2022)

مصطلحات موضوعية: covid-19, encephalomyelitis, acute disseminated encephalomyelitis, immunotherapy, neuroimaging, Neurology. Diseases of the nervous system, RC346-429

الوصف: Background Acute disseminated encephalomyelitis (ADEM)-like white matter disease, a rare complication of coronavirus disease 2019 (COVID-19), is a potentially life-threatening neurological disorder. The objective of this study was to report the successful treatment of post–COVID-19 ADEM with urgent immunotherapy and neurointensive management. Case Report A 53-year-old female patient was referred to our hospital with a 2-day history of progressive mental deterioration and was diagnosed with ADEM after COVID-19. The patient's symptoms worsened despite the administration of high-dose steroids, and targeted temperature management was employed to manage brain edema. Additionally, the neurointensivist decided to use intravenous immunoglobulin early for intractable post–COVID-19 ADEM. Her mental status and neuroimaging findings showed rapid improvement at about 3 months after admission. Conclusion This case highlights that if the patient's symptoms worsen despite high-dose steroid administration in the acute stage, early use of intravenous immunoglobulin is expected to have a positive effect on the prognosis of patients with post–COVID-19 ADEM.

وصف الملف: electronic resource

العلاقة: http://www.e-jnc.org/upload/pdf/jnc-220078.pdfTest; https://doaj.org/toc/2005-0348Test; https://doaj.org/toc/2508-1349Test

الوصول الحر: https://doaj.org/article/c81b38df078245d8927cb586ff075e56Test

المؤلفون: Hong Jun Kim, Sa-Yoon Kang

المصدر: Journal of Medicine and Life Science, Vol 19, Iss 3, Pp 134-136 (2022)

مصطلحات موضوعية: cerebellum, essential tremor, transcranial direct current stimulation, Medicine

وصف الملف: electronic resource

العلاقة: http://www.e-jmls.org/upload/pdf/jmls-2022-19-3-134.pdfTest; https://doaj.org/toc/2671-4922Test

الوصول الحر: https://doaj.org/article/56030d43f92a4366a7484e7e9970c658Test

المؤلفون: Yaewon Yang, Hong Jun Kim, Se-il Go, Woo Kyun Bae, Eun-Kee Song, Seonggyu Byeon, Hee Kyung Kim, Yusook Jeong, Jihyun Kwon, Ki Hyeong Lee, Hee Bok Chae, Seung-Myoung Son, Dae Hoon Kim, Hyo Yung Yun, Hye Sook Han

المصدر: The Korean Journal of Helicobacter and Upper Gastrointestinal Research, Vol 22, Iss 1, Pp 38-49 (2022)

مصطلحات موضوعية: ascites, biomakers, tumor, diagnosis, stomach neoplasms, Internal medicine, RC31-1245

الوصف: Background/Aims Peritoneal carcinomatosis with malignant ascites is common in patients with advanced gastric cancer (GC). The detection of tumor cells is the gold standard for the diagnosis of malignant ascites; however, it often requires complementary tests because of its low sensitivity. Herein, we measured the levels of tumor markers in the malignant ascites of GC patients (GC-ascites) and benign ascites of liver cirrhosis patients (LC-ascites) to elucidate the diagnostic value of tumor markers in GC-ascites. Materials and Methods The levels of CEA, cancer antigen 72-4 (CA 72-4), CA 19-9, and CA 125 were measured in 138 GC-ascites and 64 LC-ascites samples obtained from the National Biobank of Korea. We performed receiver operating characteristic curve analysis to determine the optimal cutoff value for each tumor marker. Results CEA, CA 72-4, and CA 19-9 levels were significantly higher in GC-ascites than in LC-ascites. There was no difference in tumor marker levels between GC-ascites samples irrespective of cytology. CEA, CA 72-4, and CA 19-9 had sensitivities of 85.5%, 79.0%, and 61.6%, respectively, and specificities of 96.8%, 100.0%, and 89.1%, respectively, for distinguishing GC-ascites samples from LC-ascites samples. The diagnostic accuracy was improved by combining two or more tumor markers. The combination of CEA and CA 72-4 showed the highest sensitivity (86.2%) and specificity (100%). Conclusions Measurement of tumor markers, such as CEA, CA 72-4, and CA 19-9, in ascites samples could help diagnose GC-ascites, and combining two or more tumor markers could further increase the diagnostic yield, even in cytology-negative patients.

وصف الملف: electronic resource

العلاقة: http://helicojournal.org/upload/pdf/kjhugr-2021-0058.pdfTest; https://doaj.org/toc/1738-3331Test

الوصول الحر: https://doaj.org/article/46b4f70e956e4ac488355d437999a76cTest

المؤلفون: Joong-Goo Kim, Jay Chol Choi, Hong Jun Kim, Jong Kook Rhim, Tae Jun Jung, Chang-Lim Hyun, Jin Deok Joo

المصدر: Journal of Neurocritical Care, Vol 14, Iss 2, Pp 98-102 (2021)

مصطلحات موضوعية: tuberous sclerosis, astrocytoma, stroke, intracranial pressure, hydrocephalus, Neurology. Diseases of the nervous system, RC346-429

الوصف: Background Acute increased intracranial pressure (IICP) is a life-threatening condition that requires urgent treatment. Rapid IICP with hydrocephalus may be complicated by ischemic stroke, convulsions, loss of consciousness, brain herniation, and death. Extremely rare complications include intracranial vessel entrapment and ischemic stroke due to sudden IICP in cases with benign tumors. Case Report We report a case of bilateral posterior cerebral artery region infarction and complicated hydrocephalus with subependymal giant cell astrocytoma in a patient with tuberous sclerosis. Conclusion We postulate that the temporary IICP induced by seizure led to transient bilateral posterior cerebral artery entrapment, causing ischemic stroke without vascular occlusion.

وصف الملف: electronic resource

العلاقة: http://e-jnc.org/upload/pdf/jnc-210034.pdfTest; https://doaj.org/toc/2005-0348Test; https://doaj.org/toc/2508-1349Test

الوصول الحر: https://doaj.org/article/2e1c7a778daa4c6d9e6eb5ada5e2d4b9Test