المؤلفون: Moushira Zaki, Hisham A. Orban, Marwa Mahmoud, Eman R. Youness, Hoda F. Booles, Wagdy K. B. Khalil, Wafaa Wafy, Kamal A. El-Atrebi, Khaled Hamed, Hala T. El-Bassyouni

المصدر: Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-7 (2024)

مصطلحات موضوعية: Adropin, cDNA, FGF-1, Inflammatory bowel disease, TLR1, Medicine (General), R5-920, Genetics, QH426-470

الوصف: Abstract Background Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of unknown etiology and unpredictable course. The aim of the work was to assess the levels of adropin, fibroblast growth factor-1 (FGF-1), and Toll-like receptor-1 (TLR1) biomarkers in IBD patients compared to controls and evaluate the gene expression of TNF-α as a marker of disease severity. Methods Adropin, fasting serum FGF-1 levels, TLR1, and TNF-α were measured in 60 IBD patients. They were also compared with 58 healthy controls matching age and gender. Moreover, the blood cells cDNA copy number of TNF-α were determined as a marker of severity. Results Adropin and TLR1 levels were significantly lower in patients than controls. FGF-1 was reduced but not statistically significant. The expression of TNF-α gene in the IBD patients was significantly increased (42%) in comparison with control samples (P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2090-2441Test

الوصول الحر: https://doaj.org/article/fdf4fdd43cfb42c3bd378172c6b1d881Test

المؤلفون: Hesham A. Eissa, Zeinab Y. Abdallah, Wagdy K.B. Khalil, Wafaa A. Ibrahim, Hoda F. Booles, Mahrousa M. Hassanane

المصدر: Journal of Genetic Engineering and Biotechnology, Vol 15, Iss 2, Pp 443-451 (2017)

مصطلحات موضوعية: PAL enzyme, Egg white, Mushroom flour, PKU, DNA, Mice, Biotechnology, TP248.13-248.65, Genetics, QH426-470

الوصف: PKU patients react to therapy with a low phenylalanine diet, but adherence to this diet is troublesome, subsequently the expansion of alternative ways is demand. Phenylalanine ammonia lyase (PAL) is one of this ways, which converts phenylalanine to harmless metabolites; trans-cinnamic acid and ammonia. In the current study, the extraction of PAL enzyme was used to investigate the efficiency for production of functional PKU egg white and mushroom flour with good quality by evaluation of colour characteristics, determination of phenylalanine concentrations and genetic materials expression of PKU related genes and DNA damage. Results indicated that the PAL enzyme treated of egg white and mushroom flour was stable colour and the calculated reduction per cent in phenylalanine concentration from female mice fed on untreated and PAL–treated samples was 22.77% in egg white and 31.37% in mushroom flour. Also, the results revealed that female mice fed on diet contained treated egg white exhibited low expression levels of PKU exons (3, 6, 7, 11, and 12) and low DNA damage which were similar to those in control mice.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1687157X17300689Test; https://doaj.org/toc/1687-157XTest

الوصول الحر: https://doaj.org/article/9e95dc4b16d7457094c5094b819f334bTest

المؤلفون: Nahla Radwan, Hanan Farouk Aly, Somaia A. Abd Elkarim, Manal M. Anwar, Yasmin M. Seyam, Samia A. Segeni, Kawkab A. Ahmed, Hoda F. Booles, Mohamed B. Shalaby, Wagdy K. B. Khalil, Rajat Sandhir, Sonam Deshwal, Maha Z. Rizk

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0d7699deb511dcbdbcd7c20ebb5866e7Test
https://doi.org/10.2139/ssrn.4391587Test

المؤلفون: Hoda F. Booles, Hesham A. Eissa, Wagdy K. B. Khalil, Zeinab Y. Abdallah, Wafaa A. Ibrahim, Mahrousa M. Hassanane

المصدر: Journal of Genetic Engineering and Biotechnology, Vol 15, Iss 2, Pp 443-451 (2017)
Journal of Genetic Engineering & Biotechnology

مصطلحات موضوعية: 0301 basic medicine, lcsh:QH426-470, DNA damage, lcsh:Biotechnology, Low phenylalanine diet, Phenylalanine, Phenylalanine ammonia-lyase, Biology, 03 medical and health sciences, Mice, 0302 clinical medicine, lcsh:TP248.13-248.65, General Materials Science, Food science, Gene, PAL enzyme, chemistry.chemical_classification, Mushroom, DNA, Animal Biotechnology, humanities, lcsh:Genetics, 030104 developmental biology, Enzyme, Mushroom flour, chemistry, PKU, Egg white, 030217 neurology & neurosurgery

الوصف: PKU patients react to therapy with a low phenylalanine diet, but adherence to this diet is troublesome, subsequently the expansion of alternative ways is demand. Phenylalanine ammonia lyase (PAL) is one of this ways, which converts phenylalanine to harmless metabolites; trans-cinnamic acid and ammonia. In the current study, the extraction of PAL enzyme was used to investigate the efficiency for production of functional PKU egg white and mushroom flour with good quality by evaluation of colour characteristics, determination of phenylalanine concentrations and genetic materials expression of PKU related genes and DNA damage. Results indicated that the PAL enzyme treated of egg white and mushroom flour was stable colour and the calculated reduction per cent in phenylalanine concentration from female mice fed on untreated and PAL–treated samples was 22.77% in egg white and 31.37% in mushroom flour. Also, the results revealed that female mice fed on diet contained treated egg white exhibited low expression levels of PKU exons (3, 6, 7, 11, and 12) and low DNA damage which were similar to those in control mice.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21854537ba226ce33cad3dd49f6e68cfTest
http://www.sciencedirect.com/science/article/pii/S1687157X17300689Test

المؤلفون: Jihan Hussein, Dalia Medhat, Wagdy K. B. Khalil, Safaa Morsy, Mehrez E. El-Naggar, Abdel Razik H. Farrag, Hoda F. Booles, Yasmine Abdel Latif, Mohamed F. Attia, Mona Anwar, Zakaria El-Khayat

المصدر: Biomedicine & Pharmacotherapy. 91:1006-1016

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Antioxidant, medicine.medical_treatment, Metal Nanoparticles, Antineoplastic Agents, Apoptosis, Caspase 3, 02 engineering and technology, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Antioxidants, Ehrlich ascites carcinoma, Mice, chemistry.chemical_compound, In vivo, medicine, Animals, Carcinoma, Ehrlich Tumor, Solid Carcinoma, Pharmacology, Dextrans, General Medicine, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Oxidative Stress, Dextran, Liver, chemistry, Cancer research, Female, Gold, Drug Screening Assays, Antitumor, 0210 nano-technology, Oxidative stress

الوصف: Dextran-capped gold nanoparticles (Au-dextran NPs) were prepared exploiting the natural polysaccharide polymer as both reducing and stabilizing agent in the synthesis process, aiming at studying their antitumor effect on solid carcinoma and EAC-bearing mice. To this end, Au-dextran NPs were designed via simple eco-friendly chemical reaction and they were characterized revealing the monodispersed particles with narrow distributed size of around 49nm with high negative charge. In vivo experiments were performed on mice. Biochemical analysis of liver and kidney functions and oxidation stress ratio in addition to histopathological investigations of such tumor tissues were done demonstrating the potentiality of Au-dextran NPs as antitumor agent. The obtained results revealed that EAC and solid tumors caused significant increase in liver and kidney functions, liver oxidant parameters, alpha feto protein levels and diminished liver antioxidant accompanied by positive expression of tumor protein p53 of liver while the treatment with Au-dextran NPs for both types caused improvement in liver and kidney functions, increased liver antioxidant, increased the expression level of B-cell lymphoma 2 gene and subsequently suppressed the apoptotic pathway. As a result, the obtained data provides significant antitumor effects of the Au-dextran NPs in both Ehrlich ascites and solid tumor in mice models.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0a7b3e4cdee4583874530c1c44f7d5Test
https://doi.org/10.1016/j.biopha.2017.05.043Test

المؤلفون: Hanan F. Aly, Hoda F. Booles, Farouk El-Baz, Wagdy K. B. Khalil

المصدر: International Journal of Pharma and Bio Sciences. 7

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Reactive oxygen species, Antioxidant, Lipid peroxide, medicine.medical_treatment, Cell Biology, Glutathione, Berry, Pharmacology, Biology, Biochemistry, PON1, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Enzyme, chemistry, Apoptosis, medicine, Molecular Biology, 030217 neurology & neurosurgery, Biotechnology

الوصف: This study was designed to evaluate the neuro-ameliorative effect of red (Morus rubra) and white berry (Morus alba) extracts against Alzheimers disease (AD) in male rats. AlCl3 was administered orally to male albino rats (100 mg/kg/day for 6 weeks) while, berry extracts (300 mg/kg/day for six weeks) was administered orally post AlCl3 administration. The data showed markedly elevation in lipid peroxide, apoptotic marker enzyme (caspase-8) and calmodulin (CaM) levels while, reduced glutathione (GSH) level and antioxidant enzyme; paraoxanase-1 (PON1) were reduced in AD rats when compared with normal control one. The treatment of rats with AlCl3 induced AD was associated with increase in the 8- OHdG/2-dG ratio and decreased the expression of DHCR24 and FKBP1B genes. However, the treatment of AD-induced rats with red and white berry extracts exhibited low 8-OHdG/ 2-dG ratio and increase the expression of the DHCR24 and FKBP1B genes. The results suggested the attenuated role of berry extracts which could be attributed to the inhibition of reactive oxygen species (ROS), increase in the antioxidant enzymes activity as well as inhibition in the occurrence of apoptotic related enzymes such as caspases-8.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e829a2481fb2d4f67cc5562e9ab27480Test
https://doi.org/10.22376/ijpbs.2016.7.4.b548-558Test

المؤلفون: Hanaa H. Ahmed, Hoda F. Booles, Nevein N. Fadl, AH Sayed

المصدر: Human & Experimental Toxicology. 32:721-735

مصطلحات موضوعية: Male, Proteases, Disintegrins, Health, Toxicology and Mutagenesis, Rat model, Disease, Biology, Toxicology, Serine, ADAM10 Protein, chemistry.chemical_compound, Alzheimer Disease, Transforming Growth Factor beta, Animals, Cholinesterases, Subtilisins, fas Receptor, Insulin-Like Growth Factor I, Interleukin-6, Brain-Derived Neurotrophic Factor, Proteolytic enzymes, Brain, General Medicine, Pathophysiology, Rats, ADAM Proteins, Disease Models, Animal, chemistry, Immunology, Nattokinase, Peptide Hydrolases

الوصف: Serrapeptase (SP) and nattokinase (NK) are proteolytic enzymes belonging to serine proteases. In this study, we hypothesized that SP and NK could modulate certain factors that are associated with Alzheimer’s disease (AD) pathophysiology in the experimental model. Oral administration of aluminium chloride (AlCl3) in a dose of 17 mg/kg body weight (bw) daily for 45 days induced AD-like pathology in male rats with a significant increase in brain acetylcholinesterase (AchE) activity, transforming growth factor β (TGF-β), Fas and interleukin-6 (IL-6) levels. Meanwhile, AlCl3 supplementation produced significant decrease in brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) when compared with control values. Also, AlCl3 administration caused significant decline in the expression levels of disintegrin and metalloproteinase domain 9 ( ADAM9) and a disintegrin and metalloproteinase domain 10 ( ADAM10) genes in the brain. Histological investigation of brain tissue of rat model of AD showed neuronal degeneration in the hippocampus and focal hyalinosis with cellular as well as a cellular amyloid plaques formation. Oral administration of SP or NK in a rat model of AD daily for 45 days resulted in a significant decrease in brain AchE activity, TGF-β, Fas and IL-6 levels. Also, the treatment with these enzymes produced significant increase in BDNF and IGF-1 levels when compared with the untreated AD-induced rats. Moreover, both SP and NK could markedly increase the expression levels of ADAM9 and ADAM10 genes in the brain tissue of the treated rats. These findings were well confirmed by the histological examination of the brain tissue of the treated rats. The present results support our hypothesis that the oral administration of proteolytitc enzymes, SP and/or NK, would have an effective role in modulating certain factors characterizing AD. Thus, these enzymes may have a therapeutic application in the treatment of AD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86428a9b4a55f3b1779e5a14e3633513Test
https://doi.org/10.1177/0960327112467040Test

المؤلفون: Wagdy K. B. Khalil, Hoda F. Booles, Hassan M. El Ashmaoui, Samir M. Othman, Hanaa H. Ahmed

المصدر: American Journal of Biochemistry and Biotechnology. 9:144-161

مصطلحات موضوعية: medicine.medical_specialty, Aché, medicine.medical_treatment, Neurodegeneration, Biology, medicine.disease, medicine.disease_cause, Biochemistry, Acetylcholinesterase, language.human_language, chemistry.chemical_compound, Insulin-like growth factor, Endocrinology, chemistry, Neurotrophic factors, Internal medicine, language, medicine, biology.protein, Cyclooxygenase, Oxidative stress, Biotechnology, Neurotrophin

الوصف: The present article aimed to investigate the potent ial role of the ethanolic extracts of the aerial pa rts of Jasonia candicans and Jasonia montana in management of Alzheimer’s Disease (AD) in experimental model. Supplementation of drinking water AlCl 3 (0.3%) for 16 weeks induced AD in male rats with siginifcant increase in brain Acetylcholinesterase (AchE) activity, Tumour Necrosis Factor (TNF-α), Transforming Growth Factor β (TGF-β) and 8 hydroxydeoxyguanosine (8-OHdG) levels. AlCl3 supplementation produced significant decrease in Br ain insulin Like Growth Factor (IGF-1) and Derived Neurotrophic Factor (BDNF) levels as compared to the control values. Also, AlCl 3 supplementation caused significant decline in the expression levels of nuc leoporin P 62 (P 62 ) and a disintegrin and metalloproteinase 17 (ADAM 17) genes accompanied with significant elevation in the expression levels of brain cyclooxygenase (Cox-2) gene. Brain histopa thological examination of AD-induced rats showed formation of amyloid plaques in hippocampus and cerebrum. Oral administration of each of selected extract (150 mg/kg b.wt) in AD-induced rats daily f or 6 weeks resulted in significant decrease in brai n AchE activity, TNF-α, TGF-β and 8-OHdG levels. The treatment produced signific ant increase in brain IGF-1 and BDNF levels as compared to AD-induced rats. The treatment with these extracts could significantly increase the gene expression levels o f brain P 62 and ADAM17 accompanied with significant decrease in the expression levels of Cox-2 gene in the brain. Histopathological examination of brain tissue of the treated rats showed marked improvement in the morphological structure of the brain especially in the hippocampus and cerebrum areas. H igh content of terpenes, sesquiterpenes and flavonoids in the ethanolic extract of the selected plants may responsible for the anticholinesterase activity, anti-inflammatory action, antioxidant cap acity and neurotrophic effect as well as antiamyloidogenic potential of these extracts. These re sults suggest that these extracts may effectively ameliorate the inflammation and neurodegeneration characterizing AD. Thus, these extracts may have a therapeutic application in the treatment of Alzheim er’s disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::46bcbb8d9e2ac235415b453e5b0360c3Test
https://doi.org/10.3844/ajbbsp.2013.144.161Test

المؤلفون: Hoda F. Booles, Wagdy K. B. Khalil

المصدر: Archives of Industrial Hygiene and Toxicology. 62:121-129

مصطلحات موضوعية: Male, CYP3A, Population, Gene Expression, chemistry.chemical_element, Apoptosis, Pharmacology, Toxicology, Cresols, Selenium, parasitic diseases, Gene expression, Animals, education, education.field_of_study, Inhalation, Reverse Transcriptase Polymerase Chain Reaction, Chemistry, Prostate, Public Health, Environmental and Occupational Health, Rats, Up-Regulation, Real-time polymerase chain reaction, Liver, Toxicity, Carcinogens

الوصف: Protective Role of Selenium Against Over-Expression of Cancer-Related Apoptotic Genes Induced ByO-Cresol in RatsCresols are monomethyl derivatives of phenol frequently used as solvents and intermediates in the production of disinfectants, fragrances, pesticides, dyes, and explosives, which is probably why they are widely distributed in the environment. General population may be exposed to cresols mainly through inhalation of contaminated air. In this study we evaluated the toxicological effects ofo-cresol on differential gene expression profile of rat liver and prostate. Experiments were conducted on 80 male rats, 60 of which were exposed too-cresol (1.5 g kg-1, 5 g kg-1, or 15 g kg-1) through feed for 8 weeks. Three groups of rats were supplemented with 0.1 mg kg-1selenium (Se, in the form of, sodium selenite) in addition too-cresol to evaluate its effectiveness againsto-cresol toxicity. Control group received neither o-cresol nor Se, while one group received Se alone. Survival was similar between the exposed and control animals. Rats exposed to 15 g kg-1ofo-cresol showed a 16 % loss in body weight by the end of the study, which may have been related too-cresol making feed unpalatable at this concentration. Liver and prostate tissue samples were collected at the end of the treatment. mRNA analysis revealed that apoptotic genes (CYP3A, COX-2, PPARγ, BAX, BCL2, AKT-1, and PKCα) related to cancer were up-regulated in liver and prostate tissues isolated from groups exposed to 5 g kg-1and 15 g kg-1o-cresol in comparison to control. Changes in gene expression profile were prevented when rats were supplemented with Se. The exact mechanisms underlying its protective effect remain to be clarified by future studies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654f744ca15ec754cc72c1c5ca4113e5Test
https://doi.org/10.2478/10004-1254-62-2011-2074Test

المؤلفون: Ekram S. Ahmed, Sabah Linjawi, Wagdy Kb Khalil, Hoda F. Booles

المصدر: Egyptian Journal of Genetics and Cytology. 40:61-80

مصطلحات موضوعية: chemistry.chemical_classification, education.field_of_study, Reactive oxygen species, biology, Population, Glutathione, Pharmacology, medicine.disease_cause, Lipid peroxidation, chemistry.chemical_compound, chemistry, Biochemistry, Gene expression, Amyloid precursor protein, biology.protein, medicine, education, Literature survey, Oxidative stress

الوصف: Oxidative stress-induced damage was shown to be one of the important mechanisms to indicate that aluminum has an association with the etiology of Alzheimer's disease (Kumar et al., 2009). Increased generation of reactive oxygen species (ROS) and lipid peroxidation has been found to be involved in the pathogenesis of many diseases of known and unknown etiology and in the toxic actions of many compounds (Andallu and Varadacharyulu, 2003). Aluminium is a nonredox active metal which is capable of increasing the cellular oxidative milieu by potentiating the pro-oxidant properties of transition metals such as iron and copper (Bjertness et al., 1996). An unusual aspect of the biochemistry of this non-redox active metal is its pro-oxidant activity, which might be explained by the formation of an Al superoxide semi-reduced biological macromolecules, including lipids, proteins, nucleic acids, and carbohydrates. The resulting stress increases neuronal death, which contributes to the neuropathology associated with several diseases (Baydas et al., 2003). Gene expression changes in the forebrain occur during normal and pathological aging. Altered gene expression is thought to contribute to the balance between normal aging and age-related memory disorders, including Alzheimer's dis- ease (AD) (Berchtold et al., 2008). Synap- tic dysfunction in AD is apparent before synapse and neuron loss and caused likely by accumulation of β-amyloid (Aβ) pep- tides (Selkoe, 2002). The cellular mecha- nisms underlying synaptic and memory dysfunction caused by altered activity- dependent gene transcription in AD are radical ion (AlO2) (Exley, 2005). It has largely unknown. Understanding the mobeen shown that chronic aluminium exposure is involved in the impairment of mitochondrial electron transport chain (ETC) and increased production of ROS (Kumar et al., 2008). The formation of excessive ROS and reactive nitrogen species (RNS) can lead to oxidative injury. Reactive oxygen species (ROS) interact with all lecular pathways regulating gene expression profiles in memory disorders may allow the identification of new signaling pathways for drug discovery (Altar et al., 2009). Several PCR techniques are used to determine the changes in the gene expression, in which the most aqurat one is Realtime-PCR (RT-PCR). It is became the most popular method of quantitating steady-state mRNA levels (Bustin, 2000). It is most often used for two reasons: either as a primary investigative tool to determine gene expression or as a secondary tool to validate the results of DNA microarrays. Because of the precision and sensitivity of real-time RT-PCR, even subtle changes in gene expression can be detected. Thus real-time PCR can be used to assess RNA levels with great sensitivity and precision. There are several genes play main role in occurrence the AD diseases. The generation of amyloid β-peptide (Aβ) is widely held to play an early and critical role in the pathogenesis of Alzheimer’s disease (Hardy and Selkoe, 2002). Aβ is generated from the large precursor protein amyloid precursor protein (APP) by the sequential action of two proteases, β and γ-secretase. β-secretase has been identified as β-site APP-cleaving enzyme 1 (BACE1) which, together with its homolog BACE2, forms a novel subfamily of transmembrane aspartic proteases within the pepsin family (Vassar and Citron, 2000). The formation of Alzheimer’s Aβ peptide is initiated when the amyloid precursor protein (APP) is cleaved by the enzyme β-secretase (BACE1); inhibition of this cleavage has been proposed as a means of treating Alzheimer’s disease. Cyclooxygenase (COX-2) is continuously expressed within a distinct population of neurons in the brain (Breder et al., 1995), which is a common attribute in enzymes involved in physiological functions of the central nervous system such as memory, sensory integration, and autonomic regulation (Kaufmann et al., 1997). On the other hand, in various neuropathological conditions accompanied by inflammatory reaction, such as stroke (Tomimoto et al., 2000) and amyotrophic lateral sclerosis (ALS) (Yasojima et al., 2001), COX-2 up-regulation is thought to mediate neuronal damage presumably by producing excessive amounts of harmful prostanoids and free radicals. In AD brains, it has been reported that the expression of COX-2 mRNA and protein was elevated (Yasojima et al., 1999). However, it is not yet completely delineated how and in what type of cells COX-2 is increased in the AD brain. Aluminum-induced depletion of antioxidants such as glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST) and catalase (CAT) (Mahieu et al., 2005). Antioxidants thus play key roles in the protection against damage caused by reactive oxygen species (Baynes, 1991). Many plant extracts and plant products have been shown to have significant antioxidant activity (Anjali and Manoj, 1995), which may be an important property of medicinal plants associated with the treatment of several diseases including neurodegenerative diseases. Thus, herbal plants are considered useful means to prevent and/or ameliorate certain disorders, such as Alzheimer's disease. Among these herbal resources, the plant Jasonia montana and Jasonia candicans occur in the Mediterranean and surrounding areas (Merxmuller et al., 1977), including the Sinai Peninsula (Tackholm, 1974). The herb has a strong aromatic odor and is used in traditional medicine for diarrhea, stomach ache, and chest diseases (Tackholm, 1969). A literature survey indicated that some mono- and ses- quiterpenes (Ahmed and Jakupovic, 1990; Ahmed, 1991), flavonoids (Ahmed et al., 1989) and essential oils (Hammerschmidt et al., 1993) have been reported from the plant. Rivastigmine is a carbamate derivative pseudo-irreversible cholinesterase inhibitor which can both inhibit acetylcho-linesterase (AChE) and butyrylcholi-nesterase (BuChE1). This drug is licensed for use in the UK for the symptomatic treatment of mild-to-moderately severe AD due to its inhibitory action on AchE activity (Foye et al., 1995). Rivastigmine has been reported to protect mice against cognitive impairment caused by oxygen deficit, improve learning in rats, and antagonize scopolamine induced impairment of cognitive function in rats (Desai and Grossberg, 2001; Howes et al., 2003). It has been demonstrated that Rivastigmine supplementation increased the concentration of acetylcholine and inhibited acetylcholine esterase activity (Liang and Tang, 2004). The present study was designed to investigate the potential role of J. montanta and J. candicans total extracts against AlCl3-induced oxidative stress and gene expression alteration of AD-related enzymes characterizing Alzheimer's disease in male rats.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c7eabf2dd1ab0a2ee2963bb94a2e3a43Test
https://doi.org/10.21608/ejgc.2011.11039Test