المؤلفون: Anouk E J Latenstein, Marian A. E. de van der Schueren, Ignace H. J. T. de Hingh, Johanna W. Wilmink, Sandra Beijer, Willemieke P M Dijksterhuis, Tara M. Mackay, Hjalmar C. van Santvoort, Jeanne H.M. de Vries, Marc G. Besselink, Judith de Vos-Geelen, Martijn G.H. van Oijen, I. Quintus Molenaar, Hanneke W. M. van Laarhoven, Casper H.J. van Eijck

المساهمون: Surgery, Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Methodology, APH - Quality of Care, Oncology, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy

المصدر: Cancer Medicine
Cancer Medicine, 9(24), 9385-9395. John Wiley & Sons Ltd.
Cancer Medicine 9 (2020) 24
Cancer medicine, 9(24), 9385-9395. John Wiley and Sons Ltd
Cancer Medicine, 9(24), 9385-9395. Wiley
Cancer Medicine, 9(24), 9385-9395
Cancer Medicine (Malden, Ma)

مصطلحات موضوعية: Cancer Research, Cachexia, SURGERY, pancreatic cancer, GUIDELINES, Body Mass Index, QUALITY-OF-LIFE, Weight loss, Periampullary cancer, CRITERIA, Prospective Studies, Referral and Consultation, Original Research, Netherlands, Palliative Care, nutritional interventions, Middle Aged, people.cause_of_death, Survival Rate, Oncology, CLINICAL NUTRITION, Patient-reported outcome, medicine.symptom, Cohort study, medicine.medical_specialty, Ampulla of Vater, Dietetics, Common Bile Duct Neoplasms, MASS, DIAGNOSIS, cachexia, AGE, SDG 3 - Good Health and Well-being, Internal medicine, Pancreatic cancer, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, VLAG, Aged, Neoplasm Staging, Global Nutrition, Wereldvoeding, business.industry, Clinical Cancer Research, medicine.disease, dietetic consultation, Cancer registry, Pancreatic Neoplasms, NUTRITIONAL SUPPORT, weight loss, people, business

الوصف: It is unclear to what extent patients with pancreatic cancer have cachexia and had a dietetic consult for nutritional support. The aim was to assess the prevalence of cachexia, dietitian consultation, and overall survival in these patients. This prospective multicenter cohort study included patients with pancreatic cancer, who participated in the Dutch Pancreatic Cancer Project and completed patient reported outcome measures (2015–2018). Additional data were obtained from the Netherlands Cancer Registry. Cachexia was defined as self‐reported >5% body weight loss, or >2% in patients with a BMI
The extent of cachexia and dietetic consultation in patients with pancreatic cancer in the real‐world setting is unclear. This prospective multicenter cohort study found that in patients, diagnosed between 2015 and 2018, two‐third presented with cachexia of whom nearly half had no dietetic consultation. Survival was comparable in patients with and without cachexia, but decreased in patients with more severe weight loss.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae2596e1a5c6542070672a08f6392cbTest
http://europepmc.org/articles/PMC7774726Test

المؤلفون: Lotte Boxhoorn, Rogier P Voermans, Stefan A Bouwense, Marco J Bruno, Robert C Verdonk, Marja A Boermeester, Hjalmar C van Santvoort, Marc G Besselink

المساهمون: Gastroenterology & Hepatology

المصدر: The Lancet, 396(10252), 726-734. Elsevier Ltd.

مصطلحات موضوعية: Pancreatitis, Alcoholic, FLUID COLLECTIONS, Gallstones, PERSISTENT ORGAN FAILURE, Diabetes Mellitus, Secondary Prevention, Humans, Cholecystectomy, STEP-UP APPROACH, Ultrasonography, MILD GALLSTONE PANCREATITIS, Cholangiopancreatography, Endoscopic Retrograde, EXOCRINE INSUFFICIENCY, Nutritional Support, Pancreatitis, Acute Necrotizing, DUAL-MODALITY DRAINAGE, Lipase, General Medicine, RANDOMIZED CONTROLLED-TRIAL, Magnetic Resonance Imaging, Anti-Bacterial Agents, Pancreatitis, ALCOHOL-ASSOCIATED PANCREATITIS, Amylases, Drainage, Fluid Therapy, Exocrine Pancreatic Insufficiency, Stents, LACTATED RINGERS SOLUTION, Tomography, X-Ray Computed, INFECTED NECROTIZING PANCREATITIS

الوصف: Acute pancreatitis is an unpredictable and potentially lethal disease. The prognosis mainly depends on the development of organ failure and secondary infection of pancreatic or peripancreatic necrosis. In the past 10 years, treatment of acute pancreatitis has moved towards a multidisciplinary, tailored, and minimally invasive approach. Despite improvements in treatment and critical care, severe acute pancreatitis is still associated with high mortality rates. In this Seminar, we outline the latest evidence on diagnostic and therapeutic strategies for acute pancreatitis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929c83bc73e746d5e6b722e358be248aTest
https://doi.org/10.1016/s0140-6736Test(20)31310-6

المؤلفون: Geert Kazemier, Olivier R. Busch, Lois A. Daamen, I. Q. Molenaar, Vincent E de Meijer, Vincent B. Nieuwenhuijs, Bas Groot Koerkamp, Marc G. Besselink, Hjalmar C. van Santvoort, Robert C. Verdonk, Mihaela G Raicu, Sebastiaan Festen, Geert A. Cirkel, Ronald M. van Dam, Nadia Haj Mohammad, Ignace H. J. T. de Hingh, Martijn Intven, Gert J. Meijer, Helena M. Verkooijen, Jennifer M.J. Schreinemakers, Erwin van der Harst, Maartje Los, Bobby K Pranger, Koop Bosscha, Vincent P. Groot, Martijn W J Stommel

المساهمون: RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Surgery, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, Groningen Institute for Organ Transplantation (GIOT), Center for Liver, Digestive and Metabolic Diseases (CLDM), CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

المصدر: Annals of Surgery, 275, 4, pp. 769-775
Annals of Surgery, 275(4), 769-775. LIPPINCOTT WILLIAMS & WILKINS
Annals of surgery, 275(4), 769-775. Lippincott Williams and Wilkins
Annals of Surgery, 275(4), 769-775. Lippincott Williams & Wilkins
Annals of Surgery, 275, 769-775

مصطلحات موضوعية: medicine.medical_specialty, RESECTION, pancreatic ductal adenocarcinoma, DUCTAL ADENOCARCINOMA, GUIDELINES, Asymptomatic, THERAPY, 03 medical and health sciences, disease recurrence, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Interquartile range, Internal medicine, Pancreatic cancer, ISOLATED LOCAL RECURRENCE, SURVEILLANCE, Adjuvant therapy, follow-up, Humans, Medicine, Prospective Studies, Prospective cohort study, Netherlands, Retrospective Studies, business.industry, Proportional hazards model, Hazard ratio, PDAC, Perioperative, ASSOCIATION, medicine.disease, Pancreatic Neoplasms, FOLFIRINOX, GEMCITABINE, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, Neoplasm Recurrence, Local, medicine.symptom, business, Carcinoma, Pancreatic Ductal

الوصف: OBJECTIVE: To evaluate whether detection of recurrent pancreatic ductal adenocarcinoma (PDAC) in an early, asymptomatic stage increases the number of patients receiving additional treatment, subsequently improving survival.SUMMARY OF BACKGROUND DATA: International guidelines disagree on the value of standardized postoperative surveillance for early detection and treatment of PDAC recurrence.METHODS: A nationwide, observational cohort study was performed including all patients who underwent PDAC resection (2014-2016). Prospective baseline and perioperative data were retrieved from the Dutch Pancreatic Cancer Audit. Data on follow-up, treatment, and survival were collected retrospectively. Overall survival (OS) was evaluated using multivariable Cox regression analysis, before and after propensity-score matching, stratified for patients with symptomatic and asymptomatic recurrence.RESULTS: Eight hundred thirty-six patients with a median follow-up of 37 months (interquartile range 30-48) were analyzed. Of those, 670 patients (80%) developed PDAC recurrence after a median follow-up of 10 months (interquartile range 5-17). Additional treatment was performed in 159/511 patients (31%) with symptomatic recurrence versus 77/159 (48%) asymptomatic patients (P < 0.001). After propensity-score matching on lymph node ratio, adjuvant therapy, disease-free survival, and recurrence site, additional treatment was independently associated with improved OS for both symptomatic patients [hazard ratio 0.53 (95% confidence interval 0.42-0.67); P < 0.001] and asymptomatic patients [hazard ratio 0.45 (95% confidence interval 0.29-0.70); P < 0.001].CONCLUSIONS: Additional treatment of PDAC recurrence was independently associated with improved OS, with asymptomatic patients having a higher probability to receive recurrence treatment. Therefore, standardized postoperative surveillance aiming to detect PDAC recurrence before the onset of symptoms has the potential to improve survival. This provides a rationale for prospective studies on standardized surveillance after PDAC resection.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9726c81fbaec8b7ad68e857af12a15aTest
https://repository.ubn.ru.nl/handle/2066/247921Test

المؤلفون: Marc G. Besselink, Tobias Keck, Tara M. Mackay, Hjalmar C. van Santvoort, Louisa Bolm, Bas Groot Koerkamp, Ekaterina Petrova, Hryhoriy Lapshyn, Ulrich F. Wellner, Dgav StuDoQ|Pancreas, Kim C. Honselmann, J. Annelie Suurmeijer

المساهمون: Surgery, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

المصدر: Surgery, 170(6), 1799-1806. Mosby Inc.
Surgery (United States), 170(6), 1799-1806. Mosby Inc.

مصطلحات موضوعية: Male, medicine.medical_specialty, Audit, Anastomosis, Pancreaticoduodenectomy, Pancreatic surgery, Pancreatic Fistula, Postoperative Complications, SDG 3 - Good Health and Well-being, Germany, Pancreaticojejunostomy, Pancreatic cancer, medicine, Humans, Registries, Major complication, Aged, Netherlands, Retrospective Studies, Aged, 80 and over, Gastrostomy, business.industry, Pancreatic Ducts, Middle Aged, medicine.disease, Surgery, medicine.anatomical_structure, Pancreatic fistula, Female, Pancreas, business

الوصف: Background: Evidence on the optimal pancreatic anastomosis during pancreatoduodenectomy is inconclusive. Large multicenter and nationwide registries may provide additional insights. The study compared the practice and outcome of different pancreatic anastomoses during pancreatoduodenectomy, focusing on the rate of postoperative pancreatic fistula, in two large audits of pancreatic surgery.Methods: Posthoc analysis of patients after pancreatoduodenectomy in the Dutch Pancreatic Cancer Audit and the German DGAV StuDoQ vertical bar Pancreas registries (January 2014 to December 2017). Postoperative pancreatic fistula (International Study Group of Pancreatic Surgery B/C), postpancreatectomy hemorrhage (International Study Group of Pancreatic Surgery B/C) and Clavien-Dindo >= 3 complications rates were compared for the three most common anastomoses: duct-to-mucosa pancreatojejunostomy, non-duct-to-mucosa pancreatojejunostomy, and non-duct-to-mucosa pancreatogastrostomy. Multivariable adjustment for potential confounders was performed.Results: Overall, 6,149 patients were included. The most common anastomosis was duct-to-mucosa pancreatojejunostomy (duct-to-mucosa pancreatojejunostomy 59.8%, non-duct-to-mucosa pancreatojejunostomy 21.1%, non-duct-to-mucosa pancreatogastrostomy 12.4%). The overall postoperative pancreatic fistula rate was 14%: duct-to-mucosa pancreatojejunostomy 12.9%, non-duct-to-mucosa pancreatojejunostomy 14.4% (P = .162), non-duct-to-mucosa pancreatogastrostomy 18.3% (P < .001). The rate of postpancreatectomy hemorrhage was the lowest after duct-to-mucosa pancreatojejunostomy: duct-to-mucosa pancreatojejunostomy 6.9%, non-duct-to-mucosa pancreatojejunostomy 10% (P < .001), non-duct-to-mucosa pancreatogastrostomy 17.9% (P < .001). The rate of Clavien-Dindo >= 3 complications was the lowest after duct-to-mucosa pancreatojejunostomy: duct-to-mucosa pancreatojejunostomy 28%, non-duct-to-mucosa pancreatojejunostomy 32.7% (P = .002), non-duct-to-mucosa pancreatogastrostomy 43.1% (P < .001). In the multivariable analysis, the risk of postoperative pancreatic fistula did not differ significantly between the three anastomoses. The risk of hemorrhage (odds ratio 2.4, 95% confidence interval 1.6-3.5, P < .001) and Clavien-Dindo >= 3 (odds ratio 1.6, 95% confidence interval 1.2-2.1, P = .001) remained significantly higher only for non-duct-to-mucosa pancreatogastrostomy.Conclusion: Data from two national audits showed no difference in the risk-adjusted postoperative pancreatic fistula rate among the three most used pancreatic anastomoses during pancreatoduodenectomy. Pancreatogastrostomy was inferior to pancreatojejunostomy regarding bleeding and overall major complications. (C) 2021 Elsevier Inc. All rights reserved.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a883272d5c6563da75f98e321852aa1Test
https://pure.eur.nl/en/publications/f9c79b64-af0c-4d17-84ac-3a84f10dac1dTest

المؤلفون: Lilly J H Brada, Quintus Molenaar, Koop Bosscha, Ronald M. van Dam, Ignace H. J. T. de Hingh, Vincent E de Meijer, Frank J. Wessels, Sebastiaan Festen, Yung C Nio, Lisa G Magermans, Jan J. J. de Vries, Rutger C G Bruijnen, Marco B. Polee, Krijn P van Lienden, Mike S L Liem, Olivier R. Busch, Lois A. Daamen, Hjalmar C. van Santvoort, Marc G. Besselink, Casper H.J. van Eijck, Gijs A. Patijn, Martijn W J Stommel, Hanneke Wilmink, Bas Groot Koerkamp, M.S. Walma, Diba Latifi

المساهمون: Groningen Institute for Organ Transplantation (GIOT), Center for Liver, Digestive and Metabolic Diseases (CLDM), Surgery, Radiology and Nuclear Medicine, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Oncology, MUMC+: MA Heelkunde (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Epidemiologie

المصدر: Annals of Surgery, 274(5), 729-735. LIPPINCOTT WILLIAMS & WILKINS
Annals of surgery, 274(5), 729-735. Lippincott Williams and Wilkins
Annals of Surgery, 274, 729-735
Annals of Surgery, 274(5), 729-735. Lippincott Williams & Wilkins
Annals of Surgery, 274, 5, pp. 729-735

مصطلحات موضوعية: Male, Oxaliplatin/therapeutic use, FOLFIRINOX, SURGERY, IMPACT, Leucovorin, urologic and male genital diseases, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], QUALITY-OF-LIFE, Antineoplastic Combined Chemotherapy Protocols, Medicine, Prospective Studies, resection, Prospective cohort study, Netherlands, BORDERLINE, Survival Rate/trends, OUTCOMES, Leucovorin/therapeutic use, Hazard ratio, Middle Aged, locally advanced pancreatic cancer, Oxaliplatin, Survival Rate, Pancreatectomy/methods, Response Evaluation Criteria in Solid Tumors, Cohort, Female, Fluorouracil, medicine.medical_specialty, Irinotecan/therapeutic use, Urology, Antineoplastic Agents, Netherlands/epidemiology, Pancreas/pathology, Irinotecan, Fluorouracil/therapeutic use, Pancreatectomy, SDG 3 - Good Health and Well-being, Humans, Pancreatic Neoplasms/diagnosis, Propensity Score, Pancreas, NEOADJUVANT THERAPY, Neoplasm Staging, business.industry, Proportional hazards model, Antineoplastic Agents/therapeutic use, ADENOCARCINOMA, Confidence interval, Pancreatic Neoplasms, Propensity score matching, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, business, Follow-Up Studies

الوصف: Contains fulltext : 239076.pdf (Publisher’s version ) (Closed access) OBJECTIVE: This study compared median OS after resection of LAPC after upfront FOLFIRINOX versus a propensity-score matched cohort of LAPC patients treated with FOLFIRINOX-only (ie, without resection). BACKGROUND: Because the introduction of FOLFIRINOX chemotherapy, increased resection rates in LAPC patients have been reported, with improved OS. Some studies have also reported promising OS with FOLFIRINOX-only treatment in LAPC. Multicenter studies assessing the survival benefit associated with resection of LAPC versus patients treated with FOLFIRINOX-only are lacking. METHODS: Patients with non-progressive LAPC after 4 cycles of FOLFIRINOX treatment, both with and without resection, were included from a prospective multicenter cohort in 16 centers (April 2015-December 2019). Cox regression analysis identified predictors for OS. One-to-one propensity score matching (PSM) was used to obtain a matched cohort of patients with and without resection. These patients were compared for OS. RESULTS: Overall, 293 patients with LAPC were included, of whom 89 underwent a resection. Resection was associated with improved OS (24 vs 15 months, P < 0.01), as compared to patients without resection. Before PSM, resection, Charlson Comorbidity Index, and Response Evaluation Criteria in Solid Tumors (RECIST) response were predictors for OS. After PSM, resection remained associated with improved OS [Hazard Ratio (HR) 0.344, 95% confidence interval (0.222-0.534), P < 0.01], with an OS of 24 versus 15 months, as compared to patients without resection. Resection of LAPC was associated with improved 3-year OS (31% vs 11%, P < 0.01). CONCLUSIONS: Resection of LAPC after FOLFIRINOX was associated with increased OS and 3-year survival, as compared to propensity-score matched patients treated with FOLFIRINOX-only.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ef9fb25d1e317bffbe82956feddc65Test
https://research.rug.nl/en/publications/879dd244-9b84-48da-b3fe-2dc2b8df7b87Test

المؤلفون: Olaf J. Bakker, Niels G. Venneman, Ben J.M. Witteman, Marie-Paule Anten, B W Marcel Spanier, Hendrik M. van Dullemen, Nora D L Hallensleben, Matthijs P. Schwartz, Erik J. Schoon, Rutger Quispel, René W M van der Hulst, Hjalmar C. van Santvoort, David W da Costa, Adriaan C.I.T.L. Tan, Janneke van Grinsven, Tessa E H Römkens, Rogier de Ridder, Wim van de Vrie, Sjoerd D. Kuiken, Carola H.M. Ruigrok, Robbert A. Hollemans, Robert C. Verdonk, Marc G. Besselink, Xavier J N M Smeets, Frank P. Vleggaar, Marco J. Bruno, Frank J G M Kubben, Robert J.F. Laheij, Casper H.J. van Eijck, Thomas L. Bollen, Jeroen M. Jansen, Jeanin E. van Hooft, Nicole S. Erler, Robin Timmer, Foke van Delft, Marno C.M. Rijk, Marcel G. W. Dijkgraaf, Paul Fockens, Sven M. van Dijk, Erwin J M van Geenen, Nicolien J. Schepers, Willem J. Thijs, G. Willemien Erkelens

المساهمون: Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Epidemiology and Data Science, APH - Methodology, Gastroenterology and Hepatology, Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: FHML non-thematic output, Gastroenterology & Hepatology, Epidemiology, Center for Liver, Digestive and Metabolic Diseases (CLDM)

المصدر: The Lancet (London), 396, 10245, pp. 167-176
The Lancet, 396(10245), 167-176. Elsevier Limited
The Lancet (London), 396, 167-176
Lancet, 396(10245), 167-176. Elsevier Science
Lancet (UK), 396(10245), 167-176. Elsevier Ltd.
The Lancet, 396(10245), 167-176. ELSEVIER SCIENCE INC

مصطلحات موضوعية: Male, medicine.medical_specialty, PATHOGENESIS, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], Gallstones, 030204 cardiovascular system & hematology, Conservative Treatment, DISEASE, law.invention, Sphincterotomy, Endoscopic, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, ACUTE NECROTIZING PANCREATITIS, 0302 clinical medicine, Randomized controlled trial, Cholestasis, law, EARLY DUCTAL DECOMPRESSION, MANAGEMENT, medicine, Clinical endpoint, Humans, EPIDEMIOLOGY, 030212 general & internal medicine, Aged, ACUTE CHOLANGITIS, Cholangiopancreatography, Endoscopic Retrograde, ACUTE BILIARY PANCREATITIS, Endoscopic retrograde cholangiopancreatography, Intention-to-treat analysis, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, Combined Modality Therapy, Surgery, Clinical trial, Treatment Outcome, Pancreatitis, Relative risk, Acute Disease, Female, OBSTRUCTION, business, CLINICAL-TRIALS

الوصف: BACKGROUND: It remains unclear whether urgent endoscopic retrograde cholangiopancreatography (ERCP) with biliary sphincterotomy improves the outcome of patients with gallstone pancreatitis without concomitant cholangitis. We did a randomised trial to compare urgent ERCP with sphincterotomy versus conservative treatment in patients with predicted severe acute gallstone pancreatitis.METHODS: In this multicentre, parallel-group, assessor-masked, randomised controlled superiority trial, patients with predicted severe (Acute Physiology and Chronic Health Evaluation II score ≥8, Imrie score ≥3, or C-reactive protein concentration >150 mg/L) gallstone pancreatitis without cholangitis were assessed for eligibility in 26 hospitals in the Netherlands. Patients were randomly assigned (1:1) by a web-based randomisation module with randomly varying block sizes to urgent ERCP with sphincterotomy (within 24 h after hospital presentation) or conservative treatment. The primary endpoint was a composite of mortality or major complications (new-onset persistent organ failure, cholangitis, bacteraemia, pneumonia, pancreatic necrosis, or pancreatic insufficiency) within 6 months of randomisation. Analysis was by intention to treat. This trial is registered with the ISRCTN registry, ISRCTN97372133.FINDINGS: Between Feb 28, 2013, and March 1, 2017, 232 patients were randomly assigned to urgent ERCP with sphincterotomy (n=118) or conservative treatment (n=114). One patient from each group was excluded from the final analysis because of cholangitis (urgent ERCP group) and chronic pancreatitis (conservative treatment group) at admission. The primary endpoint occurred in 45 (38%) of 117 patients in the urgent ERCP group and in 50 (44%) of 113 patients in the conservative treatment group (risk ratio [RR] 0·87, 95% CI 0·64-1·18; p=0·37). No relevant differences in the individual components of the primary endpoint were recorded between groups, apart from the occurrence of cholangitis (two [2%] of 117 in the urgent ERCP group vs 11 [10%] of 113 in the conservative treatment group; RR 0·18, 95% CI 0·04-0·78; p=0·010). Adverse events were reported in 87 (74%) of 118 patients in the urgent ERCP group versus 91 (80%) of 114 patients in the conservative treatment group.INTERPRETATION: In patients with predicted severe gallstone pancreatitis but without cholangitis, urgent ERCP with sphincterotomy did not reduce the composite endpoint of major complications or mortality, compared with conservative treatment. Our findings support a conservative strategy in patients with predicted severe acute gallstone pancreatitis with an ERCP indicated only in patients with cholangitis or persistent cholestasis.FUNDING: The Netherlands Organization for Health Research and Development, Fonds NutsOhra, and the Dutch Patient Organization for Pancreatic Diseases.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8b6e095acc878d6c1c962ca25da56aTest
https://doi.org/10.1016/s0140-6736Test(20)30539-0

المؤلفون: Markus W. Büchler, Catherine Morgan, Kevin C. Conlon, Keith D. Lillemoe, John P. Neoptolemos, Massimo Falconi, Helmut Friess, Carlos Fernandez-del Castillo, Dejan Radenkovic, Nicholas J. Zyromski, Martin Smith, S. Burmeister, Claudio Bassi, Richard D. Schulick, Santhalingam Jegatheeswaran, Marc G. Besselink, Ajith K. Siriwardena, Hjalmar C. van Santvoort, Shailesh V. Shrikhande, John A. Windsor, Jakob R. Izbicki, Luca Gianotti, Christos Dervenis, Giovanni Marchegiani, Roland Andersson, Attila Oláh, Minas Baltatzis, J. Devar, Marco Del Chiaro, Mustapha Adham, Igor Khatkov, Olivier R. Busch, Thilo Hackert, David B. Adams, Giuseppe Garcea, Andrew Smith, Charles M. Vollmer, Ioannis Passas

المساهمون: Surgery, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, Siriwardena, A, Windsor, J, Zyromski, N, Marchegiani, G, Radenkovic, D, Morgan, C, Passas, I, Olah, A, Conlon, K, Smith, M, Busch, O, Baltatzis, M, Besselink, M, Vollmer, C, Castillo, C, Friess, H, Garcea, G, Burmeister, S, Hackert, T, Lillemoe, K, Schulick, R, Shrikhande, S, Smith, A, Gianotti, L, Falconi, M, Adams, D, Adham, M, Andersson, R, Del Chiaro, M, Devar, J, Jegatheeswaran, S, van Santvoort, H, Khatkov, I, Izbicki, J, Buchler, M, Neoptolemos, J, Bassi, C, Dervenis, C

المصدر: Surgery, 168(1), 101-105. Mosby Inc.

مصطلحات موضوعية: medicine.medical_specialty, Outcome Assessment, medicine.medical_treatment, education, MEDLINE, Disease, 030230 surgery, Outcome assessment, Pancreatic surgery, Pancreaticoduodenectomy, 03 medical and health sciences, 0302 clinical medicine, Pancreatitis, Chronic, Pancreaticojejunostomy, Outcome Assessment, Health Care, medicine, Humans, Chronic, Pancreas, Project group, business.industry, medicine.disease, 3. Good health, Surgery, Health Care, medicine.anatomical_structure, Pancreatitis, 030220 oncology & carcinogenesis, business

الوصف: Background: The International Study Group for Pancreatic Surgery provides globally accepted definitions for reporting of complications after pancreatic surgery. This International Study Group for Pancreatic Surgery project aims to provide a standardized framework for reporting of the results of operative treatment for chronic pancreatitis. Methods: An International Study Group for Pancreatic Surgery project circulation list was created with pre-existing and new members and including gastroenterologists in addition to surgeons. A computerized search of the literature was undertaken for articles reporting the operative treatment of chronic pancreatitis. The results of the literature search were presented at the first face-to-face meeting of this International Study Group for Pancreatic Surgery project group. A document outlining proposed reporting standards was produced by discussion during an initial meeting of the International Study Group for Pancreatic Surgery. An electronic questionnaire was then sent to all current members of the International Study Group for Pancreatic Surgery. Responses were collated and further discussed at international meetings in North America, Europe, and at the International Association of Pancreatology World Congress in 2019. A final consensus document was produced by integration of multiple iterations. Results: The International Study Group for Pancreatic Surgery consensus standards for reporting of surgery in chronic pancreatitis recommends 4 core domains and the necessary variables needed for reporting of results: clinical baseline before operation; the morphology of the diseased gland; a new, standardized, operative terminology; and a minimum outcome dataset. The 4 domains combine to give a comprehensive framework for reports. Conclusion: Adoption of the 4 domains of the International Study Group for Pancreatic Surgery reporting standards for surgery for chronic pancreatitis will facilitate comparison of results between centers and help to improve the care for patients with this debilitating disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aade38ef66997d06bb111a48894c2a75Test
http://www.scopus.com/inward/record.url?scp=85081662284&partnerID=8YFLogxKTest

المؤلفون: I. Quintus Molenaar, Susan van Dieren, Mirjam A. G. Sprangers, Marjolein Y.V. Homs, Casper H.J. van Eijck, Marc G. Besselink, Ignace H. J. T. de Hingh, Johanna W. Wilmink, Lydia G. M. van der Geest, Geert-Jan Creemers, Gijs A. Patijn, Jan-Willem B de Groot, Tara M. Mackay, Lonneke V. van de Poll-Franse, Judith de Vos-Geelen, Bas Groot Koerkamp, Hanneke W. M. van Laarhoven, Evelien J M de Jong, Anouk E J Latenstein, Hjalmar C. van Santvoort

المساهمون: Medical and Clinical Psychology, Surgery, Medical Oncology, Medical Psychology, APH - Mental Health, APH - Personalized Medicine, CCA - Cancer Treatment and Quality of Life, APH - Methodology, Oncology, CCA -Cancer Center Amsterdam, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy

المصدر: Journal of the National Comprehensive Cancer Network, 18(10), 1354-1363. Cold Spring Publishing LLC
Journal of the National Comprehensive Cancer Network, 18(10), 1354-+. Cold Spring Publishing LLC
Journal of the National Comprehensive Cancer Network, 18(10), 1354-1363. Harborside Press

مصطلحات موضوعية: medicine.medical_specialty, Multivariate analysis, RESECTION, IMPACT, Adenocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Quality of life, SDG 3 - Good Health and Well-being, Internal medicine, Surveys and Questionnaires, medicine, Periampullary cancer, Humans, REPORTED OUTCOMES, Patient Reported Outcome Measures, Prospective Studies, Registries, HEAD, Netherlands, Proportional hazards model, business.industry, STATEMENT, Hazard ratio, QLQ-C30, people.cause_of_death, humanities, Cancer registry, Pancreatic Neoplasms, Survival Rate, TRIALS, Oncology, 030220 oncology & carcinogenesis, Cohort, Quality of Life, 030211 gastroenterology & hepatology, HEALTH, business, people, Cohort study

الوصف: Background: A relationship between quality of life (QoL) and survival has been shown for several types of cancer, mostly in clinical trials with highly selected patient groups. The relationship between QoL and survival for patients with pancreatic or periampullary cancer is unclear. Methods: This study analyzed QoL data from a prospective multicenter patient-reported outcome registry in patients with pancreatic or periampullary carcinoma registered in the nationwide Netherlands Cancer Registry (2015–2018). Baseline and delta QoL, between baseline and 3-month follow-up, were assessed with the Happiness, EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), and QLQ-PAN26 questionnaires. The relationship between QoL and survival was assessed using Cox regression models, and additional prognostic value of separate items was assessed using Nagelkerke R2 (explained variance). Results: For the baseline and delta analyses, 233 and 148 patients were available, respectively. Most were diagnosed with pancreatic adenocarcinoma (n=194; 83.3%) and had stage III disease (n=77; 33.0%), with a median overall survival of 13.6 months. Multivariate analysis using baseline scores indicated several scales to be of prognostic value for the total cohort (ie, happiness today, role functioning, diarrhea, pancreatic pain, and body image; hazard ratios all PP5% of the additional explained variance and were of added prognostic value. Multivariate analysis using delta QoL revealed that only constipation was of prognostic value for the total cohort, whereas no association with survival was found for subgroups with or without resection. Conclusions: In a multicenter cohort of patients with pancreatic or periampullary carcinoma, QoL scores predicted survival regardless of patient, tumor, and treatment characteristics. QoL scores may thus be used for shared decision-making regarding disease management and treatment choice.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1cecba50c06fdfca2aede68f3d2eefTest
https://doi.org/10.6004/jnccn.2020.7579Test

المؤلفون: Tara M. Mackay, Judith de Vos-Geelen, Anouk E J Latenstein, Ignace H. J. T. de Hingh, Bert A. Bonsing, Johanna W. Wilmink, Lydia G. M. van der Geest, Olivier R. Busch, Marjolein Y.V. Homs, Casper H.J. van Eijck, Hjalmar C. van Santvoort, I. Quintus Molenaar, Marc G. Besselink, Hanneke W. M. van Laarhoven, Jeanin E. van Hooft, Bas Groot Koerkamp, Marco J. Bruno, Martijn W J Stommel

المساهمون: Gastroenterology & Hepatology, Surgery, Medical Oncology, Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, Oncology, CCA -Cancer Center Amsterdam, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy

المصدر: Pancreatology, 20, 8, pp. 1723-1731
Pancreatology, 20(8), 1723-1731. Elsevier
Pancreatology, 20, 1723-1731
Pancreatology, 20(8), 1723-1731. S. Karger AG
Pancreatology, 20(8). ELSEVIER

مصطلحات موضوعية: Change over time, medicine.medical_specialty, ENHANCED RECOVERY, SURGERY, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Disease, PREOPERATIVE BILIARY DRAINAGE, Guideline, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], ADJUVANT CHEMOTHERAPY, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Multidisciplinary approach, Pancreatic cancer, medicine, FAILURE, Humans, Netherlands, Chemotherapy, Hepatology, business.industry, General surgery, Gastroenterology, Guideline compliance, CARE, medicine.disease, Cancer registry, Management, FOLFIRINOX, Pancreatic Neoplasms, GEMCITABINE, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, PANCREATICODUODENECTOMY, 030211 gastroenterology & hepatology, Guideline Adherence, business, Follow-Up Studies, Compliance

الوصف: Background: Compliance with national guidelines on pancreatic cancer management could improve patient outcomes. Early compliance with the Dutch guideline was poor. The aim was to assess compliance with this guideline during six years after publication.Materials and methods: Nationwide guideline compliance was investigated for three subsequent time periods (2012-2013 vs. 2014-2015 vs. 2016-2017) in patients with pancreatic cancer using five quality indicators in the Netherlands Cancer Registry: 1) discussion in multidisciplinary team meeting (MDT), 2) maximum 3-week interval from final MDT to start of treatment, 3) preoperative biliary drainage when bilirubin >250 mu mol/L, 4) use of adjuvant chemotherapy, and 5) chemotherapy for inoperable disease (non-metastatic and metastatic).Results: In total, 14 491 patients were included of whom 2290 (15.8%) underwent resection and 4561 (31.5%) received chemotherapy. Most quality indicators did not change over time: overall, 88.8% of patients treated with curative intent were discussed in a MDT, 42.7% were treated with curative intent within the 3-week interval, 62.7% with a resectable head tumor and bilirubin >250 mu mol/L underwent preoperative biliary drainage, 57.2% received chemotherapy after resection, and 36.6% with metastatic disease received chemotherapy. Only use of chemotherapy for non-metastatic, non-resected disease improved over time (23.4% vs. 25.6% vs. 29.7%).Conclusion: Nationwide compliance to five quality indicators for the guideline on pancreatic cancer management showed little to no improvement during six years after publication. Besides critical review of the current quality indicators, these outcomes may suggest that a nationwide implementation program is required to increase compliance to guideline recommendations. (C) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55f85485da1891dd3e0c53ef622b7d3Test
https://doi.org/10.1016/j.pan.2020.10.032Test

المؤلفون: Olivier R. Busch, I. Quintus Molenaar, F. Jasmijn Smits, Marc G. Besselink, Hjalmar C. van Santvoort, Casper H.J. van Eijck, Inne H.M. Borel Rinkes

المساهمون: Surgery

المصدر: HPB, 22(1), 1-11. John Wiley & Sons Inc.

مصطلحات موضوعية: medicine.medical_specialty, Computed tomography, 030230 surgery, Elevated serum, Pancreatic Fistula, 03 medical and health sciences, Pancreatectomy, Postoperative Complications, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Early prediction, Humans, Medicine, Elevated white blood cell count, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, medicine.disease, Surgery, Early Diagnosis, Pancreatic fistula, 030220 oncology & carcinogenesis, business, Systematic search

الوصف: Background: Early recognition of postoperative pancreatic fistula might decrease the risk of subsequent life threatening complications. The aim of this review was to systematically evaluate the accuracy of postoperative clinical, biochemical and radiologic variables for early recognition of clinically relevant postoperative pancreatic fistula. Methods: A systematic literature search was performed up to August 2018. Clinical studies reporting on the association between postoperative variables and clinically relevant postoperative pancreatic fistula were included. Variables were stratified: early prediction (postoperative day 1–2) versus early diagnosis (day 3) and had to be reported in 2 cohorts. Results: Overall, 37 included studies reported on 17 different diagnostic variables after 8701 pancreatic resections. Clinically relevant postoperative pancreatic fistula occurred in 1532/8701 patients (18%). Early prediction variables included elevated serum and drain amylase (day 1). Identified variables for early diagnosis were: non-serous drain efflux (day 3); positive drain culture (day 3); elevated temperature (any day); elevated C-Reactive Protein (CRP; day 4); elevated white blood cell count (day 4) and peripancreatic collections on computed tomography (CT; day 5–10). Conclusion: This review provides a comprehensive overview of postoperative variables associated with clinically relevant pancreatic fistula. Incorporation of variables in future algorithms could potentially mitigate the clinical impact of postoperative pancreatic fistula.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167a6fc1101f907f2e0473478b2daeb4Test
https://doi.org/10.1016/j.hpb.2019.07.005Test