المؤلفون: Raymond J. Pierce, Wolfgang Sippl, Julien Lancelot, Karin Schmidtkunz, Alokta Chakrabarti, Dina Robaa, Jelena Melesina, Tajith B. Shaik, Christophe Romier, Conrad V. Simoben, Manfred Jung, Srinivasaraghavan Kannan, Martin Marek

المساهمون: Romier, Christophe, Martin-Luther-Universität Halle Wittenberg (MLU), Albert-Ludwigs-Universität Freiburg, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), This work and the authors of this article received funding from the European Union’s Seventh Framework Programme for Research, Technological Development and Demonstration under Grant Agreements 241865 (SEtTReND) and 602080 (A-ParaDDisE). Further support was received by the Deutsche Forschungsgemeinschaft (Ju-295/13-1, SI-868/13-1). MM, TBS and CR are supported by institutional funds from the Centre National de la Recherche Scientifique (CNRS), the Institut National de la Santé et de la Recherche Médicale (INSERM) and the Université de Strasbourg., The authors acknowledge the support and the use of resources of the French Infrastructure for Integrated Structural Biology FRISBI ANR-10-INBS-05 and of Instruct-ERIC. We wish to thank members of the ESRF-EMBL joint structural biology groups and the SOLEIL synchrotron for the use of their beamline facilities and for help during data collection. We are grateful to Pierre Legrand (SOLEIL) for his kind assistance for data processing, Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)

المصدر: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules; Volume 23; Issue 3; Pages: 566
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩

مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, MESH: Helminth Proteins/metabolism, MESH: Histone Deacetylases/metabolism, MESH: Histone Deacetylases/genetics, Pharmaceutical Science, MESH: Protein Structure, Secondary, Gene Expression, Apoptosis, Crystallography, X-Ray, Hydroxamic Acids, Molecular Docking Simulation, MESH: Helminth Proteins/antagonists & inhibitors, MESH: Chelating Agents/chemical synthesis, Protein Structure, Secondary, Analytical Chemistry, 0302 clinical medicine, MESH: Structure-Activity Relationship, MESH: Hydroxamic Acids/chemical synthesis, Drug Discovery, MESH: Zinc/metabolism, MESH: Animals, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Histone Deacetylase Inhibitors/pharmacology, Chelating Agents, Anthelmintics, biology, Chemistry, MESH: Anthelmintics/pharmacology, Helminth Proteins, Schistosoma mansoni, epigenetics, crystal structure, docking, histone deacetylase (HDAC) inhibitors, schistosomiasis, virtual screening, MESH: Histone Deacetylases/chemistry, 3. Good health, MESH: Schistosoma mansoni/drug effects, MESH: Pyrrolidines/pharmacology, Zinc, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, Protein Binding, MESH: Apoptosis/drug effects, MESH: Gene Expression, In silico, 030231 tropical medicine, MESH: Zinc/chemistry, Article, Histone Deacetylases, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, MESH: Molecular Docking Simulation, Structure–activity relationship, MESH: Protein Binding, Animals, MESH: Helminth Proteins/genetics, Protein Interaction Domains and Motifs, Physical and Theoretical Chemistry, MESH: Histone Deacetylase Inhibitors/chemical synthesis, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Virtual screening, MESH: Protein Interaction Domains and Motifs, Binding Sites, Organic Chemistry, MESH: Hydroxamic Acids/pharmacology, HDAC8, MESH: Schistosoma mansoni/growth & development, Epigenome, biology.organism_classification, MESH: Crystallography, X-Ray, MESH: Anthelmintics/chemical synthesis, Histone Deacetylase Inhibitors, 030104 developmental biology, MESH: Binding Sites, Docking (molecular), MESH: Chelating Agents/pharmacology, MESH: Schistosoma mansoni/enzymology, MESH: Helminth Proteins/chemistry, MESH: Schistosoma mansoni/genetics, MESH: Pyrrolidines/chemical synthesis

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57756972e5c4439f4e393638be3994bTest
http://europepmc.org/articles/PMC6017931Test

المؤلفون: Tasset, Celine, Singh Yadav, Avilash, Sureshkumar, Sridevi, Singh, Rupali, van der Woude, Lennard, Nekrasov, Maxim, Tremethick, David, van Zanten, Martijn, Balasubramanian, Sureshkumar, Sub Molecular Plant Physiology, Molecular Plant Physiology

المساهمون: Sub Molecular Plant Physiology, Molecular Plant Physiology

المصدر: PLoS Genetics, Vol 14, Iss 3, p e1007280 (2018)
PLoS Genetics, 14(3). Public Library of Science
PLoS Genetics

مصطلحات موضوعية: 0301 basic medicine, 0106 biological sciences, Cancer Research, Fruit and Seed Anatomy, Arabidopsis, Histones/metabolism, Gene Expression, Plant Science, Biochemistry, 01 natural sciences, Histones, Histone methylation, Morphogenesis, Arabidopsis thaliana, Histone code, Genetics (clinical), Plant Growth and Development, Regulation of gene expression, 2. Zero hunger, Genetics, 0303 health sciences, Chromosome Biology, Plant Anatomy, Temperature, Eukaryota, food and beverages, Acetylation, Genomics, Plants, Hypocotyl, Chromatin, Nucleosomes, Cell biology, Arabidopsis Proteins/genetics, Histone, Experimental Organism Systems, Histone methyltransferase, Embryogenesis, Epigenetics, Transcriptome Analysis, Research Article, lcsh:QH426-470, Arabidopsis Thaliana, Transcription Factors/genetics, Plant Development, Brassica, SAP30, Biology, Research and Analysis Methods, Histone Deacetylases, Chromatin remodeling, 03 medical and health sciences, Model Organisms, Histone H1, Plant and Algal Models, DNA-binding proteins, Histone H2A, Nucleosome, Gene Regulation, Arabidopsis/genetics, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Biology and life sciences, Plant Embryo Anatomy, Arabidopsis Proteins, HDAC9, Organisms, Proteins, Computational Biology, Cell Biology, Genome Analysis, biology.organism_classification, lcsh:Genetics, 030104 developmental biology, Mutation, biology.protein, Histone Deacetylases/metabolism, Plant Embryogenesis, Developmental Biology, Transcription Factors, 010606 plant biology & botany

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57a60975b88b4bf219bb7925e75a4bbTest
https://doi.org/10.1101/186916Test

المؤلفون: Egbert K. O. Kruithof, Sylvie Dunoyer-Geindre

المصدر: Cardiovascular Research, Vol. 90, No 3 (2011) pp. 457-63
Cardiovascular research

مصطلحات موضوعية: Tissue Plasminogen Activator/biosynthesis/genetics, RNA, Messenger/genetics/metabolism, Physiology, Histones/metabolism, 030204 cardiovascular system & hematology, Epigenesis, Genetic/drug effects, Histone Deacetylases, Epigenesis, Genetic, Histones, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Humans, RNA, Messenger, Epigenetics, Promoter Regions, Genetic, Cells, Cultured, DNA Primers, 030304 developmental biology, ddc:616, DNA Primers/genetics, 0303 health sciences, Base Sequence, biology, T-plasminogen activator, Hepatocytes/metabolism, Endothelial Cells, DNA Methylation, Molecular biology, Histone Deacetylase Inhibitors, Endothelial Cells/drug effects/metabolism, Histone, PCAF, Acetylation, Tissue Plasminogen Activator, DNA methylation, Hepatocytes, biology.protein, Histone Deacetylases/metabolism, Histone deacetylase, Cardiology and Cardiovascular Medicine, Plasminogen activator, Histone Deacetylase Inhibitors/pharmacology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d74d00f0995ff382c4671138dfe0327Test
http://doc.rero.ch/record/296785/files/cvr028.pdfTest

المؤلفون: Anand, C., Garg, R., Ghosh, S., Nagaraja, V.

المصدر: Biochemical and Biophysical Research Communications, vol. 493, no. 3, pp. 1204-1209

مصطلحات موضوعية: Acetylation, Bacterial Proteins/genetics, Bacterial Proteins/metabolism, DNA, Bacterial/chemistry, Bacterial/metabolism, DNA-Binding Proteins/genetics, DNA-Binding Proteins/metabolism, Histone Deacetylases/genetics, Histone Deacetylases/metabolism, Mycobacterium tuberculosis/genetics, Mycobacterium tuberculosis/metabolism, Deacetylation, HU, Nucleoid associated proteins, Rv1151c, Sirtuin

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28935371; info:eu-repo/semantics/altIdentifier/eissn/1090-2104; https://serval.unil.ch/notice/serval:BIB_93F9B9A2866ETest; urn:issn:0006-291X

الإتاحة: https://doi.org/10.1016/j.bbrc.2017.09.087Test
https://serval.unil.ch/notice/serval:BIB_93F9B9A2866ETest

المؤلفون: Krieger, Viktoria, Hamacher, Alexandra, Gertzen, Christoph, Senger, Johanna, Zwinderman, Martijn, Marek, Martin, Romier, Christophe, Dekker, Frank, Kurz, Thomas, Jung, Manfred, Gohlke, Holger, Kassack, Matthias, Hansen, Finn

المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Medical Chemistry ; https://hal.science/hal-03682266Test ; Journal of Medical Chemistry, 2017, 60 (13), pp.5493-5506. ⟨10.1021/acs.jmedchem.7b00197⟩ ; http://www.ncbi.nlm.nih.gov/pubmed/28574690Test

مصطلحات موضوعية: Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology, Cell Line, Tumor, Cell Proliferation/drug effects, Dose-Response Relationship, Drug, Drug Design, Drug Screening Assays, Antitumor, Histone Deacetylase Inhibitors/chemical synthesis/chemistry/*pharmacology, Histone Deacetylases/*metabolism, Humans, Models, Molecular, Molecular Structure, Peptoids/chemical synthesis/chemistry/*pharmacology, Small Molecule Libraries/chemical synthesis/chemistry/*pharmacology, Structure-Activity Relationship, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

العلاقة: hal-03682266; https://hal.science/hal-03682266Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.7b00197Test
https://hal.science/hal-03682266Test

المؤلفون: Stenzel, Katharina, Hamacher, Alexandra, Hansen, Finn, Gertzen, Christoph, Senger, Johanna, Marquardt, Viktoria, Marek, Linda, Marek, Martin, Romier, Christophe, Remke, Marc, Jung, Manfred, Gohlke, Holger, Kassack, Matthias, Kurz, Thomas

المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0022-2623.

مصطلحات موضوعية: Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Histone Deacetylase Inhibitors/chemical synthesis/chemistry/*pharmacology, Histone Deacetylases/*metabolism, Humans, Molecular Docking Simulation, Molecular Structure, Structure-Activity Relationship, Antineoplastic Agents/chemistry/*pharmacology, Apoptosis/drug effects, Cell Line, Tumor, Cell Proliferation/drug effects, Cisplatin/chemistry/*pharmacology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

العلاقة: hal-03691179; https://hal.science/hal-03691179Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.6b01538Test
https://hal.science/hal-03691179Test

المؤلفون: Scott W. Hiebert, Emma De Fabiani, Cinzia Magagnotti, Erika Fiorino, Donatella Caruso, Béatrice Desvergne, Annapaola Andolfo, Maurizio Crestani, Rui Silva, Gaia Cermenati, Nico Mitro, Federica Gilardi, Raffaella Longo, Alessandra Ferrari

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications, vol. 8, no. 1, pp. 93

مصطلحات موضوعية: Male, 0301 basic medicine, Adipose Tissue, White, Science, General Physics and Astronomy, Adipose tissue, Adipocytes/physiology, Adipose Tissue, Brown/physiology, Adipose Tissue, White/physiology, Animals, Cell Line, Diet, High-Fat, Gene Expression Regulation/physiology, Gene Silencing, Histone Deacetylases/genetics, Histone Deacetylases/metabolism, Lipid Metabolism, Mice, Mice, Knockout, White adipose tissue, Biology, Histone Deacetylases, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Adipose Tissue, Brown, Adipocytes, PPARA Gene, Fatty acid synthesis, Multidisciplinary, Fatty acid metabolism, Futile cycle, nutritional and metabolic diseases, food and beverages, Lipid metabolism, General Chemistry, HDAC3, 030104 developmental biology, Gene Expression Regulation, chemistry, Biochemistry, lipids (amino acids, peptides, and proteins), hormones, hormone substitutes, and hormone antagonists

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c512383fec48820206bfc3269b78fc0bTest
https://doi.org/10.1038/s41467-017-00182-7Test

المؤلفون: Finn K. Hansen, Christophe Romier, Linda Marek, Martin Marek, Manfred Jung, Christoph G. W. Gertzen, Johanna Senger, Katharina Stenzel, Viktoria Marquardt, Marc Remke, Thomas Kurz, Alexandra Hamacher, Holger Gohlke, Matthias U. Kassack

المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (13), pp.5334-5348. ⟨10.1021/acs.jmedchem.6b01538⟩

مصطلحات موضوعية: 0301 basic medicine, Histone Deacetylases/*metabolism, Antineoplastic Agents, Apoptosis, Pharmacology, Drug Screening Assays, Cisplatin/chemistry/*pharmacology, Histone Deacetylases, Cell Line, Dose-Response Relationship, Cell Proliferation/drug effects, 03 medical and health sciences, Structure-Activity Relationship, Antineoplastic Agents/chemistry/*pharmacology, Cell Line, Tumor, Drug Discovery, medicine, Urea, Structure–activity relationship, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Histone Deacetylase Inhibitors/chemical synthesis/chemistry/*pharmacology, Cell Proliferation, Cisplatin, Tumor, Dose-Response Relationship, Drug, Molecular Structure, Cell growth, Chemistry, Apoptosis/drug effects, HDAC8, Antitumor, Squamous carcinoma, Histone Deacetylase Inhibitors, Molecular Docking Simulation, 030104 developmental biology, Cell culture, Molecular Medicine, Histone deacetylase, Drug Screening Assays, Antitumor, Drug, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae45bc45d6f85c20596af1b3e2cbe58Test
https://hal.archives-ouvertes.fr/hal-03691179Test

المؤلفون: Vincent, Zwick, Pierre-Marie, Allard, Lucie, Ory, Claudia A, Simões-Pires, Laurence, Marcourt, Katia, Gindro, Jean-Luc, Wolfender, Muriel, Cuendet

المصدر: Phytochemical Analysis, Vol. 28, No 2 (2017) pp. 93-100

مصطلحات موضوعية: ddc:615, Chromatography, Fungi/metabolism, Tandem Mass Spectrometry, High Pressure Liquid/methods, Fungi, Histone Deacetylases/metabolism, Tandem Mass Spectrometry/methods, Chromatography, High Pressure Liquid, Histone Deacetylases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7d23d944ae6a405da182e153d0412746Test
https://archive-ouverte.unige.ch/unige:94971Test

المؤلفون: Team1 Carmen, Hubert VIDAL, Team2 Carmen, Luciano Pirola, Carmen Lab

المساهمون: Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)

المصدر: Biochemistry and Cell Biology
Biochemistry and Cell Biology, NRC Research Press, 2014, 92 (1), pp.61-7. ⟨10.1139/bcb-2013-0071⟩

مصطلحات موضوعية: Histones/*metabolism, medicine.drug_class, [SDV]Life Sciences [q-bio], Muscle Fibers, Skeletal, 030209 endocrinology & metabolism, SAP30, Biology, Muscle Fibers, Biochemistry, Histone Deacetylases, Histones, Promoter Regions, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, Hexokinase/metabolism, Insulin/*metabolism/pharmacology, 0302 clinical medicine, Genetic, Histone H1, Hexokinase, Histone H2A, medicine, Insulin, Humans, Animals, Histone code, Promoter Regions, Genetic, Molecular Biology, Transcription Initiation Site, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Histone deacetylase 2, Histone deacetylase inhibitor, Acetylation, Cell Biology, HDAC4, Molecular biology, Rats, Class Ia Phosphatidylinositol 3-Kinase, Class Ia Phosphatidylinositol 3-Kinase/metabolism, Gene Expression Regulation, Insulin Receptor Substrate Proteins, Histone Deacetylases/metabolism, Insulin Receptor Substrate Proteins/metabolism, Histone deacetylase, Phosphatidylinositol 3-Kinases/metabolism, Skeletal/drug effects/*metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ee74892e18d034649a649e0cef462Test
https://doi.org/10.1139/bcb-2013-0071Test