المؤلفون: Bibhash Gogoi, Bikash Kumar Singh

مصطلحات موضوعية: ovarian masses, fine needle aspiration, Histological correlation, diagnostic accuracy

الوصف: Background: Several variables affect the efficacy and accuracy of image-guided FNAC in the pre-operative identification of ovarian masses. However, this approach makes it challenging to diagnose borderline tumours. However, epithelial tumours can be correctly identified as benign or malignant. This study’s primary goal was to evaluate the USG-guided FNAC’s sensitivity, specificity, and diagnostic accuracy in neoplastic and non-neoplastic ovarian masses using histopathology as the gold standard. Methods: This study comprised 80 patients who were identified as having probable ovarian masses by clinical and imaging methods between February 2022 and January 2023. FNA was carried out under USG guidance, and a diagnosis was made. Histopathological analysis supported the cytological diagnosis. To find the association between cytological and histological diagnosis, descriptive statistics were used. Results: Twelve cases of benign non-neoplastic cysts were identified after investigation of the fine needle aspirated ... : Background: Several variables affect the efficacy and accuracy of image-guided FNAC in the pre-operative identification of ovarian masses. However, this approach makes it challenging to diagnose borderline tumours. However, epithelial tumours can be correctly identified as benign or malignant. This study’s primary goal was to evaluate the USG-guided FNAC’s sensitivity, specificity, and diagnostic accuracy in neoplastic and non-neoplastic ovarian masses using histopathology as the gold standard. Methods: This study comprised 80 patients who were identified as having probable ovarian masses by clinical and imaging methods between February 2022 and January 2023. FNA was carried out under USG guidance, and a diagnosis was made. Histopathological analysis supported the cytological diagnosis. To find the association between cytological and histological diagnosis, descriptive statistics were used. Results: Twelve cases of benign non-neoplastic cysts were identified after investigation of the fine needle aspirated ...

العلاقة: https://dx.doi.org/10.5281/zenodo.12510399Test

الإتاحة: https://doi.org/10.5281/zenodo.1251040010.5281/zenodo.12510399Test

المؤلفون: Varsha Somabhai Khant, Hiren Nanjibhai Judal, Akash Suryakant Prajapati, Nuthi Vamsi Krishna

مصطلحات موضوعية: Thyroid Nodules, Cytological Diagnosis, Histological Correlation.

الوصف: Introduction: This cross-sectional study aims to examine the correlation between cytological and histological diagnoses in thyroid nodules, shedding light on the reliability of these diagnostic methods.Methods: A total of 200 thyroid nodules were included in this study. A cross-sectional design was employed, and the sample was selected based on predefined criteria. Cytological diagnoses were obtained through fine-needle aspiration (FNA), while histological diagnoses were derived using surgical biopsy.Results: The examination of 200 thyroid nodules revealed a correlation between cytological and histological diagnoses in the majority of cases. Nevertheless, noteworthy disparities were detected in 15% of the nodules. These findings carry substantial implications for the accuracy and consistency of thyroid nodule diagnoses. Conclusion: This study contributes valuable insights into the correlation between cytological and histological diagnoses in thyroid nodules. The observed discrepancies underscore the need for ... : Introduction: This cross-sectional study aims to examine the correlation between cytological and histological diagnoses in thyroid nodules, shedding light on the reliability of these diagnostic methods.Methods: A total of 200 thyroid nodules were included in this study. A cross-sectional design was employed, and the sample was selected based on predefined criteria. Cytological diagnoses were obtained through fine-needle aspiration (FNA), while histological diagnoses were derived using surgical biopsy.Results: The examination of 200 thyroid nodules revealed a correlation between cytological and histological diagnoses in the majority of cases. Nevertheless, noteworthy disparities were detected in 15% of the nodules. These findings carry substantial implications for the accuracy and consistency of thyroid nodule diagnoses. Conclusion: This study contributes valuable insights into the correlation between cytological and histological diagnoses in thyroid nodules. The observed discrepancies underscore the need for ...

العلاقة: https://dx.doi.org/10.5281/zenodo.11222227Test

الإتاحة: https://doi.org/10.5281/zenodo.1122222610.5281/zenodo.11222227Test

المؤلفون: Negi, Soma, Mardi, Kavita, Sood, Shivani, Gupta, Neelam, Mohindroo, N. K., Kumar, Muninder, Azad, Ramesh, Chaudhary, Ashish, Negi, Gunjita

المساهمون: nil

المصدر: International Journal of Research in Medical Sciences; Vol 10, No 2 (2022): February 2022; 425-430 ; 2320-6012 ; 2320-6071

مصطلحات موضوعية: Cyto-histological correlation, FNAC, Salivary glands

الوصف: Background: Fine needle aspiration cytology (FNAC) has an essential proven role in diagnosing most of the common and benign salivary gland lesions. However, limited cellularity and morphological heterogeneity of the lesion can pose diagnostic challenges. The present study was conducted in a tertiary care centre over a period of one year with an objective to study the cyto-morphological features of salivary gland lesions and correlate cytological findings with histopathology.Methods: The study was carried out over a period of one year from January 2014 to December 2014. FNA specimens obtained from 78 patients were analyzed. Of these, only 51 patients underwent biopsy or surgery and their specimens were subjected to histopathological examination. Validation of cytological diagnosis was done on the basis of histopathological diagnosis.Results: A total 78 patients with salivary gland lesions were subjected to FNAC. Non neoplastic lesions constituted 19 cases (25%) and benign lesions constituted 46 cases (80.70%). Malignant lesions constituted 11 cases (19.30%). Two cases were inconclusive due to inadequate aspirated material. Overall sensitivity, specificity and diagnostic accuracy were 95.98%, 99.20% and 98.09% respectively.Conclusions: FNAC continues to be an accurate diagnostic technique in the hands of an experienced cytopathologist. It is a highly sensitive and specific technique for rapid diagnosis of most of the salivary gland swellings.

وصف الملف: application/pdf

العلاقة: https://www.msjonline.org/index.php/ijrms/article/view/9926/6978Test; https://www.msjonline.org/index.php/ijrms/article/downloadSuppFile/9926/9598Test; https://www.msjonline.org/index.php/ijrms/article/downloadSuppFile/9926/9630Test; https://www.msjonline.org/index.php/ijrms/article/downloadSuppFile/9926/9631Test; https://www.msjonline.org/index.php/ijrms/article/view/9926Test

الإتاحة: https://doi.org/10.18203/2320-6012.ijrms20220286Test
https://www.msjonline.org/index.php/ijrms/article/view/9926Test

المؤلفون: Singh, Dinesh Kumar^{1, 1}, Singh, Anju², Kharbanda, Paras¹

المصدر: Indian Journal of Public Health Research & Development 10(2):138-142. 2019

المؤلفون: Jui-Chung Wang, Jui-Ting Hu, Chih-Yu Hsu

المصدر: Reports; Volume 4; Issue 3; Pages: 20

مصطلحات موضوعية: cytology, metastatic hepatocellular carcinoma, endobronchus, neck lymph node, face, abdominal wall, cyto-histological correlation

الوصف: The diagnosis of primary hepatocellular carcinoma (HCC) in high risk patients, such as those with chronic hepatitis B or C with/without cirrhosis of the liver, can be made with relevant image studies alone; however, morphologic confirmation by cytology or histopathology is essential to the diagnosis of metastatic HCC because the treatment of the latter differs from that of primary extrahepatic malignancy. Although both cytology and histopathology are important tools in the diagnosis of malignancy, histopathology almost always plays a confirmatory and pivotal role, and also a gold standard in cyto-histological correlation. We present two patients of metastatic HCC to rare sites; endobronchus in one, and neck lymph nodes, face and the abdominal wall in the other. Repeated bronchial biopsy in the first patient and excisional biopsy from the metastatic sites of the second patient failed to make a conclusive diagnosis of metastatic HCC. However, bronchial brushing in the first patient and fine needle aspiration cytology from the respective metastatic sites of the second patient consistently showed characteristic HCC features and provided clinicians with the rationale for ongoing treatment. The diagnostic issues and possible pitfalls are discussed. Cytology and histopathology appear equipollent; sometimes cytology can play a diagnostic role when histopathology fails its expected role in this scenario.

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/reports4030020Test

الإتاحة: https://doi.org/10.3390/reports4030020Test

المؤلفون: Jinnan Li, Sha Zhao, Wenyan Zhang, Yong Jiang, Xianglan Zhu, Xueqin Den, Weiping Liu, Xueying Su

المصدر: Frontiers in Medicine, Vol 7 (2020)

مصطلحات موضوعية: hematopoietic malignancies, serous effusions, ancillary studies, cytology, cyto-histological correlation, Medicine (General), R5-920

الوصف: Background: The aim of this study was to establish the liability of cytological diagnostic and, along with ancillary techniques, to sub-classify hematopoietic malignancies in serous effusions.Methods: We retrospectively reviewed the serous effusions of hematopoietic malignancies over an 11-year period, along with ancillary studies, clinical and histological data. We compared cytological along with histological diagnosis to evaluate the value of cytology itself. Furthermore, the discrepant cases were reviewed.Results: In this study, a total of 242 cases were identified as hematopoietic malignancies. Ancillary technologies were performed: in 24 cases FCM, 242 cases ICC, 35 cases ISH, 81 cases PCR and 10 cases FISH. Cyto-histological correlation was available for 122 cases. The subtyping of hematopoietic malignancies was achieved using cytological material in 65/122 cases (53.3%). Of the 65 cases, T-Acute lymphoblastic leukemia/lymphoma (22.1%) was the leading subtype, followed by Burkitt lymphoma (5.7%), plasmacytoma (5.7%). Cyto-histological correlation showed a 100% concordant rate of diagnosis for hematopoietic malignancies and a high degree of agreement on sub-classification (51.6%). In this regard, T-acute lymphoblastic leukemia/lymphoma, plasmacytoma, extranodal NK/T-cell lymphoma, nasal type, anaplastic large cell lymphoma, myeloid sarcoma, and follicular lymphoma showed the highest degree of agreement (100%). The sub-classification on cytology was achieved in 53 out of the remaining 120 cases without histological diagnosis (44.2%). T-acute lymphoblastic leukemia/lymphoma (20.8%) was again the most frequently encountered subtype, followed by plasmacytoma (5.8%) and Burkitt lymphoma (4.2%).Conclusions: This large series study provided evidence that combining cytology and ancillary studies enabled the accurate serous effusions cytological diagnoses and subsequent sub-classification for the described malignancies.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmed.2020.615080/fullTest; https://doaj.org/toc/2296-858XTest

الوصول الحر: https://doaj.org/article/f58639c0002e49348a8367c5ff3a25d2Test

المؤلفون: Kariya, Krishna, Mistry, Hetvi, Shah, Jayshree M.

المصدر: Indian Journal of Applied-Basic Medical Sciences; Vol. 22 No. 35 (2020): Indian Journal of Applied-Basic Medical Science - Volume: 22(B), No. 35, (Jul 2020); 453-460 ; 2249-7935 ; 0975-8917

مصطلحات موضوعية: Cyto-histological correlation, carcinoma breast, fine needle aspiration

الوصف: BACKGROUND:Breast lesions in women are most common, which require pathological confirmation by FNAC and histopathological correlation. Recent approach to breast masses is to get cytopathological diagnosis before surgery. Aim of study: To study the diagnostic role of Fine Needle Aspiration Cytology and its histopathological correlation in Malignant breast lesions. METHOD: The study was conducted in department of pathology; AMC MET Medical College, Maninagar, Ahmedabad, Gujarat, India, for duration of 1 year from January 2019 to December 2019. During the study period, 40 cases of fine needle aspiration cytology of malignant breast lesions were performed. Formalin fixed (10%), resected specimens were received and were prepared for histopathological diagnosis. The cytological and histopathological slides were stained, studied, analyzed and correlated. RESULT:During the study period 918 FNAC were undertaken of which 40 FNAC were of malignant breast lesions. Correlation of FNAC with histopathologic tissue was possible in 20 cases, for which FNAC data was available. 99% were from female and 01% was from male patients. The age of patient ranged from 26 to 95 Years. CONCLUSION:FNAC is useful in diagnosing malignant breast lesions, as this procedure is easy, cost effective and less time consuming.

وصف الملف: application/pdf

العلاقة: https://acspublisher.com/journals/index.php/ijabms/article/view/1505/1488Test; https://acspublisher.com/journals/index.php/ijabms/article/view/1505Test

الإتاحة: https://doi.org/10.48165/ijabms.2020.22238Test
https://acspublisher.com/journals/index.php/ijabms/article/view/1505Test

المؤلفون: Claudia Dittfeld, Alice Mieting, Cindy Welzel, Anett Jannasch, Klaus Matschke, Sems-Malte Tugtekin, Gerald Steiner

المصدر: Crystals; Volume 10; Issue 9; Pages: 763

مصطلحات موضوعية: FT-IR spectroscopy, aortic valve tissue, biomineralization, bioprosthesis, PCA, von Kossa staining, histological correlation

الوصف: Pathological ECM remodelling and biomineralization in human aortic valve and bioprosthesis tissue were investigated by Fourier transformed infrared (FT-IR) spectroscopic imaging and multivariate data analysis. Results of histological von Kossa staining to monitor hydroxyapatite biomineralization correlated to the definition of mineralized tissue using FT-IR spectroscopic imaging. Spectra exhibit signals of carbonate and phosphate groups of hydroxyapatite. Proteins could be identified by the amide I and amide II bands. Proteins were detected in the calcified human aortic valve tissue, but no absorption signals of proteins were observed in the mineralized bioprosthesis sample region. A shift of the amide I band from 1654 cm−1 to 1636 cm−1 was assumed to result from β-sheet structures. This band shift was observed in regions where the mineralization process had been identified but also in non-mineralized bioprosthesis tissue independent of prior implantation. The increased occurrence of β-sheet conformation is hypothesized to be a promoter of the biomineralization process. FT-IR spectroscopic imaging offers a wealth of chemical information. For example, slight variations in band position and intensity allow investigation of heterogeneity across aortic valve tissue sections. The exact evaluation of these properties and correlation with conventional histological staining techniques give insights into aortic valve tissue remodelling and calcific pathogenesis.

وصف الملف: application/pdf

العلاقة: Mineralogical Crystallography and Biomineralization; https://dx.doi.org/10.3390/cryst10090763Test

الإتاحة: https://doi.org/10.3390/cryst10090763Test

المؤلفون: Bhatnagar, Avni, Mardi, Kavita, Sood, Shivani, Kaushal, Vijay, Gupta, Kanishk

المصدر: International Journal of Research in Medical Sciences; Vol 8, No 10 (2020): October 2020; 3670-3677 ; 2320-6012 ; 2320-6071

مصطلحات موضوعية: CYTO-histological correlation, Malignancy risk, TBSRTC

الوصف: Background: The Bethesda system for reporting thyroid cytology (TSBRTC) was devised by the National Cancer Institute (NCI) to obtain uniformity, reproducibility and a defined management protocol while dealing with thyroid lesions. This study was undertaken with the aim to see the benefits of adopting TBSRTC in the diagnosis of thyroid FNAC, and identify the malignancy risk of each category.Methods: This cross-sectional study was conducted in Indira Gandhi Medical College, Shimla, Himachal Pradesh from June 2016 to July 2017 on 181 thyroid FNACs which were reported according to the Bethesda system for reporting thyroid cytopathology (TBSRTC) under six categories: (I) non-diagnostic/unsatisfactory (II) benign (III) atypia of undetermined significance/follicular lesion of undetermined significance (IV) follicular neoplasm/suspicious for follicular neoplasm (specify if Hurthle cell (oncocytic) type (V) suspicious for malignancy (VI) malignant. Histopathological diagnosis was available for 65 cases where thyroidectomy was performed. Malignancy risk was calculated for each category. Sensitivity, specificity, positive and negative predictive values for TBSRCT were also calculated. All the data was analyzed in SPSS software version 22.0 (IBM, USA).Results: Benign lesions constituted the major bulk. After the use of TBSRTC, there was increased ability to look for follicular neoplasms, improvement in making definitive diagnosis of the cases, an improvement in diagnostic accuracy, and we were in line with the implied risk outlined by TBSRTC in most of the cases.Conclusions: Application of TBSRTC results in uniformity in reporting among pathologists and better interdisciplinary communication and patient management.

وصف الملف: application/pdf

العلاقة: https://www.msjonline.org/index.php/ijrms/article/view/8646/6022Test; https://www.msjonline.org/index.php/ijrms/article/downloadSuppFile/8646/7656Test; https://www.msjonline.org/index.php/ijrms/article/downloadSuppFile/8646/7657Test; https://www.msjonline.org/index.php/ijrms/article/view/8646Test

الإتاحة: https://doi.org/10.18203/2320-6012.ijrms20204249Test
https://www.msjonline.org/index.php/ijrms/article/view/8646Test

المؤلفون: Atsuko Yamamoto, Kai Takaki, Kiyoshi Murata, Ryuta Ito, Shigehiro Morikawa

المصدر: Magnetic Resonance in Medical Sciences. 2021, 20(3):264