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1دورية أكاديمية
المؤلفون: Ghoussaini, M, French, JD, Michailidou, K, Nord, S, Beesley, J, Canisus, S, Hillman, KM, Kaufmann, S, Sivakumaran, H, Marjaneh, MM, Lee, JS, Dennis, J, Bolla, MK, Wang, Q, Dicks, E, Milne, RL, Hopper, JL, Southey, MC, Schmidt, MK, Broeks, A, Muir, K, Lophatananon, A, Fasching, PA, Beckmann, MW, Fletcher, O, Johnson, N, Sawyer, EJ, Tomlinson, I, Burwinkel, B, Marme, F, Guenel, P, Truong, T, Bojesen, SE, Flyger, H, Benitez, J, Gonzalez-Neira, A, Alonso, R, Pita, G, Neuhausen, SL, Anton-Culver, H, Brenner, H, Arndt, V, Meindl, A, Schmutzler, RK, Brauch, H, Hamann, U, Tessier, DC, Vincent, D, Nevanlinna, H, Khan, S, Matsuo, K, Ito, H, Dork, T, Bogdanova, NV, Lindblom, A, Margolin, S, Mannermaa, A, Kosma, VM, Wu, AH, Van den Berg, D, Lambrechts, D, Floris, G, Chang-Claude, J, Rudolph, A, Radice, P, Barile, M, Couch, FJ, Hallberg, E, Giles, GG, Haiman, CA, Le Marchand, L, Goldberg, MS, Teo, SH, Yip, CH, Borresen-Dale, AL, Zheng, W, Cai, QY, Winqvist, R, Pylkas, K, Andrulis, IL, Devilee, P, Tollenaar, RAEM, Garcia-Closas, M, Figueroa, J, Hall, P, Czene, K, Brand, JS, Darabi, H, Eriksson, M, Hooning, MJ, Koppert, LB, Li, JM, Shu, XO, Zheng, Y, Cox, A, Cross, SS, Shah, M, Rhenius, V, Choi, JY, Kang, D, Hartman, M, Chia, KS, Kabisch, M, Torres, D, Luccarini, C, Conroy, DM, Jakubowska, A, Lubinski, J, Sangrajrang, S, Brennan, P, Olswold, C, Slager, S, Shen, CY, Hou, MF, Swerdlow, A, Schoemaker, MJ, Simard, J, Pharoah, PDP, Kristensen, V, Chenevix-Trench, G, Easton, DF, Dunning, AM, Edwards, SL
المصدر: American journal of human genetics. 99(4):903-911
مصطلحات موضوعية: Medicin och hälsovetenskap
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2دورية أكاديمية
المؤلفون: Painter, JN, Kaufmann, S, O'Mara, TA, Hillman, KM, Sivakumaran, H, Darabi, H, Cheng, THT, Pearson, J, Kazakoff, S, Waddell, N, Hoivik, EA, Goode, EL, Scott, RJ, Tomlinson, I, Dunning, AM, Easton, DF, French, JD, Salvesen, HB, Pollock, PM, Thompson, DJ, Spurdle, AB, Edwards, SL
المصدر: American journal of human genetics. 98(6):1159-1169
مصطلحات موضوعية: Medicin och hälsovetenskap
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3دورية أكاديمية
المؤلفون: Painter, JN, O'Mara, TA, Batra, J, Cheng, T, Lose, FA, Dennis, J, Michailidou, K, Tyrer, JP, Ahmed, S, Ferguson, K, Healey, CS, Kaufmann, S, Hillman, KM, Walpole, C, Moya, L, Pollock, P, Jones, A, Howarth, K, Martin, L, Gorman, M, Hodgson, S, De Polanco, MME, Sans, M, Carracedo, A, Castellvi-Bel, S, Rojas-Martinez, A, Santos, E, Teixeira, MR, Carvajal-Carmona, L, Shu, XO, Long, JR, Zheng, W, Xiang, YB, Montgomery, GW, Webb, PM, Scott, RJ, McEvoy, M, Attia, J, Holliday, E, Martin, NG, Nyholt, DR, Henders, AK, Fasching, PA, Hein, A, Beckmann, MW, Renner, SP, Doerk, T, Hillemanns, P, Durst, M, Runnebaum, I, Lambrechts, D, Coenegrachts, L, Schrauwen, S, Amant, F, Winterhoff, B, Dowdy, SC, Goode, EL, Teoman, A, Salvesen, HB, Trovik, J, Njolstad, TS, Werner, HMJ, Ashton, K, Proietto, T, Otton, G, Tzortzatos, G, Mints, M, Tham, E, Hall, P, Czene, K, Liu, JJ, Li, JM, Hopper, JL, Southey, MC, Ekici, AB, Ruebner, M, Johnson, N, Peto, J, Burwinkel, B, Marme, F, Brenner, H, Dieffenbach, AK, Meindl, A, Brauch, H, Lindblom, A, Depreeuw, J, Moisse, M, Chang-Claude, J, Rudolph, A, Couch, FJ, Olson, JE, Giles, GG, Bruinsma, F, Cunningham, JM, Fridley, BL, Borresen-Dale, AL, Kristensen, VN, Cox, A, Swerdlow, AJ, Orr, N, Bolla, MK, Wang, Q, Weber, RP, Chen, Z, Shah, M, French, JD, Pharoah, PDP, Dunning, AM, Tomlinson, I, Easton, DF, Edwards, SL, Thompson, DJ, Spurdle, AB
المصدر: Human molecular genetics. 24(5):1478-1492
مصطلحات موضوعية: Medicin och hälsovetenskap
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4دورية أكاديمية
المؤلفون: Glubb, DM, Maranian, MJ, Michailidou, K, Pooley, KA, Meyer, KB, Kar, S, Carlebur, S, O'Reilly, M, Betts, JA, Hillman, KM, Kaufmann, S, Beesley, J, Canisius, S, Hopper, JL, Southey, MC, Tsimiklis, H, Apicella, C, Schmidt, MK, Broeks, A, Hogervorst, FB, van der Schoot, CE, Muir, K, Lophatananon, A, Stewart-Brown, S, Siriwanarangsan, P, Fasching, PA, Ruebner, M, Ekici, AB, Beckmann, MW, Peto, J, Dos-Santos-Silva, I, Fletcher, O, Johnson, N, Pharoah, PDP, Bolla, MK, Wang, Q, Dennis, J, Sawyer, EJ, Tomlinson, I, Kerin, MJ, Miller, N, Burwinkel, B, Marme, F, Yang, RX, Surowy, H, Guenel, P, Truong, T, Menegaux, F, Sanchez, M, Bojesen, SE, Nordestgaard, BG, Nielsen, SF, Flyger, H, Gonzelez-Neira, A, Benitez, J, Zamora, MP, Perez, JIA, Anton-Culver, H, Neuhausen, SL, Brenner, H, Dieffenbach, AK, Arndt, V, Stegmaier, C, Meindl, A, Schmutzler, RK, Brauch, H, Ko, YD, Bruning, T, Nevanlinna, H, Muranen, TA, Aittomaki, K, Blomqvist, C, Matsuo, K, Ito, H, Iwata, H, Tanaka, H, Dork, T, Bogdanova, NV, Helbig, S, Lindblom, A, Margolin, S, Mannermaa, A, Kataja, V, Kosma, VM, Hartikainen, JM, Wu, AH, Tseng, CC, Van den Berg, D, Stram, DO, Lambrechts, D, Zhao, H, Weltens, C, van Limbergen, E, Chang-Claude, J, Flesch-Janys, D, Rudolph, A, Seibold, P, Radice, P, Peterlongo, P, Barile, M, Capra, F, Couch, FJ, Olson, JE, Hallberg, E, Vachon, C, Giles, GG, Milne, RL, McLean, C, Haiman, CA, Henderson, BE, Schumacher, F, Le Marchand, L, Simard, J, Goldberg, MS, Labreche, F, Dumont, M, Teo, SH, Yip, CH, See, MH, Cornes, B, Cheng, CY, Ikram, MK, Kristensen, V, Zheng, W, Halverson, SL, Shrubsole, M, Long, J, Winqvist, R, Pylkas, K, Jukkola-Vuorinen, A, Kauppila, S, Andrulis, IL, Knight, JA, Glendon, G, Tchatchou, S, Devilee, P, Tollenaar, RAEM, Seynaeve, C, Van Asperen, CJ, Garcia-Closas, M, Figueroa, J, Chanock, SJ, Lissowska, J, Czene, K, Klevebring, D, Darabi, H, Eriksson, M, Hooning, MJ, Hollestelle, A, Martens, JWM, Collee, JM, Hall, P, Li, JM, Humphreys, K, Shu, XO, Lu, W, Gao, YT, Cai, H, Cox, A, Cross, SS, Reed, MWR, Blot, W, Signorello, LB, Cai, QY, Shah, M, Ghoussaini, M, Kang, D, Choi, JY, Park, SK, Noh, DY, Hartman, M, Miao, H, Lim, WY, Tang, A, Hamann, U, Torres, D, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Sangrajrang, S, Gaborieau, V, Brennan, P, McKay, J, Olswold, C, Slager, S, Toland, AE, Yannoukakos, D, Shen, CY, Wu, PE, Yu, JC, Hou, MF, Swerdlow, A, Ashworth, A, Orr, N, Jones, M, Pita, G, Alonso, MR, Alvarez, N, Herrero, D, Tessier, DC, Vincent, D, Bacot, F, Luccarini, C, Baynes, C, Ahmed, S, Healey, CS, Brown, MA, Ponder, BAJ, Chenevix-Trench, G, Thompson, DJ, Edwards, SL, Easton, DF, Dunning, AM, French, JD
المصدر: American journal of human genetics. 96(1):5-20
مصطلحات موضوعية: Medicin och hälsovetenskap
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5دورية أكاديمية
المؤلفون: Bojesen, SE, Pooley, KA, Johnatty, SE, Beesley, J, Michailidou, K, Tyrer, JP, Edwards, SL, Pickett, HA, Shen, HC, Smart, CE, Hillman, KM, Mai, PL, Lawrenson, K, Stutz, MD, Lu, Y, Karevan, R, Woods, N, Johnston, RL, French, JD, Chen, XQ, Weischer, M, Nielsen, SF, Maranian, MJ, Ghoussaini, M, Ahmed, S, Baynes, C, Bolla, MK, Wang, Q, Dennis, J, McGuffog, L, Barrowdale, D, Lee, A, Healey, S, Lush, M, Tessier, DC, Vincent, D, Bacot, F, Vergote, I, Lambrechts, S, Despierre, E, Risch, HA, Gonzaalez-Neira, A, Rossing, MA, Pita, G, Doherty, JA, Alvarez, N, Larson, MC, Fridley, BL, Schoof, N, Chang-Claude, J, Cicek, MS, Peto, J, Kalli, KR, Broeks, A, Armasu, SM, Schmidt, MK, Braaf, LM, Winterhoff, B, Nevanlinna, H, Konecny, GE, Lambrechts, D, Rogmann, L, Guenel, P, Teoman, A, Milne, RL, Garcia, JJ, Cox, A, Shridhar, V, Burwinkel, B, Marme, F, Hein, R, Sawyer, EJ, Haiman, CA, Wang-Gohrke, S, Andrulis, IL, Moysich, KB, Hopper, JL, Odunsi, K, Lindblom, A, Giles, GG, Brenner, H, Simard, J, Lurie, G, Fasching, PA, Carney, ME, Radice, P, Wilkens, LR, Swerdlow, A, Goodman, MT, Brauch, H, Garcia-Closas, M, Hillemanns, P, Winqvist, R, Durst, M, Devilee, P, Runnebaum, I, Jakubowska, A, Lubinski, J, Mannermaa, A, Butzow, R, Bogdanova, NV, Dork, T, Pelttari, LM, Zheng, W, Leminen, A, Anton-Culver, H, Bunker, CH, Kristensen, V, Ness, RB, Muir, K, Edwards, R, Meind, A, Heitz, F, Matsuo, K, du Bois, A, Wu, AH, Harter, P, Teo, SH, Schwaab, I, Shu, XO, Blot, W, Hosono, S, Kang, D, Nakanishi, T, Hartman, M, Yatabe, Y, Hamann, U, Karlan, BY, Sangrajrang, S, Kjaer, SK, Gaborieau, V, Jensen, A, Eccles, D, Hogdall, E, Shen, CY, Brown, J, Woo, YL, Shah, M, Azmi, MAN, Luben, R, Omar, SZ, Czene, K, Vierkant, RA, Nordestgaard, BG, Flyger, H, Vachon, C, Olson, JE, Wang, XS, Levine, DA, Rudolph, A, Weber, RP, Flesch-Janys, D, Iversen, E, Nickels, S, Schildkraut, JM, Silva, ID, Cramer, DW, Gibson, L, Terry, KL, Fletcher, O, Vitonis, AF, van der Schoot, CE, Poole, EM, Hogervorst, FBL, Tworoger, SS, Liu, JJ, Bandera, EV, Li, JM, Olson, SH, Humphreys, K, Row, I, Blomqvist, C, Rodriguez-Rodriguez, L, Aittomaki, K, Salvesen, HB, Muranen, TA, Wik, E, Brouwers, B, Krakstad, C, Wauters, E, Halle, MK, Wildiers, H, Kiemeney, LA, Mulot, C, Aben, KK, Laurent-Puig, P, Altena, AM, Truong, T, Massuger, LFAG, Benitez, J, Pejovic, T, Perez, JIA, Hoatlin, M, Zamora, MP, Cook, LS, Balasubramanian, SP, Kelemen, LE, Schneeweiss, A, Le, ND, Sohn, C, Brooks-Wilson, A, Tomlinson, I, Kerin, MJ, Miller, N, Cybulski, C, Henderson, BE, Menkiszak, J, Schumacher, F, Wentzensen, N, Le Marchand, L, Yang, HP, Mulligan, AM, Glendon, G, Engelholm, SA, Knight, JA, Hogdall, CK, Apicella, C, Gore, M, Tsimiklis, H, Song, HL, Southey, MC, Jager, A, den Ouweland, AMW, Brown, R, Martens, JWM, Flanagan, JM, Kriege, M, Paul, J, Margolin, S, Siddiqui, N, Severi, G, Whittemore, AS, Baglietto, L, McGuire, V, Stegmaier, C, Sieh, W, Muller, H, Arndt, V, Labreche, F, Gao, YT, Goldberg, MS, Yang, G, Dumont, M, McLaughlin, JR, Hartmann, A, Ekici, AB, Beckmann, MW, Phelan, CM, Lux, MP, Permuth-Wey, J, Peissel, B, Sellers, TA, Ficarazzi, F, Barile, M, Ziogas, A, Ashworth, A, Gentry-Maharaj, A, Jones, M, Ramus, SJ, Orr, N, Menon, U, Pearce, CL, Bruning, T, Pike, MC, Ko, YD, Lissowska, J, Figueroa, J, Kupryjanczyk, J, Chanock, SJ, Dansonka-Mieszkowska, A, Jukkola-Vuorinen, A, Rzepecka, IK, Pylkas, K, Bidzinski, M, Kauppila, S, Hollestelle, A, Seynaeve, C, Tollenaar, RAEM, Durda, K, Jaworska, K, Hartikainen, JM, Kosma, VM, Kataja, V, Antonenkova, NN, Long, JR, Shrubsole, M, Deming-Halverson, S, Lophatananon, A, Siriwanarangsan, P, Stewart-Brown, S, Ditsch, N, Lichtner, P, Schmutzler, RK, Ito, H, Iwata, H, Tajima, K, Tseng, CC, Stram, DO, van den Berg, D, Yip, CH, Ikrarn, MK, Teh, YC, Cai, H, Lu, W, Signorello, LB, Cai, QY, Noh, DY, Yoo, KY, Miao, H, Iau, PTC, Teo, YY, McKay, J, Shapiro, C, Ademuyiwa, F, Fountzilas, G, Hsiung, CN, Yu, JC, Hou, MF, Healey, CS, Luccarini, C, Peock, S, Stoppa-Lyonnet, D, Peterlongo, P, Rebbeck, TR, Piedmonte, M, Singer, CF, Friedman, E, Thomassen, M, Offit, K, Hansen, TVO, Neuhausen, SL, Szabo, CI, Blanco, I, Garber, J, Narod, SA, Weitzel, JN, Montagna, M, Olah, E, Godwin, AK, Yannoukakos, D, Goldgar, DE, Caldes, T, Imyanitov, EN, Tihomirova, L, Arun, BK, Campbell, I, Mensenkamp, AR, van Asperen, CJ, van Roozendaa, KEP, Meijers-Heijboer, H, Collee, JM, Oosterwijk, JC, Hooning, MJ, Rookus, MA, van der Luijt, RB, Os, TAM, Evans, DG, Frost, D, Fineberg, E, Barwell, J, Walker, L, Kennedy, MJ, Platte, R, Davidson, R, Ellis, SD, Cole, T, Bressac-de Paillerets, B, Buecher, B, Damiola, F, Faivre, L, Frenay, M, Sinilnikova, OM, Caron, O, Giraud, S, Mazoyer, S, Bonadona, V, Caux-Moncoutier, V, Toloczko-Grabarek, A, Gronwald, J, Byrski, T, Spurdle, AB, Bonanni, B, Zaffaroni, D, Giannini, G, Bernard, L, Dolcetti, R, Manoukian, S, Arnold, N, Engel, C, Deissler, H, Rhiem, K, Niederacher, D, Pendl, H, Sutter, C, Wappenschmidt, B, Borg, A, Mein, B, Rantala, J, Soller, M, Nathanson, KL, Domchek, SM, Rodriguez, GC, Salani, R, Kaulich, DG, Tea, MK, Paluch, SS, Laitman, Y, Skytte, AB, Kruse, TA, Jensen, UB, Robson, M, Gerdes, AM, Ejlertsen, B, Foretova, L, Savage, SA, Lesterm, J, Soucy, P, Kuchenbaecker, KB, Olswold, C, Cunningham, JM, Slager, S, Pankratz, VS, Dicks, E, Lakhani, SR, Couch, FJ, Hall, P, Monteiro, ANA, Gayther, SA, Pharoah, PDP, Reddel, RR, Goode, EL, Greene, MH, Easton, DF, Berchuck, A, Antoniou, AC, Chenevix-Trench, G, Dunning, AM
المصدر: Nature genetics. 45(4):371-384
مصطلحات موضوعية: Medicin och hälsovetenskap
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6دورية أكاديمية
المؤلفون: French, JD, Ghoussaini, M, Edwards, SL, Meyer, KB, Michailidou, K, Ahmed, S, Khan, S, Maranian, MJ, O'Reilly, M, Hillman, KM, Betts, JA, Carro, T, Bailey, PJ, Dicks, E, Beesley, J, Tyrer, J, Maia, AT, Beck, A, Knoblauch, NW, Chen, C, Kraft, P, Barnes, D, Gonzalez-Neira, A, Alonso, MR, Herrero, D, Tessier, DC, Vincent, D, Bacot, F, Luccarini, C, Baynes, C, Conroy, D, Dennis, J, Bolla, MK, Wang, Q, Hopper, JL, Southey, MC, Schmidt, MK, Broeks, A, Verhoef, S, Cornelissen, S, Muir, K, Lophatananon, A, Stewart-Brown, S, Siriwanarangsan, P, Fasching, PA, Loehberg, CR, Ekici, AB, Beckmann, MW, Peto, J, Silva, IDS, Johnson, N, Aitken, Z, Sawyer, EJ, Tomlinson, I, Kerin, MJ, Miller, N, Marme, F, Schneeweiss, A, Sohn, C, Burwinkel, B, Guenel, P, Truong, T, Laurent-Puig, P, Menegaux, F, Bojesen, SE, Nordestgaard, NG, Nielsen, SF, Flyger, H, Milne, RL, Zamora, MP, Perez, JIA, Benitez, J, Anton-Culver, H, Brenner, H, Muller, H, Arndt, V, Stegmaier, C, Meind, A, Lichtner, P, Schmutzler, RK, Engel, C, Brauch, H, Hamann, U, Justenhoven, C, Aaltonen, K, Heikkila, P, Aittomaki, K, Blomqvist, C, Matsuo, K, Ito, H, Iwata, H, Sueta, A, Bogdanova, NV, Antonenkova, NN, Dork, T, Lindblom, A, Margolin, S, Mannermaa, A, Kataja, V, Kosma, VM, Hartikainen, JM, Wu, AH, Tseng, CC, Van Den Berg, D, Stram, DO, Lambrechts, D, Peeters, S, Smeets, A, Floris, G, Chang-Claude, J, Rudolph, A, Nickels, S, Flesch-Janys, D, Radice, P, Peterlongo, P, Bonanni, B, Sardella, D, Couch, FJ, Wang, XS, Pankratz, VS, Lee, A, Giles, GG, Severi, G, Baglietto, L, Haiman, CA, Henderson, BE, Schumacher, F, Le Marchand, L, Simard, J, Goldberg, MS, Labreche, F, Dumont, M, Teo, SH, Yip, CH, Ng, CH, Vithana, EN, Kristensen, V, Zheng, W, Deming-Halverson, S, Shrubsole, M, Long, JR, Winqvist, R, Pylkas, K, Jukkola-Vuorinen, A, Grip, M, Andrulis, IL, Knight, JA, Glendon, G, Mulligan, AM, Devilee, P, Seynaeve, C, Garcia-Closas, M, Figueroa, J, Chanock, SJ, Lissowska, J, Czene, K, Klevebring, D, Schoof, N, Hooning, MJ, Martens, JWM, Collee, JM, Tilanus-Linthorst, M, Hall, P, Li, JM, Liu, JJ, Humphreys, K, Shu, XO, Lu, W, Gao, YT, Cai, H, Cox, A, Balasubramanian, SP, Blot, W, Signorello, LB, Cai, QY, Pharoah, PDP, Healey, CS, Shah, M, Pooley, KA, Kang, D, Yoo, KY, Noh, DY, Hartman, M, Miao, H, Sng, JH, Sim, X, Jakubowska, A, Lubinski, J, Jaworska-Bieniek, K, Durda, K, Sangrajrang, S, Gaborieau, V, McKay, J, Toland, AE, Ambrosone, CB, Yannoukakos, D, Godwin, AK, Shen, CY, Hsiung, CN, Wu, PE, Chen, ST, Swerdlow, A, Ashworth, A, Orr, N, Schoemaker, MJ, Ponder, BAJ, Nevanlinna, H, Brown, MA, Chenevix-Trench, G, Easton, DF, Dunning, AM
المصدر: American journal of human genetics. 92(4):489-503
مصطلحات موضوعية: Medicin och hälsovetenskap
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7دورية أكاديمية
المؤلفون: Sanchez, D, Brennan, K, Al Sayfe, M, Shunker, SA, Bogdanoski, T, Hedges, S, Hou, YC, Lynch, J, Hunt, L, Alexandrou, E, Saxena, M, Abel, S, Lakshmanan, R, Bhonagiri, D, Parr, MJ, Aneman, A, Chroinin, DN, Hillman, KM, Frost, SA, Aneman, Erik
المصدر: urn:ISSN:1364-8535 ; urn:ISSN:1466-609X ; Critical Care, 24, 1, 609
مصطلحات موضوعية: Aging, Patient Safety, Brain Disorders, Clinical Research, 7.1 Individual care needs, 7 Management of diseases and conditions, 3 Good Health and Well Being, Aged, 80 and over, Delirium, Female, Frailty, Hospital Mortality, Hospitalization, Humans, Intensive Care Units, Male, Middle Aged, ICU outcomes, anzsrc-for: 11 Medical and Health Sciences
الوصف: Background: Clinical frailty among older adults admitted to intensive care has been proposed as an important determinant of patient outcomes. Among this group of patients, an acute episode of delirium is also common, but its relationship to frailty and increased risk of mortality has not been extensively explored. Therefore, the aim of this study was to explore the relationship between clinical frailty, delirium and hospital mortality of older adults admitted to intensive care. Methods: This study is part of a Delirium in Intensive Care (Deli) Study. During the initial 6-month baseline period, clinical frailty status on admission to intensive care, among adults aged 50 years or more; acute episodes of delirium; and the outcomes of intensive care and hospital stay were explored. Results: During the 6-month baseline period, 997 patients, aged 50 years or more, were included in this study. The average age was 71 years (IQR, 63–79); 55% were male (n = 537). Among these patients, 39.2% (95% CI 36.1–42.3%, n = 396) had a Clinical Frailty Score (CFS) of 5 or more, and 13.0% (n = 127) had at least one acute episode of delirium. Frail patients were at greater risk of an episode of delirium (17% versus 10%, adjusted rate ratio (adjRR) = 1.71, 95% confidence interval (CI) 1.20–2.43, p = 0.003), had a longer hospital stay (2.6 days, 95% CI 1–7 days, p = 0.009) and had a higher risk of hospital mortality (19% versus 7%, adjRR = 2.54, 95% CI 1.72–3.75, p < 0.001), when compared to non-frail patients. Patients who were frail and experienced an acute episode of delirium in the intensive care had a 35% rate of hospital mortality versus 10% among non-frail patients who also experienced delirium in the ICU. Conclusion: Frailty and delirium significantly increase the risk of hospital mortality. Therefore, it is important to identify patients who are frail and institute measures to reduce the risk of adverse events in the ICU such as delirium and, importantly, to discuss these issues in an open and empathetic way with the patient ...
وصف الملف: application/pdf
العلاقة: http://hdl.handle.net/1959.4/unsworks_85645Test; https://unsworks.unsw.edu.au/bitstreams/15289013-f3df-4881-a6e6-820a1488d603/downloadTest; https://doi.org/10.1186/s13054-020-03318-2Test
الإتاحة: https://doi.org/10.1186/s13054-020-03318-2Test
http://hdl.handle.net/1959.4/unsworks_85645Test
https://unsworks.unsw.edu.au/bitstreams/15289013-f3df-4881-a6e6-820a1488d603/downloadTest -
8دورية أكاديمية
المؤلفون: Moradi Marjaneh, M, Beesley, J, O'Mara, TA, Mukhopadhyay, P, Koufariotis, LT, Kazakoff, S, Hussein, N, Fachal, L, Bartonicek, N, Hillman, KM, Kaufmann, S, Sivakumaran, H, Smart, CE, McCart Reed, AE, Ferguson, K, Saunus, JM, Lakhani, SR, Barnes, DR, Antoniou, AC, Dinger, ME, Waddell, N, Easton, DF, Dunning, AM, Chenevix-Trench, G, Edwards, SL, French, JD
المصدر: urn:ISSN:1474-7596 ; urn:ISSN:1474-760X ; Genome Biology, 21, 1, 7
مصطلحات موضوعية: Prevention, Human Genome, Genetics, Cancer, Breast Cancer, 2.1 Biological and endogenous factors, 2 Aetiology, Breast Neoplasms, Genome-Wide Association Study, Humans, RNA, Untranslated, Sequence Analysis, anzsrc-for: 05 Environmental Sciences, anzsrc-for: 06 Biological Sciences, anzsrc-for: 08 Information and Computing Sciences
الوصف: Background: Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements such as enhancers and promoters. However, the contribution of non-coding RNAs to complex traits is not clear. Results: Using targeted RNA sequencing, we systematically annotated multi-exonic non-coding RNA (mencRNA) genes transcribed from 1.5-Mb intervals surrounding 139 breast cancer GWAS signals and assessed their contribution to breast cancer risk. We identify more than 4000 mencRNA genes and show their expression distinguishes normal breast tissue from tumors and different breast cancer subtypes. Importantly, breast cancer risk variants, identified through genetic fine-mapping, are significantly enriched in mencRNA exons, but not the promoters or introns. eQTL analyses identify mencRNAs whose expression is associated with risk variants. Furthermore, chromatin interaction data identify hundreds of mencRNA promoters that loop to regions that contain breast cancer risk variants. Conclusions: We have compiled the largest catalog of breast cancer-associated mencRNAs to date and provide evidence that modulation of mencRNAs by GWAS variants may provide an alternative mechanism underlying complex traits.
وصف الملف: application/pdf
العلاقة: http://hdl.handle.net/1959.4/unsworks_69058Test; https://unsworks.unsw.edu.au/bitstreams/b2a476cb-b607-41a3-84ac-2f801c67831c/downloadTest; https://doi.org/10.1186/s13059-019-1876-zTest
الإتاحة: https://doi.org/10.1186/s13059-019-1876-zTest
http://hdl.handle.net/1959.4/unsworks_69058Test
https://unsworks.unsw.edu.au/bitstreams/b2a476cb-b607-41a3-84ac-2f801c67831c/downloadTest -
9دورية أكاديمية
المؤلفون: Dunning, AM, Michailidou, K, Kuchenbaecker, KB, Thompson, D, French, JD, Beesley, J, Healey, CS, Kar, S, Pooley, KA, Lopez-Knowles, E, Dicks, E, Barrowdale, D, Sinnott-Armstrong, NA, Sallari, RC, Hillman, KM, Kaufmann, S, Sivakumaran, H, Marjaneh, MM, Lee, JS, Hills, M, Jarosz, M, Drury, S, Canisius, S, Bolla, MK, Dennis, J, Wang, Q, Hopper, JL, Southey, MC, Broeks, A, Schmidt, MK, Lophatananon, A, Muir, K, Beckmann, MW, Fasching, PA, dos-Santos-Silva, I, Peto, J, Sawyer, EJ, Tomlinson, I, Burwinkel, B, Marme, F, Guenel, P, Truong, T, Bojesen, SE, Flyger, H, Gonzalez-Neira, A, Perez, JIA, Anton-Culver, H, Eunjung, L, Arndt, V, Brenner, H, Meindl, A, Schmutzler, RK, Brauch, H, Hamann, U, Aittomaki, K, Blomqvist, C, Ito, H, Matsuo, K, Bogdanova, N, Dork, T, Lindblom, A, Margolin, S, Kosma, VM, Mannermaa, A, Tseng, CC, Wu, AH, Lambrechts, D, Wildiers, H, Chang-Claude, J, Rudolph, A, Peterlongo, P, Radice, P, Olson, JE, Giles, GG, Milne, RL, Haiman, CA, Henderson, BE, Goldberg, MS, Teo, SH, Yip, CH, Nord, S, Borresen-Dale, AL, Kristensen, V, Long, J, Zheng, W, Pylkas, K, Winqvist, R, Andrulis, IL, Knight, JA, Devilee, P, Seynaeve, C, Figueroa, J, Sherman, ME, Czene, K, Darabi, H, Hollestelle, A, van den Ouweland, AMW, Humphreys, K, Gao, YT, Shu, XO, Cox, A, Cross, SS, Blot, W, Cai, Q, Ghoussaini, M, Perkins, BJ, Shah, M, Choi, JY, Kang, D, Lee, SC, Hartman, M, Kabisch, M, Torres, D, Jakubowska, A, Lubinski, J, Brennan, P, Sangrajrang, S, Ambrosone, CB, Toland, AE, Shen, CY, Wu, PE, Orr, N, Swerdlow, A, McGuffog, L, Healey, S, Lee, A, Kapuscinski, M, John, EM, Terry, MB, Daly, MB, Goldgar, DE, Buys, SS, Janavicius, R, Tihomirova, L, Tung, N, Dorfling, CM, van Rensburg, EJ, Neuhausen, SL, Ejlertsen, B, Hansen, TVO, Osorio, A, Benitez, J, Rando, R, Weitzel, JN, Bonanni, B, Peissel, B, Manoukian, S, Papi, L, Ottini, L, Konstantopoulou, I, Apostolou, P, Garber, J, Rashid, MU, Frost, D, Izatt, L, Ellis, S, Godwin, AK, Arnold, N, Niederacher, D, Rhiem, K, Bogdanova-Markov, N, Sagne, C, Stoppa-Lyonnet, D, Damiola, F, Sinilnikova, OM, Mazoyer, S, Isaacs, C, Claes, KBM, De Leeneer, K, De la Hoya, M, Caldes, T, Nevanlinna, H, Khan, S, Mensenkamp, AR, Hooning, MJ, Rookus, MA, Kwong, A, Olah, E, Diez, O, Brunet, J, Pujana, MA, Gronwald, J, Huzarski, T, Barkardottir, RB, Laframboise, R, Soucy, P, Montagna, M, Agata, S, Teixeira, MR, Park, SK, Lindor, N, Couch, FJ, Tischkowitz, M, Foretova, L, Vijai, J, Offit, K, Singer, CF, Rappaport, C, Phelan, CM, Greene, MH, Mai, PL, Rennert, G, Imyanitov, EN, Hulick, PJ, Phillips, KA, Piedmonte, M, Mulligan, AM, Glendon, G, Bojesen, A, Thomassen, M, Caligo, MA, Yoon, SY, Friedman, E, Laitman, Y, Borg, A, Von Wachenfeldt, A, Ehrencrona, H, Rantala, J, Olopade, OI, Ganz, PA, Nussbaum, RL, Gayther, SA, Nathanson, KL, Domchek, SM, Arun, BK, Mitchell, G, Karlan, BY, Lester, J, Maskarinec, G, Woolcott, C, Scott, C, Stone, J, Apicella, C, Tamimi, R, Luben, R, Khaw, KT, Helland, A, Haakensen, V, Dowsett, M, Pharoah, PDP, Simard, J, Hall, P, Garcia-Closas, M, Vachon, C, Chenevix-Trench, G, Antoniou, AC, Easton, DF, Edwards, SL
المصدر: Nature genetics. 48(4):374
مصطلحات موضوعية: Medicin och hälsovetenskap
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10دورية أكاديمية
المؤلفون: Alexandrou, E, Ramjan, LM, Spencer, T, Frost, SA, Salamonson, Y, Davidson, PM, Hillman, KM
مصطلحات موضوعية: Clinical sciences, Science & Technology, Life Sciences & Biomedicine, Nursing
الوصف: On the last page of this article (pg. 301), in the References list, reference #18 was not correctly listed. The correct reference is: Alexandrou E, Ramjan LM, Spencer T, Frost SA, Salamonson Y, Davidson PM, Hillman KM. The use of midline catheters in the adult acute care setting–clinical implications and recommendations for practice. Journal of the Association for Vascular Access. 2011;16(1):35-41. doi:10.2309/java.16-1-5 ; No Full Text
العلاقة: Advances in Neonatal Care; Alexandrou, E; Ramjan, LM; Spencer, T; Frost, SA; Salamonson, Y; Davidson, PM; Hillman, KM, The Extended Dwell Peripheral Intravenous Catheter Is an Alternative Method of NICU Intravenous Access (vol 18, pg 295, 2018), Advances in Neonatal Care, 2018, 18 (6), pp. 506-506; http://hdl.handle.net/10072/392113Test