المؤلفون: Bonilla Guijarro, Amparo, Bonilla Guijarro, Elena, Thuissard Vasallo, Israel John, Bailén Andrino, María, Hernando Jeréz, María Asunción

مصطلحات موضوعية: Prescripción electrónica, Industria farmacéutica, Consumidor, Encuesta social

الوصف: Objetivo: diseñar un cuestionario para conocer la satisfacción y percepciones de los pacientes con el sistema de prescripción de receta electrónica. Métodos: el cuestionario se desarrolló en tres fases. Primera, búsqueda y selección de los atributos del cuestionario. Segunda, análisis del cuestionario por expertos mediante grupo focal multidisciplinar con farmacéuticos, médicos y enfermeros. Tercera, estudio piloto, observacional en 50 pacientes usuarios de receta electrónica durante al menos un año. Se valoró la consistencia interna del cuestionario, la fiabilidad intraobservador y la validez. Resultados: de la primera y segunda fase resultó un cuestionario que incluye 5 atributos y 17 ítems. En el estudio psicométrico, el alfa de Cronbach fue de 0,77 (IC 95 %: 0,66-0,85), siendo el atributo de “satisfacción” el más valorado. La fiabilidad intraobservador tuvo un coeficiente de correlación de 0,96 (IC 95 %: 0,91-0,98). La validez de criterio quedó confirmada a través de la correlación de Spearman con una escala EVA. La validez convergente fue estadísticamente significativa (p=0,04) para el nivel de estudios y no mostró relación con el número de tratamientos prescritos. Conclusión: el cuestionario diseñado presenta adecuada fiabilidad y validez, y puede ser una herramienta útil para el trabajo en la farmacia comunitaria y para su uso en otras comunidades autónomas. ; Sin financiación ; No data 2021 ; UEM

العلاقة: https://doi.org/10.33620/FC.2173-9218Test.(2021/Vol13).002.07; Bonilla Guijarro, A., Bonilla Guijarro, E., Thuissard Vasallo, I. J., Bailén Andrino, M., y Hernando Jeréz, A. (2021). Diseño de un cuestionario para conocer la satisfacción y percepción de los pacientes con el sistema de prescripción de receta electrónica. Farmacéuticos Comunitarios, 13(1), 42-48. https://doi.org/10.33620/FC.2173-9218Test.(2021/Vol13).002.07; http://hdl.handle.net/11268/12294Test

الإتاحة: https://doi.org/10.33620/FC.2173-9218Test.(2021/Vol13).002.07
http://hdl.handle.net/11268/12294Test

المؤلفون: Suárez García, Inés, Alejos, Belén, Pérez Elías, María Jesús, Iribarren, José Antonio, Hernando Jeréz, María Asunción, Ramírez, Margarita, Tasias, María, Pascual, Mario, Jarrín, Inmaculada, Hernando, Victoria

مصطلحات موضوعية: Menopausia, Ansiedad, Depresión, Salud de la mujer, Sida

الوصف: Background: To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods: Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results: Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p ...

العلاقة: https://doi.org/10.1186/s12905-021-01370-wTest; Suárez-García, I., Alejos, B., Pérez-Elías, M. J., Iribarren, J. A., Hernando, A., Ramírez, M., Tasias, M., Pascual, M., Jarrin, I., Hernando, V., & CoRIS Cohort (2021). How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort. BMC Women's Health, 21(1), 223. https://doi.org/10.1186/s12905-021-01370-wTest; http://hdl.handle.net/11268/12145Test

الإتاحة: https://doi.org/10.1186/s12905-021-01370-wTest
http://hdl.handle.net/11268/12145Test

المؤلفون: Montesinos Marín, Francisco, Rodríguez Rey, Rocío, Hernando Jeréz, María Asunción, Páez Blarrina, Marisa, Álvarez Comino, María José, González-Baeza, Alicia, Pulido, Federico

مصطلحات موضوعية: Psicología, VIH (Virus), Sida

الوصف: Dados los resultados obtenidos hasta ahora en el ámbito de las enfermedades crónicas, se considera que la terapia de aceptación y compromiso (ACT) puede ser una intervención útil para el afrontamiento del VIH, mejorando la actividad, el funcionamiento social, y la calidad de vida. Dada la juventud de esta terapia, y la escasez de investigaciones en este campo, se diseñó un estudio que aportara evidencias sobre su impacto y viabilidad. ; UEM/CIPI/002/15 ; No data 2019 ; UEM

العلاقة: https://doi.org/10.23923/cnp2019.absTest; Montesinos, F., Rodríguez-Rey, R., Hernando, A., Páez, M., Álvarez, M. J., González-Baez, A., Bermejo, L., Santacreu, M., Bisbal, O., y Pulido, F. (2019). Promoviendo la aceptación psicológica en pacientes con VIH: un ensayo clínico. En Libro de resúmenes del IV Congreso Nacional de Psicología e International Symposium on Psychological Prevention. Consejo General de Colegios Oficiales de Psicólogos. https://doi.org/10.23923/cnp2019.absTest; http://hdl.handle.net/11268/8574Test

الإتاحة: https://doi.org/10.23923/cnp2019.absTest
http://hdl.handle.net/11268/8574Test

المؤلفون: Hernández Walias, Francisco J., Vázquez, Esther, Pacheco, Yolanda, Rodríguez Fernández, José M., Pérez Elías, María J., Dronda, Fernando, Casado Osorio, José L., Moreno, Ana, Hernando Jeréz, María Asunción, Vallejo, Alejandro

مصطلحات موضوعية: VIH (Virus), Cáncer, Tecnología médica, Sida, Tratamiento médico

الوصف: The incidence of classical Hodgkin lymphoma (cHL) in the HIV-1 setting has increased 5-25-fold compared to that observed in the general population. This study aimed to determine whether selected micro RNAs (miRs) and other soluble biomarkers and cellular subsets are dysregulated in cHL and could be used as biomarkers. This was a retrospective and longitudinal matched case-control study of 111 Caucasian, HIV-1-infected adult individuals, including 37 individuals with cHL and 74 with no type of cancer. Immunovirological data, plasma exosome-derived miR-16, miR-20a, miR-21, miR-221, miR-223, miR-106a, miR-185, miR-23, miR-30d, miR-222, miR-146a and miR-324, plasma IL-6, sCD14, sCD27, sCD30, sIL-2R, TNFR1, and cell phenotyping of T and B lymphocytes and natural killer (NK) cells were analyzed. Before cHL diagnosis, miR-20a, miR-21, and sCD30 were higher in cHL (p = 0.008, p = 0.009 and p = 0.042, respectively), while miR-16 was down-regulated (p = 0.040). miR-20a and miR-21 were independently associated with cHL (p = 0.049 and p = 0.035, respectively). The combination of miR-20a and miR-21 showed a good AUC value of 0.832 with a moderate likelihood ratio positive (LR+) value of 5.6 and a slight likelihood ratio negative (LR-) value of 0.23. At cHL diagnosis, miR-20a, miR-21 and miR-324 were overexpressed in cHL (p = 0.005, p = 0.024, and p = 0.001, respectively), while miR-223, miR-16, miR-185 and miR-106a were down regulated (p = 0.042, p = 0.007, p = 0.006, and p = 0.002, respectively). In addition, sCD14, sCD27, sCD30 and IL2R levels were higher in these individuals (p = 0.038, p = 0.010, p = 0.030, p = 0.006, respectively). miR-20a was independently associated with cHL (p = 0.011). The diagnostic value of miR-20a showed good AUC value of 0.754 (p = 0.074) with a slight LR+ value of 2 and a slight LR- of 0.25. After chemotherapy, miR-20a was higher in those individuals who had an adverse outcome (p < 0.001), while sCD14 and sCD30 were higher (p < 0.001). A specific signature of miRs and cytokines associated ...

العلاقة: Hernández-Walias, F. J., Vázquez, E., Pacheco, Y., Rodríguez-Fernández, J. M., Pérez-Elías, M. J., Dronda, F., Casado, J. L., Moreno, A., Hermida, J. M., Quereda, C., Hernando, A., Tejerina-Picado, F., Asensi, V., Galindo, M. J., Leal, M., Moreno, S., & Vallejo, A. (2020). Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21. Journal of Clinical Medicine, 9(3), 760. https://doi.org/10.3390/jcm9030760Test; http://hdl.handle.net/11268/9167Test

الإتاحة: https://doi.org/10.3390/jcm9030760Test
http://hdl.handle.net/11268/9167Test

المؤلفون: Miguel, Rosa de, Rial Crestelo, David, Domínguez Domínguez, Lourdes, Montejano, Rocío, Esteban Cantos, Andrés, Aranguren Rivas, Paula, Stella Ascariz, Natalia, Bisbal, Otilia, Hernando Jeréz, María Asunción, Arribas, José R.

مصطلحات موضوعية: VIH (Virus), Farmacología, Sida

الوصف: Background We investigated the efficacy of a switch to dolutegravir plus lamivudine in aviremic individuals without evidence of persistent lamivudine resistance-associated mutations in baseline proviral DNA population sequencing. Methods Open-label, single-arm, 48-week pilot trial. HIV-1 infected adults, naïve to integrase inhibitors, with CD4+ above 350 cell/μL and fewer than 50 HIV-1 RNA copies per mL the year prior to study entry switched to dolutegravir plus lamivudine. Participants were excluded if baseline proviral DNA population genotyping detected lamivudine resistance-associated mutations. To detect resistance minority variants, proviral DNA next-generation sequencing was retrospectively performed from baseline samples. Primary efficacy endpoint was proportion of participants with fewer than 50 HIV-1 RNA copies per mL at week 48. Safety and tolerability outcomes were incidence of adverse events and treatment discontinuations. ART-PRO is registered with ClinicalTrials.gov, NCT03539224. Findings 41 participants switched to dolutegravir plus lamivudine, 21 with lamivudine resistance mutations in historical plasma genotypes. Baseline next-generation sequencing detected lamivudine resistance mutations (M184V/I and/or K65R/E/N) over a 5% threshold in 15/21 (71·4%) and 3/20 (15%) of participants with and without history of lamivudine resistance, respectively. At week 48, 92·7% of participants (38/41) had fewer than 50 HIV-1 RNA copies per mL. There were no cases of virologic failure. Three participants with historical lamivudine resistance were prematurely discontinued from the study (2 protocol violations, one adverse event). Ten participants (4 in the group with historical lamivudine resistance) had a transient viral rebound, all resuppressed on dolutegravir plus lamivudine. There were 28 drug-related adverse events, only one leading to discontinuation. Interpretation In this pilot trial, dolutegravir plus lamivudine was effective in maintaining virologic control despite past historical lamivudine resistance ...

العلاقة: Miguel, R. de, Rial-Crestelo, D., Domínguez-Domínguez, L., Montejano, R., Esteban-Cantos, A., Aranguren-Rivas, P., Stella-Ascariz, N., Bisbal, O., Bermejo-Plaza, L., García-Álvarez, M., Alejos, B., Hernando, A., Santacreu-Guerrero, M., Cadiñanos, J., Mayoral, M., Castro, J. M., Moreno, V., Martín-Carbonero, L., Delgado, R., … Arribas, J. R. (2020). Dolutegravir plus lamivudine for maintenance of HIV viral suppression in adults with and without historical resistance to lamivudine: 48-week results of a non-randomized, pilot clinical trial (ART-PRO). EBioMedicine, 55, 102779. https://doi.org/10.1016/j.ebiom.2020.102779Test; http://hdl.handle.net/11268/9166Test

الإتاحة: https://doi.org/10.1016/j.ebiom.2020.102779Test
http://hdl.handle.net/11268/9166Test

المؤلفون: Pérez Bueno, Francisco Javier, Mohedano del Pozo, Rosa Belén, Hernando Jeréz, María Asunción

مصطلحات موضوعية: Atención farmacéutica, Residencias de ancianos, Anciano, Medicamento

الوصف: Introducción: la consulta a los profesionales implicados en el proceso de suministro de medicación a los centros sociosanitarios permite conocer su percepción sobre dicho proceso y las posibles mejoras que se puedan introducir en él, como la implantación de un protocolo que estandarice toda la cadena de suministro. Material y métodos: estudio observacional descriptivo realizado en dos residencias de ancianos con una muestra de 50 profesionales voluntarios, que respondieron de forma anónima a un cuestionario elaborado ad hoc para la investigación. Resultados: un 76 % da mucha importancia a la cadena de suministro de medicación al anciano. El 78 % vio relevante la implantación de un protocolo que regule el proceso. El 72 % destacó como muy importante la relación entre farmacia comunitaria y residencia. El 54 % opinó que la limitada legibilidad de lo escrito en la orden de prescripción produce errores. El 34 % señaló que nunca hay errores por confusión de horarios de administración, dosis o duración de tratamientos. El 58 % indicó que pocas veces hay errores relacionados con la transmisión de información. El 86 % opinó que nunca se producen errores por el envío de la orden de prescripción a la farmacia comunitaria. Conclusiones: la atención farmacéutica al anciano en centros sociosanitarios y la implantación de un protocolo que regule todo el proceso de suministro de medicación fueron consideradas muy importantes por la mayoría de los profesionales implicados en el proceso. El ambiente positivo de colaboración generado por la consulta ha llevado a plantear a los participantes el diseño de un protocolo. ; Sin financiación ; No data 2019 ; UEM

العلاقة: Pérez, F. J., Mohedano, R. B., y Hernando M. A. (2019). Estudio de la percepción de los profesionales implicados en el proceso de suministro de medicación a ancianos que viven en residencias desde una farmacia comunitaria. Farmacéuticos Comunitarios, 11(4), 49-55. http://dx.doi.org/10.5672/FC.2173-9218Test.(2019/Vol11).004.05; http://hdl.handle.net/11268/8572Test

الإتاحة: https://doi.org/10.5672/FC.2173-9218Test.(2019/Vol11).004.05
http://hdl.handle.net/11268/8572Test

المؤلفون: Domínguez Domínguez, Lourdes, Matarranz, Mariano, Lagarde, María, Bisbal, Otilia, Hernando Jeréz, María Asunción, Lumbreras Bermejo, Carlos, Rubio, Rafael, Pulido, Federico

مصطلحات موضوعية: Hepatitis C, VIH (Virus), Sida, Virus, Enfermedad transmisible

الوصف: Introduction: liver laboratory tests improve in hepatitis C virus (HCV)-monoinfected and cirrhotic patients who achieve HCV cure after interferon-free treatment. Objective and methods: this study evaluates the changes in those tests in human immunodeficiency virus (HIV)-positive subjects with an eradicated HCV-coinfection using direct-acting antivirals and with a pre-therapy liver stiffness ≥ 14.6 kPa or clinical data of cirrhosis. Serum albumin, bilirubin, creatinine, platelet count and international normalized ratio (INR) values were collected at baseline, week 4, at the end of treatment and 24 weeks after the end-of-treatment. Fibrosis-4 score (FIB4) and Model for End-stage Liver Disease (MELD) score values were calculated and liver stiffness was estimated by transient elastography at baseline and 24 weeks after the end-of-treatment. The means were compared with the Student’s t test or the repeated measures ANOVA test. Results: direct-acting antivirals were prescribed to 131 HIV/HCV-coinfected cirrhotic patients. A sustained virological response was confirmed in 120 cases. Albumin, bilirubin and platelet count values improved in the entire population 24 weeks after the end-of-treatment. INR and MELD score values decreased when patients with atazanavir and/or acenocoumarol were excluded and liver fibrosis tests significantly diminished. Nine patients developed liver decompensation and there were three deaths. Conclusion: in conclusion, HCV eradication was associated with a short-term improvement in biochemical liver function and fibrosis tests in HIV-coinfected patients with cirrhosis, although clinical events still occur. ; Sin financiación ; 1.591 JCR (2019) Q4, 81/88 Gastroenterology & Hepatology ; 0.383 SJR (2019) Q3, 92/145 Gastroenterology, 1505/2754 Medicine (miscellaneous) ; No data IDR 2019 ; UEM

العلاقة: https://doi.org/10.17235/reed.2019.6086/2018Test; Domínguez Domínguez, L., Matarranz, M., Lagarde, M., Bisbal, O., Hernando, A., Lumbreras, C., Rubio, R., & Pulido, F. (2019). HCV eradication with all-oral therapy in cirrhotic HIV-coinfected patients: an observational study of early changes in liver function and fibrosis tests. Revista Española de Enfermedades Digestivas, 111(8). https://doi.org/10.17235/reed.2019.6086/2018Test; http://hdl.handle.net/11268/8553Test

الإتاحة: https://doi.org/10.17235/reed.2019.6086/2018Test
http://hdl.handle.net/11268/8553Test

المؤلفون: González Cuevas, Gustavo, Rubio Alonso, Margarita, Hernando Jeréz, María Asunción, Tabera Galván, María Victoria, Álvarez Comino, María José

مصطلحات موضوعية: Estudiantes universitarios, Investigación activa, Investigación pedagógica, Enseñanza superior

الوصف: Tackling difficulties related to student participation in the college classroom is central on the learning process. In this action-research study, we designed and implemented an action plan to boost participation on the grounds of (1) explaining the objectives and procedures for each activity to students; (2) requesting student participation by name; (3) giving them time to reflect before participating; and (4) requesting that students who are not paying attention participate. A survey was used in order to assess students' perceptions of the action plan. The questionnaire included 10 items (1-4 Likert scale) and was completed by a total of 103 students. The scores’ mean was 3.19, demonstrating a positive student perception of the action plan. The statements with the highest average scores were: “Teacher allows time for reflection after posing a question” and “Teacher addresses specific students by name.” The instructors recorded their perceptions into writing, providing opinions on the development of the action plan. These teachers' comments were summarized into categories. In conclusion, we considered that the action plan helped to improve student participation, and we believe that in order to obtain sufficient participation we have to attain a classroom environment that favors motivation, confidence and respect for students. ; 2015_UEM44 ; No data (2017) ; UEM

العلاقة: Gonzalez-Cuevas, G., Rubio, M., Hernando, A., Alvarez, M.J. & Tavera, M.V. (2017). Action research plan to boost participation in college students. 3rd International Conference on Higher Education Advances, HEAd’17, Valencia. DOI:10.4995/HEAD17.2017.6713; http://hdl.handle.net/11268/7041Test

الإتاحة: https://doi.org/10.4995/HEAD17.2017.6713Test
http://hdl.handle.net/11268/7041Test

المؤلفون: González Cuevas, Gustavo, López del Hierro Casado, Marta, Hernando Jeréz, María Asunción, Martínez Alsina, Nieves

مصطلحات موضوعية: Estudiantes universitarios, Ciencias de la salud, Estudiante universitario, Salud

الوصف: The main objective of this study was to design a new tool to explore the perception of professionally-related ethical values in Health Sciences undergraduate students. For this purpose, 24 conversational interviews, as well as an extensive literature review, were initially employed. Then, five ethical values were selected: respect for the patient, altruism, empathy, responsibility for my actions, and lifelong learning. Next, twenty cases with ethical dilemmas were created with protagonists pertaining to four degrees in the Health Sciences: Nursing, Dentistry, Physical Therapy, and Medicine. These cases were examined by professionals from these fields and presented to a sample of students to analyze their functioning. Our results indicate that the cases are easy to understand as most cases were identified correctly. Interestingly, students reported “respect for the patient” as the most important ethical value. The least important value was “altruism.” This new tool adds a practical perspective based on clinical cases with real-life dilemmas. Further studies are needed to continue exploring this topic. ; Sin financiación ; No data (2017) ; UEM

العلاقة: González Cuevas, G., López del Hierro Casado, M., Hernando Jeréz, M. A., & Martínez Alsina, N. (2017). A case-based tool to assess college students’ perceptions about ethical competence. In 3rd International Conference on Higher Education Advances: HEAd’17 (Universitat Politècnica de València, June 21-23, 2017).; http://hdl.handle.net/11268/6752Test

الإتاحة: https://doi.org/10.4995/HEAd17.2017.5581Test
http://hdl.handle.net/11268/6752Test

المؤلفون: Rubio Alonso, Margarita, Sánchez-Ronco, María, Mohedano del Pozo, Rosa Belén, Hernando Jeréz, María Asunción

مصطلحات موضوعية: Estudiantes universitarios, Ciencias de la salud, Epidemiología, Enseñanza superior, Ciencias médicas

الوصف: Statistics and Epidemiology are crucial both in clinical decision-making and clinical research. Teaching these disciplines in a Bachelor’s Degree in Medicine is a significant challenge. In this paper, we aim to describe two participatory teaching methods used in a yearlong second-year course that includes both Epidemiology and Statistics, and to analyze how these two methodologies affect the students’ perception of the course and their abilities related to these subjects. Both methodologies consist in carrying out a specific practical activity. The first practical activity is carried out using a website and aims to help students understand concepts and interpret information; the second involves analyzing a database using a statistical package and, subsequently, producing a scientific report. In addition, we prepared a questionnaire to find out the students’ perception of these issues. The nine questionnaire items were assessed using a rating scale and adapted to characteristics of the course, which covers Epidemiology and Statistics in an integrated manner. Then we assessed the differences in perception before and after the activities were carried out. The results show that the students’ perception improved significantly in the following items: “importance of Statistics and Epidemiology in Medicine”; “usefulness in clinical practice”; “understanding concepts”; “ability to perform a statistical analysis”; and “ability to sort data”. The difference was not significant in the remaining four items. In conclusion, the students’ perception of their ability in Statistics and Epidemiology significantly improved after completing the practical activities, and their perception of importance and usefulness of these subjects also improved. ; Sin financiación ; 2.776 JCR (2018) Q2, 24/69 Multidisciplinary Sciences ; 1.100 SJR (2018) Q1, 33/297 Agricultural and Biological Sciences (miscellaneous), ; No data IDR 2018 ; UEM

العلاقة: Rubio, M., Sánchez-Ronco, M., Mohedano, R., & Hernando, A. (2018). The impact of participatory teaching methods on medical students’ perception of their abilities and knowledge of epidemiology and statistics. PloS One, 13(8), e0202769. https://doi.org/10.1371/journal.pone.0202769Test; http://hdl.handle.net/11268/7429Test

الإتاحة: https://doi.org/10.1371/journal.pone.0202769Test
http://hdl.handle.net/11268/7429Test