المؤلفون: Correa Hernando, Eva Cristina, Diezma Iglesias, Belen, Haro Hidalgo, Rosario, Arroyo Sanz, Juan Manuel, Ayuga Téllez, Francisco, Esteve Bengoechea, Paloma, Garcia Rebollar, Paloma, Gonzalez-Melendi de Leon, Pablo, Lopéz Díaz, Carmen, Palmero Llamas, Daniel, Pereira Jerez, David

المصدر: Libro de Resúmenes XVI Jornadas de Innovación Docente e Investigación Educativa | XVI Jornadas de Innovación Docente e Investigación Educativa: Competencias transversales para la formación y la profesionalidad | 18-19 de enero de 2024 | Zaragoza

مصطلحات موضوعية: Agricultura, Educación

الوصف: En el curso académico 2021-2022 se inició un proyecto con la finalidad de desarrollar e implementar un plan completo de trabajo para garantizar que las Competencias Transversales definidas en las memorias de verificación se alcancen plena y satisfactoriamente, en los títulos oficiales de la ETSIAAB.

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/UPM//IE23_2003; https://oa.upm.es/78713Test/

الإتاحة: https://oa.upm.es/78713Test/

المؤلفون: Biermann, Jana, Melms, Johannes C, Amin, Amit Dipak, Wang, Yiping, Caprio, Lindsay A, Karz, Alcida, Tagore, Somnath, Barrera, Irving, Ibarra-Arellano, Miguel A, Andreatta, Massimo, Fullerton, Benjamin T, Gretarsson, Kristjan H, Sahu, Varun, Mangipudy, Vaibhav S, Nguyen, Trang TT, Nair, Ajay, Rogava, Meri, Ho, Patricia, Koch, Peter D, Banu, Matei, Humala, Nelson, Mahajan, Aayushi, Walsh, Zachary H, Shah, Shivem B, Vaccaro, Daniel H, Caldwell, Blake, Mu, Michael, Wünnemann, Florian, Chazotte, Margot, Berhe, Simon, Luoma, Adrienne M, Driver, Joseph, Ingham, Matthew, Khan, Shaheer A, Rapisuwon, Suthee, Slingluff, Craig L, Eigentler, Thomas, Röcken, Martin, Carvajal, Richard, Atkins, Michael B, Davies, Michael A, Agustinus, Albert, Bakhoum, Samuel F, Azizi, Elham, Siegelin, Markus, Lu, Chao, Carmona, Santiago J, Hibshoosh, Hanina, Ribas, Antoni, Canoll, Peter, Bruce, Jeffrey N, Bi, Wenya Linda, Agrawal, Praveen, Schapiro, Denis, Hernando, Eva, Macosko, Evan Z, Chen, Fei, Schwartz, Gary K, Izar, Benjamin

المصدر: Cell. 185(14)

مصطلحات موضوعية: Cancer, Biotechnology, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Brain Neoplasms, CD8-Positive T-Lymphocytes, Ecosystem, Humans, Melanoma, RNA-Seq, brain metastasis, chromosomal instability, melanoma, neuronal-like cell state, single-cell genomics, spatial transcriptomics, tumor-microenvironment, Biological Sciences, Medical and Health Sciences, Developmental Biology

الوصف: Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary. Here, we performed single-cell/nucleus RNA-seq in 22 treatment-naive MBMs and 10 extracranial melanoma metastases (ECMs) and matched spatial single-cell transcriptomics and T cell receptor (TCR)-seq. Cancer cells from MBM were more chromosomally unstable, adopted a neuronal-like cell state, and enriched for spatially variably expressed metabolic pathways. Key observations were validated in independent patient cohorts, patient-derived MBM/ECM xenograft models, RNA/ATAC-seq, proteomics, and multiplexed imaging. Integrated spatial analyses revealed distinct geography of putative cancer immune evasion and evidence for more abundant intra-tumoral B to plasma cell differentiation in lymphoid aggregates in MBM. MBM harbored larger fractions of monocyte-derived macrophages and dysfunctional TOX+CD8+ T cells with distinct expression of immune checkpoints. This work provides comprehensive insights into MBM biology and serves as a foundational resource for further discovery and therapeutic exploration.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3087t3dxTest

المؤلفون: Atkins, Michael B, Curiel-Lewandrowski, Clara, Fisher, David E, Swetter, Susan M, Tsao, Hensin, Aguirre-Ghiso, Julio A, Soengas, Maria S, Weeraratna, Ashani T, Flaherty, Keith T, Herlyn, Meenhard, Sosman, Jeffrey A, Tawbi, Hussein A, Pavlick, Anna C, Cassidy, Pamela B, Chandra, Sunandana, Chapman, Paul B, Daud, Adil, Eroglu, Zeynep, Ferris, Laura K, Fox, Bernard A, Gershenwald, Jeffrey E, Gibney, Geoffrey T, Grossman, Douglas, Hanks, Brent A, Hanniford, Douglas, Hernando, Eva, Jeter, Joanne M, Johnson, Douglas B, Khleif, Samir N, Kirkwood, John M, Leachman, Sancy A, Mays, Darren, Nelson, Kelly C, Sondak, Vernon K, Sullivan, Ryan J, Merlino, Glenn, Foundation, on behalf of the Melanoma Research

المصدر: Clinical Cancer Research. 27(10)

مصطلحات موضوعية: Prevention, Cancer, Biomedical Research, COVID-19, Humans, Medical Oncology, Melanoma, Practice Guidelines as Topic, SARS-CoV-2, Skin Neoplasms, Melanoma Research Foundation, Oncology and Carcinogenesis, Oncology & Carcinogenesis

الوصف: Five years ago, the Melanoma Research Foundation (MRF) conducted an assessment of the challenges and opportunities facing the melanoma research community and patients with melanoma. Since then, remarkable progress has been made on both the basic and clinical research fronts. However, the incidence, recurrence, and death rates for melanoma remain unacceptably high and significant challenges remain. Hence, the MRF Scientific Advisory Council and Breakthrough Consortium, a group that includes clinicians and scientists, reconvened to facilitate intensive discussions on thematic areas essential to melanoma researchers and patients alike, prevention, detection, diagnosis, metastatic dormancy and progression, response and resistance to targeted and immune-based therapy, and the clinical consequences of COVID-19 for patients with melanoma and providers. These extensive discussions helped to crystalize our understanding of the challenges and opportunities facing the broader melanoma community today. In this report, we discuss the progress made since the last MRF assessment, comment on what remains to be overcome, and offer recommendations for the best path forward.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8515461sTest

المؤلفون: Cerpa Bernal, Rafael Mauricio, Matiz Chicacausa, Andrea, Jiménez Ariza, Heidi Tatiana, Valero Ubierna, Constantino, Correa Hernando, Eva Cristina, Diezma Iglesias, Belén, Valencia Rodríguez, Marino, Rojas, José Alberto, Ayora, Claudia Ximena, Poveda Perdomo, Luis Gabriel, Grande Tovar, Carlos David, Delgado Ospina, Johannes, Cuervo Mulet, Raúl Alberto, Valencia, Marino, Castellanos Hernández, Wilder Eduardo, Rodríguez Acevedo, Julián Severiano, Contreras Gelves, Gloria Amparo, de Castro Cuevas, Osberth Cristhian Luef, Buenaño Palacios, Yamil, Rodríguez Cortés, César Alejandro, Méndez Olaya, David Santiago, Delgadillo Romero, Kevin Andrey, Luis García, Luis Carlos, Alvarado Moreno, José David, Celis, Julián Camilo, Santamaría, Alejandro, Vargas Ávila, Yalily, Villarreal Lopez, Edwin, Coral-Enriquez, Horacio, Chaves Acosta, Julián, Fazi, Filippo Maria, Tafur Jimenez, Luis Alberto, Murillo Gómez, Diego Mauricio, Rincón Flórez, Raúl Enrique, Pachón Martínez, Sergio, Jiménez Soler, Pedro Luis, Hoyos, Sebastián, Sierra Vargas, Fabio Emiro, Gaitán Aroca, Jorge Eliecer, Silva Rodríguez, Jorge Andrés, Hernández Miranda, Juan Sebastián, Agudelo Noreña, Daniel, Acosta León, Harold Julián, Meneses, Diana, Hernández, Carlos Arturo, Merchán R., Fabio Alejandro, Kilsch Castro, Holger Camilo, Tarazona Romero, Myriam Andrea, Bedoya, Luis, Arango Gómez, Jorge, Rodríguez, Ginna, Fernández, Fabián

المساهمون: Jiménez Ariza, Heidi Tatiana, Calderón Díaz, Morian Nair, Herrera Martínez, Marcelo, Sotaquira Gutierrez, Miguel Angel, Porras Perucho, Henry Andrés, Tarazona Romero, Myriam Andrea

مصطلحات موضوعية: 620 - Ingeniería y operaciones afines, Ingeniería – Investigaciones, Ingeniería – Innovaciones tecnológicas, Aeronáutica – Investigaciones, Ingeniería Electrónica – Investigaciones, Ingeniería Mecatrónica – Investigaciones, Ingeniería de Sonido -Investigaciones

الوصف: La Facultad de Ingeniería de la Universidad de SanBuenaventura sede Bogotá, cuenta con tres grupos de investigación, los cuales desde su fundación se han enfocado en ahondar en las líneas de investigación planteadas desde los mismos y alineadas a las Políticas corporativas de la Universidad. El grupo Acústica Aplicada ha buscado el fortalecimiento en las temáticas de Acústica y vibraciones, Producción de audio y tecnología para la música, Diseño de Sistemas de Sonido y Aplicaciones sonoras para la Salud; por su parte, el grupo AEROTECH ha estado trabajando en las temáticas de Diseño vehículos, Energía y Propulsión, Mantenimiento y Gestión, Materiales y Estructuras, Mecánica Computacional y Sistemas de aeronaves y teledetección; finalmente, el grupo de SOLSYTEC se ha enfocado en las líneas de Análisis y Procesamiento de Señales, Automatización y Control, Robótica, Internet de las Cosas (IoT) y Análisis de Datos, Contenidos Digitales y Diseño de Experiencias inmersivas, Tecnologias en salud y ciberseguridad, y Tecnologías de la Información y la Comunicación. En conjunto se ha realizado una gran labor para reflejar su trabajo investigativo en el libro “Avances de la Ingeniería Bonaventuriana”. ; Primera edición

وصف الملف: application/pdf

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الإتاحة: https://hdl.handle.net/10819/11418Test

المؤلفون: Nuñez Cárdenas, Pablo Marcos, San Miguel Alfaro, Guillermo, Rosa, José María de la, Diezma Iglesias, Belen, Valero Ubierna, Constantino, Correa Hernando, Eva Cristina

المصدر: Proceedings of 18th International Conference on Environmental Science and Technology | CEST2023.18th International Conference on Environmental Science and Technology | 30 August to 2 September 2023 | Athens, Greece

مصطلحات موضوعية: Agricultura

الوصف: Precision agriculture is a powerful solution to mitigate the environmental impact of agricultural systems, optimize crop inputs and cost reduction. The aim of this work is to analyze the benefits of precision farming practices (irrigation, fertilization and phytosanitary treatment) through a life cycle sustainability assessment (environmental, economic and social impacts) using a detailed life cycle inventory for stone fruit production compared to traditional production. The 8-year life cycle inventory was provided by a local producer in southern Spain. The system boundaries include a "gate to farm gate" approach using 1 kg of stone fruit as the functional unit. The streamlined analysis incorporates environmental, life cycle cost and social risk analysis for this crop production. The results show that the reduced input requirements of the precision agriculture scenario led to lower environmental damage, reduced economic costs and lower social risks, with average impact reductions ranging between 20-30% in most sustainability categories.

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/MINECO//RTI2018-099139-B-C22; https://oa.upm.es/78715Test/

الإتاحة: https://oa.upm.es/78715Test/

المؤلفون: Diezma Iglesias, Belen, Correa Hernando, Eva Cristina, Haro Hidalgo, Rosario, Arroyo, J.M., Ayuga Téllez, Francisco, Carabaño Luengo, Rosa María, Esteve Bengoechea, Paloma, Gonzalez-Melendi de Leon, Pablo, López, C., Palmero Llamas, Daniel, Pereira Jerez, David

المصدر: INTED2023 Proceedings 17th International Technology, Education and Development Conference | 17th Annual International Technology, Education and Development Conference | 6-8 de marzo de 2023 | Valencia

مصطلحات موضوعية: Agricultura, Educación

الوصف: For more than three decades, efforts have been made to achieve the consensus that higher education should train professionals with subject-specific knowledge and skills and generic competencies that will enable them to perform successfully in their studies, jobs, and social life contexts. This requires the adoption of curriculum design approaches capable of contextualizing the form and scope of these crucial generic competencies to support both student learning on the course and graduate attributes for employability and career progression. Despite the long history of the concept of generic competencies, the integration of these generic competencies into discipline-specific learning outcomes remains a challenge today. Moreover, it has recently become clear that the definition and approach to generic competencies in higher education requires a context-dependent perspective, given the peculiarities of each subject area. Aware of this difficulty, the Spanish Institute of Engineering has promoted the creation of a forum in which different Spanish higher education institutions involved in engineering participate. The aim of this forum is analysing and improving the treatment of generic skills in these disciplines. The School of Agricultural, Food and Biosystems Engineering (ETSIAAB), one of the institutions participating in the forum, is taking advantage of the analysis of its curricula to initiate a project focused on improving the generic skills defined for their programmes of study.

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/UPM//IE23_2003; https://oa.upm.es/76755Test/

الإتاحة: https://oa.upm.es/76755Test/

المؤلفون: Garrido Izard, Miguel, Correa Hernando, Eva Cristina, Requejo Puerto, José María, Diezma Iglesias, Belen

المصدر: Libro de Actas: XII Congreso Ibérico de Agroingeniería | XII Congreso Ibérico de Agroingeniería | 4-6 septiembre de 2023 | Sevilla

مصطلحات موضوعية: Agricultura

الوصف: Electronic feeding stations are frequently used to automatically record feeding behavior in pigs by collecting feed ingested and live mass in each visit. In breeding programmes, the identification of the most efficient animals is a priority objective. To achieve this, they combine the information provided by the electronic feeding stations with that derived from growth models previously adjusted according to the line of animals. It has been found that this practice eliminates infrequent but possible events by substituting intake and body weight values collected by the stations with values interpolated according to the growth models. This results in a double estimation of efficiency, one derived solely from the debugged records of the feeding stations and the other from the growth models. It has been shown that selection of animals according to efficiencies determined only by the growth model leaves out individuals with real efficiencies according to stations above 0.47. Consideration of both efficiencies in the classification of animals would lead to more robust selection procedures.

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/MINECO//RTC-2017-5977-2; https://oa.upm.es/76063Test/

الإتاحة: https://oa.upm.es/76063Test/

المؤلفون: Milara Hernando, Eva, Alonso, Rafael, Masseing, Lena, Seiffert, Alexander Peter, Gómez Grande, Adolfo, Gomez Aguilera, Enrique Javier, Martínez López, Joaquin, Sánchez González, Patricia

المصدر: Physical And Engineering Sciences In Medicine, ISSN 26624729, 2023-06-01, Vol. 46, No. 2

مصطلحات موضوعية: Medicina, Robótica e Informática Industrial

الوصف: The combination of visual assessment of whole body [18F]FDG PET images and evaluation of bone marrow samples by Multiparameter Flow Cytometry (MFC) or Next-Generation Sequencing (NGS) is currently the most common clinical practice for the detection of Measurable Residual Disease (MRD) in Multiple Myeloma (MM) patients. In this study, radiomic features extracted from the bone marrow biopsy locations are analyzed and compared to those extracted from the whole bone marrow in order to study the representativeness of these biopsy locations in the image-based MRD assessment. Whole body [18F]FDG PET of 39 patients with newly diagnosed MM were included in the database, and visually evaluated by experts in nuclear medicine. A methodology for the segmentation of biopsy sites from PET images, including sternum and posterior iliac crest, and their subsequent quantification is proposed. First, starting from the bone marrow segmentation, a segmentation of the biopsy sites is performed. Then, segmentations are quantified extracting SUV metrics and radiomic features from the [18F]FDG PET images and are evaluated by Mann–Whitney U-tests as valuable features differentiating PET+/PET− and MFC+ /MFC− groups. Moreover, correlation between whole bone marrow and biopsy sites is studied by Spearman ρ rank. Classification performance of the radiomics features is evaluated applying seven machine learning algorithms. Statistical analyses reveal that some images features are significant in PET+/PET− differentiation, such as SUVmax, Gray Level Non-Uniformity or Entropy, especially with a balanced database where 16 of the features show a p value < 0.001. Correlation analyses between whole bone marrow and biopsy sites results in significant and acceptable coefficients, with 11 of the variables reaching a correlation coefficient greater than 0.7, with a maximum of 0.853. Machine learning algorithms demonstrate high performances in PET+/PET− classification reaching a maximum AUC of 0.974, but not for MFC+/MFC− classification. The results ...

وصف الملف: application/pdf

العلاقة: https://link.springer.com/article/10.1007/s13246-023-01265-0Test; https://oa.upm.es/81089Test/

الإتاحة: https://doi.org/10.1007/s13246-023-01265-0Test
https://oa.upm.es/81089Test/

المؤلفون: Correa Hernando, Eva Cristina, Castillejo, Noelia, Barreiro Elorza, Pilar, Diezma Iglesias, Belen, Garrido Izard, Miguel, Barbosa Menezes, Jossivan, Aguayo, Encarna

المصدر: Agronomy, ISSN 2073-4395, 2023, Vol. 13, No. 33

مصطلحات موضوعية: Agricultura

الوصف: To supply the off-season melon market, Europe imports from distant markets in other countries, mainly Brazil. Cold transportation takes at least 15–20 days, thus increasing the risk of quality losses. Moreover, product deliveries, especially in international markets, can result in supply chain inefficiencies that negatively affect carbon footprint and expected freshness. Implementing quality sensors and advanced cold chain management could help to reduce these problems. The objective of this work was to monitor a real transoceanic intermodal transport of melons (Brazil to Spain), through the implementation of multi-distributed environmental sensors (15 ibuttons loggers) to evaluate the remaining shelf-life (RSHL) of melons at destination. The sensors’ location within the cargo reached a maximum variability range of 4 ◦C. Using digital sensors to track temperature variations, it was verified that in different locations in the container, the melon RSHL at the end of the journey, was nine days and 19 h in colder spots, while in the hottest spot, the RSHL was reduced to five days and 22 h. This fact has substantial implications for improved tracking of temperature to maintain fruit quality for market, potentially reducing waste, and contributing to higher profit margins for international food supply chains.

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/MINECO//RTI2018-099139-B; https://oa.upm.es/72331Test/

الإتاحة: https://doi.org/10.3390Test/ agronomy13010033
https://oa.upm.es/72331Test/

المؤلفون: Orlow, Irene, Sadeghi, Keimya D., Edmiston, Sharon N., Kenney, Jessica M., Lezcano, Cecilia, Wilmott, James S., Cust, Anne E., Scolyer, Richard A., Mann, Graham J., Lee, Tim K., Burke, Hazel, Jakrot, Valerie, Shang, Ping, Ferguson, Peter M., Boyce, Tawny W., Ko, Jennifer S., Ngo, Peter, Funchain, Pauline, Rees, Judy R., O’Connell, Kelli, Hao, Honglin, Parrish, Eloise, Conway, Kathleen, Googe, Paul B., Ollila, David W., Moschos, Stergios J., Hernando, Eva, Hanniford, Douglas, Argibay, Diana, Amos, Christopher I., Lee, Jeffrey E., Osman, Iman, Luo, Li, Kuan, Pei-Fen, Aurora, Arshi, Gould Rothberg, Bonnie E., Bosenberg, Marcus W., Gerstenblith, Meg R., Thompson, Cheryl, Bogner, Paul N., Gorlov, Ivan P., Holmen, Sheri L., Brunsgaard, Elise K., Saenger, Yvonne M., Shen, Ronglai, Seshan, Venkatraman, Nagore Enguidanos, Eduardo, Ernstoff, Marc S., Busam, Klaus J., Begg, Colin B., Thomas, Nancy E., Berwick, Marianne

مصطلحات موضوعية: RNA, DNA, Biorepository, Clinical database, Melanoma, 32 Ciencias Médicas

الوصف: We are conducting a multicenter study to identify classifiers predictive of disease-specific survival in patients with primary melanomas. Here we delineate the unique aspects, challenges, and best practices for optimizing a study of generally small-sized pigmented tumor samples including primary melanomas of at least 1.05mm from AJTCC TNM stage IIA-IIID patients. We also evaluated tissue-derived predictors of extracted nucleic acids’ quality and success in downstream testing. This ongoing study will target 1,000 melanomas within the international InterMEL consortium. ; Medicina

العلاقة: http://hdl.handle.net/20.500.12466/3227Test

الإتاحة: https://doi.org/20.500.12466/3227Test
https://doi.org/10.1371/journal.pone.0269324Test
https://hdl.handle.net/20.500.12466/3227Test