المؤلفون: Figueiredo, Sofia Rosário, Borges, Ana Raquel, Henriques, Marta, Rodrigues, Ivo

المصدر: Brazilian Journal of Food Technology. January 2021 24

مصطلحات موضوعية: Arbutus unedo L., Rendimento de extração, Viscozyme® L, Pectinex® Ultra SP-L, Viscosidade, Sólidos solúveis (°Brix)

الوصف: Os medronhos são frutos com um alto teor de açúcares (40%), antioxidantes e vitaminas, tais como vitamina C, β-caroteno, niacina, tocoferóis e ácidos orgânicos. No entanto, o rendimento de extração da polpa pelos métodos convencionais é baixo, correspondendo aproximadamente a 42%. Este estudo teve como objetivo avaliar o potencial uso de duas carboidrases comerciais, Viscozyme® L e Pectinex® Ultra SP-L, na extração de polpa de medronho e a sua influência nas características físico-químicas e reológicas da polpa extraída. As carboidrases foram testadas sob diferentes temperaturas (20 ºC a 25 ºC e 45 ºC), concentrações (1, 2 e 4 μL/g de fruto macerado) e tempos de reação (30 e 60 min). As mesmas condições foram aplicadas a amostras-controle sem adição de enzima. Foram determinados os rendimentos de extração (g de polpa extraída/ 100 g de fruto macerado), viscosidade aparente (a 20,0 ± 0,1 ºC), cor, acidez titulável, pH, sólidos solúveis (°Brix) e sólidos totais das polpas obtidas. A polpa com menor viscosidade aparente (0,88 ± 0,38 Pa.s) foi obtida pela aplicação da Viscozyme® L a 4 μL/g, 45 ºC, após 30 minutos de incubação. A Pectinex® Ultra SP-L foi responsável pelo rendimento de extração de polpa mais elevado (54,9 ± 1,1%) após 30 min, quando aplicada a 2 μL/g e 45 ºC. Foi também responsável pelo maior teor de sólidos solúveis (27,3 ± 0,1 °Brix), à temperatura ambiente (20 ºC a 25 ºC) após 60 minutos para a concentração 4 μL/g. Não foram encontradas diferenças significativas (p > 0,05) para as demais características físico-químicas das polpas, entre as condições testadas. A metodologia de extração de polpa assistida por carboidrases forneceu resultados promissores para a diversificação de produtos de valor acrescentado derivados do medronho, com elevado potencial de utilização na indústria alimentar (bebidas de fruta, doces e geleias, gelados, entre outros).

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1981-67232021000100407Test

المؤلفون: HENRIQUES, Marta Helena Fernandes, GOMES, David Manuel Gama Simões, BORGES, Ana Raquel, PEREIRA, Carlos José Dias

المصدر: Food Science and Technology. June 2020 40(2)

مصطلحات موضوعية: liquid whey protein concentrate, acid-induced gel, lactic acid bacteria, glucono-δ-lactone, texture, rheology

الوصف: The replacement of dehydrated products such as whey protein concentrates and isolates (WPC and WPI) by liquid whey protein concentrates (LWPC) obtained by ultrafiltration can be an excellent alternative for the production of innovative dairy products. Thus, the aim of this work is to study the gelation properties of LWPC as raw material for acid-induced dairy gels. Acid-induced gels were produced with non-defatted LWPC, with or without fortification with skimmed milk powder (SMP), by bacterial fermentation and by glucono-δ-lactone (GDL) acidification. The fermented systems (yogurt type acid gels) produced weaker gel structures than the equivalent chemically acidified gels (dessert type acid gels). It was also observed that molecular rearrangement continues during cold storage and that fortification with SMP favoured gelation. Whey-based dairy gels obtained by fermentation or by glucono-δ-lactone acidification presented viscoelastic behaviour, appealing functional and nutritional properties, and their utilization can effectively contribute to the reduction of waste.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000200361Test

المؤلفون: Dantas, Paulo E. C., Nishiwaki-Dantas, M. Cristina, Henriques, Marta Junqueira, Almeida, Geraldo V. de

المصدر: Arquivos Brasileiros de Oftalmologia. February 1998 61(1)

مصطلحات موضوعية: Anestesia local (regional), Retrobulbar, Peribulbar, Subtenoniana, Complicações

الوصف: Dentre as complicações associadas à anestesia retrobulbar e peribulbar, perfuração do globo ocular parece ser das mais importantes. Recente estudo ultrassonográfico demonstrou que, em pacientes submetidos à anestesia retrobulbar para cirurgia de catarata com comprimento axial normal, a ponta da agulha usada para injeção retrobulbar se encontrava muito próxima do globo ocular, as vezes até indentando sua parede. Tal fato pode se tornar extremamente perigoso em olhos com comprimento axial aumentado, como nos altos míopes. Demonstramos a eficácia e segurança do uso da técnica de anestesia retrobulbar com catéter flexível de Teflon em 15 pacientes com comprimento axial ocular ântero-posterior aumentado e candidatos à facectomia.

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27491998000100100Test

المؤلفون: Montoro, Juan, Ngoya, Maud, Kulagin, Alexander, Giebel, Sebastian, Broers, Annoek E C, Bramanti, Stefania, Halahleh, Khalid, Perez-Simon, Jose Antonio, Solano, Carlos, Ozcelik, Tulay, Blaise, Didier, Sanz, Jaime, Henriques, Marta, Peffault de Latour, Régis, Martino, Rodrigo, Scheid, Christof, Fox, Laura, Gromek, Tomasz, Jurado, Manuel, Sakellari, Ioanna, van Gorkom, Gwendolyn, Matteucci, Paola, Nagler, Arnon, Koc, Yener, Glass, Bertram

المصدر: Montoro , J , Ngoya , M , Kulagin , A , Giebel , S , Broers , A E C , Bramanti , S , Halahleh , K , Perez-Simon , J A , Solano , C , Ozcelik , T , Blaise , D , Sanz , J , Henriques , M , Peffault de Latour , R , Martino , R , Scheid , C , Fox , L , Gromek , T , Jurado , M , Sakellari , I , van Gorkom , G , Matteucci , P , Nagler , A , Koc ....

الوصف: Studies comparing the efficacy of post-transplant cyclophosphamide (PTCy) to conventional calcineurin inhibitor (CNI)-based GVHD prophylaxis regimens in Hodgkin lymphoma (HL) patients are scarce. This study aimed to compare the outcomes of HL patients undergoing hematopoietic stem cell transplantation from HLA-matched donors who received GVHD prophylaxis with either PTCy or conventional CNI-based regimens, using data reported to the EBMT database between January 2015 and December 2022. Among the cohort, 270 recipients received conventional CNI-based prophylaxis and 176 received PTCy prophylaxis. Notably, PTCy prophylaxis was associated with delayed hematopoietic recovery, but also with a lower risk of chronic (25% versus 43%, p<0.001) and extensive chronic GVHD (13% versus 28% p=0.003) compared to the CNI-based cohort. The 2-year cumulative incidence of non-relapse mortality and relapse were 11% versus 17% (p=0.12), and 17% versus 30% (p=0.007) for PTCy and CNI-based, respectively. Moreover, the 2-year overall survival, progression-free survival and GVHD-free, relapse-free survival were all significantly better in the PTCy group compared with the CNI-based group: 85% versus 72% (p=0.005), 72% versus 53% (p<0.001), and 59% versus 31% (p<0.001), respectively. In multivariable analysis, PTCy was associated with a lower risk of chronic and extensive chronic GVHD, reduced relapse, and better OS, PFS, and GRFS compared to the CNI-based platform. Our findings suggest that PTCy as GVHD prophylaxis offers more favorable outcomes compared to conventional CNI-based prophylaxis in adult patients with HL undergoing HSCT from HLA-matched donors.

العلاقة: https://cris.maastrichtuniversity.nl/en/publications/af2ee11c-3c40-43d9-8ac1-a7f723b885f8Test

الإتاحة: https://doi.org/10.1182/bloodadvances.2024013328Test
https://cris.maastrichtuniversity.nl/en/publications/af2ee11c-3c40-43d9-8ac1-a7f723b885f8Test

المؤلفون: Henriques, Marta Alexandra de Oliveira

المساهمون: Corvo, Marta, Henriques, Célia, RUN

مصطلحات موضوعية: Hydrogels, Conductive Polymers, Ionic Liquids, Tissue Engineering, Domínio/Área Científica::Engenharia e Tecnologia::Engenharia dos Materiais

الوصف: A medicina regenerativa depende da Engenharia de Tecidos para encontrar scaffolds ade- quados para esta área biomédica. Há uma necessidade de desenvolver materiais biocompatíveis e biodegradáveis capazes de produzir suporte mecânico para a regeneração de tecidos biológi- cos e polímeros condutores para possibilitar estímulos elétricos a tecidos lesados. O presente trabalho destina-se à obtenção de hidrogéis condutores apropriados para a En- genharia de Tecidos. Hidrogéis eletricamente condutores (HECs) são um pequeno grupo de biomateriais que combinam propriedades intrínsecas de componentes condutores com as redes hidrofílicas e biocompatíveis dos hidrogéis, no entanto, os métodos convencionais da sua pro- dução contam com inúmeras restrições técnicas como a citotoxicidade, baixa solubilidade e biodegradabilidade. Neste trabalho, os HECs foram produzidos a partir de três polímeros pro- missores: gelatina metacrilada (GelMA), alginato e diacrilato de polietileno glicol (PEGDA). A exposição à luz UV levou à gelação das amostras que foram posteriormente liofilizadas. O polímero condutor poli(3,4-etilenodioxitiofeno); (PEDOT), foi gerado in situ através do método dos 3 banhos. A influência dos poli-líquidos iónicos (PIL) e misturas eutécticas (ME) foi ava- liada. Os HECs foram caracterizados através de análise elementares, Microscopia Eletrónica de Varrimento, Espectroscopia no Infravermelho por Transformada de Fourier, Análise Termo- gravimétrica e Calorimetria Diferencial de Varrimento. Medidas de condutividade através da técnica das quatro pontas e estudos de citotoxicidade foram realizados para avaliar a eficácia e a biocompatibilidade dos materiais obtidos. Os resultados deste estudo confirmam que a polimerização in situ do PEDOT nos hidrogéis melhora a condutividade das amostras. Tanto a adição do PIL como da ME exibiram um incre- mento de condutividade mais notável para os HECs de GelMA, com um máximo de 0,291 mS/cm para GelMA/PIL/PEDOT. Os HECs de GelMA mostram uma porosidade hierárquica, que é benéfica para aplicações na Engenharia de Tecidos e uma boa compatibilidade, com mais de 90% de viabilidade celular relativa.

الوصف (مترجم): Regenerative medicine relies on Tissue Engineering to provide adequate scaffolds for this biomedical field. There is a need for biocompatible and biodegradable materials able to produce mechanical support for the regeneration of biological tissues and conductive polymers to enable electrical stimulation to the damaged tissues. The present work aimed to obtain conductive hydrogels suitable for Tissue Engineering. Electrically conductive hydrogels (ECHs) are a small group of smart biomaterials that combine the properties of intrinsically conductive components with hydrophilic and biocompatible hy- drogels networks, however, the conventional methods of producing them have several technical restrictions such as toxicity, low solubility, and biodegradability. Herein, ECHs were produced from three promising polymers: Gelatine Methacrylate (GelMA), alginate, and polyethylene glycol diacrylate (PEGDA). UV exposure led to the gelation of the samples that were subse- quently freeze-dried. The conductive polymer poly(3,4-ethylenedioxythiophene), (PEDOT), was generated in situ through the 3-bath method. The influence of poly(ionic) liquids (PIL) and eutectic mixtures (EM) was evaluated. The obtained ECHs were characterized by elemental analysis, Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Thermo- gravimetric Analysis and Differential Scanning Calorimetry. Conductivity measurements using the four-point-probe technique and cytotoxicity tests were also performed to evaluate the effi- cacy and biocompatibility of the obtained materials. The results of this study confirm that in situ polymerization of PEDOT in the hydrogels improved the overall conductivity of the samples. Both the addition of PIL and EM exhibited a more noticeable conductivity increment for GelMA ECHs, with a maximum of 0,291 mS/cm for GelMA/PIL/PEDOT. GelMA ECHs show a hierarchical porosity that is beneficial for Tis- sue Engineering applications and good biocompatibility, with over 90% of relative cell viabil- ity.

وصف الملف: application/pdf

الإتاحة: http://hdl.handle.net/10362/160347Test

المؤلفون: Garcia, Cátia Domingues, Dias, Maria Inês, Henriques, Marta H. F., Barros, Lillian, Ramos, Fernando

مصطلحات موضوعية: Pterospartum tridentatum, liqueur, physicochemical characteristics, HPLC-DAD/ESI-MSn, sensory analysis, Phenols, Flavonoids, Antioxidants, Prunus dulcis, Genista

الوصف: With great cultural significance, spirits and distillate beverages constitute an important niche market in Europe. The development of new food products, particularly for the functionalization of these beverages, is increasing exponentially. The present work aimed to develop a new wine spirit beverage aged with almond shells and flowers of P. tridentatum for further characterization of bioactive and phenolic compounds, coupled with a sensorial study to evaluate the acceptance of this new product by the market. Twenty-one phenolic compounds were identified, mainly isoflavonoids and O- and C-glycosylated flavonoids, especially in P. tridentatum flowers, indicating that it is a highly aromatizing agent. The developed liqueur and wine spirits (almonds and flowers) showed distinct physicochemical properties, with the last two samples showing greater appreciation and purchase intention by consumers due to their sweetness and smoothness. The most promising results were found for the carqueja flower, which should be further investigated in an industrial context to contribute to its valorization in its regions of origin, such as Beira Interior and Trás-os-Montes (Portugal).

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; UIDB/00690/2020; UIDP/00690/2020; LA/P/0007/2020; UIDB/50006/2020; FCT, P.I., through the institutional scientific employment program; https://hdl.handle.net/10316/113267Test

الإتاحة: https://doi.org/10.3390/molecules28114455Test
https://hdl.handle.net/10316/113267Test

المؤلفون: Malta, José F., Henriques, Marta S. C., Paixão, José A., Gonçalves, António P.

مصطلحات موضوعية: skyrmions, Jahn–Teller distortion, lacunar spinel, GaMo4Se8

الوصف: GaMo4Se8, is a lacunar spinel where skyrmions have been recently reported. This compound belongs to the GaM4X8 family, where M is a transition metal (V or Mo) and X is a chalcogenide (S or Se). In this work, we have obtained pure GaMo4Se8 in polycrystalline form through an innovative two-step synthetic route. Phase purity and chemical composition were confirmed through the Rietveld refinement of the powder XRD pattern, the sample characterisation having been complemented with SEM analysis. The magnetic phase diagram was investigated using DC (VSM) and AC magnetometry, which disclosed the presence of cycloidal, skyrmionic and ferromagnetic phases in polycrystalline GaMo4Se8.

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; José F. Malta’s PhD grant was supported by FCT-Fundação para a Ciência e a Tecnologia through the ChemMat PhD programme. Access to the TAIL-UC facility supported by the QREN-Mais Centro programme ICT_2009_02_012_1890 is gratefully acknowledged. This work was partially supported by funds from FEDER (Programa Operacional Factores de Competitividade COMPETE) and from FCT under the projects UIDB/FIS/04564/2020, UIDP/FIS/ 04564/2020 and PTDC/FISMAC/ 32229/2017.; https://hdl.handle.net/10316/112592Test

الإتاحة: https://doi.org/10.3390/magnetochemistry9070182Test
https://hdl.handle.net/10316/112592Test

المؤلفون: Silva, Tânia, Pires, Arona, Gomes, David, Viegas, Jorge, Pereira-Dias, Susana, Pintado, Manuela E., Henriques, Marta, Pereira, Carlos Dias

المصدر: Silva , T , Pires , A , Gomes , D , Viegas , J , Pereira-Dias , S , Pintado , M E , Henriques , M & Pereira , C D 2023 , ' Sheep’s butter and correspondent buttermilk produced with sweet cream and cream fermented by aromatic starter, kefir and probiotic culture ' , Foods , vol. 12 , no. 2 , 331 . https://doi.org/10.3390/foods12020331Test

مصطلحات موضوعية: Aromatic, Butter, Kefir, Probiotics, Sheep

الوصف: Small ruminant dairy products are common in some Mediterranean countries, in the Middle East and Africa, and can play a particular role in the development of rural areas. Butter has been the object of few research studies aimed at evaluating its potential as a vehicle for probiotic microorganisms. Moreover, the recovery of fermented buttermilk with functional properties can be considered an excellent opportunity to value this dairy byproduct. Therefore, the purpose of the present work was to develop different sheep butters and respective buttermilks after cream fermentation by: (1) a mesophilic aromatic starter (A); (2) a kefir culture (K); and (3) a mixture of probiotic bacteria (P). The butters and buttermilk produced with fermented cream were compared with non-fermented sweet cream (S) butter or buttermilk, respectively, regarding their physicochemical, microbiological and sensory characteristics. The adjusted production (%, w/v) obtained for butter were: S (44.48%), A (36.82%), K (41.23%) and P (43.36%). S, A and K butters had higher solids, fat and ashes contents than P butter. The probiotic butter had a total fat of ca. 75% (w/w), below the legal limits, while all others had fat levels above 81.5%. In all samples, the pH decreased and the acidity increased over 90 days of refrigerated storage. These variations were more evident in the P butter, which agrees with the highest lactic acid bacteria counts found in this sample. Differences in color between samples and due to storage time were also observed. In general, the butter samples tended to become darker and yellower after the 60th day of storage. Texture analysis showed comparable results between samples and greater hardness was observed for the P butter, most probably due to its higher relative saturated fatty acids content (66.46% compared to 62–64% in S, A and K butters). Regarding rheological properties, all butters showed pseudoplastic behavior, but butter P had the lowest consistency index (249 kPa.s n−1 ). The probiotic butter and the ...

وصف الملف: application/pdf

العلاقة: https://ciencia.ucp.pt/en/publications/637b553f-bc0f-4ab3-b428-36709fb444caTest

الإتاحة: https://doi.org/10.3390/foods12020331Test
https://ciencia.ucp.pt/en/publications/637b553f-bc0f-4ab3-b428-36709fb444caTest
https://ciencia.ucp.pt/ws/files/62652831/62652667.pdfTest
http://www.scopus.com/inward/record.url?scp=85146764984&partnerID=8YFLogxKTest
http://hdl.handle.net/10400.14/40216Test

المؤلفون: Jorge, Alexandre M.S., Gaspar, Marisa C., Henriques, Marta H.F., Braga, Mara E.M.

مصطلحات موضوعية: Edible films, Circular economy, Agrifood, By-products, Wastes, Agro-industrial

الوصف: Acknowledgements This work was financially supported by Projetos Semente SantanderUC through the Santander Universidades and University of Coimbra award, and by COMPETE 2020, Fundaçao ˜ para a Ciˆencia e Tecnologia (FCT, Portugal), through the projects CIEPQPF (UIDB/00102/2020 and UIDP/00102/2020), and ciTechCare (UI/05704/2020). M. C. Gaspar acknowledges FCT for the financial support under Scientific Employment Stimulus (CEECIND/00527/2017 and CEECINST/00060/2021). ; This study aims to develop edible films using agrifood by-products (pumpkin seeds, broken rice and orange pectin) and wastes (quince peel, potato peel, potato pulp, orange peel, pumpkin peel). The physicochemical characteristics of the films were investigated, including their mechanical and barrier properties. Higher amounts of plasticizer induced poorer mechanical and barrier properties in the films. The most promising ones were obtained with orange pectin, broken rice and pumpkin peel, with water contact angles (WCA) between 48° and 57°, maximum water vapor transmission rate and water vapor permeability of 575 g.m−2.d−1 and 108 × 10−12 g.Pa−1.s−1.m−1, respectively, Young's modulus between 350 and 800 MPa, maximum tensile strength between 9.0 and 26.25 MPa, and elongation at break between 2.28 and 9.3%. Orange pectin and broken rice are promising raw materials since they led to higher WCA, better barrier and mechanical properties. Broken rice and quince peel can be good substitutes for commercial starch and glycerol, respectively. Agro-industrial by-products and wastes revealed potential for the production of sustainable edible films. ; info:eu-repo/semantics/acceptedVersion

العلاقة: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00102%2F2020/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00102%2F2020/PT; info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00527%2F2017%2FCP1460%2FCT0017/PT; info:eu-repo/grantAgreement/FCT/CEEC INST 2ed/CEECINST%2F00060%2F2021%2FCP2799%2FCT0001/PT; https://www.sciencedirect.com/science/article/pii/S1466856423001765?via%3DihubTest; Jorge, A. M., Gaspar, M. C., Henriques, M. H., & Braga, M. E. (2023). Edible films produced from agrifood by-products and wastes. Innovative Food Science & Emerging Technologies, 88, 103442.; http://hdl.handle.net/10400.8/9107Test; https://doi.org/10.1016/j.ifset.2023.103442Test

الإتاحة: https://doi.org/10.1016/j.ifset.2023.103442Test
http://hdl.handle.net/10400.8/9107Test

المؤلفون: Marques, Ines Dos Santos, Soares, Maria José, Barbosa, Aida, Calderon, Ian, Henriques, Marta, Reis, Cátia Sol, Baptista, Pedro, Pardal, André, Pires, Jorge Cancela, Aguiar, Eliana, Bergantim, Rui, Trigo, Fernanda

المصدر: HemaSphere ; volume 7, issue S3, page e760070c ; ISSN 2572-9241

الإتاحة: https://doi.org/10.1097/01.hs9.0000975220.76007.0cTest