يعرض 1 - 10 نتائج من 112 نتيجة بحث عن '"Heizmann, J"', وقت الاستعلام: 1.08s تنقيح النتائج
  1. 1
    تقرير

    المؤلفون: Aker, M., Altenmüller, K., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Blaum, K., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Bouquet, H., Brunst, T., Caldwell, T. S., Chilingaryan, S., Choi, W., Debowski, K., Deffert, M., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Dyba, S., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Eversheim, D., Fedkevych, M., Felden, A., Formaggio, J. A., Fränkle, F., Franklin, G. B., Frankrone, H., Friedel, F., Fulst, A., Gauda, K., Gil, W., Glück, F., Grohmann, S., Grössle, R., Gumbsheimer, R., Hackenjos, M., Hannen, V., Hartmann, J., Haußmann, N., Heizmann, F., Heizmann, J., Helbing, K., Hickford, S., Hillesheimer, D., Hinz, D., Höhn, T., Holzapfel, B., Holzmann, S., Houdy, T., Jansen, A., Karl, C., Kellerer, J., Kernert, N., Kippenbrock, L., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., Kuffner, B., Kunka, N., Lasserre, T., La Cascio, L., Lebeda, O., Lehnert, B., Letnev, J., Leven, F., Le, T. L., Lichter, S., Lokhov, A., Machatschek, M., Malcherek, E., Marsteller, A., Martin, E. L., Melzer, C., Menshikov, A., Mertens, S., Monreal, B., Müller, K., Naumann, U., Neumann, H., Niemes, S., Noe, M., Ortjohann, H. -W., Osipowicz, A., Otten, E., Parno, D. S., Pollithy, A., Poon, A. W. P., Poyato, J. M. L., Priester, F., Ranitzsch, P. C. -O., Rest, O., Rinderspacher, R., Robertson, R. G. H., Rodenbeck, C., Rohr, P., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Schäfer, P., Schimpf, L., Schlösser, K., Schlösser, M., Schlüter, L., Schrank, M., Schulz, B., Seitz-Moskaliuk, H., Seller, W., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Steven, M., Sturm, M., Suesser, M., Sun, M., Tcherniakhovski, D., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Trost, N., Valerius, K., Vénos, D., Vianden, R., Hernández, A. P. Vizcaya, Weber, M., Weinheimer, C., Weiss, C., Welte, S., Wendel, J., Wilkerson, J. F., Wolf, J., Wüstling, S., Xu, W., Yen, Y. -R., Zadoroghny, S., Zeller, G.

    المصدر: Eur. Phys. J. C (2020) 80: 821

    مصطلحات موضوعية: Physics - Instrumentation and Detectors

    الوصف: The KArlsruhe TRItium Neutrino experiment (KATRIN) aims to determine the effective electron (anti)neutrino mass with a sensitivity of $0.2\textrm{ eV/c}^2$ (90$\%$ C.L.) by precisely measuring the endpoint region of the tritium $\beta$-decay spectrum. It uses a tandem of electrostatic spectrometers working as MAC-E (magnetic adiabatic collimation combined with an electrostatic) filters. In the space between the pre-spectrometer and the main spectrometer, an unavoidable Penning trap is created when the superconducting magnet between the two spectrometers, biased at their respective nominal potentials, is energized. The electrons accumulated in this trap can lead to discharges, which create additional background electrons and endanger the spectrometer and detector section downstream. To counteract this problem, "electron catchers" were installed in the beamline inside the magnet bore between the two spectrometers. These catchers can be moved across the magnetic-flux tube and intercept on a sub-ms time scale the stored electrons along their magnetron motion paths. In this paper, we report on the design and the successful commissioning of the electron catchers and present results on their efficiency in reducing the experimental background.
    Comment: - 12 pages, 14 figures, LaTeX; typos corrected, references added; precised a few arguments, added additional discussions, results unchanged

    الوصول الحر: http://arxiv.org/abs/1911.09633Test

  2. 2
    تقرير

    المؤلفون: Aker, M., Altenmüller, K., Arenz, M., Baek, W. -J., Barrett, J., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Blaum, K., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Bouquet, H., Brunst, T., Caldwell, T. S., Chilingaryan, S., Choi, W., Debowski, K., Deffert, M., Descher, M., Barrero, D. Díaz, Doe, P. J., Dragoun, O., Drexlin, G., Dyba, S., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Eversheim, D., Fedkevych, M., Felden, A., Formaggio, J. A., Fränkle, F. M., Franklin, G. B., Frankrone, H., Friedel, F., Fuchs, D., Fulst, A., Gauda, K., Gil, W., Glück, F., Grohmann, S., Grössle, R., Gumbsheimer, R., Hackenjos, M., Hannen, V., Hartmann, J., Haußmann, N., Minh, M. Ha, Heizmann, F., Heizmann, J., Helbing, K., Hickford, S., Hillesheimer, D., Hinz, D., Höhn, T., Holzapfel, B., Holzmann, S., Houdy, T., Howe, M. A., Huber, A., Jansen, A., Karl, C., Kellerer, J., Kernert, N., Kippenbrock, L., Kleesiek, M., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., Kuffner, B., Kunka, N., Lasserre, T., La Cascio, L., Lebeda, O., Lebert, M., Lehnert, B., Letnev, J., Leven, F., Le, T. L., Lichter, S., Lokhov, A., Machatschek, M., Malcherek, E., Mark, M., Marsteller, A., Martin, E. L., Megas, F., Melzer, C., Menshikov, A., Mertens, S., Meier, M., Mirz, S., Monreal, B., Guzmán, P. I. Morales, Müller, K., Naumann, U., Neumann, H., Niemes, S., Noe, M., Off, A., Ortjohann, H. -W., Osipowicz, A., Otten, E., Parno, D. S., Pollithy, A., Poon, A. W. P., Poyato, J. M. L., Priester, F., Ranitzsch, P. C. -O., Rest, O., Rinderspacher, R., Robertson, R. G. H., Rodenbeck, C., Rohr, P., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Schäfer, P., Schimpf, L., Schlösser, K., Schlösser, M., Schlüter, L., Schrank, M., Schulz, B., Seitz-Moskaliuk, H., Seller, W., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Steven, M., Sturm, M., Suesser, M., Sun, M., Tcherniakhovski, D., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Trost, N., Urban, K., Valerius, K., Vénos, D., Vianden, R., Hernández, A. P. Vizcaya, Weber, M., Weinheimer, C., Weiss, C., Welte, S., Wendel, J., Wilkerson, J. F., Wolf, J., Wüstling, S., Xu, W., Yen, Y. -R., Zadorozhny, S., Zeller, G.

    الوصف: The determination of the neutrino mass is one of the major challenges in astroparticle physics today. Direct neutrino mass experiments, based solely on the kinematics of beta-decay, provide a largely model-independent probe to the neutrino mass scale. The Karlsruhe Tritium Neutrino (KATRIN) experiment is designed to directly measure the effective electron antineutrino mass with a sensitivity of 0.2 eV 90% CL. In this work we report on the first operation of KATRIN with tritium which took place in 2018. During this commissioning phase of the tritium circulation system, excellent agreement of the theoretical prediction with the recorded spectra was found and stable conditions over a time period of 13 days could be established. These results are an essential prerequisite for the subsequent neutrino mass measurements with KATRIN in 2019.

    الوصول الحر: http://arxiv.org/abs/1909.06069Test

  3. 3
    دورية أكاديمية

    المصدر: European Physical Journal C. 80(9)

    الوصف: The KArlsruhe TRItium Neutrino experiment (KATRIN) aims to determine the effective electron (anti)-neutrino mass with a sensitivity of 0.2eV/c2 by precisely measuring the endpoint region of the tritium β-decay spectrum. It uses a tandem of electrostatic spectrometers working as magnetic adiabatic collimation combined with an electrostatic (MAC-E) filters. In the space between the pre-spectrometer and the main spectrometer, creating a Penning trap is unavoidable when the superconducting magnet between the two spectrometers, biased at their respective nominal potentials, is energized. The electrons accumulated in this trap can lead to discharges, which create additional background electrons and endanger the spectrometer and detector section downstream. To counteract this problem, “electron catchers” were installed in the beamline inside the magnet bore between the two spectrometers. These catchers can be moved across the magnetic-flux tube and intercept on a sub-ms time scale the stored electrons along their magnetron motion paths. In this paper, we report on the design and the successful commissioning of the electron catchers and present results on their efficiency in reducing the experimental background.

    وصف الملف: application/pdf

  4. 4
    دورية أكاديمية

    المصدر: European Physical Journal C. 80(3)

    الوصف: The determination of the neutrino mass is one of the major challenges in astroparticle physics today. Direct neutrino mass experiments, based solely on the kinematics of β -decay, provide a largely model-independent probe to the neutrino mass scale. The Karlsruhe Tritium Neutrino (KATRIN) experiment is designed to directly measure the effective electron antineutrino mass with a sensitivity of 0.2eV (90 % CL). In this work we report on the first operation of KATRIN with tritium which took place in 2018. During this commissioning phase of the tritium circulation system, excellent agreement of the theoretical prediction with the recorded spectra was found and stable conditions over a time period of 13 days could be established. These results are an essential prerequisite for the subsequent neutrino mass measurements with KATRIN in 2019.

    وصف الملف: application/pdf

  5. 5
  6. 6
    دورية أكاديمية

    المؤلفون: Aker, M., Altenmüller, K., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Blaum, K., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Bouquet, H., Brunst, T., Caldwell, T. S., Chilingaryan, S., Choi, W., Debowski, K., Deffert, M., Descher, M., Díaz Barrero, D., Doe, P. J., Dragoun, O., Drexlin, G., Dyba, S., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Eversheim, D., Fedkevych, M., Felden, A., Formaggio, J. A., Fränkle, F., Franklin, G. B., Frankrone, H., Friedel, F., Fulst, A., Gauda, K., Gil, W., Glück, F., Grohmann, S., Grössle, R., Gumbsheimer, R., Hackenjos, M., Hannen, V., Hartmann, J., Haußmann, N., Heizmann, F., Heizmann, J., Helbing, K., Hickford, S., Hillesheimer, D., Hinz, D., Höhn, T., Holzapfel, B., Holzmann, S., Houdy, T., Jansen, A., Karl, C., Kellerer, J., Kernert, N., Kippenbrock, L., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., Kuffner, B., Kunka, N., Lasserre, T., La Cascio, L., Lebeda, O., Lehnert, B., Letnev, J., Leven, F., Le, T. L., Lichter, S., Lokhov, A., Machatschek, M., Malcherek, E., Marsteller, A., Martin, E. L., Melzer, C., Menshikov, A., Mertens, S., Mirz, S., Monreal, B., Müller, K., Naumann, U., Neumann, H., Niemes, S., Noe, M., Ortjohann, H.-W., Osipowicz, A., Otten, E., Parno, D. S., Pollithy, A., Poon, A. W. P., Poyato, J. M. L., Priester, F., Ranitzsch, P. C.-O., Rest, O., Rinderspacher, R., Robertson, R. G. H., Rodenbeck, C., Rohr, P., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Schäfer, P., Schimpf, L., Schlösser, K., Schlösser, M., Schlüter, L., Schrank, M., Schulz, B., Seitz-Moskaliuk, H., Seller, W., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Steven, M., Sturm, M., Suesser, M., Sun, M., Tcherniakhovski, D., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Trost, N., Valerius, K., Vénos, D., Vianden, R., Vizcaya Hernández, A. P., Weber, M., Weinheimer, C., Weiss, C., Welte, S., Wendel, J., Wilkerson, J. F., Wolf, J., Wüstling, S., Xu, W., Yen, Y.-R., Zadoroghny, S., Zeller, G.

    المصدر: The European physical journal / C, 80 (9), Article: 821 ; ISSN: 1434-6044, 1434-6052

    مصطلحات موضوعية: ddc:530, Physics, info:eu-repo/classification/ddc/530

    الوصف: The KArlsruhe TRItium Neutrino experiment (KATRIN) aims to determine the effective electron (anti)-neutrino mass with a sensitivity of 0.2eV/c$^{2}$ by precisely measuring the endpoint region of the tritium β-decay spectrum. It uses a tandem of electrostatic spectrometers working as magnetic adiabatic collimation combined with an electrostatic (MAC-E) filters. In the space between the pre-spectrometer and the main spectrometer, creating a Penning trap is unavoidable when the superconducting magnet between the two spectrometers, biased at their respective nominal potentials, is energized. The electrons accumulated in this trap can lead to discharges, which create additional background electrons and endanger the spectrometer and detector section downstream. To counteract this problem, “electron catchers” were installed in the beamline inside the magnet bore between the two spectrometers. These catchers can be moved across the magnetic-flux tube and intercept on a sub-ms time scale the stored electrons along their magnetron motion paths. In this paper, we report on the design and the successful commissioning of the electron catchers and present results on their efficiency in reducing the experimental background.

    وصف الملف: application/pdf

    العلاقة: info:eu-repo/semantics/altIdentifier/wos/000569786700005; info:eu-repo/semantics/altIdentifier/issn/1434-6044; info:eu-repo/semantics/altIdentifier/issn/1434-6052; https://publikationen.bibliothek.kit.edu/1000123468Test; https://publikationen.bibliothek.kit.edu/1000123468/86993338Test; https://doi.org/10.5445/IR/1000123468Test

  7. 7
    دورية أكاديمية

    المؤلفون: Aker, Max, Altenmüller, K., Arenz, M., Baek, W.-J., Barrett, J., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Blaum, K., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Bouquet, H., Brunst, T., Caldwell, T.S., Chilingaryan, S., Choi, W., Debowski, K., Deffert, M., Descher, M., Díaz Barrero, D., Doe, P.J., Dragoun, O., Drexlin, G., Dyba, S., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Eversheim, D., Fedkevych, M., Felden, A., Formaggio, J.A., Fränkle, F.M., Franklin, G.B., Frankrone, H., Friedel, F., Fuchs, D., Fulst, A., Gauda, K., Gil, W., Glück, F., Grohmann, S., Grössle, R., Gumbsheimer, R., Hackenjos, M., Hannen, V., Hartmann, J., Hauss{}mann, N., Ha Minh, M., Heizmann, F., Heizmann, J., Helbing, K., Hickford, S., Hillesheimer, D., Hinz, D., Höhn, T., Holzapfel, B., Holzmann, S., Houdy, T., Howe, M.A., Huber, A., Jansen, A., Karl, C., Kellerer, J., Kernert, N., Kippenbrock, L., Kleesiek, M., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., Kuffner, B., Kunka, N., Lasserre, T., La Cascio, L., Lebeda, O., Lebert, M., Lehnert, B., Letnev, J., Leven, F., Le, T.L., Lichter, S., Lokhov, A., Machatschek, M., Malcherek, E., Mark, M., Marsteller, A., Martin, E.L., Megas, F., Melzer, C., Menshikov, A., Mertens, S., Meier, M., Mirz, S., Monreal, B., Morales Guzmán, P.I., Müller, K., Naumann, U., Neumann, H., Niemes, S., Noe, M., Off, A., Ortjohann, H.-W., Osipowicz, A., Otten, E., Parno, D.S., Pollithy, A., Poon, A.W.P., Poyato, J.M.L., Priester, F., Ranitzsch, P.C.-O., Rest, O., Rinderspacher, R., Robertson, R.G.H., Rodenbeck, C., Rohr, P., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Schäfer, P., Schimpf, L., Schlösser, K., Schlösser, M., Schlüter, L., Schrank, M., Schulz, B., Seitz-Moskaliuk, H., Seller, W., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Steven, M., Sturm, M., Suesser, M., Sun, M., Tcherniakhovski, D., Telle, H.H., Thorne, L.A., Thümmler, T., Titov, N., Tkachev, I., Trost, N., Urban, K., Valerius, K., Vénos, D., Vianden, R., Vizcaya Hernández, A.P., Weber, M., Weinheimer, C., Weiss, C., Welte, S., Wendel, J., Wilkerson, J.F., Wolf, J., Wüstling, S., Xu, W., Yen, Y.-R., Zadorozhny, S., Zeller, G.

    المساهمون: AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), KATRIN

    المصدر: Eur.Phys.J.C ; https://hal.science/hal-02327789Test ; Eur.Phys.J.C, 2020, 80 (3), pp.264. ⟨10.1140/epjc/s10052-020-7718-z⟩

    الوصف: International audience ; The determination of the neutrino mass is one of the major challenges in astroparticle physics today. Direct neutrino mass experiments, based solely on the kinematics of $\upbeta $-decay, provide a largely model-independent probe to the neutrino mass scale. The Karlsruhe Tritium Neutrino (KATRIN) experiment is designed to directly measure the effective electron antineutrino mass with a sensitivity of $0.2\hbox { eV}$ ($90\%$ CL). In this work we report on the first operation of KATRIN with tritium which took place in 2018. During this commissioning phase of the tritium circulation system, excellent agreement of the theoretical prediction with the recorded spectra was found and stable conditions over a time period of 13 days could be established. These results are an essential prerequisite for the subsequent neutrino mass measurements with KATRIN in 2019.

    العلاقة: info:eu-repo/semantics/altIdentifier/arxiv/1909.06069; hal-02327789; https://hal.science/hal-02327789Test; ARXIV: 1909.06069; INSPIRE: 1754139

  8. 8
    دورية أكاديمية

    المؤلفون: The KATRIN Collaboration, Aker, M., Altenmüller, K., Arenz, M., Baek, W., Barrett, J., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Blaum, K., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Bouquet, H., Brunst, T., Caldwell, T., Chilingaryan, S., Choi, W., Debowski, K., Deffert, M., Descher, M., Díaz Barrero, D., Doe, P., Dragoun, O., Drexlin, G., Dyba, S., Edzards, F., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Eversheim, D., Fedkevych, M., Felden, A., Formaggio, J., Fränkle, F., Franklin, G., Frankrone, H., Friedel, F., Fuchs, D., Fulst, A., Gauda, K., Gil, W., Glück, F., Grohmann, S., Grössle, R., Gumbsheimer, R., Hackenjos, M., Hannen, V., Hartmann, J., Haußmann, N., Ha Minh, M., Heizmann, F., Heizmann, J., Helbing, K., Hickford, S., Hillesheimer, D., Hinz, D., Höhn, T., Holzapfel, B., Holzmann, S., Houdy, T., Howe, M., Huber, A., Jansen, A., Karl, C., Kellerer, J., Kernert, N., Kippenbrock, L., Kleesiek, M., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., Kuffner, B., Kunka, N., Lasserre, T., La Cascio, L., Lebeda, O., Lebert, M., Lehnert, B., Letnev, J., Leven, F., Le, T., Lichter, S., Lokhov, A., Machatschek, M., Malcherek, E., Mark, M., Marsteller, A., Martin, E., Megas, F., Melzer, C., Menshikov, A., Meier, S., Mirz, S., Monreal, B., Morales Guzmán, P., Müller, K., Naumann, U., Neumann, H., Niemes, S., Noe, M., Off, A., Ortjohann, H., Osipowicz, A., Otten, E., Parno, D., Pollithy, A., Poon, A., Poyato, J., Priester, F., Ranitzsch, P., Rest, O., Rinderspacher, R., Robertson, R., Rodenbeck, C., Rohr, P., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Schäfer, P., Schimpf, L., Schlösser, K., Schlösser, M., Schlüter, L., Schrank, M., Schulz, B., Seitz-Moskaliuk, H., Seller, W., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Steven, M., Sturm, M., Suesser, M., Sun, M., Tcherniakhovski, D., Telle, H., Thorne, L., Thümmler, T., Titov, N., Tkachev, I., Trost, N., Urban, K., Valerius, K., Vénos, D., Vianden, R., Vizcaya Hernández, A., Weber, M., Weinheimer, C., Weiss, C., Welte, S., Wendel, J., Wilkerson, J., Wolf, J., Wüstling, S., Xu, W., Yen, Y., Zadorozhny, S., Zeller, G.

    المصدر: European Physical Journal C

    الوصف: The determination of the neutrino mass is one of the major challenges in astroparticle physics today. Direct neutrino mass experiments, based solely on the kinematics of beta-decay, provide a largely model-independent probe to the neutrino mass scale. The Karlsruhe Tritium Neutrino (KATRIN) experiment is designed to directly measure the effective electron antineutrino mass with a sensitivity of 0.2 eV 90% CL. In this work we report on the first operation of KATRIN with tritium which took place in 2018. During this commissioning phase of the tritium circulation system, excellent agreement of the theoretical prediction with the recorded spectra was found and stable conditions over a time period of 13 days could be established. These results are an essential prerequisite for the subsequent neutrino mass measurements with KATRIN in 2019.

    العلاقة: info:eu-repo/semantics/altIdentifier/urn/https://publications.mppmu.mpg.de/?action=search&mpi=MPP-2019-349Test; info:eu-repo/semantics/altIdentifier/arxiv/arxiv:1909.06069; info:eu-repo/semantics/altIdentifier/urn/https://inspirehep.net/literature?q=find%20eprint%201909.06069Test; http://hdl.handle.net/21.11116/0000-0008-1BE3-ATest

  9. 9
    دورية أكاديمية

    الوصف: The determination of in vitro release kinetics of peptides from poly(d,l-lactide-co-glycolide) (PLGA) microspheres generally requires optimization of the test conditions for a given formulation. This is particularly important when in vitro/in vivo correlation should be determined. Here, the somatostatin analogue vapreotide pamoate, an octapeptide, was microencapsulated into PLGA 50:50 by spray-drying. The solubility of this peptide and its in vitro release kinetics from the microspheres were studied in various test media. The solubility of vapreotide pamoate was approximately 20–40 μg/ml in 67 mM phosphate buffer saline (PBS) at pH 7.4, but increased to approximately 500–1000 μg/ml at a pH of 3.5. At low pH, the solubility increased with the buffer concentration (1–66 mM). Very importantly, proteins (aqueous bovine serum albumin (BSA) solution or human serum) appeared to solubilize the peptide pamoate, resulting in solubilities ranging from 900 to 6100 μg/ml. The release rate was also greatly affected by the medium composition. Typically, in PBS of pH 7.4, only 33±1% of the peptide were released within 4 days, whereas 53±2 and 61±0.9% were released in 1% BSA solution and serum, respectively. The type of medium was found critical for the estimation of the in vivo release. The in vivo release kinetics of vapreotide pamoate from PLGA microspheres following administration to rats were qualitatively in good agreement with those obtained in vitro using serum as release medium. Finally, sterilization by γ-irradiation had only a minor effect on the in vivo pharmacokinetics.

    وصف الملف: application/pdf

  10. 10

    المؤلفون: Aker, M., Altenmüller, K., Beglarian, A., Behrens, J., Berlev, A., Besserer, U., Blaum, K., Block, F., Bobien, S., Bornschein, B., Bornschein, L., Bouquet, H., Brunst, T., Caldwell, T. S., Chilingaryan, S., Choi, W., Debowski, K., Deffert, M., Descher, M., Díaz Barrero, D., Doe, P. J., Dragoun, O., Drexlin, G., Dyba, S., Eitel, K., Ellinger, E., Engel, R., Enomoto, S., Eversheim, D., Fedkevych, M., Felden, A., Formaggio, J. A., Fränkle, F., Franklin, G. B., Frankrone, H., Friedel, F., Fulst, A., Gauda, K., Gil, W., Glück, F., Grohmann, S., Grössle, R., Gumbsheimer, R., Hackenjos, M., Hannen, V., Hartmann, J., Haußmann, N., Heizmann, F., Heizmann, J., Helbing, K., Hickford, S., Hillesheimer, D., Hinz, D., Höhn, T., Holzapfel, B., Holzmann, S., Houdy, T., Jansen, A., Karl, C., Kellerer, J., Kernert, N., Kippenbrock, L., Klein, M., Köhler, C., Köllenberger, L., Kopmann, A., Korzeczek, M., Kovalík, A., Krasch, B., Krause, H., Kuffner, B., Kunka, N., Lasserre, T., La Cascio, L., Lebeda, O., Lehnert, B., Letnev, J., Leven, F., Le, T. L., Lichter, S., Lokhov, A., Machatschek, M., Malcherek, E., Marsteller, A., Martin, E. L., Melzer, C., Menshikov, A., Mertens, S., Mirz, S., Monreal, B., Müller, K., Naumann, U., Neumann, H., Niemes, S., Noe, M., Ortjohann, H. -W., Osipowicz, A., Otten, E., Parno, D. S., Pollithy, A., Poon, A. P., Poyato, J. L., Priester, F., Ranitzsch, P. C.-O., Rest, O., Rinderspacher, R., Robertson, R. H., Rodenbeck, C., Rohr, P., Röllig, M., Röttele, C., Ryšavý, M., Sack, R., Saenz, A., Schäfer, P., Schimpf, L., Schlösser, K., Schlösser, M., Schlüter, L., Schrank, M., Schulz, B., Seitz-Moskaliuk, H., Seller, W., Sibille, V., Siegmann, D., Slezák, M., Spanier, F., Steidl, M., Steven, M., Sturm, M., Suesser, M., Sun, M., Tcherniakhovski, D., Telle, H. H., Thorne, L. A., Thümmler, T., Titov, N., Tkachev, I., Trost, N., Valerius, K., Vénos, D., Vianden, R., Vizcaya Hernández, A. P., Weber, M., Weinheimer, C., Weiss, C., Welte, S., Wendel, J., Wilkerson, J. F., Wolf, J., Wüstling, S., Xu, W., Yen, Y. -R., Zadoroghny, S., Zeller, G.

    الوصف: The KArlsruhe TRItium Neutrino experiment (KATRIN) aims to determine the effective electron (anti)-neutrino mass with a sensitivity of 0.2eV/c \(^2\) by precisely measuring the endpoint region of the tritium \(\beta \) -decay spectrum. It uses a tandem of electrostatic spectrometers working as magnetic adiabatic collimation combined with an electrostatic (MAC-E) filters. In the space between the pre-spectrometer and the main spectrometer, creating a Penning trap is unavoidable when the superconducting magnet between the two spectrometers, biased at their respective nominal potentials, is energized. The electrons accumulated in this trap can lead to discharges, which create additional background electrons and endanger the spectrometer and detector section downstream. To counteract this problem, “electron catchers” were installed in the beamline inside the magnet bore between the two spectrometers. These catchers can be moved across the magnetic-flux tube and intercept on a sub-ms time scale the stored electrons along their magnetron motion paths. In this paper, we report on the design and the successful commissioning of the electron catchers and present results on their efficiency in reducing the experimental background.

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