يعرض 1 - 10 نتائج من 87 نتيجة بحث عن '"Hazari, Puja Panwar"', وقت الاستعلام: 1.07s تنقيح النتائج
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    دورية أكاديمية
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    دورية أكاديمية
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    دورية أكاديمية

    المساهمون: Ministry of Electronics and Information technology, Defence Research and Development Organisation, Ministry of Defence

    المصدر: ACS Omega ; volume 7, issue 15, page 12509-12523 ; ISSN 2470-1343 2470-1343

    مصطلحات موضوعية: General Chemical Engineering, General Chemistry

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    كتاب
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    كتاب
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    دورية أكاديمية

    المساهمون: Ministry of Electronics and Information technology

    المصدر: ACS Omega ; volume 5, issue 41, page 26297-26306 ; ISSN 2470-1343 2470-1343

    مصطلحات موضوعية: General Chemical Engineering, General Chemistry

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    دورية أكاديمية

    المصدر: Drug Delivery & Translational Research; Oct2023, Vol. 13 Issue 10, p2604-2613, 10p

    مستخلص: Glioma refers to the most atypical variant of the malignant central nervous system tumors posturing massive challenge to the research fraternity owing to the flimsy improvement in the patient survival rate over the past years. The aim of the proposed work was developing a diagnostic aid for brain tumors, which could be administered via the non-invasive intranasal route. Since overexpression of folate receptors in the central nervous system tumors is 500 times more than the normal healthy cells, we aimed at fabricating a radiolabeled folate encapsulated micellar delivery system to be given via the nasal route. Folate conjugated bifunctional chelating agent was synthesized, radiolabeled with 99mTc, and encapsulated in a micellar carrier. The fabricated micelles were further evaluated for in vivo nasal toxicity in rats and the same were found safe for intranasal administration. The fabricated micelles owing to their nano size, mucoadhesive nature, and enhanced permeation were observed to have a higher uptake into the brain (around 16% in 4 h) than as compared to the radiolabeled conjugated folate solution when studied for in vivo biodistribution in mice. Single-photon emission computerized tomography imaging performed in higher animals upon intranasal administration of the micellar formulation revealed enhanced uptake of the micelles into the animal brain. It is believed that the aforementioned formulation can be of a great diagnostic value in the detection of not only brain tumors but also other folate expressing cancers such as cervical, breast, and lungs as the system is fast, non-toxic, accurate, non-invasive, and simple. [ABSTRACT FROM AUTHOR]

    : Copyright of Drug Delivery & Translational Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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    دورية أكاديمية
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    دورية أكاديمية
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    دورية أكاديمية

    المساهمون: University Grants Commission, Defence Research and Development Organisation

    المصدر: ACS Omega ; volume 3, issue 6, page 6497-6505 ; ISSN 2470-1343 2470-1343

    مصطلحات موضوعية: General Chemical Engineering, General Chemistry