المؤلفون: Hayley James, Grace L. Paley, Richard Brasington, Philip L. Custer, Todd P. Margolis, Michael A. Paley

المصدر: American Journal of Ophthalmology Case Reports, Vol 22, Iss , Pp 101104- (2021)

مصطلحات موضوعية: Ocular cicatricial pemphigoid, Mucous membrane pemphigoid, Tofacitinib, JAK, STAT, JAK inhibitor, Ophthalmology, RE1-994

الوصف: Purpose: To report the successful use of tofacitinib in the treatment of refractory ocular mucous membrane pemphigoid (MMP). Observations: Two patients with ocular MMP presented with refractory disease after failure of multiple therapies. Treatment with tofacitinib led to durable control of conjunctival inflammation within 8 weeks and no apparent progression of sub-conjunctival fibrosis. One patient maintained absence of apparent disease activity over 16 months of follow-up. Cessation of tofacitinib in the other patient led to disease relapse which was reversed by re-initiation of therapy. Conclusions and importance: Small molecule inhibitors of Janus kinases, such as tofacitinib, may offer an effective treatment option for refractory ocular MMP.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2451993621001134Test; https://doaj.org/toc/2451-9936Test

الوصول الحر: https://doaj.org/article/c1f96d7e002d4812bcc5ab45a2d4c618Test

المؤلفون: Lynn M. Hassman, MD, PhD, Michael A. Paley, MD, PhD, Ekaterina Esaulova, MS, Grace L. Paley, MD, PhD, Philip A. Ruzycki, PhD, Nicole Linskey, BS, Jennifer Laurent, BS, Lacey Feigl-Lenzen, Luke Springer, BA, Cynthia L. Montana, MD, PhD, Karen Hong, MD, MPhil, Jennifer Enright, MD, PhD, Hayley James, MD, Maxim N. Artyomov, PhD, Wayne M. Yokoyama, MD

المصدر: Ophthalmology Science, Vol 1, Iss 1, Pp 100010- (2021)

مصطلحات موضوعية: B cells, single cell RNA sequencing, clonal expansion, T cells, Uveitis, Ophthalmology, RE1-994

الوصف: Purpose: To identify molecular features that distinguish individuals with shared clinical features of granulomatous uveitis. Design: Cross-sectional observational study. Participants: Four eyes from patients with active granulomatous uveitis. Methods: We performed single-cell RNA sequencing with antigen-receptor sequence analysis to obtain an unbiased gene expression survey of ocular immune cells and to identify clonally expanded lymphocytes. Main Outcomes Measures: For each inflamed eye, we measured the proportion of distinct immune cell types, the amount of B- or T-cell clonal expansion, and the transcriptional profile of T and B cells. Results: Each individual showed robust clonal expansion arising from a single T- or B-cell lineage, suggesting distinct, antigen-driven pathogenic processes in each patient. This variability in clonal expansion was mirrored by individual variability in CD4 T-cell populations, whereas ocular CD8 T cells and B cells were more similar transcriptionally among patients. Finally, ocular B cells displayed evidence of class switching and plasmablast differentiation within the ocular microenvironment, providing additional support for antigen-driven immune responses in granulomatous uveitis. Conclusions: Collectively, our study identified both conserved and individualized features of granulomatous uveitis, illuminating parallel pathophysiologic mechanisms and suggesting that future personalized therapeutic approaches may be warranted.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666914521000087Test; https://doaj.org/toc/2666-9145Test

الوصول الحر: https://doaj.org/article/525d86a6314048059ed212f74515126cTest

المؤلفون: Hayley James, Ariane Agunsoye

المصدر: New Political Economy. :1-18

مصطلحات موضوعية: Political Science and International Relations, Geography, Planning and Development, Development

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::432fd20ba83f7ccb6bb0870afc3723a6Test
https://doi.org/10.1080/13563467.2022.2149720Test

المؤلفون: Hayley James, Ariane Agunsoye

المصدر: Review of International Political Economy. :1-24

مصطلحات موضوعية: Economics and Econometrics, Sociology and Political Science, Political Science and International Relations

الوصف: Bringing together insights from feminist political economy and everyday financialization, this paper explores the complex nature of women’s pension decisions. Women in the UK experience structural constraints originating from a pension system which ignores socially reproductive activities, and they face limitations in pension planning due to prevalent gender norms. Both aspects have a significant impact on women’s long-term financial wellbeing and yet little attention has been paid to how they operate within these constraints, ultimately leading to women’s behaviors being construed as passive or irrational. Drawing on 61 interviews, our paper conceptualizes pension practices adopted by women through gendered finance rationality, defined as variegated financial practices shaped by the gendered context in which they arise. Rather than being irrational or passive victims of an unequal welfare system, women actively engage with the limitations of the pension system and seek out asset strategies which seem more suited to their life trajectories, but implicitly reinforce gendered wealth inequalities.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a9f1431c0617486d8c6190eff04427Test
https://doi.org/10.1080/09692290.2022.2113114Test

المؤلفون: Ellie Suh, Hayley James

المصدر: Youth Employment Insecurity and Pension Adequacy ISBN: 9781802208580

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cdce5aa59752fde81470018dd38c7f98Test
https://doi.org/10.4337/9781802208580.00015Test

المؤلفون: Susan John, Michelle Bates, Muhammad Sabar, Sam Cole, Louise Coley, Mark Cowen, Laura Doverty, Joanne Evans, Dale Fowler, Pinelopi Gkogkou, Charlotte Ingle, Rafiqul Islam, Hayley James, Jaak Joe, Rachel Kirby, Alex Martin, Natasa Solomou, John Sprunt, Zacharias Tasigiannopoulos, Sarah Treece, Huiqi Yang, Kent Yip, Kamalram Thippu Jayaprakash

المصدر: Lung Cancer. 178:S65-S66

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Cancer Research, Oncology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1aee22b8f9c6ddc92b23635fd815eb06Test
https://doi.org/10.1016/s0169-5002Test(23)00577-9

المؤلفون: Hayley James, James Nazroo, Georgia Chatzi, Paul Simpson

المصدر: James, H, Nazroo, J, Chatzi, G & Simpson, P 2022, ' How Do Women and Men Negotiate Sex in Later Life Relationships? A Qualitative Analysis of Data from the English Longitudinal Study of Aging ', The Journal of Sex Research, pp. 1-13 . https://doi.org/10.1080/00224499.2022.2112934Test

مصطلحات موضوعية: Gender Studies, Sexual activity, History and Philosophy of Science, Sociology and Political Science, ResearchInstitutes_Networks_Beacons/cathie_marsh_institute, qualitative analysis, relationships, Cathie Marsh Institute, General Psychology, older adults

الوصف: Later life relationships and in particular the role of sex within them, have often been neglected in research due to assumptions of decline and sexlessness. We contribute to a growing body of work which counters these stereotypes by examining sexual scripts within the socio-cultural context of later life relationships. We analyzed open-text comments from the English Longitudinal Study of Aging (ELSA) collected as part of a self-completion questionnaire. In Wave 6, 1065 participants (M age 67.5, SD 9.6 years) and in Wave 8, 922 participants (M age 69.1, SD 9.01 years) responded to an open-text box question. Across both waves, 38% of respondents were men and 62% were women. The analysis used a coding template developed from existing literature and adjusted to accommodate emerging topics. A gendered analysis of the interrelated topics of relationships, sex and sexuality resulted in themes which illustrate similarities and differences in how men and women negotiate sex in later life relationships. The findings confirm that sex remains integral to intimacy in later life relationships for many men and women. However, they also demonstrate that norms of age and gender interact to shape sex and relationship practices in later life. These norms limit some people's experiences, for example, preventing them from seeking new relationships, as well as creating challenges for intimacy in partnerships. These findings extend the theoretical understanding of relationships and sex in later life.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685a3efda41bee7f81d8831a21e81310Test
https://doi.org/10.1080/00224499.2022.2112934Test

المؤلفون: Lacey Feigl-Lenzen, Maxim N. Artyomov, Grace L. Paley, Cynthia L. Montana, Lynn M. Hassman, Wayne M. Yokoyama, Philip A. Ruzycki, Karen Hong, Luke E. Springer, Nicole Linskey, Hayley James, Jennifer M. Enright, Jennifer Laurent, Ekaterina Esaulova, Michael A. Paley

المصدر: Ophthalmol Sci
Ophthalmology Science, Vol 1, Iss 1, Pp 100010-(2021)

مصطلحات موضوعية: B cells, biology, Innate lymphoid cell, B-cell receptor, T cells, clonal expansion, General Medicine, Human leukocyte antigen, RE1-994, medicine.disease, Major histocompatibility complex, Article, Uveitis, Ophthalmology, Immune system, Immunoglobulin class switching, single cell RNA sequencing, Immunology, medicine, biology.protein, Cytotoxic T cell

الوصف: Purpose To identify molecular features that distinguish individuals with shared clinical features of granulomatous uveitis. Design Cross-sectional observational study. Participants Four eyes from patients with active granulomatous uveitis. Methods We performed single-cell RNA sequencing with antigen-receptor sequence analysis to obtain an unbiased gene expression survey of ocular immune cells and to identify clonally expanded lymphocytes. Main Outcomes Measures For each inflamed eye, we measured the proportion of distinct immune cell types, the amount of B- or T-cell clonal expansion, and the transcriptional profile of T and B cells. Results Each individual showed robust clonal expansion arising from a single T- or B-cell lineage, suggesting distinct, antigen-driven pathogenic processes in each patient. This variability in clonal expansion was mirrored by individual variability in CD4 T-cell populations, whereas ocular CD8 T cells and B cells were more similar transcriptionally among patients. Finally, ocular B cells displayed evidence of class switching and plasmablast differentiation within the ocular microenvironment, providing additional support for antigen-driven immune responses in granulomatous uveitis. Conclusions Collectively, our study identified both conserved and individualized features of granulomatous uveitis, illuminating parallel pathophysiologic mechanisms and suggesting that future personalized therapeutic approaches may be warranted.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60553a85d13c8fb89ec71448ed8ce859Test
https://pubmed.ncbi.nlm.nih.gov/35937550Test

المؤلفون: Hayley James

المصدر: Journal of Cultural Economy. 14:627-643

مصطلحات موضوعية: Cultural Studies, Typology, Pension, Public economics, Business

الوصف: In the UK, individuals are increasingly responsible for achieving an adequate retirement income, yet many people are not saving enough for later life. While we understand some of the structures tha...

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::34eb605134fcb2a4ad2f7231f10c6315Test
https://doi.org/10.1080/17530350.2021.1927146Test

المؤلفون: Hayley James, Tine Buffel

المصدر: James, H & Buffel, T 2022, ' Co-research with older people: a systematic literature review ', Ageing & Society, pp. 1 . https://doi.org/10.1017/S0144686X21002014Test

مصطلحات موضوعية: Health (social science), social inequality, ResearchInstitutes_Networks_Beacons/MICRA, Social Psychology, Public Health, Environmental and Occupational Health, social exclusion, ResearchInstitutes_Networks_Beacons/02/11, ResearchInstitutes_Networks_Beacons/03/01, Global inequalities, older people, Ageing, Policy@Manchester, Arts and Humanities (miscellaneous), Manchester Institute for Collaborative Research on Ageing, social justice, Participatory, Coproduction, Geriatrics and Gerontology

الوصف: Interest in co-research with older adults has grown in the past 20 years, yet few published studies have addressed why and how older people have been involved as partners in research. This article presents a systematic review of the literature, examining the aims and challenges of co-research and the ways in which older adults can be involved in research. Systematic searches covering several databases were conducted, yielding a total of 3,293 articles, with 27 papers reviewed which involved older people as co-researchers across more than one stage of the research cycle. We find that co-research with older people offers improved understandings of the issues facing older people; more inclusive and responsive policy, practice and service design; and opportunities for co-researchers to develop new skills whilst giving voice to marginalised groups of older people. The analysis highlights the different ways in which older adults can be involved across phases of research, and identifies ethical, methodological and practical challenges encountered in the process. Involving older adults as co-researchers, while labour intensive and practically challenging, holds promise as an underdeveloped resource for social gerontology, as well as older people themselves. The paper identifies four pathways for improving and extending co-research: developing diversified structures of involvement, supporting co-researchers, embedding research rigour and ensuring co-ownership of change.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e9a6aae30a2df79ce3c7091bf01177Test
https://www.research.manchester.ac.uk/portal/en/publications/coresearch-with-older-people-a-systematic-literature-reviewTest(1bbf7551-4517-4d85-aa3f-033cc3a12917).html