المؤلفون: Lawrence, Michael S, Sougnez, Carrie, Lichtenstein, Lee, Cibulskis, Kristian, Lander, Eric, Gabriel, Stacey B, Getz, Gad, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Bowlby, Reanne, Brooks, Denise, Butterfield, Yaron SN, Carlsen, Rebecca, Cheng, Dean, Chu, Andy, Dhalla, Noreen, Guin, Ranabir, Holt, Robert A, Jones, Steven JM, Lee, Darlene, Li, Haiyan I, Marra, Marco A, Mayo, Michael, Moore, Richard A, Mungall, Andrew J, Gordon Robertson, A, Schein, Jacqueline E, Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Wong, Tina, Protopopov, Alexei, Santoso, Netty, Lee, Semin, Parfenov, Michael, Zhang, Jianhua, Mahadeshwar, Harshad S, Tang, Jiabin, Ren, Xiaojia, Seth, Sahil, Haseley, Psalm, Zeng, Dong, Yang, Lixing, Xu, Andrew W, Song, Xingzhi, Pantazi, Angeliki, Bristow, Christopher A, Hadjipanayis, Angela, Seidman, Jonathan, Chin, Lynda, Park, Peter J, Kucherlapati, Raju, Akbani, Rehan, Casasent, Tod, Liu, Wenbin, Lu, Yiling, Mills, Gordon, Motter, Thomas, Weinstein, John, Diao, Lixia, Wang, Jing, Hong Fan, You, Liu, Jinze, Wang, Kai, Todd Auman, J, Balu, Saianand, Bodenheimer, Thomas, Buda, Elizabeth, Neil Hayes, D, Hoadley, Katherine A, Hoyle, Alan P, Jefferys, Stuart R, Jones, Corbin D, Kimes, Patrick K, Liu, Yufeng, Marron, JS, Meng, Shaowu, Mieczkowski, Piotr A, Mose, Lisle E, Parker, Joel S, Perou, Charles M, Prins, Jan F, Roach, Jeffrey, Shi, Yan, Simons, Janae V, Singh, Darshan, Soloway, Matthew G, Tan, Donghui, Veluvolu, Umadevi, Walter, Vonn, Waring, Scot, Wilkerson, Matthew D, Wu, Junyuan, Zhao, Ni, Cherniack, Andrew D, Hammerman, Peter S, Tward, Aaron D, Sekhar Pedamallu, Chandra, Saksena, Gordon

المصدر: Nature. 517(7536)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Human Genome, Biotechnology, Dental/Oral and Craniofacial Disease, Cancer, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Carcinoma, Squamous Cell, DNA Copy Number Variations, DNA, Neoplasm, Female, Gene Expression Regulation, Neoplastic, Genome, Human, Genomics, Head and Neck Neoplasms, Humans, Male, Molecular Targeted Therapy, Mutation, Oncogenes, RNA, Neoplasm, Signal Transduction, Squamous Cell Carcinoma of Head and Neck, Transcription Factors, Cancer Genome Atlas Network, General Science & Technology

الوصف: The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 mutations and CDKN2A inactivation with frequent copy number alterations including amplification of 3q26/28 and 11q13/22. A subgroup of oral cavity tumours with favourable clinical outcomes displayed infrequent copy number alterations in conjunction with activating mutations of HRAS or PIK3CA, coupled with inactivating mutations of CASP8, NOTCH1 and TP53. Other distinct subgroups contained loss-of-function alterations of the chromatin modifier NSD1, WNT pathway genes AJUBA and FAT1, and activation of oxidative stress factor NFE2L2, mainly in laryngeal tumours. Therapeutic candidate alterations were identified in most HNSCCs.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/91s7f5c0Test

المؤلفون: Parfenov, Michael, Pedamallu, Chandra Sekhar, Gehlenborg, Nils, Freeman, Samuel S, Danilova, Ludmila, Bristow, Christopher A, Lee, Semin, Hadjipanayis, Angela G, Ivanova, Elena V, Wilkerson, Matthew D, Protopopov, Alexei, Yang, Lixing, Seth, Sahil, Song, Xingzhi, Tang, Jiabin, Ren, Xiaojia, Zhang, Jianhua, Pantazi, Angeliki, Santoso, Netty, Xu, Andrew W, Mahadeshwar, Harshad, Wheeler, David A, Haddad, Robert I, Jung, Joonil, Ojesina, Akinyemi I, Issaeva, Natalia, Yarbrough, Wendell G, Hayes, D Neil, Grandis, Jennifer R, El-Naggar, Adel K, Meyerson, Matthew, Park, Peter J, Chin, Lynda, Seidman, JG, Hammerman, Peter S, Kucherlapati, Raju, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Bowlby, Reanne, Butterfield, Yaron SN, Carlsen, Rebecca, Cheng, Dean, Chu, Andy, Dhalla, Noreen, Guin, Ranabir, Holt, Robert A, Jones, Steven JM, Lee, Darlene, Li, Haiyan I, Marra, Marco A, Mayo, Michael, Moore, Richard A, Mungall, Andrew J, Robertson, A Gordon, Schein, Jacqueline E, Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Wong, Tina, Mahadeshwar, Harshad S, Haseley, Psalm, Zeng, Dong, Bristow, Christopher, Hadjipanayis, Angela, Seidman, Jonathan, Akbani, Rehan, Casasent, Tod, Liu, Wenbin, Lu, Yiling, Mills, Gordon, Motter, Thomas, Weinstein, John, Diao, Lixia, Wang, Jing, Fan, You Hong, Liu, Jinze, Wang, Kai, Auman, J Todd, Balu, Saianand, Bodenheimer, Tom, Buda, Elizabeth, Hoadley, Katherine A, Hoyle, Alan P

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 111(43)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Bioinformatics and Computational Biology, Genetics, Oncology and Carcinogenesis, Rare Diseases, Human Genome, Sexually Transmitted Infections, Cervical Cancer, Infectious Diseases, Dental/Oral and Craniofacial Disease, HIV/AIDS, Cancer, 2.2 Factors relating to the physical environment, Aetiology, 2.1 Biological and endogenous factors, Infection, Base Sequence, DNA Methylation, Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Genome, Human, Head and Neck Neoplasms, Host-Pathogen Interactions, Humans, Molecular Sequence Data, Papillomaviridae, Virus Integration, cancer, head and neck, papilloma virus, genome rearrangement, integration sites, Cancer Genome Atlas Network

الوصف: Previous studies have established that a subset of head and neck tumors contains human papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display distinct biological and clinical features. HPV is known to drive cancer by the actions of the E6 and E7 oncoproteins, but the molecular architecture of HPV infection and its interaction with the host genome in head and neck cancers have not been comprehensively described. We profiled a cohort of 279 head and neck cancers with next generation RNA and DNA sequencing and show that 35 (12.5%) tumors displayed evidence of high-risk HPV types 16, 33, or 35. Twenty-five cases had integration of the viral genome into one or more locations in the human genome with statistical enrichment for genic regions. Integrations had a marked impact on the human genome and were associated with alterations in DNA copy number, mRNA transcript abundance and splicing, and both inter- and intrachromosomal rearrangements. Many of these events involved genes with documented roles in cancer. Cancers with integrated vs. nonintegrated HPV displayed different patterns of DNA methylation and both human and viral gene expressions. Together, these data provide insight into the mechanisms by which HPV interacts with the human genome beyond expression of viral oncoproteins and suggest that specific integration events are an integral component of viral oncogenesis.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/52z6c2whTest

المؤلفون: Ho, Joshua WK, Jung, Youngsook L, Liu, Tao, Alver, Burak H, Lee, Soohyun, Ikegami, Kohta, Sohn, Kyung-Ah, Minoda, Aki, Tolstorukov, Michael Y, Appert, Alex, Parker, Stephen CJ, Gu, Tingting, Kundaje, Anshul, Riddle, Nicole C, Bishop, Eric, Egelhofer, Thea A, Hu, Sheng'en Shawn, Alekseyenko, Artyom A, Rechtsteiner, Andreas, Asker, Dalal, Belsky, Jason A, Bowman, Sarah K, Chen, Q Brent, Chen, Ron A-J, Day, Daniel S, Dong, Yan, Dose, Andrea C, Duan, Xikun, Epstein, Charles B, Ercan, Sevinc, Feingold, Elise A, Ferrari, Francesco, Garrigues, Jacob M, Gehlenborg, Nils, Good, Peter J, Haseley, Psalm, He, Daniel, Herrmann, Moritz, Hoffman, Michael M, Jeffers, Tess E, Kharchenko, Peter V, Kolasinska-Zwierz, Paulina, Kotwaliwale, Chitra V, Kumar, Nischay, Langley, Sasha A, Larschan, Erica N, Latorre, Isabel, Libbrecht, Maxwell W, Lin, Xueqiu, Park, Richard, Pazin, Michael J, Pham, Hoang N, Plachetka, Annette, Qin, Bo, Schwartz, Yuri B, Shoresh, Noam, Stempor, Przemyslaw, Vielle, Anne, Wang, Chengyang, Whittle, Christina M, Xue, Huiling, Kingston, Robert E, Kim, Ju Han, Bernstein, Bradley E, Dernburg, Abby F, Pirrotta, Vincenzo, Kuroda, Mitzi I, Noble, William S, Tullius, Thomas D, Kellis, Manolis, MacAlpine, David M, Strome, Susan, Elgin, Sarah CR, Liu, Xiaole Shirley, Lieb, Jason D, Ahringer, Julie, Karpen, Gary H, Park, Peter J

المصدر: Nature. 512(7515)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Immunization, Human Genome, Genetics, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Animals, Caenorhabditis elegans, Cell Line, Centromere, Chromatin, Chromatin Assembly and Disassembly, DNA Replication, Drosophila melanogaster, Enhancer Elements, Genetic, Epigenesis, Genetic, Heterochromatin, Histones, Humans, Molecular Sequence Annotation, Nuclear Lamina, Nucleosomes, Promoter Regions, Genetic, Species Specificity, General Science & Technology

الوصف: Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation of chromatin components and mechanisms. Nevertheless, the three organisms have markedly different genome sizes, chromosome architecture and gene organization. On human and fly chromosomes, for example, pericentric heterochromatin flanks single centromeres, whereas worm chromosomes have dispersed heterochromatin-like regions enriched in the distal chromosomal 'arms', and centromeres distributed along their lengths. To systematically investigate chromatin organization and associated gene regulation across species, we generated and analysed a large collection of genome-wide chromatin data sets from cell lines and developmental stages in worm, fly and human. Here we present over 800 new data sets from our ENCODE and modENCODE consortia, bringing the total to over 1,400. Comparison of combinatorial patterns of histone modifications, nuclear lamina-associated domains, organization of large-scale topological domains, chromatin environment at promoters and enhancers, nucleosome positioning, and DNA replication patterns reveals many conserved features of chromatin organization among the three organisms. We also find notable differences in the composition and locations of repressive chromatin. These data sets and analyses provide a rich resource for comparative and species-specific investigations of chromatin composition, organization and function.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6f66s6x2Test

المؤلفون: Chang, Kyle, Creighton, Chad J, Davis, Caleb, Donehower, Lawrence, Drummond, Jennifer, Wheeler, David, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Butterfield, Yaron SN, Chu, Andy, Chuah, Eric, Chun, Hye-Jung E, Dhalla, Noreen, Guin, Ranabir, Hirst, Martin, Hirst, Carrie, Holt, Robert A, Jones, Steven JM, Lee, Darlene, Li, Haiyan I, Marra, Marco A, Mayo, Michael, Moore, Richard A, Mungall, Andrew J, Robertson, A Gordon, Schein, Jacqueline E, Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Varhol, Richard J, Beroukhim, Rameen, Bhatt, Ami S, Brooks, Angela N, Cherniack, Andrew D, Freeman, Samuel S, Gabriel, Stacey B, Helman, Elena, Jung, Joonil, Meyerson, Matthew, Ojesina, Akinyemi I, Pedamallu, Chandra Sekhar, Saksena, Gordon, Schumacher, Steven E, Tabak, Barbara, Zack, Travis, Lander, Eric S, Bristow, Christopher A, Hadjipanayis, Angela, Haseley, Psalm, Kucherlapati, Raju, Lee, Semin, Lee, Eunjung, Luquette, Lovelace J, Mahadeshwar, Harshad S, Pantazi, Angeliki, Parfenov, Michael, Park, Peter J, Protopopov, Alexei, Ren, Xiaojia, Santoso, Netty, Seidman, Jonathan, Seth, Sahil, Song, Xingzhi, Tang, Jiabin, Xi, Ruibin, Xu, Andrew W, Yang, Lixing, Zeng, Dong, Auman, J Todd, Balu, Saianand, Buda, Elizabeth, Fan, Cheng, Hoadley, Katherine A, Jones, Corbin D, Meng, Shaowu, Mieczkowski, Piotr A, Parker, Joel S, Perou, Charles M, Roach, Jeffrey, Shi, Yan, Silva, Grace O, Tan, Donghui, Veluvolu, Umadevi, Waring, Scot, Wilkerson, Matthew D, Wu, Junyuan, Zhao, Wei, Bodenheimer, Tom, Hayes, D Neil, Hoyle, Alan P, Jeffreys, Stuart R, Mose, Lisle E, Simons, Janae V, Soloway, Mathew G, Baylin, Stephen B, Berman, Benjamin P, Bootwalla, Moiz S, Danilova, Ludmila, Herman, James G

المصدر: Nature Genetics. 45(10)

مصطلحات موضوعية: Biological Sciences, Genetics, Cancer, Human Genome, Rare Diseases, Good Health and Well Being, Gene Expression Profiling, Genome, Humans, Neoplasms, Cancer Genome Atlas Research Network, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology

الوصف: The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5kk2153sTest

المؤلفون: Hammerman, Peter S, Lawrence, Michael S, Voet, Douglas, Jing, Rui, Cibulskis, Kristian, Sivachenko, Andrey, Stojanov, Petar, McKenna, Aaron, Lander, Eric S, Gabriel, Stacey, Getz, Gad, Sougnez, Carrie, Imielinski, Marcin, Helman, Elena, Hernandez, Bryan, Pho, Nam H, Meyerson, Matthew, Chu, Andy, Chun, Hye-Jung E, Mungall, Andrew J, Pleasance, Erin, Gordon Robertson, A, Sipahimalani, Payal, Stoll, Dominik, Balasundaram, Miruna, Birol, Inanc, Butterfield, Yaron SN, Chuah, Eric, Coope, Robin JN, Corbett, Richard, Dhalla, Noreen, Guin, Ranabir, He, An, Hirst, Carrie, Hirst, Martin, Holt, Robert A, Lee, Darlene, Li, Haiyan I, Mayo, Michael, Moore, Richard A, Mungall, Karen, Ming Nip, Ka, Olshen, Adam, Schein, Jacqueline E, Slobodan, Jared R, Tam, Angela, Thiessen, Nina, Varhol, Richard, Zeng, Thomas, Zhao, Yongjun, Jones, Steven JM, Marra, Marco A, Saksena, Gordon, Cherniack, Andrew D, Schumacher, Stephen E, Tabak, Barbara, Carter, Scott L, Nguyen, Huy, Onofrio, Robert C, Crenshaw, Andrew, Ardlie, Kristin, Beroukhim, Rameen, Winckler, Wendy, Protopopov, Alexei, Zhang, Jianhua, Hadjipanayis, Angela, Lee, Semin, Xi, Ruibin, Yang, Lixing, Ren, Xiaojia, Zhang, Hailei, Shukla, Sachet, Chen, Peng-Chieh, Haseley, Psalm, Lee, Eunjung, Chin, Lynda, Park, Peter J, Kucherlapati, Raju, Socci, Nicholas D, Liang, Yupu, Schultz, Nikolaus, Borsu, Laetitia, Lash, Alex E, Viale, Agnes, Sander, Chris, Ladanyi, Marc, Todd Auman, J, Hoadley, Katherine A, Wilkerson, Matthew D, Shi, Yan, Liquori, Christina, Meng, Shaowu, Li, Ling, Turman, Yidi J, Topal, Michael D, Tan, Donghui

المصدر: Nature. 489(7417)

مصطلحات موضوعية: Human Genome, Biotechnology, Genetics, Rare Diseases, Cancer, Lung Cancer, Lung, Aetiology, 2.1 Biological and endogenous factors, Adenocarcinoma, Adenocarcinoma of Lung, Carcinoma, Squamous Cell, DNA Mutational Analysis, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, p16, Genes, p53, Genome, Human, Genomics, Humans, Lung Neoplasms, Molecular Targeted Therapy, Mutation, Mutation Rate, Phosphatidylinositol 3-Kinases, Signal Transduction, Cancer Genome Atlas Research Network, General Science & Technology

الوصف: Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have been specifically developed for its treatment. As part of The Cancer Genome Atlas, here we profile 178 lung squamous cell carcinomas to provide a comprehensive landscape of genomic and epigenomic alterations. We show that the tumour type is characterized by complex genomic alterations, with a mean of 360 exonic mutations, 165 genomic rearrangements, and 323 segments of copy number alteration per tumour. We find statistically recurrent mutations in 11 genes, including mutation of TP53 in nearly all specimens. Previously unreported loss-of-function mutations are seen in the HLA-A class I major histocompatibility gene. Significantly altered pathways included NFE2L2 and KEAP1 in 34%, squamous differentiation genes in 44%, phosphatidylinositol-3-OH kinase pathway genes in 47%, and CDKN2A and RB1 in 72% of tumours. We identified a potential therapeutic target in most tumours, offering new avenues of investigation for the treatment of squamous cell lung cancers.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9mx9x8h2Test

المؤلفون: Weinstein, John N., Collisson, Eric A., Mills, Gordon B., Shaw, Kenna R Mills, Ozenberger, Brad A., Ellrott, Kyle, Sander, Chris, Stuart, Joshua M., Chang, Kyle, Creighton, Chad J., Davis, Caleb, Donehower, Lawrence, Drummond, Jennifer, Wheeler, David, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Butterfield, Yaron S.N., Chu, Andy, Chuah, Eric, Chun, Hye-Jung E., Dhalla, Noreen, Guin, Ranabir, Hirst, Martin, Hirst, Carrie, Holt, Robert A., Jones, Steven J.M., Lee, Darlene, Li, Haiyan I., Marra, Marco A., Mayo, Michael, Moore, Richard A., Mungall, Andrew J., Robertson, A Gordon, Schein, Jacqueline E., Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Varhol, Richard J., Beroukhim, Rameen, Bhatt, Ami S., Brooks, Angela N., Cherniack, Andrew D., Freeman, Samuel S., Gabriel, Stacey B., Helman, Elena, Jung, Joonil, Meyerson, Matthew, Ojesina, Akinyemi I., Pedamallu, Chandra Sekhar, Saksena, Gordon, Schumacher, Steven E., Tabak, Barbara, Zack, Travis, Lander, Eric S., Bristow, Christopher A., Hadjipanayis, Angela, Haseley, Psalm, Kucherlapati, Raju, Lee, Semin, Lee, Eunjung, Luquette, Lovelace J., Mahadeshwar, Harshad S., Pantazi, Angeliki, Parfenov, Michael, Park, Peter J., Protopopov, Alexei, Ren, Xiaojia, Santoso, Netty, Seidman, Jonathan, Seth, Sahil, Song, Xingzhi, Tang, Jiabin, Xi, Ruibin, Xu, Andrew W., Yang, Lixing, Zeng, Dong, Auman, J Todd, Balu, Saianand, Buda, Elizabeth, Fan, Cheng, Hoadley, Katherine A., Jones, Corbin D., Meng, Shaowu, Mieczkowski, Piotr A., Parker, Joel S, Perou, Charles M., Roach, Jeffrey, Shi, Yan, Silva, Grace O., Tan, Donghui, Veluvolu, Umadevi, Waring, Scot, Wilkerson, Matthew D., Wu, Junyuan, Zhao, Wei, Bodenheimer, Tom, Hayes, D Neil, Hoyle, Alan P., Jeffreys, Stuart R., Mose, Lisle E., Simons, Janae V., Soloway, Mathew G., Baylin, Stephen B., Berman, Benjamin P., Bootwalla, Moiz S., Danilova, Ludmila, Herman, James G., Hinoue, Toshinori, Laird, Peter W., Rhie, Suhn K., Shen, Hui, Triche, Timothy, Weisenberger, Daniel J., Carter, Scott L., Cibulskis, Kristian, Chin, Lynda, Zhang, Jianhua, Sougnez, Carrie, Wang, Min, Getz, Gad, Dinh, Huyen, Doddapaneni, Harsha Vardhan, Gibbs, Richard, Gunaratne, Preethi, Han, Yi, Kalra, Divya, Kovar, Christie, Lewis, Lora, Morgan, Margaret, Morton, Donna, Muzny, Donna, Reid, Jeffrey, Xi, Liu, Cho, Juok, Dicara, Daniel, Frazer, Scott, Gehlenborg, Nils, Heiman, David I., Kim, Jaegil, Lawrence, Michael S., Lin, Pei, Liu, Yingchun, Noble, Michael S., Stojanov, Petar, Voet, Doug, Zhang, Hailei, Zou, Lihua, Stewart, Chip, Bernard, Brady, Bressler, Ryan, Eakin, Andrea, Iype, Lisa, Knijnenburg, Theo, Kramer, Roger, Kreisberg, Richard, Leinonen, Kalle, Lin, Jake, Liu, Yuexin, Miller, Michael, Reynolds, Sheila M., Rovira, Hector, Shmulevich, Ilya, Thorsson, Vesteinn, Yang, Da, Zhang, Wei, Amin, Samirkumar, Wu, Chang-Jiun, Wu, Chia-Chin, Akbani, Rehan, Aldape, Kenneth, Baggerly, Keith A., Broom, Bradley, Casasent, Tod D., Cleland, James, Dodda, Deepti, Edgerton, Mary, Han, Leng, Herbrich, Shelley M., Ju, Zhenlin, Kim, Hoon, Lerner, Seth, Li, Jun, Liang, Han, Liu, Wenbin, Lorenzi, Philip L., Lu, Yiling, Melott, James, Nguyen, Lam, Su, Xiaoping, Verhaak, Roeland, Wang, Wenyi, Wong, Andrew, Yang, Yang, Yao, Jun, Yao, Rong, Yoshihara, Kosuke, Yuan, Yuan, Yung, Alfred K., Zhang, Nianxiang, Zheng, Siyuan, Ryan, Michael, Kane, David W., Aksoy, B Arman, Ciriello, Giovanni, Dresdner, Gideon, Gao, Jianjiong, Gross, Benjamin, Jacobsen, Anders, Kahles, Andre, Ladanyi, Marc, Lee, William, Lehmann, Kjong-Van, Miller, Martin L., Ramirez, Ricardo, Rätsch, Gunnar, Reva, Boris, Schultz, Nikolaus, Senbabaoglu, Yasin, Shen, Ronglai, Sinha, Rileen, Sumer, S Onur, Sun, Yichao, Taylor, Barry S., Weinhold, Nils, Fei, Suzanne, Spellman, Paul, Benz, Christopher, Carlin, Daniel, Cline, Melisssa, Craft, Brian, Goldman, Mary, Haussler, David, Ma, Singer, Ng, Sam, Paull, Evan, Radenbaugh, Amie, Salama, Sofie, Sokolov, Artem, Swatloski, Teresa, Uzunangelov, Vladislav, Waltman, Peter, Yau, Christina, Zhu, Jing, Hamilton, Stanley R., Abbott, Scott, Abbott, Rachel, Dees, Nathan D., Delehaunty, Kim, Ding, Li, Dooling, David J., Eldred, Jim M., Fronick, Catrina C., Fulton, Robert, Fulton, Lucinda L., Kalicki-Veizer, Joelle, Kanchi, Krishna-Latha, Kandoth, Cyriac, Koboldt, Daniel C., Larson, David E., Ley, Timothy J., Lin, Ling, Lu, Charles, Magrini, Vincent J., Mardis, Elaine R., McLellan, Michael D., McMichael, Joshua F., Miller, Christopher A., O'Laughlin, Michelle, Pohl, Craig, Schmidt, Heather, Smith, Scott M., Walker, Jason, Wallis, John W., Wendl, Michael C., Wilson, Richard K., Wylie, Todd, Zhang, Qunyuan, Burton, Robert, Jensen, Mark A., Kahn, Ari, Pihl, Todd, Pot, David, Wan, Yunhu, Levine, Douglas A., Black, Aaron D., Bowen, Jay, Frick, Jessica, Gastier-Foster, Julie M., Harper, Hollie A., Helsel, Carmen, Leraas, Kristen M., Lichtenberg, Tara M., McAllister, Cynthia, Ramirez, Nilsa C., Sharpe, Samantha, Wise, Lisa, Zmuda, Erik, Chanock, Stephen J., Davidsen, Tanja, Demchok, John A., Eley, Greg, Felau, Ina, Sheth, Margi, Sofia, Heidi, Staudt, Louis, Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Zhang, Jiashan, Omberg, Larsson, Margolin, Adam, Raphael, Benjamin J., Vandin, Fabio, Wu, Hsin-Ta, Leiserson, Mark D.M., Benz, Stephen C., Vaske, Charles J., Noushmehr, Houtan, Wolf, Denise, Veer, Laura Van'T, Anastassiou, Dimitris, Yang, Tai-Hsien Ou, Lopez-Bigas, Nuria, Gonzalez-Perez, Abel, Tamborero, David, Xia, Zheng, Li, Wei, Cho, Dong-Yeon, Przytycka, Teresa, Hamilton, Mark, McGuire, Sean, Nelander, S., Johansson, Patrik, Jörnsten, Rebecka, 1971, Kling, Teresia, 1985, Sánchez, José, 1979

المصدر: Nature Genetics. 45(10):1113-1120

الوصف: The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.

وصف الملف: electronic

الوصول الحر: https://research.chalmers.se/publication/216680Test
https://research.chalmers.se/publication/216680/file/216680_Fulltext.pdfTest

المؤلفون: Lee, Eunjung, Iskow, Rebecca, Yang, Lixing, Gokcumen, Omer, Haseley, Psalm, Luquette, Lovelace J., Lohr, Jens G., Harris, Christopher C., Ding, Li, Wilson, Richard K., Wheeler, David A., Gibbs, Richard A., Kucherlapati, Raju, Lee, Charles, Kharchenko, Peter V., Park, Peter J.

المصدر: Science, 2012 Aug . 337(6097), 967-971.

الوصول الحر: http://dx.doi.org/10.1126/science.1222077Test

المؤلفون: Yang, Lixing, Lee, Mi-Sook, Lu, Hengyu, Oh, Doo-Yi, Kim, Yeon Jeong, Park, Donghyun, Park, Gahee, Ren, Xiaojia, Bristow, Christopher A., Haseley, Psalm S., Lee, Soohyun, Pantazi, Angeliki, Kucherlapati, Raju, Park, Woong-Yang, Scott, Kenneth L., Choi, Yoon-La, Park, Peter J.

المصدر: The American Journal of Human Genetics ; volume 98, issue 5, page 843-856 ; ISSN 0002-9297

مصطلحات موضوعية: Genetics (clinical), Genetics

الإتاحة: https://doi.org/10.1016/j.ajhg.2016.03.017Test
https://api.elsevier.com/content/article/PII:S0002929716300520?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0002929716300520?httpAccept=text/plainTest

المؤلفون: Evrony, Gilad D., Lee, Eunjung, Mehta, Bhaven K., Benjamini, Yuval, Johnson, Robert M., Cai, Xuyu, Yang, Lixing, Haseley, Psalm, Lehmann, Hillel S., Park, Peter J., Walsh, Christopher A.

المصدر: Neuron ; volume 85, issue 1, page 49-59 ; ISSN 0896-6273

مصطلحات موضوعية: General Neuroscience

الإتاحة: https://doi.org/10.1016/j.neuron.2014.12.028Test
https://api.elsevier.com/content/article/PII:S0896627314011374?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0896627314011374?httpAccept=text/plainTest

المؤلفون: Lee, Eunjung, Iskow, Rebecca, Yang, Lixing, Gokcumen, Omer, Haseley, Psalm, Luquette, Lovelace J, Lohr, Jens G, Harris, Christopher C, Ding, Li, Wilson, Richard K, Wheeler, David A, Gibbs, Richard A, Kucherlapati, Raju, Lee, Charles, Kharchenko, Peter V, Park, Peter J

العلاقة: http://www.biomedcentral.com/1753-6561/6/S6/O23Test

الإتاحة: http://www.biomedcentral.com/1753-6561/6/S6/O23Test