المؤلفون: Choi, Yeon, Yin, Rose, Avila, Raudel, Pfenniger, Anna, Yoo, Jaeyoung, Lee, Jong, Tzavelis, Andreas, Lee, Young, Chen, Sheena, Knight, Helen, Kim, Seungyeob, Ahn, Hak-Young, Wickerson, Grace, Vázquez-Guardado, Abraham, Higbee-Dempsey, Elizabeth, Russo, Bender, Napolitano, Michael, Holleran, Timothy, Razzak, Leen, Miniovich, Alana, Lee, Geumbee, Geist, Beth, Kim, Brandon, Han, Shuling, Brennan, Jaclyn, Aras, Kedar, Kwak, Sung, Kim, Joohee, Waters, Emily, Yang, Xiangxing, Burrell, Amy, San Chun, Keum, Liu, Claire, Wu, Changsheng, Rwei, Alina, Spann, Alisha, Banks, Anthony, Johnson, David, Zhang, Zheng, Haney, Chad, Jin, Sung, Sahakian, Alan, Huang, Yonggang, Trachiotis, Gregory, Knight, Bradley, Arora, Rishi, Efimov, Igor, Rogers, John, Jeong, Hyoyoung

المصدر: Science. 376(6596)

مصطلحات موضوعية: Absorbable Implants, Animals, Cardiac Pacing, Artificial, Dogs, Heart Rate, Humans, Pacemaker, Artificial, Postoperative Care, Rats, Wireless Technology

الوصف: Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/387971d5Test

المؤلفون: Choi, Yeon, Yin, Rose, Pfenniger, Anna, Koo, Jahyun, Avila, Raudel, Benjamin Lee, K, Chen, Sheena, Lee, Geumbee, Li, Gang, Qiao, Yun, Murillo-Berlioz, Alejandro, Kiss, Alexi, Han, Shuling, Lee, Seung, Li, Chenhang, Xie, Zhaoqian, Chen, Yu-Yu, Burrell, Amy, Geist, Beth, Kim, Joohee, Yoon, Hong-Joon, Banks, Anthony, Kang, Seung-Kyun, Zhang, Zheng, Haney, Chad, Sahakian, Alan, Johnson, David, Efimova, Tatiana, Huang, Yonggang, Trachiotis, Gregory, Knight, Bradley, Arora, Rishi, Efimov, Igor, Rogers, John, Jeong, Hyoyoung

المصدر: Nature Biotechnology. 39(10)

مصطلحات موضوعية: Absorbable Implants, Animals, Atrioventricular Block, Disease Models, Animal, Dogs, Equipment Design, Humans, Mice, Pacemaker, Artificial, Rabbits, Rats, Wireless Technology

الوصف: Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7r6663rrTest

المؤلفون: Liu, Chao, Ruan, Yuli, Huang, Rui, Fang, Lin, Wu, Tong, Lv, Ying, Cui, Luying, Liao, Yuanyu, Wang, Bojun, Chen, Zhuo, Su, Dan, Ma, Yue, Han, Shuling, Guan, Xin, Cui, Jie, Yao, Yang, Wang, Yao, Wang, Mengmeng, Liu, Ruiqi, Zhang, Yanqiao

المصدر: Cancer Immunology, Immunotherapy; Aug2024, Vol. 73 Issue 8, p1-14, 14p

مستخلص: Background: Although, immune checkpoint inhibitors (ICIs) have been widely applied in the therapy of malignant tumors, the efficacy and safety of ICIs in patients with tumors and pre-existing CAD, especially chronic coronary syndromes (CCS) or their risk factors (CRF), is not well identified. Methods: This was a nationwide multicenter observational study that enrolled participants who diagnosed with solid tumors and received ICIs therapy. The main efficacy indicators were progression-free survival (PFS) and overall survival (OS), followed by objective response rate (ORR) and disease control rate (DCR). Safety was assessed by describing treatment-related adverse events (TRAEs) during ICIs therapy evaluated by the Common Terminology Criteria for Adverse Events 5.0 (CTCAE 5.0). Results: In the current research, we retrospectively analyzed the data of 551 patients diagnosed with solid tumors and received ICIs therapy, and these patients were divided into CCS/CRF group and non-CCS/CRF group. Patients with CCS/CRF had more favorable PFS and OS than patients without CCS/CRF (P < 0.001) and the pre-existing CCS/CRF was a protective factor for survival. The ORR (51.8% vs. 39.1%) and DCR (95.8% vs. 89.2%) were higher in CCS/CRF group than in non-CCS/CRF group (P = 0.003, P = 0.006). In this study, there was no significant difference in treatment-related adverse events (TRAEs), including immune-related adverse events (irAEs), between the two groups. Conclusions: We concluded that ICIs appear to have better efficacy in malignant solid tumor patients with pre-existing CCS/CRF and are not accompanied by more serious irAEs. [ABSTRACT FROM AUTHOR]

: Copyright of Cancer Immunology, Immunotherapy is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Zou, Haoyi, Liu, Chao, Ruan, Yuli, Fang, Lin, Wu, Tong, Han, Shuling, Dang, Tianjiao, Meng, Hongxue, Zhang, Yanqiao

المساهمون: National Natural Science Foundation of China, Natural Science Foundation of Heilongjiang Province, Key Research and Development Program of Heilongjiang

المصدر: Expert Review of Clinical Immunology ; page 1-12 ; ISSN 1744-666X 1744-8409

الإتاحة: https://doi.org/10.1080/1744666x.2024.2328746Test

المؤلفون: Liu, Chao, Xiao, Huiting, Cui, Luying, Fang, Lin, Han, Shuling, Ruan, Yuli, Zhao, Wenyuan, Zhang, Yanqiao

المصدر: Frontiers in Immunology ; volume 13 ; ISSN 1664-3224

الوصف: Background Combination therapy with immune checkpoint inhibitors (ICIs) may benefit approximately 10-20% of microsatellite-stable colorectal cancer (MSS-CRC) patients. However, there is a lack of optimal biomarkers. This study aims to understand the predictive value of epigenetic-related gene mutations in ICIs therapy in MSS-CRC patients. Methods We analyzed DNA sequences and gene expression profiles from The Cancer Genome Atlas (TCGA) to examine their immunological features. The Harbin Medical University Cancer Hospital (HMUCH) clinical cohort of MSS-CRC patients was used to validate the efficacy of ICIs in patients with epigenetic-related gene mutations (Epigenetic_Mut). Results In TCGA, 18.35% of MSS-CRC patients (78/425) had epigenetic-related gene mutations. The Epigenetic_Mut group had a higher tumor mutation burden (TMB) and frameshift mutation (FS_mut) rates. In all MSS-CRC samples, Epigenetic_Mut was elevated in the immune subtype (CMS1) and had a strong correlation with immunological features. Epigenetic_Mut was also associated with favorable clinical outcomes in MSS-CRC patients receiving anti-PD-1-based therapy from the HMUCH cohort. Using immunohistochemistry and flow cytometry, we demonstrated that Epigenetic_Mut samples were associated with increased anti-tumor immune cells both in tumor tissues and peripheral blood. Conclusion MSS-CRC patients with epigenetic regulation impairment exhibit an immunologically active environment and may be more susceptible to treatment strategies based on ICIs.

الإتاحة: https://doi.org/10.3389/fimmu.2022.1039631Test

المؤلفون: Yao, Yang, Liu, Chao, Wang, Bojun, Guan, Xin, Fang, Lin, Zhan, Fei, Sun, Haoxiu, Li, Hengzhen, Lou, Changjie, Yan, Feihu, Lu, Xiaolin, Cui, Luying, Liao, Yuanyu, Han, Shuling, Yao, Yuanfei, Zhang, Yanqiao

المصدر: Cancer Letters ; volume 533, page 215595 ; ISSN 0304-3835

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1016/j.canlet.2022.215595Test
https://api.elsevier.com/content/article/PII:S0304383522000702?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0304383522000702?httpAccept=text/plainTest

المؤلفون: Fang, Lin, Yao, Yang, Guan, Xin, Liao, Yuanyu, Wang, Bojun, Cui, Luying, Han, Shuling, Zou, Haoyi, Su, Dan, Ma, Yue, Liu, Biao, Wang, Yao, Huang, Rui, Ruan, Yuli, Yu, Xuefan, Yao, Yuanfei, Liu, Chao, Zhang, Yanqiao

المصدر: International Journal of Cancer; Dec2023, Vol. 153 Issue 11, p1904-1915, 12p

مصطلحات موضوعية: ADJUVANT chemotherapy, COLORECTAL cancer, CANCER chemotherapy, PROPORTIONAL hazards models, T cells, H7N9 Influenza, HEREDITARY nonpolyposis colorectal cancer

مصطلحات جغرافية: CHINA

مستخلص: Novel biomarkers are essential to improve the treatment efficacy and overall survival of stage II and III colorectal cancer (CRC), allowing for personalized treatment decisions. Here, the densities of CD8+ and FOXP3+ T cells in the tumor and invasive margin were processed by immunohistochemistry and digital pathology to form a scoring system named regulatory‐Immunoscore (RIS). Cox proportional hazards regression models were used to determine the risk factors associated with time to recurrence. Harrell's concordance index and the time‐dependent area under the curve were used to assess model performance. A total of 1213 stage I‐III DNA mismatch repair‐proficient colorectal cancer (pMMR CRC) patients were randomly assigned to a training set (n = 642) and a validation set (n = 571). From the Cox multivariable analysis, the association of RIS with survival was independent of patient age, sex and anatomy‐based tumor risk parameters (P <.0001). For stage II patients, chemotherapy was significantly associated with better recurrence time in patients with low (95% confidence interval [CI]: 0.11‐0.54, P =.001) and intermediate (95% CI = 0.25‐0.57, P <.001) RIS values. In stage III patients treated with adjuvant chemotherapy, a treatment duration of 6 or more months was significantly associated with better recurrence time in patients with intermediate RIS values (95% CI = 0.38‐0.90, P =.016) when compared with duration under 6 months. Therefore, these findings suggest that RIS is reliable for predicting recurrence risk and treatment responsiveness for patients with stage I‐III pMMR CRC. [ABSTRACT FROM AUTHOR]

: Copyright of International Journal of Cancer is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Liu, Chao, Liu, Ruiqi, Wang, Bojun, Lian, Jie, Yao, Yang, Sun, Haoxiu, Zhang, Chunhui, Fang, Lin, Guan, Xin, Shi, Jiaqi, Han, Shuling, Zhan, Fei, Luo, Shengnan, Yao, Yuanfei, Zheng, Tongsen, Zhang, Yanqiao

المساهمون: Provincial Natural Science Foundation Outstanding Youth Project, National Natural Science Foundation of China, Central guides local science and technology development project, National Youth Talent Support Program, National key R&D program of China, Nn10 Excellent Discipline Construction Program, Applied technology research and development program of Heilongjiang Province, China postdoctoral science foundation grant, Haiyan Research Fund of HMU Cancer Hospital, Heilongjiang postdoctoral fund

المصدر: Journal for ImmunoTherapy of Cancer ; volume 9, issue 1, page e001895 ; ISSN 2051-1426

الوصف: Background Immune checkpoint inhibitors (ICIs), including anti-PD-1 therapy, have limited efficacy in patients with microsatellite stable (MSS) colorectal cancer (CRC). Interleukin 17A (IL-17A) activity leads to a protumor microenvironment, dependent on its ability to induce the production of inflammatory mediators, mobilize myeloid cells and reshape the tumor environment. In the present study, we aimed to investigate the role of IL-17A in resistance to antitumor immunity and to explore the feasibility of anti-IL-17A combined with anti-PD-1 therapy in MSS CRC murine models. Methods The expression of programmed cell death-ligand 1 (PD-L1) and its regulation by miR-15b-5p were investigated in MSS CRC cell lines and tissues. The effects of miR-15b-5p on tumorigenesis and anti-PD-1 treatment sensitivity were verified both in vitro and in colitis-associated cancer (CAC) and APC min/+ murine models. In vivo efficacy and mechanistic studies were conducted using antibodies targeting IL-17A and PD-1 in mice bearing subcutaneous CT26 and MC38 tumors. Results Evaluation of clinical pathological specimens confirmed that PD-L1 mRNA levels are associated with CD8+ T cell infiltration and better prognosis. miR-15b-5p was found to downregulate the expression of PD-L1 at the protein level, inhibit tumorigenesis and enhance anti-PD-1 sensitivity in CAC and APC min/+ CRC models. IL-17A led to high PD-L1 expression in CRC cells through regulating the P65/NRF1/miR-15b-5p axis. Combined IL-17A and PD-1 blockade had efficacy in CT26 and MC38 tumors, with more cytotoxic T lymphocytes cells and fewer myeloid-derived suppressor cells in tumors. Conclusions IL-17A increases PD-L1 expression through the p65/NRF1/miR-15b-5p axis and promotes resistance to anti-PD-1 therapy. Blocking IL-17A improved the efficacy of anti-PD-1 therapy in MSS CRC murine models. IL-17A might serve as a therapeutic target to sensitize patients with MSS CRC to ICI therapy.

الإتاحة: https://doi.org/10.1136/jitc-2020-001895Test

المؤلفون: Huang, Ivy, Zhang, Yamin, Arafa, Hany M., Li, Shupeng, Vazquez-Guardado, Abraham, Ouyang, Wei, Liu, Fei, Madhvapathy, Surabhi, Song, Joseph Woojin, Tzavelis, Andreas, Trueb, Jacob, Choi, Yeonsik, Jeang, William J., Forsberg, Viviane, 1981, Higbee-Dempsey, Elizabeth, Ghoreishi-Haack, Nayereh, Stepien, Iwona, Bailey, Keith, Han, Shuling, Zhang, Zheng Jenny, Good, Cameron, Huang, Yonggang, Bandodkar, Amay J., Rogers, John A.

المصدر: Energy & Environmental Science. 15(10):4095-4108

الوصف: Batteries represent the dominant means for storing electrical energy, but many battery chemistries create waste streams that are difficult to manage, and most possess toxic components that limit their use in biomedical applications. Batteries constructed from materials capable of complete, harmless resorption into the environment or into living organisms after a desired period of operation bypass these disadvantages. However, previously reported eco/bioresorbable batteries offer low operating voltages and modest energy densities. Here, we introduce a magnesium-iodine chemistry and dual (ionic liquid/aqueous) electrolyte to overcome these limitations, enabling significant improvements in voltage, areal capacity, areal energy, areal power, volumetric energy, and volumetric power densities over any alternative. Systematic studies reveal key materials and design considerations. Demonstrations of this technology include power supplies for cardiac pacemakers, wireless environmental monitors, and thermal sensors/actuators. These results suggest strong potential for applications where commercial battery alternatives pose risks to the environment or the human body.

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-46079Test

المؤلفون: Han, Shuling, Zhang, Aiying, Xie, Yonghui, Liu, Yang

المصدر: 2022 3rd International Conference on Education, Knowledge and Information Management (ICEKIM)

الإتاحة: https://doi.org/10.1109/icekim55072.2022.00024Test
http://xplorestaging.ieee.org/ielx7/10027170/10027208/10027268.pdf?arnumber=10027268Test