المؤلفون: Kodama, Satoshi, Jo, Taisuke, Yasunaga, Hideo, Ohbe, Hiroyuki, Michihata, Nobuaki, Matsui, Hiroki, Okada, Akira, Shirota, Yuichiro, Fushimi, Kiyohide, Toda, Tatsushi, Hamada, Masashi

المساهمون: Japan Society for the Promotion of Science, Ministry of Health, Labour and Welfare

المصدر: Movement Disorders Clinical Practice ; volume 10, issue 11, page 1650-1658 ; ISSN 2330-1619 2330-1619

الوصف: Background Perioperative discontinuation of oral anti‐parkinsonian medication can negatively impact the prognosis of abdominal surgery in patients with Parkinson's disease. Although intravenous levodopa may be an alternative, its efficacy has not yet been investigated. Objectives To determine the efficacy of intravenous levodopa as an alternative to oral anti‐Parkinsonian drugs during gastric or colorectal cancer surgery. Methods We identified patients with Parkinson's disease who underwent surgery for gastric or colorectal cancer between April 2010 and March 2020, using the Diagnosis Procedure Combination database, a nationwide inpatient database in Japan. Patients were divided into two groups: those who received intravenous levodopa during the perioperative period and those who did not. We compared in‐hospital mortalities, major complications, and postoperative length of stay between the groups after adjusting for background characteristics with overlap weights based on propensity scores. Results We identified 648 patients who received intravenous levodopa and 1207 who did not receive levodopa during the perioperative period. In the adjusted cohort, the mean postoperative length of stay was 24.7 and 29.0 days (percent difference, −7.7%; 95% confidence interval, −13.1 to −1.5); in‐hospital death was 3.2% and 3.3% (adjusted odds ratio, 0.95; 95% CI: 0.54–1.67); and incidence of major complications were 21.4% and 19.3% (adjusted odds ratio, 0.89; 95% confidence interval, 0.70–1.13) in those with and without intravenous levodopa, respectively. Conclusions Intravenous levodopa was associated with a shorter postoperative length of stay, but not with mortality or morbidity. Intravenous levodopa may improve perioperative care in patients with Parkinson's disease.

الإتاحة: https://doi.org/10.1002/mdc3.13894Test

المؤلفون: Tokushige, Shin-ichi, Matsumoto, Hideyuki, Matsuda, Shun-ichi, Inomata-Terada, Satomi, Kotsuki, Naoki, Hamada, Masashi, Tsuji, Shoji, Ugawa, Yoshikazu, Terao, Yasuo

المساهمون: Ministry of Education, Culture, Sports, Science and Technology, Ministry of Internal Affairs and Communications

المصدر: Frontiers in Aging Neuroscience ; volume 15 ; ISSN 1663-4365

الوصف: Background Patients with Alzheimer’s disease (AD) are known to exhibit visuospatial processing impairment, as reflected in eye movements from the early stages of the disease. We investigated whether the pattern of gaze exploration during visual tasks could be useful for detecting cognitive decline at the earliest stage. Methods Sixteen AD patients (age: 79.1 ± 7.9 years, Mini Mental State Examination [MMSE] score: 17.7 ± 5.3, mean ± standard deviation) and 16 control subjects (age: 79.4 ± 4.6, MMSE score: 26.9 ± 2.4) participated. In the visual memory task, subjects memorized presented line drawings for later recall. In the visual search tasks, they searched for a target Landolt ring of specific orientation (serial search task) or color (pop-out task) embedded among arrays of distractors. Using video-oculography, saccade parameters, patterns of gaze exploration, and pupil size change during task performance were recorded and compared between AD and control subjects. Results In the visual memory task, the number of informative regions of interest (ROIs) fixated was significantly reduced in AD patients compared to control subjects. In the visual search task, AD patients took a significantly longer time and more saccades to detect the target in the serial but not in pop-out search. In both tasks, there was no significant difference in the saccade frequency and amplitude between groups. On-task pupil modulation during the serial search task was decreased in AD. The number of ROIs fixated in the visual memory task and search time and saccade numbers in the serial search task differentiated both groups of subjects with high sensitivity, whereas saccade parameters of pupil size modulation were effective in confirming normal cognition from cognitive decline with high specificity. Discussion Reduced fixation on informative ROIs reflected impaired attentional allocation. Increased search time and saccade numbers in the visual search task indicated inefficient visual processing. Decreased on-task pupil size during visual ...

الإتاحة: https://doi.org/10.3389/fnagi.2023.1123456Test

المؤلفون: Inomata-Terada, Satomi, Fukuda, Hideki, Tokushige, Shin-ichi, Matsuda, Shun-ichi, Hamada, Masashi, Ugawa, Yoshikazu, Tsuji, Shoji, Terao, Yasuo

المساهمون: Government of Japan Ministry of Education Culture Sports Science and Technology

المصدر: Clinical Neurophysiology ; volume 154, page 70-84 ; ISSN 1388-2457

مصطلحات موضوعية: Physiology (medical), Neurology (clinical), Neurology, Sensory Systems

الإتاحة: https://doi.org/10.1016/j.clinph.2023.07.006Test
https://api.elsevier.com/content/article/PII:S1388245723006855?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1388245723006855?httpAccept=text/plainTest

المؤلفون: Ma, Ke, Hamada, Masashi, Di Lazzaro, Vincenzo, Hand, Brodie, Guerra, Andrea, Opie, George M., Goetz, Stephan M.

المساهمون: National Institutes of Health

المصدر: Brain Stimulation ; volume 16, issue 6, page 1686-1688 ; ISSN 1935-861X

مصطلحات موضوعية: Neurology (clinical), Biophysics, General Neuroscience

الإتاحة: https://doi.org/10.1016/j.brs.2023.11.009Test
https://api.elsevier.com/content/article/PII:S1935861X23019526?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1935861X23019526?httpAccept=text/plainTest

المؤلفون: Nakatani-Enomoto, Setsu, Hanajima, Ritstuko, Hamada, Masashi, Matsumoto, Hideyuki, Terao, Yasuo, Jun Groiss, Stefan, Murakami, Takenobu, Abe, Mitsunari, Enomoto, Hiroyuki, Kawai, Kensuke, Kan, Rumiko, Niwa, Shin-ichi, Yabe, Hirooki, Ugawa, Yoshikazu

المساهمون: Government of Japan Ministry of Education Culture Sports Science and Technology

المصدر: Clinical Neurophysiology Practice ; volume 8, page 137-142 ; ISSN 2467-981X

مصطلحات موضوعية: Physiology (medical), Neurology (clinical), Neurology

الإتاحة: https://doi.org/10.1016/j.cnp.2023.07.001Test
https://api.elsevier.com/content/article/PII:S2467981X23000173?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2467981X23000173?httpAccept=text/plainTest

المؤلفون: Tsuboyama, Yoko, Takahashi, Akiko, Furukawa, Sawako, Almansour, Asem, Hamada, Masashi, Kubota, Akatsuki, Shimizu, Jun, Kinoshita, Makoto, Fujimoto, Chisato, Mitsui, Jun, Matsukawa, Takashi, Naruse, Hiroya, Ishiura, Hiroyuki, Tsuji, Shoji, Toda, Tatsushi

المصدر: Journal of Neurology; Jul2024, Vol. 271 Issue 7, p4635-4638, 4p

مصطلحات موضوعية: CEREBELLUM degeneration, SPINOCEREBELLAR ataxia, SYNCOPE, STRETCH reflex, HTLV-I

مستخلص: This document is a letter to the editors of the Journal of Neurology discussing a case of RFC1-related disorder presenting recurrent syncope. RFC1-related disorder is a neurodegenerative disorder characterized by cerebellar ataxia, sensory neuropathy, and bilateral vestibular dysfunction. The patient in this case was an 81-year-old man who experienced repeated episodes of syncope. The letter provides a detailed description of the patient's symptoms and medical history, as well as the diagnostic tests conducted. The authors conclude that RFC1-related disorder should be considered in cases of autonomic dysfunction and syncope. [Extracted from the article]

: Copyright of Journal of Neurology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Nakashima, Saki, Hamada, Masashi, Kimura, Tomohiko, Tanifuji, Shuichi, Takahashi, Akiko, Yashita, Daiki, Kakimoto, Yu, Matsukawa, Takashi, Ishiura, Hiroyuki, Toda, Tatsushi

المصدر: Intern Med ; ISSN:1349-7235 ; Volume:63 ; Issue:12

مصطلحات موضوعية: cerliponase alfa, motor language score, neuronal ceroid lipofuscinosis, seizure, tripeptidyl peptidase 1

الوصف: Neuronal ceroid lipofuscinosis type 2 (CLN2) is an autosomal recessive lysosomal disease caused by decreased activity of the enzyme tripeptidyl peptidase 1 (TPP1) due to pathogenic variants in the TPP1 gene. Cerliponase alfa, a recombinant proenzyme form of TPP1, has shown efficacy in preventing motor and language function decline in early-stage CLN2. However, the safety and effects of this therapy in advanced-stage CLN2 are unclear. We herein report a case of intraventricular cerliponase alfa treatment for over a year in a patient with advanced-stage CLN2. The results suggest the safety and potential efficacy of treatment at an advanced stage of CLN2.

العلاقة: https://doi.org/10.2169/internalmedicine.2563-23Test; https://pubmed.ncbi.nlm.nih.gov/37926545Test

الإتاحة: https://doi.org/10.2169/internalmedicine.2563-23Test
https://pubmed.ncbi.nlm.nih.gov/37926545Test

المؤلفون: Sakurai, Yasuhisa, Hamada, Masashi, Takuma, Hiroshi

المساهمون: The authors did not receive support from any organization

المصدر: Neurocase ; volume 30, issue 1, page 32-38 ; ISSN 1355-4794 1465-3656

الإتاحة: https://doi.org/10.1080/13554794.2024.2353936Test

المؤلفون: Okubo, So, Kakumoto, Toshiyuki, Tsujita, Masahiko, Muramatsu, Kyosuke, Fujiwara, Sho, Hamada, Masashi, Satake, Wataru, Toda, Tatsushi

المصدر: Cureus ; ISSN:2168-8184 ; Volume:16 ; Issue:5

مصطلحات موضوعية: anti-mog antibody, longitudinally extensive transverse myelitis, mog associated antibody disease (mogad), neuro-immunology, spinal cord diseases

الوصف: Longitudinally extensive myelitis with 15 or more vertebrae in length is extremely rare, with limited evidence regarding clinical features and therapeutic response. We report a case of a 29-year-old male patient with extremely longitudinally extensive myelitis ultimately diagnosed as myelin oligodendrocyte glycoprotein-associated disease (MOGAD). The patient presented with an acute onset of meningismus, limb weakness, sensory disturbance below the C5 level, ataxia, and urinary retention. T2-weighted imaging on MRI showed an extremely longitudinally extensive spinal cord lesion ranging from C2 to the medullary conus, together with a left pontine lesion. Positive anti-myelin oligodendrocyte glycoprotein antibodies were serologically detected, which led to the diagnosis of MOGAD. Intravenous methylprednisolone followed by 1 mg/kg oral prednisolone with taper resulted in complete symptomatic and radiological resolution. The striking complete resolution despite the symptomatic and radiological severity observed in this case has been described in a few previously reported MOGAD cases. Extremely longitudinally extensive myelitis with excellent therapeutic response may be a characteristic presentation of MOGAD.

العلاقة: https://doi.org/10.7759/cureus.59938Test; https://pubmed.ncbi.nlm.nih.gov/38854217Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161715Test/

الإتاحة: https://doi.org/10.7759/cureus.59938Test
https://pubmed.ncbi.nlm.nih.gov/38854217Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161715Test/

المؤلفون: Kassavetis, Panagiotis, Chen, Robert, Ganos, Christos, Hallett, Mark, Hamada, Masashi, Latorre, Anna, Pal, Pramod Kumar, Schwingenschuh, Petra, Vial, Felipe, Tijssen, Marina A., Merchant, Shabbir

المصدر: Kassavetis , P , Chen , R , Ganos , C , Hallett , M , Hamada , M , Latorre , A , Pal , P K , Schwingenschuh , P , Vial , F , Tijssen , M A & Merchant , S 2024 , ' Global Perceptions and Utilization of Clinical Neurophysiology in Movement Disorders ' , Movement Disorders Clinical Practice , vol. 11 , no. 4 , pp. 346-351 . https://doi.org/10.1002/mdc3.13974Test

مصطلحات موضوعية: accelerometry, clinical neurophysiology, electromyography, movement disorders, tremor

الوصف: Background: Clinical neurophysiology (CNP) involves the use of neurophysiological techniques to make an accurate clinical diagnosis, to quantify the severity, and to measure the treatment response. Despite several studies showing CNP to be a useful diagnostic tool in Movement Disorders (MD), its more widespread utilization in clinical practice has been limited. Objectives: To better understand the current availability, global perceptions, and challenges for implementation of diagnostic CNP in the clinical practice of MD. Methods: The International Parkinson and Movement Disorders Society (IPMDS) formed a Task Force on CNP. The Task Force distributed an online survey via email to all the members of the IPMDS between August 5 and 30, 2021. Descriptive statistics were used for analysis of the survey results. Some results are presented by IPMDS geographical sections namely PanAmerican (PAS), European (ES), African (AFR), Asian and Oceanian (AOS). Results: Four hundred and ninety-one IPMDS members (52% males), from 196 countries, responded. The majority of responders from the AFR (65%) and PAS (63%) sections had no formal training in diagnostic CNP (40% for AOS and 37% for ES). The most commonly used techniques are electroencephalography (EEG) (72%) followed by surface EMG (71%). The majority of responders think that CNP is somewhat valuable or very valuable in the assessment of MD. All the sections identified “lack of training” as one of the biggest challenges for diagnostic CNP studies in MD. Conclusions: CNP is perceived to be a useful diagnostic tool in MD. Several challenges were identified that prevent widespread utilization of CNP in MD.

العلاقة: https://research.rug.nl/en/publications/980a7fa6-5fa0-4605-962f-522332f0a6c8Test

الإتاحة: https://doi.org/10.1002/mdc3.13974Test
https://hdl.handle.net/11370/980a7fa6-5fa0-4605-962f-522332f0a6c8Test
https://research.rug.nl/en/publications/980a7fa6-5fa0-4605-962f-522332f0a6c8Test
http://www.scopus.com/inward/record.url?scp=85184926675&partnerID=8YFLogxKTest