المؤلفون: Hallaert, G, Pinson, H, Van Roost, D, Kalala, J, Vandriessche, V, Boterberg, T

المصدر: Neuro-Oncology ; volume 21, issue Supplement_3, page iii94-iii94 ; ISSN 1522-8517 1523-5866

مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology

الوصف: BACKGROUND Residual contrast-enhancing tumor volume (RTV) is an important parameter in glioblastoma (GBM) treatment. MR imaging within 48hrs after surgery is the preferred imaging modality but is prone to variability because of different interpretation by different raters. Variability can be statistically assessed using agreement and reliability parameters. The former are underreported in medical literature and are often mixed up with the latter. But agreement parameters are to be preferred in assessment of the level of agreement between repeated measurements. A typical agreement parameter is the standard error of measurement (SEM), which is expressed in the same unit as the original variable. Reliability parameters on the other hand relate the measurement error to the variability between study objects. A typical and well-known reliability parameter is the intraclass coefficient (ICC), expressed on a scale from 0 to 1. We investigated both SEM and ICC between and within raters concerning RTV in GBM. MATERIAL AND METHODS Ten cases were randomly selected from a glioblastoma database. Three observers (a neuroradiologist, NR; a neurosurgeon, NS; a junior neurosurgical trainee, JNT) performed two sessions of volumetric assessment of RTV, blinded for each others results and independently from each other. At least 2 months passed in between sessions. Volumetric assessment was performed using Magnetisation Prepared-Rapid Echo Gradient (MPRAGE) 0.9mm images in standard neuronavigation software (Medtronic Inc, Louisville, CO, USA), in comparison with other images when deemed necessary by the individual rater. Semi-automated segmentation was applied, meaning that the rater used automated segmentation technique on each slice, but adjusted according to his of her own judgement (segmentational growing around the region of interest). Volumes were expressed in mL. Statistical analysis was performed using R software (version 3.4.3 (30-11-2017); Attached packages: psych foreign pander date knitr) to calculate ICCs. SEMs ...

الإتاحة: https://doi.org/10.1093/neuonc/noz126.344Test
http://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_3/iii94/30129056/noz126.344.pdfTest

المؤلفون: Hallaert, G, Pinson, H, Vandenbroecke, C, Vanhauwaert, D, van Roost, D, Boterberg, T

المصدر: Neuro-Oncology ; volume 20, issue suppl_3, page iii229-iii229 ; ISSN 1522-8517 1523-5866

مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology

الإتاحة: https://doi.org/10.1093/neuonc/noy139.049Test
http://academic.oup.com/neuro-oncology/article-pdf/20/suppl_3/iii229/25792506/noy139.049.pdfTest

المؤلفون: Verhoeven, J, Bolcaen, J, Donche, S, de Meulenaere, V, Descamps, B, Hallaert, G, Kersemans, K, Boterberg, T, Vanhove, C, de Vos, F, Goethals, I

المصدر: Neuro-Oncology ; volume 20, issue suppl_3, page iii299-iii299 ; ISSN 1522-8517 1523-5866

مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology

الإتاحة: https://doi.org/10.1093/neuonc/noy139.316Test
http://academic.oup.com/neuro-oncology/article-pdf/20/suppl_3/iii299/25792862/noy139.316.pdfTest

المؤلفون: Hallaert, G., Pinson, H., Van den Broecke, C., Van Roost, D., Kalala, J.P., Boterberg, T.

المصدر: Journal of Clinical Neuroscience ; volume 91, page 209-213 ; ISSN 0967-5868

مصطلحات موضوعية: Physiology (medical), Neurology (clinical), Neurology, General Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.jocn.2021.07.008Test
https://api.elsevier.com/content/article/PII:S0967586821003593?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0967586821003593?httpAccept=text/plainTest

المؤلفون: Bolcaen, J., Acou, M., Boterberg, T., Deblaere, K., De Vos, F., Hallaert, G., Kalala, J., Van den Broecke, C.

المصدر: Neuro-Oncology ; volume 16, issue suppl 2, page ii78-ii79 ; ISSN 1522-8517 1523-5866

مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology

الإتاحة: https://doi.org/10.1093/neuonc/nou174.301Test
http://academic.oup.com/neuro-oncology/article-pdf/16/suppl_2/ii78/3617308/nou174.301.pdfTest

المؤلفون: Pinson, H., Hallaert, G., Van der Meulen, J., Dedeurwaerdere, F., Vanhauwaert, D., Van den Broecke, C., Van Dorpe, J., Van Roost, D., Kalala, J. P., Boterberg, T.

المصدر: Journal of Neuro-Oncology ; volume 146, issue 1, page 55-62 ; ISSN 0167-594X 1573-7373

مصطلحات موضوعية: Cancer Research, Neurology (clinical), Neurology, Oncology

الإتاحة: https://doi.org/10.1007/s11060-019-03334-5Test

المؤلفون: Hallaert, G, Pinson, H, Vanhauwaert, D, Staelens, L, Vandenbroecke, C, Van Roost, D, Kalala, J, Boterberg, T

المصدر: Neuro-Oncology ; volume 21, issue Supplement_3, page iii95-iii96 ; ISSN 1522-8517 1523-5866

مصطلحات موضوعية: Cancer Research, Neurology (clinical), Oncology

الوصف: BACKGROUND The role of the subventricular zone (SVZ) in glioblastoma (GBM) is controversial. The past decade, several retrospective studies were published concerning the potential correlation between incidental radiation of the SVZ and survival in GBM patients. Although these publications showed conflicting results, a large study claimed an overall survival (OS) benefit for GBM patients after gross total resection if the ipsilateral SVZ received a higher dose than 40 Gy. We investigated this finding in our own population of GBM patients. MATERIAL AND METHODS A multicenter retrospective study was conducted including all adult patients treated for histologically proven GBM from 2003–2014. All patients received 60 Gy radiation therapy after surgery and concomitant temozolomide. Exclusion criteria were: infratentorial GBM; presence of other neoplasm(s); known previous history of low grade glioma; incomplete radiotherapy data. Demographic data were collected from the patient charts. O6-methylguanin-DNA-methyltransferase-promotor-gene (MGMT) methylation was determined on stored tumor samples using semi quantitative methylation-specific polymerase chain reaction (qMSP). SVZs (ipsilateral, contralateral and bilateral) were contoured on radiotherapy treatment plans. Multivariate Cox regression analysis was used to study the correlation between incidental SVZ radiation dose and OS. Age (cut-off 65 years), Karnofsky Performance Score (KPS; cut-off 70), methylation of the MGMT-promotor gene and extent of resection (biopsy; subtotal resection, groos total resection) were used as covariates. Patients alive at time of database closure were censored for analysis. RESULTS 183 patients were eligible for analysis. Mean age at diagnosis was 62 years, with an average KPS of 70. In 34% of patients, gross total resection (GTR) was achieved, while in 28% only a biopsy was taken. MGMT-promoter gene methylation was present in 39% of cases. Median ipsilateral, contralateral and bilateral SVZ doses were 46.1 Gy, 25.35 Gy and 34.8 ...

الإتاحة: https://doi.org/10.1093/neuonc/noz126.351Test
http://academic.oup.com/neuro-oncology/article-pdf/21/Supplement_3/iii95/30129188/noz126.351.pdfTest

المؤلفون: Hallaert, G.¹, Pinson, H.¹, Van den Broecke, C.², Vanhauwaert, D.³, Van Roost, D.¹, Boterberg, T.⁴, Kalala, J. P.¹

المصدر: Acta Oncologica. Dec2020, Vol. 59 Issue 12, p1474-1479. 6p. 1 Black and White Photograph, 3 Charts, 1 Graph.

مصطلحات موضوعية: *GLIOMAS, *MAGNETIC resonance imaging, *METHYLATION, *MOLECULAR biology, *MULTIVARIATE analysis, *GENETIC mutation, *SURVIVAL, *PROPORTIONAL hazards models, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *KAPLAN-Meier estimator, *TEMOZOLOMIDE, *LOG-rank test, *CHEMORADIOTHERAPY

مستخلص: Several studies show that subventricular zone (SVZ) contact of glioblastoma at diagnosis is a negative prognosticator of survival. In this report, we study glioblastoma patient survival, molecular biological and MRI-based volumetric findings according to SVZ contact. We conducted a retrospective study of adult patients diagnosed with supratentorial glioblastoma and uniformly treated with temozolomide-based chemoradiotherapy after surgery. The patient cohort was dichotomized according to tumor contact with the SVZ at diagnosis as determined on preoperative MR imaging. Tumor volume was measured using semi-automated segmentation technique. MGMT-gene promoter methylation and IDH mutation status were determined on stored tumor tissue. Kaplan-Meier survival curves were constructed. Cox regression analysis was used to adjust for known confounding factors of glioblastoma patient survival. A total of 214 patients were included in the study of whom 68% belonged to the SVZpos group. Median tumor volume was significantly larger in the SVZpos group (33,8 mL vs 15,6 mL; p <.001). MGMT-unmethylated glioblastoma was more frequent in the SVZpos group (61.4% vs 44.9%; p =.028). The overall survival and progression-free survival were 12.2 months and 5.9 months for the SVZpos patient group but 16.9 months and 10.3 months for the SVZneg group (log-rank p =.016 and.007 respectively). In multivariate Cox survival analysis, SVZ contact proved a negative prognostic parameter, independent from age, KPS, extent of resection, MGMT-methylation and IDH mutation status. This study confirms SVZ contact at diagnosis as an independent negative prognostic factor for glioblastoma patient survival. SVZpos glioblastoma had larger tumor size and a larger proportion of unmethylated tumors than SVZneg glioblastoma. Further research is needed to establish whether the observed differences are solely explained by a different molecular profile of SVZpos glioblastoma or by interaction of glioblastoma with the unique SVZ microenvironment. [ABSTRACT FROM AUTHOR]

المؤلفون: Van Lerbeirghe, J, Van Schaeybroeck, P, Robijn, H, Rasschaert, Ricky, Sys, Jan, Parlevliet, T, Hallaert, G, Van Wambeke, P, Depreitere, Bart

الوصف: The core outcome measures index (COMI) is a validated multidimensional instrument for assessing patient-reported outcome in patients with back problems. The aim of the present study is to translate the COMI into Dutch and validate it for use in native Dutch speakers with low back pain. ; status: accepted

العلاقة: European Spine Journal vol:Ahead of print; https://lirias.kuleuven.be/handle/123456789/590529Test; https://dx.doi.org/10.1007/s00586-017-5255-8Test

الإتاحة: https://doi.org/10.1007/s00586-017-5255-8Test
https://lirias.kuleuven.be/handle/123456789/590529Test

المؤلفون: Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A, CENTER TBI Participants, Investigators, Andelic N, Andreassen L, Andrews P, Audibert G, Audny A, Azouv P, Barzó P, Beer R, Bellander BM, Belli A, Benali H, Berardino M, Beretta L, Brazinová A, Binder H, Brehar F, Buki A, Bullinger M, Cakmak E, Callebaut I, Cameron P, Lozano GC, Carpenter KL, Chieregato A, Coburn M, Coles JP, Cooper J, Cnossen M, Curry N, Czeiter E, Czosnyka M, Dahyot Fitzelier C, Damas F, Dawes H, De Keyser V, De Luca A, de Ruiter GC, De Witte O, Demeter B, Depreitere B, Dippel DW, Dizdarevic K, Dreier JP, Eapen G, Ercole A, Esser P, Fabricius M, Feremans L, Feigin VL, Fossi F, Forsyth F, Florian S, Frisvold SK, Frosini C, Furmanov A, Frantzén J, Gadda D, Gagliardo P, Galanaud D, Gao G, Ghuysen A, Godbolt A, Gonšorová V, Grigore Z, Gruen R, Haagsma JA, Hallaert G, Hadzic E, Haitsma I, Hartings JA, Helbok R, Helseth E, Hoefer S, Holling M, Hunfeld M, Hutchinson PJ, Illéš R, Janssens K, Bovend'Eerdt TJ, Jiang JY, Jones KM, Kalala JP, Kalovits F, Kasprian G, Katila A, Ketharanathan N, Kolias AG, Kolibay F, Kondziella D, Koskinen LO, Lagares A, Lanyon L, Laureys S, Lefering R, Levi L, Lightfoot R, Lingsma HF, Loeckx D, Lohkamp LN, Lötjönen J, Lumenta C, Lyttle M, Maas A, Maegele M, Majdan M, Manara A, Maréchal H, Martino C, Mascia L, Mauritz W, McMahon C, Menovsky T, Mitchell P, Mladenov N, Morganti Kossmann C, Nelson D, Neugebauer E, Newcombe VF, Oddo M, Oresic M, Orzalesi V, Outtrim JG, Palotie A, Parizel P, Payen JF, Perlbarg V, Peul W, Pichon N, Piippo A, Floury SP, Ples H, Polinder S, Preiksaitis A, Psota M, Pullens P, Puybasset L, Ragauskas A, Raj R, Reiner M, Rhodes JK, Richardson S, Ripatti S, Rocka S, Roosenfeld J, Rosand J, Rosenlund C, Rosenthal G, Rossaint R, Rossi S, Rueckert D, Rusnák M, Rynkowski MA, Sahuquillo J, Sakowitz O, Sandor J, Schmidt S, Schoechl H, Schou R, Skandsen T, Sonne M, Schwendenwein E, Smeets D, Smieleweski P, Söderberg J, Stamatakis E, Stanworth S, Stefini R, Stevens R, Stewart W, Stocchetti N, Stummer W, Szabó J, Tascu A, Tenovuo O, Theadom A, Tibboel D, Tolias CM, Unterberg A, Vajkoczy P, Vargiolu A, van der Naalt J, van Essen T, Van Hecke W, Van Praag D, Van Roost D, Vandenbulcke T, vande Hauwe L, Van der Jagt M, Vega E, Verheyden J, Verma V, Vespa PM, Vik A, Vilcinis R, von Steinbüchel N, Vulekovic P, Wang KK, Wildschut E, Williams G, Wilson M, Wilson L, Wolf S, Ylén P, Zaaroor M, Zolfaghari P, Martin D, D'Orio V, Damas P, Tshibanda J.F., DELLA CORTE, Francesco

المساهمون: Maas, Ai, Menon, Dk, Steyerberg, Ew, Citerio, G, Lecky, F, Manley, Gt, Hill, S, Legrand, V, Sorgner, A, CENTER TBI, Participant, Investigators, Andelic, N, Andreassen, L, Andrews, P, Audibert, G, Audny, A, Azouv, P, Barzó, P, Beer, R, Bellander, Bm, Belli, A, Benali, H, Berardino, M, Beretta, L, Brazinová, A, Binder, H, Brehar, F, Buki, A, Bullinger, M, Cakmak, E, Callebaut, I, Cameron, P, Lozano, Gc, Carpenter, Kl, Chieregato, A, Coburn, M, Coles, Jp, Cooper, J, Cnossen, M, Curry, N, Czeiter, E, Czosnyka, M, Dahyot Fitzelier, C, Damas, F, Dawes, H, De Keyser, V, De Luca, A, de Ruiter, Gc, De Witte, O, DELLA CORTE, Francesco, Demeter, B, Depreitere, B, Dippel, Dw, Dizdarevic, K, Dreier, Jp, Eapen, G, Ercole, A, Esser, P, Fabricius, M, Feremans, L, Feigin, Vl, Fossi, F, Forsyth, F, Florian, S, Frisvold, Sk, Frosini, C, Furmanov, A, Frantzén, J, Gadda, D, Gagliardo, P, Galanaud, D, Gao, G, Ghuysen, A, Godbolt, A, Gonšorová, V, Grigore, Z, Gruen, R, Haagsma, Ja, Hallaert, G, Hadzic, E, Haitsma, I, Hartings, Ja, Helbok, R, Helseth, E, Hoefer, S, Holling, M, Hunfeld, M, Hutchinson, Pj, Illéš, R, Janssens, K, Bovend'Eerdt, Tj, Jiang, Jy, Jones, Km, Kalala, Jp, Kalovits, F, Kasprian, G, Katila, A, Ketharanathan, N

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25525693; info:eu-repo/semantics/altIdentifier/wos/WOS:000346602000015; ispartofbook:Neurosurgery; volume:76; issue:1; firstpage:67; lastpage:80; numberofpages:14; journal:NEUROSURGERY; http://hdl.handle.net/11579/58798Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925936260

الإتاحة: https://doi.org/10.1227/NEU.0000000000000575Test
http://hdl.handle.net/11579/58798Test