المؤلفون: Diane Friedman, Lamiae Grimaldi, Alain Cariou, Philippe Aegerter, Stéphane Gaudry, Abdel Ben Salah, Haikel Oueslati, Bruno Megarbane, Nicolas Meunier-Beillard, Jean-Pierre Quenot, Carole Schwebel, Laurent Jacob, Ségloène Robin Lagandré, Pierre Kalfon, Romain Sonneville, Shidasp Siami, Aurelien Mazeraud, Tarek Sharshar

المصدر: JMIR Research Protocols, Vol 12, p e47929 (2023)

مصطلحات موضوعية: Medicine, Computer applications to medicine. Medical informatics, R858-859.7

وصف الملف: electronic resource

العلاقة: https://www.researchprotocols.org/2023/1/e47929Test; https://doaj.org/toc/1929-0748Test

الوصول الحر: https://doaj.org/article/f2564283eca44835b8385d4d949d1e9bTest

المؤلفون: Diane Friedman, Lamiae Grimaldi, Alain Cariou, Philippe Aegerter, Stéphane Gaudry, Abdel Ben Salah, Haikel Oueslati, Bruno Megarbane, Nicolas Meunier-Beillard, Jean-Pierre Quenot, Carole Schwebel, Laurent Jacob, Ségloène Robin Lagandré, Pierre Kalfon, Romain Sonneville, Shidasp Siami, Aurelien Mazeraud, Tarek Sharshar

المصدر: JMIR Research Protocols, Vol 11, Iss 5, p e30496 (2022)

مصطلحات موضوعية: Medicine, Computer applications to medicine. Medical informatics, R858-859.7

الوصف: BackgroundCritically ill patients are at risk of developing a postintensive care syndrome (PICS), which is characterized by physical, psychological, and cognitive impairments and which dramatically impacts the patient’s quality of life (QoL). No intervention has been shown to improve QoL. We hypothesized that a medical, psychological, and social follow-up would improve QoL by mitigating the PICS. ObjectiveThis multicenter, randomized controlled trial (SUIVI-REA) aims to compare a multidisciplinary follow-up with a standard postintensive care unit (ICU) follow-up. MethodsPatients were randomized to the control or intervention arm. In the intervention arm, multidisciplinary follow-up involved medical, psychological, and social evaluation at ICU discharge and at 3, 6, and 12 months thereafter. In the placebo group, patients were seen only at 12 months by the multidisciplinary team. Baseline characteristics at ICU discharge were collected for all patients. The primary outcome was QoL at 1 year, assessed using the Euro Quality of Life-5 dimensions (EQ5D). Secondary outcomes were mortality, cognitive, psychological, and functional status; social and professional reintegration; and the rate of rehospitalization and outpatient consultations at 1 year. ResultsThe study was funded by the Ministry of Health in June 2010. It was approved by the Ethics Committee on July 8, 2011. The first and last patient were randomized on December 20, 2012, and September 1, 2017, respectively. A total of 546 patients were enrolled across 11 ICUs. At present, data management is ongoing, and all parties involved in the trial remain blinded. ConclusionsThe SUVI-REA multicenter randomized controlled trial aims to assess whether a post-ICU multidisciplinary follow-up improves QoL at 1 year. Trial RegistrationClinicaltrials.gov NCT01796509; https://clinicaltrials.gov/ct2/show/NCT01796509Test International Registered Report Identifier (IRRID)DERR1-10.2196/30496

وصف الملف: electronic resource

العلاقة: https://www.researchprotocols.org/2022/5/e30496Test; https://doaj.org/toc/1929-0748Test

الوصول الحر: https://doaj.org/article/3b2c9d7e558a4662ae506d48704bda78Test

المؤلفون: Alice Blet, Benjamin Deniau, Karine Santos, Dirk P. T. van Lier, Feriel Azibani, Xavier Wittebole, Benjamin G. Chousterman, Etienne Gayat, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye, Salvatore Di Somma, Thierry Dugernier, Bruno François, Stephane Gaudry, Vincent Huberlant, Jean-Baptiste Lascarrou, Gernot Marx, Emmanuelle Mercier, Haikel Oueslati, Peter Pickkers, Romain Sonneville, Matthieu Legrand, Pierre-François Laterre, Alexandre Mebazaa, AdrenOSS-1 Study Investigators

المصدر: Critical Care, Vol 25, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: DPP3, Biomarker, Outcome, Sepsis, Septic shock, Organ dysfunction, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

الوصف: Abstract Background Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the degradation of various cardiovascular and endorphin mediators. High levels of circulating DPP3 (cDPP3) indicate a high risk of organ dysfunction and mortality in cardiogenic shock patients. Methods The aim was to assess relationships between cDPP3 during the initial intensive care unit (ICU) stay and short-term outcome in the AdrenOSS-1, a prospective observational multinational study in twenty-four ICU centers in five countries. AdrenOSS-1 included 585 patients admitted to the ICU with severe sepsis or septic shock. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by the Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use and need for renal replacement therapy. cDPP3 levels were measured upon admission and 24 h later. Results Median [IQR] cDPP3 concentration upon admission was 26.5 [16.2–40.4] ng/mL. Initial SOFA score was 7 [5–10], and 28-day mortality was 22%. We found marked associations between cDPP3 upon ICU admission and 28-day mortality (unadjusted standardized HR 1.8 [CI 1.6–2.1]; adjusted HR 1.5 [CI 1.3–1.8]) and between cDPP3 levels and change in renal and liver SOFA score (p = 0.0077 and 0.0009, respectively). The higher the initial cDPP3 was, the greater the need for organ support and vasopressors upon admission; the longer the need for vasopressor(s), mechanical ventilation or RRT and the higher the need for fluid load (all p 40.4 ng/mL upon admission, a decrease in cDPP3 below 40.4 ng/mL after 24 h was associated with an improvement of organ function at 48 h and better 28-day outcome. By contrast, persistently elevated cDPP3 at 24 h was associated with worsening organ function and high 28-day mortality. Conclusions Admission levels and rapid changes in cDPP3 predict outcome during sepsis. Trial Registration ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1364-8535Test

الوصول الحر: https://doaj.org/article/00497743bbc542e38c17b2eb90d320e0Test

المؤلفون: François Dépret, Juliette Amzallag, Adrien Pollina, Laure Fayolle-Pivot, Maxime Coutrot, Maïté Chaussard, Karine Santos, Oliver Hartmann, Marion Jully, Alexandre Fratani, Haikel Oueslati, Alexandru Cupaciu, Mourad Benyamina, Lucie Guillemet, Benjamin Deniau, Alexandre Mebazaa, Etienne Gayat, Boris Farny, Julien Textoris, Matthieu Legrand, for the PRONOBURN group

المصدر: Critical Care, Vol 24, Iss 1, Pp 1-8 (2020)

مصطلحات موضوعية: Dipeptidyl peptidase-3, Burn patients, Mortality, Acute kidney injury, Biomarkers, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

الوصف: Abstract Background Dipeptidyl peptidase-3 (DPP3) is a metallopeptidase which cleaves bioactive peptides, notably angiotensin II, and is involved in inflammation regulation. DPP3 has been proposed to be a myocardial depressant factor and to be involved in circulatory failure in acute illnesses, possibly due to angiotensin II cleavage. In this study, we evaluated the association between plasmatic DPP3 level and outcome (mortality and hemodynamic failure) in severely ill burn patients. Methods In this biomarker analysis of a prospective cohort study, we included severely ill adult burn patients in two tertiary burn intensive care units. DPP3 was measured at admission (DPP3admin) and 3 days after. The primary endpoint was 90-day mortality. Secondary endpoints were hemodynamic failure and acute kidney injury (AKI). Results One hundred and eleven consecutive patients were enrolled. The median age was 48 (32.5–63) years, with a median total body surface area burned of 35% (25–53.5) and Abbreviated Burn Severity Index (ABSI) of 8 (7–11). Ninety-day mortality was 32%. The median DPP3admin was significantly higher in non-survivors versus survivors (53.3 ng/mL [IQR 28.8–103.5] versus 27.1 ng/mL [IQR 19.4–38.9]; p

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13054-020-02888-5Test; https://doaj.org/toc/1364-8535Test

الوصول الحر: https://doaj.org/article/707f320d2768488db9d6a8f8408716fcTest

المؤلفون: Alice Blet (10147295), Benjamin Deniau (3412028), Karine Santos (7148186), Dirk P. T. van Lier (10147298), Feriel Azibani (161533), Xavier Wittebole (55860), Benjamin G. Chousterman (3120000), Etienne Gayat (159635), Oliver Hartmann (357518), Joachim Struck (15613), Andreas Bergmann (15614), Massimo Antonelli (8610), Albertus Beishuizen (70118), Jean-Michel Constantin (20671), Charles Damoisel (744993), Nicolas Deye (3418184), Salvatore Di Somma (658151), Thierry Dugernier (3445457), Bruno François (38777), Stephane Gaudry (6116489), Vincent Huberlant (6116492), Jean-Baptiste Lascarrou (5514221), Gernot Marx (747251), Emmanuelle Mercier (4596301), Haikel Oueslati (6116495), Peter Pickkers (15648), Romain Sonneville (340373), Matthieu Legrand (159626), Pierre-François Laterre (3168063), Alexandre Mebazaa (58728)

مصطلحات موضوعية: Medicine, Biotechnology, Immunology, Science Policy, Infectious Diseases, DPP3, Biomarker, Outcome, Sepsis, Septic shock, Organ dysfunction

الوصف: Additional file 8: Table.

العلاقة: https://figshare.com/articles/journal_contribution/Additional_file_8_of_Monitoring_circulating_dipeptidyl_peptidase_3_DPP3_predicts_improvement_of_organ_failure_and_survival_in_sepsis_a_prospective_observational_multinational_study/14037746Test

الإتاحة: https://doi.org/10.6084/m9.figshare.14037746.v1Test

المؤلفون: Alexandre Mebazaa, Christopher Geven, Alexa Hollinger, Xavier Wittebole, Benjamin Glen Chousterman, Alice Blet, Etienne Gayat, Oliver Hartmann, Paul Scigalla, Joachim Struck, Andreas Bergmann, Massimo Antonelli, Albertus Beishuizen, Jean-Michel Constantin, Charles Damoisel, Nicolas Deye, Salvatore Di Somma, Thierry Dugernier, Bruno François, Stephane Gaudry, Vincent Huberlant, Jean-Baptiste Lascarrou, Gernot Marx, Emmanuelle Mercier, Haikel Oueslati, Peter Pickkers, Romain Sonneville, Matthieu Legrand, Pierre-François Laterre, AdrenOSS-1 study investigators

المصدر: Critical Care, Vol 22, Iss 1, Pp 1-12 (2018)

مصطلحات موضوعية: Biomarker, Outcome, Sepsis-2, Sepsis-3, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

الوصف: Abstract Background Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5–148.1 pg/ml]. Initial SOFA score was 7 [IQR 5–10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9–2.9]; adjusted HR 1.6 [CI 1.1–2.5]) and between bio-ADM levels and SOFA score (p < 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM > 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM > 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5–9.8). Conclusions AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13054-018-2243-2Test; https://doaj.org/toc/1364-8535Test

الوصول الحر: https://doaj.org/article/9abaf8c6666e4f9992a6f94c0c9e8facTest

المؤلفون: Bruno François, Simon Lambden, Tom Fivez, Sebastien Gibot, Marc Derive, Jean-Marie Grouin, Margarita Salcedo-Magguilli, Jérémie Lemarié, Nicolas De Schryver, Ville Jalkanen, Tarik Hicheur, Jean-Jacques Garaud, Valérie Cuvier, Ricard Ferrer, Morten Bestle, Ville Pettilä, Jean-Paul Mira, Camille Bouisse, Emmanuelle Mercier, Joris Vermassen, Vincent Huberlant, Isabelle Vinatier, Nadia Anguel, Mitchell Levy, Pierre-François Laterre, Pierre Asfar, Mai-Anh Nay, Christophe Guitton, Jean-Pierre Quenot, David Tran-Van, Julien Bohe, Gaëtan Plantefève, Saadalla Nseir, Jean-Yves Lefrant, Xavier Monnet, Laurent Papazian, Christophe Vinsonneau, Jean-Michel Constantin, Alexandre Mebazaa, Haikel Oueslati, Dolores Escudero, Fernando Martinez Sagasti, Enrique Piacentini, Paula Ramirez Galleymore, Thierry Dugernier, David Fagnoul, Isabelle Michaux, Allan Seibert, Matti Reinikainen, Thorbjørn Grøfte, Ignacio Martin-Loeches, John Laffey

المصدر: The Lancet Respiratory Medicine.

مصطلحات موضوعية: Pulmonary and Respiratory Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::138a93f456f842d5fea1fe47b5e1674bTest
https://doi.org/10.1016/s2213-2600Test(23)00158-3

المؤلفون: Charline Riaud, Alexandre Fratani, Kevin Serror, Maïté Chaussard, Matthieu Lafaurie, Haikel Oueslati, Alexandru Cupaciu, Lucie Guillemet, Maxime Coutrot, François Dépret, Jil Rouaux, Maud Salmona, Marc Chaouat, Matthieu Legrand, Jérôme LeGoff, Mourad Benyamina, Alexandre Mebazaa

المصدر: Burns. 48:1155-1165

مصطلحات موضوعية: medicine.medical_specialty, Critical Illness, Smoke inhalation, Critical Care and Intensive Care Medicine, law.invention, Cohort Studies, law, Smoke, Internal medicine, medicine, Humans, Herpesviridae, Retrospective Studies, medicine.diagnostic_test, business.industry, Ventilator-associated pneumonia, Pneumonia, General Medicine, Middle Aged, Smoke Inhalation Injury, Prognosis, medicine.disease, Intensive care unit, Intensive Care Units, Bronchoalveolar lavage, Emergency Medicine, Surgery, SOFA score, Burns, business, Total body surface area, Cohort study

الوصف: The aim of this study was to describe the prevalence, characteristics and outcome of critically burn patients with pulmonary HSV reactivation.Retrospective, single-center cohort study in a burn critical care unit in a tertiary center, including all consecutive severely burn patients with bronchoalveolar lavage performed for pneumoniae suspicion and screened for HSV from January 2013 and April 2017. We used logistic regression to identify factors associated with HSV reactivation and outcomes.94 patients were included, mean age was 51 (39-64) years; median total body surface area burned was 36 (25-54)% and ICU mortality 38%. Fifty-five patients (59%) had pulmonary HSV reactivation and 30 (55%) were treated with acyclovir. Patients with HSV reactivation were more severely ill with higher SOFA score at admission compared to patient without HSV reactivation (6 [3-8] vs. 2 [1-4], p0.0001 respectively). In multivariate analysis, sex, SOFA score at admission and smoke inhalation were significantly associated with HSV reactivation. Only septic shock was associated with 90-day mortality when HSV reactivation was not.Pulmonary HSV reactivation is frequent among severely ill burn patients. Initial severity and smoke inhalation are risk factors. Antiviral treatment was not associated with outcome.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7093aa271ac6ac47b66a811cbcf534a9Test
https://doi.org/10.1016/j.burns.2021.09.009Test

المؤلفون: Raphaël Cinotti, Sebastian Voicu, Samir Jaber, Benjamin Chousterman, Catherine Paugam-Burtz, Haikel Oueslati, Charles Damoisel, Anaïs Caillard, Antoine Roquilly, Fanny Feuillet, Alexandre Mebazaa, Etienne Gayat, FROG-ICU investigators

المصدر: PLoS ONE, Vol 14, Iss 10, p e0220399 (2019)

مصطلحات موضوعية: Medicine, Science

الوصف: INTRODUCTION:In critically ill patients undergoing prolonged mechanical ventilation (MV), the difference in long-term outcomes between patients with or without tracheostomy remains unexplored. METHODS:Ancillary study of a prospective international multicentre observational cohort in 21 centres in France and Belgium, including 2087 patients, with a one-year follow-up after admission. We included patients with a MV duration ≥10 days, with or without tracheostomy. We explored the one-year mortality with a classical Cox regression model (adjustment on age, SAPS II, baseline diagnosis and withdrawal of life-sustaining therapies) and a Cox regression model using tracheostomy as a time-dependant variable. RESULTS:29.5% patients underwent prolonged MV, out of which 25.6% received tracheostomy and 74.4% did not. At one-year, 45.2% patients had died in the tracheostomy group and 51.5% patients had died in the group without tracheostomy (p = 0.001). In the Cox-adjusted regression model, tracheostomy was not associated with improved one-year outcome (HR CI95 0.7 [0.5-1.001], p = 0.051), as well as in the model using tracheostomy as a time-dependent variable (OR CI 95 1 [0.7-1.4], p = 0.9). CONCLUSIONS:In our study, there was no statistically significant difference in the one-year mortality of patients undergoing prolonged MV when receiving tracheostomy or not. TRIAL REGISTRATION:NCT01367093.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/1c3615ceae1948e6b85201c0d867278aTest

المؤلفون: Etienne Gayat, Nicolas Deye, Xavier Wittebole, AdrenOSS study investigators, Pierre-François Laterre, Bruno François, Oliver Hartmann, Gernot Marx, Charles Damoisel, Vincent Huberlant, Emmanuelle Mercier, Thierry Dugernier, Alice Blet, Jean-Michel Constantin, Dirk van Lier, Karine Santos, Stéphane Gaudry, Benjamin G. Chousterman, Peter Pickkers, Jean-Baptiste Lascarrou, Salvatore Di Somma, Matthieu Legrand, Romain Sonneville, Feriel Azibani, Albertus Beishuizen, Andreas Bergmann, Alexandre Mebazaa, Benjamin Deniau, Joachim Struck, Massimo Antonelli, Haikel Oueslati

المساهمون: UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (SLuc) Service de soins intensifs

المصدر: Critical Care, Vol 25, Iss 1, Pp 1-10 (2021)
Critical care 25(1), 61 (2021). doi:10.1186/s13054-021-03471-2
Critical care (London, England), vol 25, iss 1
Critical Care, 25
Critical care, Vol. 25, no.1, p. 61 [1-10] (2021)
Critical Care
Critical Care, 25, 1

مصطلحات موضوعية: Male, Kidney Disease, Organ Dysfunction Scores, medicine.medical_treatment, Organ dysfunction, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Medical and Health Sciences, law.invention, 0302 clinical medicine, law, Septic shock, Prospective Studies, Outcome, Cardiogenic shock, Statistics, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Hematology, Middle Aged, Intensive care unit, Intensive Care Units, Infectious Diseases, AdrenOSS-1 Study Investigators, Female, SOFA score, medicine.symptom, Infection, medicine.medical_specialty, Multiple Organ Failure, DPP3, Statistics, Nonparametric, Sepsis, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Clinical Research, Internal medicine, medicine, Humans, Nonparametric, Renal replacement therapy, Mortality, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Aged, Proportional Hazards Models, Mechanical ventilation, Chi-Square Distribution, business.industry, Inflammatory and immune system, Research, 030208 emergency & critical care medicine, Biomarker, lcsh:RC86-88.9, medicine.disease, Emergency & Critical Care Medicine, Good Health and Well Being, business, Biomarkers

الوصف: Critical care 25(1), 61 (2021). doi:10.1186/s13054-021-03471-2
Published by BioMed Centra, London

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777467725b8c20d9a9e8720892bdcfe9Test
https://doaj.org/article/00497743bbc542e38c17b2eb90d320e0Test