المؤلفون: Guzman, Gabriela

مصطلحات موضوعية: Mathematics - Algebraic Geometry, Mathematics - Algebraic Topology, Mathematics - K-Theory and Homology

الوصف: Let $F$ and $k$ be perfect fields. The main goal of this paper is to investigate algebraic models for the Morel-Voevodsky unstable motivic homotopy category $\mathrm{Ho}(F)$ after $\mathbf{H}^{\mathbb{A}^1}k$ localization. More specifically, we extend results of Goerss to the $\mathbb{A}^1$-algebraic topology setting: we study the homotopy theory of the category $s\mathrm{coCAlg}_k(Sm_F)$ of presheaves of simplicial coalgebras over a field $k$ and their $\tau$ and $\mathbb{A}^1$-localizations. For $k$ algebraically closed, we show that the unit of the adjunction $k^{\delta}[-]\dashv(-)^{gp}$ determines the $\mathbf{H}^{\mathbb{A}^1}k$ homotopy type, where $k^{\delta}[-]$ is the canonical coalgebra functor induced by the diagonal map $\Delta:\mathcal{X}\rightarrow \mathcal{X}\times \mathcal{X}$. We extend this result for the category of presheaves of coalgebras over a non-algebraically closed field $k$ and the category of discrete $G$-motivic spaces, for $G=Gal(\bar{k}/k)$. On the other hand, we show that the category of coalgebra objects in $\mathrm{PST}(Sm_F,k)$ is locally presentable, where $\mathrm{PST}(Sm_F,k)$ is the category of presheaves with Voevodsky transfers and the monoidal structure is given by a Day convolution product.

الوصول الحر: http://arxiv.org/abs/1911.05061Test

المؤلفون: Guzmán, Gabriela I, Sandberg, Troy E, LaCroix, Ryan A, Nyerges, Ákos, Papp, Henrietta, de Raad, Markus, King, Zachary A, Hefner, Ying, Northen, Trent R, Notebaart, Richard A, Pál, Csaba, Palsson, Bernhard O, Papp, Balázs, Feist, Adam M

المصدر: Molecular systems biology. 15(4)

مصطلحات موضوعية: Escherichia coli K12, Succinates, Tartrates, Enzymes, Deoxyribose, Arabinose, Escherichia coli Proteins, Adaptation, Physiological, Evolution, Molecular, Substrate Specificity, Mutation, Computer Simulation, adaptive evolution, enzyme promiscuity, genome‐scale modeling, systems biology, genome-scale modeling, Bioinformatics, Biochemistry and Cell Biology, Other Biological Sciences

الوصف: Evidence suggests that novel enzyme functions evolved from low-level promiscuous activities in ancestral enzymes. Yet, the evolutionary dynamics and physiological mechanisms of how such side activities contribute to systems-level adaptations are not well characterized. Furthermore, it remains untested whether knowledge of an organism's promiscuous reaction set, or underground metabolism, can aid in forecasting the genetic basis of metabolic adaptations. Here, we employ a computational model of underground metabolism and laboratory evolution experiments to examine the role of enzyme promiscuity in the acquisition and optimization of growth on predicted non-native substrates in Escherichia coli K-12 MG1655. After as few as approximately 20 generations, evolved populations repeatedly acquired the capacity to grow on five predicted non-native substrates-D-lyxose, D-2-deoxyribose, D-arabinose, m-tartrate, and monomethyl succinate. Altered promiscuous activities were shown to be directly involved in establishing high-efficiency pathways. Structural mutations shifted enzyme substrate turnover rates toward the new substrate while retaining a preference for the primary substrate. Finally, genes underlying the phenotypic innovations were accurately predicted by genome-scale model simulations of metabolism with enzyme promiscuity.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1qm5t62jTest

المؤلفون: Barone, Jordan C., Ross, Jaclyn M., Nagpal, Anisha, Guzman, Gabriela, Berenz, Erin, Pang, Raina D., Eisenlohr‐Moul, Tory A.

المساهمون: National Institute of Mental Health, National Institute on Alcohol Abuse and Alcoholism

المصدر: Alcohol: Clinical and Experimental Research ; volume 47, issue 1, page 127-142 ; ISSN 2993-7175 2993-7175

الوصف: Background Females who misuse alcohol experience high rates of negative physical and mental health consequences. Existing findings are inconsistent but suggest a relationship between ovarian hormones and alcohol use. We aim to clarify how alcohol use and drinking motives vary across the menstrual cycle in female psychiatric outpatients using the luteinizing hormone (LH)‐confirmed cycle phase. Methods Daily self‐reports ( n = 3721) were collected from 94 naturally cycling females, recruited for past‐month suicidal ideation, during the baseline phase of three parent clinical trials between February 2017 and May 2022. Multilevel logistic and linear models estimated the relationship between the cycle phase (with LH‐surge confirmed ovulation) and daily alcohol use or drinking motives, moderated by the weekend. Models were adjusted for age, legal drinking status, substance use disorder, and the COVID‐19 pandemic, and included random effects. Results Participants were generally more likely to drink in the midluteal (vs. perimenstrual) phase, but more likely to drink heavily on weekends in periovulatory and perimenstrual (vs. midluteal) phases. Social motives for drinking were significantly higher on weekends in the periovulatory, mid‐follicular, and midluteal phases (vs. weekdays), but this finding was non‐significant in the perimenstrual phase. Participants rated drinking to cope higher in the perimenstrual phase (vs. midluteal phase), regardless of the weekend. Conclusion In a psychiatric sample with LH‐surge‐confirmed ovulation, we find an increased likelihood to drink heavily in periovulatory and perimenstrual phases on weekends. We also find that the perimenstrual phase is associated with increased drinking to cope, and relatively lower weekend social drinking. Finally, random effects across models suggest individual differences in the extent to which the cycle influences drinking. Our findings stress (1) predictable phases of increased high‐risk alcohol use across the menstrual cycle, and (2) the ...

الإتاحة: https://doi.org/10.1111/acer.14971Test

المؤلفون: Suraci, Andrea, Guzmán, Gabriela

مصطلحات موضوعية: Inclusión social, Recreación, Actividades culturales, Traducción e interpretación, Personas Sordas

الوصف: Se relata la experiencia realizada en el marco del proyecto “ContArte: Actividades Culturales/Recreativas Accesibles para Personas Sordas" cuyo objetivo era favorecer la inclusión de espectadores sordos/as (niños/as, jóvenes y adultos/as) en eventos culturales que se ofrecen en el Gran Mendoza, brindando la interpretación simultánea y de calidad en Lengua de Señas Argentina (LSA). ; Fil: Suraci, Andrea. Universidad Nacional de Cuyo. Facultad de Educación. ; Fil: Guzmán, Gabriela. Universidad Nacional de Cuyo. Facultad de Educación.

وصف الملف: application/pdf

العلاقة: http://bdigital.uncu.edu.ar/18105Test

الإتاحة: http://bdigital.uncu.edu.ar/18105Test

المؤلفون: Reynolds, Harmony R., Cyr, Derek D., Merz, C. Noel Bairey, Shaw, Leslee J., Chaitman, Bernard R., Boden, William E., Alexander, Karen P., Rosenberg, Yves D., Bangalore, Sripal, Stone, Gregg W., Held, Claes, Spertus, John, Goetschalckx, Kaatje, Bockeria, Olga, Newman, Jonathan D., Berger, Jeffrey S., Elghamaz, Ahmed, Lopes, Renato D., Min, James K., Berman, Daniel S., Picard, Michael H., Kwong, Raymond Y., Harrington, Robert A., Thomas, Boban, O'Brien, Sean M., Maron, David J., Hochman, Judith S., Mavromatis, Kreton, Linefsky, Jason, Miller, Todd, Banerjee, Subhash, Donnino, Robert M., Phillips, Lawrence M., Saric, Muhamed, Abdul‐Nour, Khaled, Stone, Peter H., Jang, James J., Yee, Gennie, Weitz, Steven, Arnold, Suzanne, O’Keefe, James Henry, Shapiro, Michael D., El‐Hajjar, Mohammad, Sidhu, Mandeep S., Fein, Steven A., Torosoff, Mikhail T., Lyubarova, Radmila, Mookherjee, Sulagna, Drzymalski, Krzysztof, McFalls, Edward O., Garcia, Santiago A., Bertog, Stefan C., Siddiqui, Rizwan A., Ishani, Areef, Hansen, Ronnell A., Khouri, Michel Georges, Goldberg, Jonathan L., Goldweit, Richard, Cohen, Ronny A., Mirrer, Brooks, Navarro, Victor, Winchester, David E., Kronenberg, Marvin, Rogal, Philip, McFarren, Christopher, Heitner, John F., Dauber, Ira M., Cannan, Charles, Sudarshan, Sriram, Mehta, Puja K., McDaniel, Michael, Lerakis, Stamatios, Quyyumi, Arshed, Wenger, Nanette K., Hedgepeth, Chester M., Hurlburt, Heather, Rosen, Alan, Sahul, Zakir, Booth, David, Leung, Steve, Abdel‐Latif, Ahmed, Reda, Hassan, Ziada, Khaled, Setty, Sampoornima, Barua, Rajat S., Hage, Fadi, Caldeira, Christiano, Davies, James E., Leesar, Massoud, Heo, Jaekyeong, Iskandrian, Amy, Al Solaiman, Firas, Singh, Satinder, Dajani, Khaled, Der Mesropian, Paul, Sacco, Joseph, McCandless, Brian, Orgera, Marisa, Arif, Imran, Kerr, Hanan, Trejo (Gutierrez), Jorge F., Fletcher, Gerald, Lane, Gary E., Neeson, Lynn M., Parikh, Pragnesh P., Pollak, Peter M., Shapiro, Brian P., Landolfo, Kevin, Gemignani, Anthony, O’Rourke, Daniel, Meadows, Judith L., Call, Jason T., Hannan, Joseph, Bojar, Robert, Kumar, Deepti, Mukai, John, Martin, Edward T., Vorobiof, Gabriel, Moorman, Alec, Kinlay, Scott, Hamburger, Robert J., Rocco, Thomas P., Bhatt, Deepak L., Croce, Kevin, Quin, Jacquelyn A., Anumpa, Jati, Zenati, Marco, Faxon, David P., Rayos, Glenn, Seedhom, Ashraf, Sullenberger, Lance, Kumkumian, Gregory, Sedlis, Steven P., Lorin, Jeffrey, Tamis‐Holland, Jacqueline E., Kornberg, Robert, Leber, Robert, Saba, Souheil, Lee, Michael W., Small, Delano R., Nona, Wassim, Alexander, Patrick B., Rehman, Iram, Badami, Umesh, Marzo, Kevin, Robbins, Inga H., Levite, Howard A., Shetty, Sanjay, Patel, Mayuri, Hamroff, Glenn S., Little, Raymond W., Zimbelman, Brandi D., Lui, Charles Y., Smith, Brigham R., Vezina, Daniel P., Khor, Lillian L., Abraham, Josephine D., Bull, David A., McKellar, Stephen H., Kotter, John, Hu, Bob, Labovitz, Arthur J., Berlowitz, Michael, Matar, Fadi, Rodriguez, Fatima, Schnittger, Ingela, Fearon, William F., Deedwania, Prakash, Reddy, Kiran, Sweeny, Joseph, Spizzieri, Christopher, Hochberg, Claudia P., Salerno, William D., Wyman, Ray, Zarka, Amer, Shah, Anil V., Haldis, Thomas, Kohn, Jeffrey A., Girotra, Saket, Almousalli, Omar, Krishnam, Mayil S., Milliken, Jeffrey C., Patel, Pranav M., Seto, Arnold H., Harley, Kevin T., Gibson, Michael A., Allen, Byron J., Coram, Rita, Thomas, Sabu, Schwartz, Ronald G., Chen, Wei, El Shahawy, Mahfouz, Stafford, James, Abernethy, William B., Zurick, Andrew, Meyer, Thomas M., Morford, Ronald G., Rutkin, Bruce, Bokhari, Sabahat, Sokol, Seth I., Meisner, Jay, Hamzeh, Ihab, Misra, Arunima, Wall, Matthew, De Rosen, Veronica Lenges, Alam, Mahboob, Turner, Michael C., Mulhearn, Thomas J., Good, Arnold P., Shammas, Nicolas W., Chilton, Robert, Nguyen, Patricia K., Jezior, Matthew, Gordon, Paul C., Crain, Thomas, Stenberg, Robert, Pedalino, Ronald P., Wiesel, Joseph, Juang, George J., Al‐Amoodi, Mohammed, Wohns, David, Lader, Ellis W., Mumma, Michael, Dharmarajan, Lekshmi, McGarvey, Joseph F. X., Downes, Thomas R., Luckasen, Gary J., Cheong, Benjamin, Potluri, Srinivasa, Mastouri, Ronald A., Breall, Jeffery A., Revtyak, George E., Bazeley, Jonathan W., Li, Dayuan, Giedd, Kenneth, Old, Wayne, Burt, Francis, Sokhon, Kozhaya, Gopal, Deepika, Valeti, Uma S., Kobashigawa, Jon, Govindan, Sajeev Chakanalil, Nair, Rajesh Gopalan, Manjunath, Cholenahally Nanjappa, Moorthy, Nagaraja, Manjunath, Satvic Cholenahally, Narayanappa, Suryaprakash, Pandit, Neeraj, Nath, Ranjit Kumar, Dwivedi, S. K., Narain, V. S., Chandra, Sharad, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Aslam, Naved, Goyal, Abhishek, Bhargava, Balram, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Verma, Sunil Kumar, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Choudhary, Shiv Kumar, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V. 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Joseph, Lam, Andy, Mehta, Shamir, Udell, Jacob, Généreux, Philippe, Hameed, Adnan, Daba, Ledjalem, Hueb, Whady, Rezende, Paulo Cury, Silva, Expedito Eustáquio Ribeiro, Hueb, Alexandre Ciappina, Smanio, Paola Emanuela Poggio, de Quadros, Alexandre Schaan, Kalil, Renato Abdala Karam, da Costa Vieira, José Luiz, Grossmann, Gabriel, de Oliveira, Pedro Píccaro, Bridi, Leonardo, Savaris, Simone, Vitola, João V., Cerci, Rodrigo J., Farias, Fabio R., Fernandes, Miguel M., Marin‐Neto, José Antonio, Schmidt, André, de Oliveira Lima Filho, Moysés, Oliveira, Ricardo Mendes, Chierice, João Reynaldo Abbud, Polanczyk, Carísi A., Furtado, Mariana V., Smidt, Luis F., Carvalho, Antonio Carlos, Pucci, Gustavo, Lyra, Flavio, Junior, Alvaro Rabelo Alves, Dracoulakis, Marianna D. A., Lima, Rodolfo G. S. 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Christian, Goebel, Bjoern, Lenk, Karsten, Nickenig, Georg, Schuchlenz, Herwig, Weikl, Stefan, Lang, Irene Marthe, Huber, Kurt, Jakl‐Kotauschek, Gabriele, Vertes, Andras, Varga, Albert, Fontos, Geza, Merkely, Bela, Kerecsen, Gabor, Hinic, Sasa, Zdravkovic, Marija, Mudrenovic, Vladan, Crnokrak, Bogdan, Beleslin, Branko D., Boskovic, Nikola N., Petrovic, Marija T., Dobric, Milan R., Markovic, Zeljko Z., Mladenovic, Ana S., Cemerlic‐Adjic, Nada, Davidovic, Goran, Vucic, Rada, Dekleva, Milica Nikola, Stankovic, Goran, Apostolovic, Svetlana, Escobedo, Jorge, Baleón‐Espinosa, Rubén, Campos‐Santaolalla, Arturo S., Durán‐Cortés, Elihú, Flores‐Palacios, José M., García‐Rincón, Andrés, Jiménez‐Santos, Moisés, Peñafiel, Joaquín V., Ortega‐Ramírez, José A., Valdespino‐Estrada, Aquiles, Rosas, Erick Alexánderson, Selvanayagam, Joseph B., Joseph, Majo X., Thambar, Suku T., Beltrame, John F., Hillis, Graham S., Thuaire, Christophe, Dutoiu, Téodora, Steg, Philippe Gabriel, Juliard, Jean‐Michel, Slama, Michel S., El Mahmoud, Rami, Nicollet, Eric, Goube, Pascal, Barone‐Rochette, Gilles, Furber, Alain, Bière, Loïc, Laucevicius, Aleksandras, Celutkiene, Jelena, Kedhi, Elvin, Timmer, Jorik, Hermanides, Rik, Kaplan, Eliza, Riezebos, Robert K., Samadi, Pouneh, van Dongen, Elise, Niehe, Sander R., Suryapranata, Harry, van Vugt, Stijn, Ramos, Ruben, Cacela, Duarte, Santana, Ana, Fiarresga, Antonio, Sousa, Lidia, Marques, Hugo, Patricio, Lino, Bernanrdes, Luis, Rio, Pedro, Carvalho, Ramiro, Ferreira, Rui, Silva, Tiago, Rodrigues, Ines, Modas, Pedro, Portugal, Guilherme, Fragata, Jose, Pinto, Fausto J., Menezes, Miguel Nobre, Lopes, Guilhermina Cantinho, Almeida, Ana Gomes, Silva, Pedro Canas, Nobre, Angelo, Francisco, Ana Rita, Ferreira, Nuno, Lopes, Ricardo L., Guzman, Luis, Figal, Julio César, Méndiz, Oscar, Cortés, Claudia, Favaloro, Roberto René, Alvarez, Carlos, Courtis, Javier, Zeballos, Gabriela, Schiavi, Lilia, Rubio, Mariano, Devlin, Gerard Patrick, Fisher, Raewyn, Stewart, Ralph Alan Huston, White, Harvey Douglas, Benatar, Jocelyne, Kedev, Sasko, Mitevska, Irena Peovska, Kostovska, Elizabeta Srbinovska, Pejkov, Hristo, Eggers, Kai, Frostfelt, Gunnar, Johnston, Nina, Olsowka, Maciej, Åkerblom, Axel, Soveri, Inga, Aspberg, Johannes, Sharir, Tali, Elian, Dan, Kerner, Arthur, Massalha, Samia, Fukuda, Keiichi, Kohsaka, Shun, Yasuda, Satoshi, Nishimura, Shigeyuki, Van de Werf, Frans, Claes, Kathleen, Hung, Chung‐Lieh, Yun, Chun‐Ho, Hou, Charles Jia‐Yin, Kuo, Jen‐Yuan, Yeh, Hung‐I, Hung, Ta‐Chuan, Li, Jiun‐Yi, Chien, Chen‐Yen, Tsai, Cheng‐Ting, Liu, Chun‐Chieh, Yu, Fa‐Chang, Lin, Yueh‐Hung, Lan, Wei‐Ren, Yen, Chih‐Hsuan, Tsai, Jui‐Peng, Sung, Kuo‐Tzu, Ntsekhe, Mpiko, Pandie, Shaheen, Viljoen, Charle A., De Andrade, Marianne, Moccetti, Tiziano, Rossi, M. Grazia, Abdelhamid, Magdy, Adel, Ahmed, Kamal, Ahmed, Mahrous, Hossam, El Kaffas, Sameh, El Fishawy, Hussien, Pop, Calin, Claudia, Matei, Popescu, Bogdan A., Ginghina, Carmen, Deleanu, Dan, Iliescu, Vlad A., Al‐Mallah, Mouaz H., Aljzeeri, Ahmed, Najm, Hani, Alghamdi, Ali, Ramos, Walter Enrique Mogrovejo, Kuanprasert, Srun, Prommintikul, Arintaya, Nawarawong, Weerachai, Woragidpoonpol, Surin, Tepsuwan, Thitipong, Taksaudom, Noppon, Rimsukcharoenchai, Chataroon, Euathrongchit, Juntima, Wannasopha, Yutthaphan, Yamwong, Sukit, Sritara, Piyamitr, Aramcharoen, Suthara, Meemuk, Krissada, Khairuddin, Ahmad, Hadi, Hafidz Abd, Yahaya, Shaiful Azmi

المساهمون: Reynolds, Harmony R., Cyr, Derek D., Merz, C. Noel Bairey, Shaw, Leslee J., Chaitman, Bernard R., Boden, William E., Alexander, Karen P., Rosenberg, Yves D., Bangalore, Sripal, Stone, Gregg W., Held, Clae, Spertus, John, Goetschalckx, Kaatje, Bockeria, Olga, Newman, Jonathan D., Berger, Jeffrey S., Elghamaz, Ahmed, Lopes, Renato D., Min, James K., Berman, Daniel S., Picard, Michael H., Kwong, Raymond Y., Harrington, Robert A., Thomas, Boban, O'Brien, Sean M., Maron, David J., Hochman, Judith S., Mavromatis, Kreton, Linefsky, Jason, Miller, Todd, Banerjee, Subhash, Donnino, Robert m., Phillips, Lawrence M., Saric, Muhamed, Abdul‐nour, Khaled, Stone, Peter H., Jang, James J., Yee, Gennie, Weitz, Steven, Arnold, Suzanne, O’Keefe, James Henry, Shapiro, Michael D., El‐hajjar, Mohammad, Sidhu, Mandeep S., Fein, Steven A., Torosoff, Mikhail T., Lyubarova, Radmila, Mookherjee, Sulagna, Drzymalski, Krzysztof, Mcfalls, Edward O., Garcia, Santiago A., Bertog, Stefan C., Siddiqui, Rizwan A., Ishani, Areef, Hansen, Ronnell A., Khouri, Michel George, Goldberg, Jonathan L., Goldweit, Richard, Cohen, Ronny A., Mirrer, Brook, Navarro, Victor, Winchester, David E., Kronenberg, Marvin, Rogal, Philip, Mcfarren, Christopher, Heitner, John F., Dauber, Ira M., Cannan, Charle, Sudarshan, Sriram, Mehta, Puja K., Mcdaniel, Michael, Lerakis, Stamatio, Quyyumi, Arshed, Wenger, Nanette K., Hedgepeth, Chester M., Hurlburt, Heather, Rosen, Alan, Sahul, Zakir, Booth, David, Leung, Steve, Abdel‐latif, Ahmed, Reda, Hassan, Ziada, Khaled, Setty, Sampoornima, Barua, Rajat S., Hage, Fadi, Caldeira, Christiano, Davies, James E., Leesar, Massoud, Heo, Jaekyeong, Iskandrian, Amy, Al Solaiman, Fira, Singh, Satinder, Dajani, Khaled, Der Mesropian, Paul, Sacco, Joseph

مصطلحات موضوعية: coronary artery disease, ischemic heart disease, sex difference, women's health

الوصف: Background: Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline-directed medical therapy, and outcomes among patients with chronic coronary disease with ischemia on stress testing, with and without invasive management. Methods and results: The ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial randomized patients with moderate or severe ischemia to invasive management with angiography, revascularization, and guideline-directed medical therapy, or initial conservative management with guideline-directed medical therapy alone. We evaluated the primary outcome (cardiovascular death, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest) and other end points, by sex, in 1168 (22.6%) women and 4011 (77.4%) men. Invasive group catheterization rates were similar, with less revascularization among women (73.4% of invasive-assigned women revascularized versus 81.2% of invasive-assigned men; P<0.001). Women had less coronary artery disease: multivessel in 60.0% of invasive-assigned women and 74.8% of invasive-assigned men, and no ≥50% stenosis in 12.3% versus 4.5% (P<0.001). In the conservative group, 4-year catheterization rates were 26.3% of women versus 25.6% of men (P=0.72). Guideline-directed medical therapy use was lower among women with fewer risk factor goals attained. There were no sex differences in the primary outcome (adjusted hazard ratio [HR] for women versus men, 0.93 [95% CI, 0.77-1.13]; P=0.47) or the major secondary outcome of cardiovascular death/myocardial infarction (adjusted HR, 0.93 [95% CI, 0.76-1.14]; P=0.49), with no significant sex-by-treatment-group interactions. Conclusions: Women had less extensive coronary artery disease and, therefore, lower revascularization rates in the invasive group. Despite lower risk factor goal attainment, women with chronic ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38410945; volume:13; issue:5; journal:JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE; https://hdl.handle.net/11577/3510849Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85187201588

الإتاحة: https://doi.org/10.1161/jaha.122.029850Test
https://hdl.handle.net/11577/3510849Test

المؤلفون: Goh, Kai Lyn, Wintergerst, Maximilian W. M., Abbott, Carla J., Hadoux, Xavier, Jannaud, Maxime, Kumar, Himeesh, Hodgson, Lauren A. B., Guzman, Gabriela, Janzen, Simon, van Wijngaarden, Peter, Finger, Robert P., Guymer, Robyn H., Wu, Zhichao

المساهمون: National Health and Medical Research Council, Macular Disease Foundation Australia, BrightFocus Foundation, Ernst und Berta Grimmke Stiftung, H&L Hecht Trust, Centre for Eye Research Australia Innovation Fund

المصدر: Retina ; volume 44, issue 2, page 214-221 ; ISSN 0275-004X

الوصف: Purpose: To investigate the prognostic value of quantifying optical coherence tomography (OCT)-defined hyperreflective foci (HRF) that do not correspond to hyperpigmentary abnormalities (HPAs) on color fundus photographs (CFPs)—HRF (OCT+/CFP−) —when considered in addition to HPA extent, for predicting late age-related macular degeneration development. This study sought to understand the impact of HRF (OCT+/CFP−) extent on visual sensitivity. Methods: Two hundred eighty eyes from 140 participants with bilateral large drusen underwent imaging and microperimetry at baseline, and then 6-monthly for 3-years. The extent of HPAs on CFPs and HRF (OCT+/CFP−) on OCT was quantified at baseline. Predictive models for progression to late age-related macular degeneration, accounting for drusen volume and age, were developed using HPA extent, with and without HRF (OCT+/CFP−) extent. The association between HPA and HRF (OCT+/CFP−) extent with sector-based visual sensitivity was also evaluated. Results: Incorporating HRF (OCT+/CFP−) extent did not improve the predictive performance for late age-related macular degeneration development ( P ≥ 0.32). Increasing HPA and HRF (OCT+/CFP−) extent in each sector were independently and significantly associated with reduced sector-based visual sensitivity ( P ≤ 0.004). Conclusion: The addition of HRF (OCT+/CFP−) extent to HPA extent did not improve the prediction of late age-related macular degeneration development. HRF (OCT+/CFP−) extent was also independently associated with local reductions in visual sensitivity, after accounting for HPAs.

الإتاحة: https://doi.org/10.1097/iae.0000000000003958Test

المؤلفون: Guzman, Gabriela

المصدر: Apuntes Filosóficos; Vol. 30 Núm. 58 (2021): Siglo XXI, Filósofas Ucevistas ; 1316-7533

وصف الملف: application/pdf

العلاقة: http://saber.ucv.ve/ojs/index.php/rev_af/article/view/23762/144814489990Test; http://190.169.94.12/ojs/index.php/rev_af/article/view/23762Test

الإتاحة: http://190.169.94.12/ojs/index.php/rev_af/article/view/23762Test

المؤلفون: Galian-Gay, Laura, Escalona Silva, Roxana Andreina, Teixido-Tura, Gisela, Casas, Guillem, Ferrer-Sistach, Elena, Mitroi, Cristina, Mingo, Susana, Monivas, Vanessa, Saura, Daniel, Vidal, Bà rbara, Trasca, Livia, Moral Torres, Sergio, Calvo Iglesias, Francisco, Castiñeira Busto, Maria, Sánchez, Violeta, Gonzalez, Ariana, Guzman, Gabriela, Mora, Marta Noris, Arnau Vives, Miguel Ãngel, Peteiro, Jesús, Bouzas, Alberto, Mas-Stachurska, Aleksandra, González-Alujas, Teresa, Gutiérrez García-Moreno, Laura, Fernandez-Galera, Rubén, Valente, Filipa, Guala, Andrea, Ruiz-Muñoz, Aroa, Sao-Avilés, Augusto, Rodriguez-Palomares, Jose F, Ferreira-Gonzalez, Ignacio, Evangelista, Artur, Universitat Autònoma de Barcelona

مصطلحات موضوعية: Aortic stenosis, Paradoxical low-flow low-gradient, Echocardiography, Aortic valve surgery, Heart valve disease

الوصف: To determine the risk of mortality and need for aortic valve replacement (AVR) in patients with low-flow low-gradient (LFLG) aortic stenosis (AS). A longitudinal multicentre study including consecutive patients with severe AS (aortic valve area [AVA] < 1.0 cm 2) and normal left ventricular ejection fraction (LVEF). Patients were classified as: high-gradient (HG, mean gradient ≥ 40 mmHg), normal-flow low-gradient (NFLG, mean gradient < 40 mmHg, indexed systolic volume (SVi) > 35 ml/m 2) and LFLG (mean gradient < 40 mmHg, SVi ≤ 35 ml/m 2). Of 1,391 patients, 147 (10.5%) had LFLG, 752 (54.1%) HG, and 492 (35.4%) NFLG. Echocardiographic parameters of the LFLG group showed similar AVA to the HG group but with less severity in the dimensionless index, calcification, and hypertrophy. The HG group required AVR earlier than NFLG (p < 0.001) and LFLG (p < 0.001), with no differences between LFLG and NFLG groups (p = 0.358). Overall mortality was 27.7% (CI 95% 25.3-30.1) with no differences among groups (p = 0.319). The impact of AVR in terms of overall mortality reduction was observed the most in patients with HG (hazard ratio [ HR ]: 0.17; 95% CI : 0.12-0.23; p < 0.001), followed by patients with LFLG (HR : 0.25; 95% CI : 0.13-0.49; p < 0.001), and finally patients with NFLG (HR : 0.29; 95% CI : 0.20-0.44; p < 0.001), with a risk reduction of 84, 75, and 71%, respectively. Paradoxical LFLG AS affects 10.5% of severe AS, and has a lower need for AVR than the HG group and similar to the NFLG group, with no differences in mortality. AVR had a lower impact on LFLG AS compared with HG AS. Therefore, the findings of the present study showed LFLG AS to have an intermediate clinical risk profile betwee the HG and NFHG groups

وصف الملف: application/pdf

العلاقة: Ministerio de Ciencia e Innovación IJC2018- 037349-I; Frontiers in Cardiovascular Medicine; Vol. 9 (april 2022); https://ddd.uab.cat/record/258078Test; urn:10.3389/fcvm.2022.852954; urn:oai:ddd.uab.cat:258078; urn:pmcid:PMC9011160; urn:pmc-uid:9011160; urn:pmid:35433871; urn:oai:pubmedcentral.nih.gov:9011160; urn:oai:egreta.uab.cat:publications/5e54c2b2-83e7-4917-b1f2-de2c3f0a3847

الإتاحة: https://ddd.uab.cat/record/258078Test

المؤلفون: Zhang, Xuhuiqun, Xiao, Di, Guzman, Gabriela, Edirisinghe, Indika, Burton-Freeman, Britt

المصدر: The Journal of Nutrition ; volume 152, issue 8, page 1851-1861 ; ISSN 0022-3166

مصطلحات موضوعية: Nutrition and Dietetics, Medicine (miscellaneous)

الإتاحة: https://doi.org/10.1093/jn/nxac126Test
https://api.elsevier.com/content/article/PII:S002231662200699X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S002231662200699X?httpAccept=text/plainTest
https://academic.oup.com/jn/article-pdf/152/8/1851/45904510/nxac126.pdfTest

المؤلفون: Menor Aguirre, Yeni Patricia, Villegas Guzman, Gabriela Sofia

المساهمون: Llontop Jesús, José Alberto

المصدر: Universidad Peruana de Ciencias Aplicadas (UPC) ; Repositorio Académico - UPC

مصطلحات موضوعية: Lean manufacturing, 5s, Value stream mapping, Estandarización de procesos, Conteo cíclico, Process standardization, Cycle count, https://purl.org/pe-repo/ocde/ford#2.11.04Test, https://purl.org/pe-repo/ocde/ford#2.00.00Test

الوصف: El sector de consumo masivo es uno de los sectores con mayor participación en el mercado global, que con la expansión del ecommerce, las ventas de muchos de los negocios que lo integran crecieron significativamente. Esta investigación se enfoca en mejorar la gestión de almacén e inventarios de una pequeña empresa del sector de consumo masivo que emplea el ecommerce como modelo de negocio, en la cual se identificó excesos de tiempos en la preparación de pedidos generando retrasos en las entregas. Esta problemática genera un impacto negativo en el desempeño económico de la empresa. Por lo que, se implementó un modelo que emplea herramientas de Lean Manufacturing, con el objetivo principal de incrementar el indicador OTIF. En la propuesta se emplea la Estandarización de procesos, 5’s y Contabilización cíclica como herramientas clave. Los resultados luego de esta implementación, obtenidos de una prueba piloto, demuestran un incremento del indicador OTIF con un valor de 90%. Por lo tanto, se concluye que el uso de la metodología Lean Manufacturing en la propuesta desarrollada genera reducción de costos y la disminución de pedidos entregados con retraso. ; The mass consumption sector is one of the sectors with the greatest participation in the global market, which with the expansion of ecommerce, the sales of many of the businesses that comprise it grew significantly. This research focuses on improving warehouse and inventory management of a small company in the mass consumption sector that uses ecommerce as a business model, in which excess times were identified in the preparation of orders, generating delays in deliveries. This problem generates a negative impact on the economic performance of the company. Therefore, a model that uses Lean Manufacturing tools was implemented, with the main objective of increasing the OTIF indicator. The proposal uses Process Standardization, 5's and Cyclical Accounting as key tools. The results after this implementation, obtained from a pilot test, demonstrate an increase in the ...

وصف الملف: application/pdf; application/epub; application/msword

العلاقة: http://hdl.handle.net/10757/671764Test; 000000012196144X

الإتاحة: http://hdl.handle.net/10757/671764Test