المؤلفون: Korbmacher, Max, Gurholt, Tiril Pedersen, de Lange, Ann Marie, Van der meer, Dennis, Beck, Dani, Eikefjord, Eli Nina, Lundervold, Arvid, Andreassen, Ole, Maximov, Ivan

المصدر: 1117732 ; Frontiers in Psychology ; 14

الوصف: Brain age refers to age predicted by brain features. Brain age has previously been associated with various health and disease outcomes and suggested as a potential biomarker of general health. Few previous studies have systematically assessed brain age variability derived from single and multi-shell diffusion magnetic resonance imaging data. Here, we present multivariate models of brain age derived from various diffusion approaches and how they relate to bio-psycho-social variables within the domains of sociodemographic, cognitive, life-satisfaction, as well as health and lifestyle factors in midlife to old age (N = 35,749, 44.6–82.8 years of age). Bio-psycho-social factors could uniquely explain a small proportion of the brain age variance, in a similar pattern across diffusion approaches: cognitive scores, life satisfaction, health and lifestyle factors adding to the variance explained, but not socio-demographics. Consistent brain age associations across models were found for waist-to-hip ratio, diabetes, hypertension, smoking, matrix puzzles solving, and job and health satisfaction and perception. Furthermore, we found large variability in sex and ethnicity group differences in brain age. Our results show that brain age cannot be sufficiently explained by bio-psycho-social variables alone. However, the observed associations suggest to adjust for sex, ethnicity, cognitive factors, as well as health and lifestyle factors, and to observe bio-psycho-social factor interactions’ influence on brain age in future studies. ; publishedVersion

وصف الملف: application/pdf

العلاقة: urn:issn:1664-1078; https://hdl.handle.net/11250/3071342Test; https://doi.org/10.3389/fpsyg.2023.1117732Test; cristin:2154120; Frontiers in Psychology. 2023, 14, 1117732.

الإتاحة: https://doi.org/10.3389/fpsyg.2023.1117732Test
https://hdl.handle.net/11250/3071342Test

المؤلفون: Korbmacher, Max, Gurholt, Tiril Pedersen, de Lange, Ann-Marie Glasø, van der Meer, Dennis, Beck, Dani, Eikefjord, Eli Nina Hølleland, Lundervold, Arvid, Andreassen, Ole, Westlye, Lars Tjelta, Maximov, Ivan

الإتاحة: https://hdl.handle.net/11250/3088100Test

المؤلفون: Korbmacher, Max, Gurholt, Tiril Pedersen, de Lange, Ann-Marie Glasø, van der Meer, Dennis, Beck, Dani, Eikefjord, Eli Nina Hølleland, Lundervold, Arvid, Andreassen, Ole, Westlye, Lars Tjelta, Maximov, Ivan

الإتاحة: https://hdl.handle.net/11250/3088106Test

المؤلفون: Chen, Xiaowan, Wei, Dang, Fang, Fang, Song, Huan, Yin, Li, Kaijser, Magnus, Gurholt, Tiril Pedersen, Andreassen, Ole Andreas, Valdimarsdóttir, Unnur, Hu, Kejia, Duan, Maoli

المصدر: BMC Medicine; 2/9/2024, Vol. 22 Issue 1, p1-10, 10p

مصطلحات موضوعية: ANXIETY disorders, VERTIGO, PROPORTIONAL hazards models, MENTAL illness, COHORT analysis, MENTAL depression

مصطلحات جغرافية: UNITED Kingdom

مستخلص: Background: Peripheral vertigo is often comorbid with psychiatric disorders. However, no longitudinal study has quantified the association between peripheral vertigo and risk of psychiatric disorders. Furthermore, it remains unknown how the white matter integrity of frontal-limbic network relates to the putative peripheral vertigo-psychiatric disorder link. Methods: We conducted a cohort study including 452,053 participants of the UK Biobank with a follow-up from 2006 through 2021. We assessed the risks of depression and anxiety disorders in relation to a hospitalization episode involving peripheral vertigo using Cox proportional hazards models. We also examined the associations of peripheral vertigo, depression, and anxiety with MRI fractional anisotropy (FA) in a subsample with brain MRI data (N = 36,087), using multivariable linear regression. Results: Individuals with an inpatient diagnosis of peripheral vertigo had elevated risks of incident depression (hazard ratio (HR) 2.18; 95% confidence interval (CI) 1.79–2.67) and anxiety (HR 2.11; 95% CI 1.71–2.61), compared to others, particularly within 2 years after hospitalization (HR for depression 2.91; 95% CI 2.04–4.15; HR for anxiety 4.92; 95% CI 3.62–6.69). Depression was associated with lower FA in most studied white matter regions, whereas anxiety and peripheral vertigo did not show statistically significant associations with FA. Conclusions: Individuals with an inpatient diagnosis of peripheral vertigo have increased subsequent risks of depression and anxiety disorders, especially within 2 years after hospitalization. Our findings further indicate a link between depression and lower microstructural connectivity as well as integrity beyond the frontal-limbic network. [ABSTRACT FROM AUTHOR]

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المؤلفون: Kong, Xiang-Zhen, Francks, Clyde, Mathias, Samuel R., Guadalupe, Tulio, Abé, Christoph, Agartz, Ingrid, Akudjedu, Theophilus, Aleman, André, Alhusaini, Saud, Allen, Nicholas B., Ames, David, Andreassen, Ole A, Vasquez, A.A., Armstrong, Nicola, Asherson, P., Bergo, F., Bastin, Mark E, Batalla, A., Bauer, Jochen, Baune, B.T., Baur-Streubel, Ramona, Biederman, J., Blaine, S.K., Boedhoe, Premika, Bøen, Erlend, Bose, Anushree, Bralten, J., Brandeis, Daniel, Brem, Silvia, Brodaty, Henry, Yüksel, Dilara, Brooks, S.J., Buitelaar, Jan K., Bürger, C., Bülow, R., Calhoun, Vince, Calvo, A., Canales-Rodriguez, Erick Jorge, Cannon, Dara, Caparelli, E.C., Castellanos, F.X., Cendes, Fernando, Chaim-Avancini, T.M., Chantiluke, K., Chen, Qunlin, Chen, X., Cheng, Y., Christakou, Anastasia, Clark, Vincent P., Coghill, David, Connolly, C.G., Conzelmann, A., Córdova-Palomera, A., Cousijn, Janna, Crow, T., Cubillo, A., Dannlowski, Udo, de Bruttopilo, S.A., de Zeeuw, P., Deary, I.J., Demeter, D.V., Di Martino, A., Dickie, E.W., Dietsche, B., Doan, N.T., Doherty, Colin P., Doyle, A., Durston, S., Earl, Eric, Ehrlich, Stefan, Ekman, Carl Johan, ElvsÃ¥shagen, T., Epstein, J.N., Fair, D.A., Faraone, S.V., Fernández, G., Flint, C., Filho, G.B., Förster, K., Fouche, J.P., Foxe, J.J., Frodl, T., Fuentes-Claramonte, Paola, Fullerton, Janice M., Garavan, H., do Santos Garcia, D., Gotlib, I.H., Goudriaan, A.E., Grabe, H.J., Groenewold, Nynke A., Grotegerd, D., Gruber, O., Gurholt, Tiril Pedersen, Haavik, J., Hahn, T., Hansell, Narelle K., Harris, M.A., Hartman, C.A., del Carmen Valdés Hernández, M., Heslenfeld, D., Hester, R., Hibar, Derrek Paul, Ho, Beng-Choon, Ho, T.C., Hoekstra, P.J., van Holst, R.J., Hoogman, Martin, Høvik, M.F., Howells, F.M., Hugdahl, K., Huyser, Chaim, Ingvar, M., Ishikawa, A., James, A., Jahanshad, Neda, Jernigan, T.L., Jönsson, Erik G., Kaleda, V., Kelly, Clare, Kerich, M., Keshavan, M.S., Khadka, S., Kircher, Tilo, Kohls, G., Konrad, K., Korucuoglu, O., Krämer, B., Krug, A., Kuntsi, J., Kwon, J.S., Lambregts-Rommelse, N., Landén, M., Lázaro, Luisa, Lebedeva, Irina S, Lenroot, R., Lesch, K.P., Li, Q., Lim, Kelvin, Liu, J., Lochner, C., London, E.D., Lorenzetti, V., Luciano, M., Luijten, M., Lundervold, A.J., Mackey, S., MacMaster, Frank, Maingault, S., Malpas, Charles B., Malt, U.F., Mataix-Cols, D., Martin-Santos, R., Mayer, A.R., McCarthy, H., Medland, Sarah E., Metha, M., Mitchell, P.B., Mueller, B.A., Maniega, S.M., Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie, McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M., Narayanaswamy, Janardhanan C., Moreira, José Carlos Vasques, Nerland, Stener, Nestor, Liam, Newman, E., Nigg, J.T., Nordvik, J.E., Novotny, S., Weiss, E.O., O'Gorman, R.L., Oosterlaan, J., Oranje, B., Orr, C., Overs, B., Paloyelis, Y., Pauli, P., Paulus, M., Plessen, K.J., von Polier, G.G., Pomarol-Clotet, E., Portella, Maria J., Qiu, J., Radua, Joaquim, Ramos-Quiroga, J.A., Reddy, Y.C.J., Reif, A., Roberts, G., Rosa, P., Rubia, K., Sacchet, M.D., Sachdev, P.S., Salvador, R., Schmaal, L., Schulte-Rüther, Martin, Schweren, L., Seitz, J., Serpa, Mauricio, Shaw, P., Shumskaya, E., Silk, Tim, Simmons, A.N., Simulionyte, E., Sinha, R., Sjoerds, Z., Smelror, R.E., Soliva, J.C., Solowij, N., Souza-Duran, Fabio Luis, Sponheim, S.R., Stein, Dan J., Stein, E.A., Stevens, M., Strike, Lachlan, Sudre, G., Sui, Jing, Tamm, L., Temmingh, H.S., Thoma, R.J., Tomyshev, A., Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, van Erp, Theo G. M., van den Heuvel, Odile A., van der Meer, Dennis, van Eijk, Liza, Vance, Alasdair, Veer, Ilya M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vilarroya Oliver, Óscar, Vives-Gilabert, Yolanda, Voineskos, Aristotle, Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna, Wen, Wei, Westlye, Lars T., Whelan, Christopher D., White, Tonya, Wiers, Reinout, Wright, Margaret J, Wittfeld, Katharina, Yang, Tony T., Yasuda, Clarissa Lin, Yoncheva, Yuliya N., Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Zhen, Zonglei, Zhu, Xing-Xing, Ziegler, Georg C., de Zubicaray, Greig, Zwiers, Marcel P, Glahn, David C., Crivello, Fabrice, Fisher, Simon E., Thompson, Paul M., Farde, Lars, Flyckt, Lena, Engberg, Goran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl, Karolinska Schizophrenia Project

مصطلحات موضوعية: Multisite collaboration, P-hacking, Publication bias, Reproducibility, Team science

الوصف: Altres ajuts: Max Planck Society (Germany). ; The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p-hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study, we mapped brain anatomical left-right asymmetries for regional measures of surface area and cortical thickness, in 99 MRI datasets from around the world, for a total of over 17,000 participants. In the present study, we revisited these hemispheric effects from the perspective of reproducibility. Within each dataset, we considered that an effect had been reproduced when it matched the meta-analytic effect from the 98 other datasets, in terms of effect direction and significance threshold. In this sense, the results within each dataset were viewed as coming from separate studies in an "ideal publishing environment," that is, free from selective reporting and p hacking. We found an average reproducibility rate of 63.2% (SD = 22.9%, min = 22.2%, max = 97.0%). As expected, reproducibility was higher for larger effects and in larger datasets. Reproducibility was not obviously related to the age of participants, scanner field strength, FreeSurfer software version, cortical regional measurement reliability, or regional size. These findings constitute an empirical illustration of reproducibility in the absence of publication bias or p hacking, when assessing realistic biological effects in heterogeneous neuroscience data, and given typically-used sample sizes.

وصف الملف: application/pdf

العلاقة: Human brain mapping; Vol. 43 Núm. 1 (january 2022), p. 244-254; https://ddd.uab.cat/record/282311Test; urn:10.1002/hbm.25154; urn:oai:ddd.uab.cat:282311; urn:scopus_id:85089785260; urn:articleid:10970193v43n1p244; urn:pmid:32841457; urn:pmc-uid:8675427; urn:pmcid:PMC8675427; urn:oai:pubmedcentral.nih.gov:8675427; urn:oai:egreta.uab.cat:publications/5a6ca7b1-b980-434b-be10-b3aa0528334e

الإتاحة: https://ddd.uab.cat/record/282311Test

المؤلفون: Barth, Claudia, Kelly, Sinead, Nerland, Stener, Jahanshad, Neda, Alloza, Clara, Ambrogi, Sonia, Andreassen, Ole, Andreou, Dimitrios, Arango, Celso, Baeza, Inmaculada, Banaj, Nerisa, Bearden, Carrie E., Berk, Michael, Bohman, Hannes, Castro-Fornieles, Josefina, Chye, Yann, Crespo-Facorro, Benedicto, de la Serna, Elena, Díaz-Caneja, Covadonga M., Gurholt, Tiril Pedersen, Hegarty, Catherine E., James, Anthony, Janssen, Joost, Johannessen, Cecilie Haggag, Jönsson, Erik Gunnar, Karlsgodt, Katherine H., Kochunov, Peter, Lois, Noemi G., Lundberg, Mathias, Myhre, Anne Margrethe, Pascual-Diaz, Saül, Piras, Fabrizio, Smelror, Runar, Spalletta, Gianfranco, Stokkan, Therese, Sugranyes, Gisela, Suo, Chao, Thomopoulos, Sophia I., Tordesillas-Gutiérrez, Diana, Vecchio, Daniela, Wedervang-Resell, Kirsten, Wortinger, Laura Anne, Thompson, Paul M., Agartz, Ingrid

المصدر: 1359-4184.

الوصف: Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results remain inconclusive. Using harmonized data processing protocols and a mega-analytic approach, we compared white matter microstructure in EOP and healthy controls using diffusion tensor imaging (DTI). Our sample included 321 adolescents with EOP (median age = 16.6 years, interquartile range (IQR) = 2.14, 46.4% females) and 265 adolescent healthy controls (median age = 16.2 years, IQR = 2.43, 57.7% females) pooled from nine sites. All sites extracted mean fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) for 25 white matter regions of interest per participant. ComBat harmonization was performed for all DTI measures to adjust for scanner differences. Multiple linear regression models were fitted to investigate case-control differences and associations with clinical variables in regional DTI measures. We found widespread lower FA in EOP compared to healthy controls, with the largest effect sizes in the superior longitudinal fasciculus (Cohen’s d = 0.37), posterior corona radiata ( d = 0.32), and superior fronto‐occipital fasciculus ( d = 0.31). We also found widespread higher RD and more localized higher MD and AD. We detected significant effects of diagnostic subgroup, sex, and duration of illness, but not medication status. Using the largest EOP DTI sample to date, our findings suggest a profile of widespread white matter microstructure alterations in adolescents with EOP, most prominently in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.

العلاقة: SKGJ/SKGJ-MED-008; NFR/288083; HSØ/2017112; NFR/250358; HSØ/2022080; NFR/2137000; NFR/223273; Barth, Claudia Kelly, Sinead Nerland, Stener Jahanshad, Neda Alloza, Clara Ambrogi, Sonia Andreassen, Ole Andreou, Dimitrios Arango, Celso Baeza, Inmaculada Banaj, Nerisa Bearden, Carrie E. Berk, Michael Bohman, Hannes Castro-Fornieles, Josefina Chye, Yann Crespo-Facorro, Benedicto de la Serna, Elena Díaz-Caneja, Covadonga M. Gurholt, Tiril Pedersen Hegarty, Catherine E. James, Anthony Janssen, Joost Johannessen, Cecilie Haggag Jönsson, Erik Gunnar Karlsgodt, Katherine H. Kochunov, Peter Lois, Noemi G. Lundberg, Mathias Myhre, Anne Margrethe Pascual-Diaz, Saül Piras, Fabrizio Smelror, Runar Spalletta, Gianfranco Stokkan, Therese Sugranyes, Gisela Suo, Chao Thomopoulos, Sophia I. Tordesillas-Gutiérrez, Diana Vecchio, Daniela Wedervang-Resell, Kirsten Wortinger, Laura Anne Thompson, Paul M. Agartz, Ingrid . In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis. Molecular Psychiatry. 2022, 1-11; http://hdl.handle.net/10852/98512Test; 2097788; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular Psychiatry&rft.volume=&rft.spage=1&rft.date=2022; Molecular Psychiatry; 11; https://doi.org/10.1038/s41380-022-01901-3Test

الإتاحة: https://doi.org/10.1038/s41380-022-01901-3Test
http://hdl.handle.net/10852/98512Test

المؤلفون: van der Meer, Dennis, Gurholt, Tiril Pedersen, Sønderby, Ida Elken, Shadrin, Alexey, Hindley, Guy Frederick Lanyon, Rahman, Zillur, de Lange, Ann-Marie Glasø, Frei, Oleksandr, Leinhard, Olof D., Linge, Jennifer, Simon, Rozalyn, Beck, Dani, Westlye, Lars Tjelta, Halvorsen, Sigrun, Dale, Anders M, Karlsen, Tom Hemming, Kaufmann, Tobias, Andreassen, Ole

المصدر: 2399-3642.

الوصف: Obesity and associated morbidities, metabolic associated fatty liver disease (MAFLD) included, constitute some of the largest public health threats worldwide. Body composition and related risk factors are known to be heritable and identification of their genetic determinants may aid in the development of better prevention and treatment strategies. Recently, large-scale whole-body MRI data has become available, providing more specific measures of body composition than anthropometrics such as body mass index. Here, we aimed to elucidate the genetic architecture of body composition, by conducting genome-wide association studies (GWAS) of these MRI-derived measures. We ran both univariate and multivariate GWAS on fourteen MRI-derived measurements of adipose and muscle tissue distribution, derived from scans from 33,588 White European UK Biobank participants (mean age of 64.5 years, 51.4% female). Through multivariate analysis, we discovered 100 loci with distributed effects across the body composition measures and 241 significant genes primarily involved in immune system functioning. Liver fat stood out, with a highly discoverable and oligogenic architecture and the strongest genetic associations. Comparison with 21 common cardiometabolic traits revealed both shared and specific genetic influences, with higher mean heritability for the MRI measures (h 2 = .25 vs. .13, p = 1.8x10 −7 ). We found substantial genetic correlations between the body composition measures and a range of cardiometabolic diseases, with the strongest correlation between liver fat and type 2 diabetes (r g = .49, p = 2.7x10 −22 ). These findings show that MRI-derived body composition measures complement conventional body anthropometrics and other biomarkers of cardiometabolic health, highlighting the central role of liver fat, and improving our knowledge of the genetic architecture of body composition and related diseases.

العلاقة: SIGMA2/NS9666S; NIHE/R01GM104400; NFR/223273; NFR/213837; NFR/225989; EC/HEU/847776; NIHE/R01MH100351; HSØ/2017-004; NFR/204966; NFR/276082; SKGJ/SKGJ-MED-021; HSØ/2022-080; NFR/229129; NFR/298646; NFR/300767; NFR/248778; ERC/802998; NFR/249795; HSØ/2015-073; HSØ/2020-060; HSØ/2017-112; HSØ/2016-064; HSØ/2013-123; HSØ/2019-101; HSØ/2014-097; van der Meer, Dennis Gurholt, Tiril Pedersen Sønderby, Ida Elken Shadrin, Alexey Hindley, Guy Frederick Lanyon Rahman, Zillur de Lange, Ann-Marie Glasø Frei, Oleksandr Leinhard, Olof D. Linge, Jennifer Simon, Rozalyn Beck, Dani Westlye, Lars Tjelta Halvorsen, Sigrun Dale, Anders M Karlsen, Tom Hemming Kaufmann, Tobias Andreassen, Ole . The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition. Communications Biology. 2022, 5(1); http://hdl.handle.net/10852/98170Test; 2090051; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Communications Biology&rft.volume=5&rft.spage=&rft.date=2022; Communications Biology; https://doi.org/10.1038/s42003-022-04237-4Test

الإتاحة: https://doi.org/10.1038/s42003-022-04237-4Test
http://hdl.handle.net/10852/98170Test

المؤلفون: Schindler, Louise S., Subramaniapillai, Sivaniya, Barth, Claudia, van der Meer, Dennis, Pedersen, Mads Lund, Kaufmann, Tobias, Maximov, Ivan, Linge, Jennifer, Leinhard, Olof Dahlqvist, Beck, Dani, Gurholt, Tiril Pedersen, Voldsbekk, Irene, Suri, Sana, Ebmeier, Klaus P., Draganski, Bogdan, Andreassen, Ole, Westlye, Lars Tjelta, de Lange, Ann-Marie Glasø

المصدر: 2213-1582.

الوصف: The menopause transition involves changes in oestrogens and adipose tissue distribution, which may influence female brain health post-menopause. Although increased central fat accumulation is linked to risk of cardiometabolic diseases, adipose tissue also serves as the primary biosynthesis site of oestrogens post-menopause. It is unclear whether different types of adipose tissue play diverging roles in female brain health post-menopause, and whether this depends on lifetime oestrogen exposure, which can have lasting effects on the brain and body even after menopause. Using the UK Biobank sample, we investigated associations between brain characteristics and visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) in 10,251 post-menopausal females, and assessed whether the relationships varied depending on length of reproductive span (age at menarche to age at menopause). To parse the effects of common genetic variation, we computed polygenic scores for reproductive span. The results showed that higher VAT and ASAT were both associated with higher grey and white matter brain age, and greater white matter hyperintensity load. The associations varied positively with reproductive span, indicating more prominent associations between adipose tissue and brain measures in females with a longer reproductive span. The effects were in general small, but could not be fully explained by genetic variation or relevant confounders. Our findings indicate that associations between abdominal adipose tissue and brain health post-menopause may partly depend on individual differences in cumulative oestrogen exposure during reproductive years, emphasising the complexity of neural and endocrine ageing processes in females.

العلاقة: Schindler, Louise S. Subramaniapillai, Sivaniya Barth, Claudia van der Meer, Dennis Pedersen, Mads Lund Kaufmann, Tobias Maximov, Ivan Linge, Jennifer Leinhard, Olof Dahlqvist Beck, Dani Gurholt, Tiril Pedersen Voldsbekk, Irene Suri, Sana Ebmeier, Klaus P. Draganski, Bogdan Andreassen, Ole Westlye, Lars Tjelta de Lange, Ann-Marie Glasø . Associations between abdominal adipose tissue, reproductive span, and brain characteristics in post-menopausal women. NeuroImage: Clinical. 2022, 36; http://hdl.handle.net/10852/98071Test; 2077374; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NeuroImage: Clinical&rft.volume=36&rft.spage=&rft.date=2022; NeuroImage: Clinical; 36; https://doi.org/10.1016/j.nicl.2022.103239Test

الإتاحة: https://doi.org/10.1016/j.nicl.2022.103239Test
http://hdl.handle.net/10852/98071Test

المؤلفون: Bell, Christina, Tesli, Natalia, Gurholt, Tiril Pedersen, Rokicki, Jaroslav, Hjell, Gabriela, Fischer-Vieler, Thomas, Melle, Ingrid, Agartz, Ingrid, Andreassen, Ole, Ringen, Petter Andreas, Rasmussen, Kirsten, Dahl, Hilde, Friestad, Christine, Haukvik, Unn Kristin Hansen

المصدر: 0803-9488.

الوصف: Background Violence in psychosis has been linked to antisocial behavior and psychopathy traits. Psychopathy comprises aspects of interpersonal, affective, lifestyle, and antisocial traits which may be differently involved in violent offending by persons with psychotic disorders. We explored psychopathy subdomains among violent offenders with and without a psychotic disorder. Methods 46 males, with a history of severe violence, with (n = 26; age 35.85 ± 10.34 years) or without (n = 20; age 39.10 ± 11.63 years) a diagnosis of a psychotic disorder, were assessed with the Psychopathy Checklist-Revised (PCL-R). PCL-R was split into subdomains following the four-facet model. Group differences in total and subdomain scores were analyzed with a general linear model with covariates. Results Total PCL-R scores did not differ between the groups (p = 0.61, Cohen’s d = 0.17). The violent offenders without psychotic disorders had higher facet 2 scores than the patient group with psychotic disorders (p = 0.029, Cohen’s d = 0.77). Facet 1, 3, or 4 scores did not differ between the groups. Controlling for age did not alter the results. Conclusion Patients with a psychotic disorder and a history of severe violence have lower affective psychopathy scores than violent offenders without psychotic disorders. This observation may point toward distinct underlying mechanisms for violence and may provide a target for focused treatment and prevention.

العلاقة: Bell, Christina Tesli, Natalia Gurholt, Tiril Pedersen Rokicki, Jaroslav Hjell, Gabriela Fischer-Vieler, Thomas Melle, Ingrid Agartz, Ingrid Andreassen, Ole Ringen, Petter Andreas Rasmussen, Kirsten Dahl, Hilde Friestad, Christine Haukvik, Unn Kristin Hansen . Psychopathy subdomains in violent offenders with and without a psychotic disorder. Nordic Journal of Psychiatry. 2022; http://hdl.handle.net/10852/98037Test; 2069321; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nordic Journal of Psychiatry&rft.volume=&rft.spage=&rft.date=2022; Nordic Journal of Psychiatry; 10; https://doi.org/10.1080/08039488.2022.2128869Test

الإتاحة: https://doi.org/10.1080/08039488.2022.2128869Test
http://hdl.handle.net/10852/98037Test

المؤلفون: Winterton, Adriano, Bettella, Francesco, Beck, Dani, Gurholt, Tiril Pedersen, Steen, Nils Eiel, Rødevand, Linn Nilsen, Westlye, Lars Tjelta, Andreassen, Ole, Quintana, Daniel

المصدر: 0306-4530.

الوصف: Increasing evidence has shown adverse effects of loneliness on cardiometabolic health. The neuromodulator and hormone oxytocin has traditionally been linked with social cognition and behaviour. However, recent implications of the oxytocin system in energy metabolism and the overrepresentation of metabolic issues in psychiatric illness suggests that oxytocin may represent a mechanism bridging mental and somatic traits. To clarify the role of the oxytocin signalling system in the link between cardiometabolic risk factors and loneliness, we calculated the contribution of single nucleotide polymorphisms (SNPs) in the oxytocin signalling pathway gene-set (154 genes) to the polygenic architecture of loneliness and body mass index (BMI). We investigated the associations of these oxytocin signalling pathway polygenic scores with body composition measured using body magnetic resonance imaging (MRI), bone mineral density (BMD), haematological markers, and blood pressure in a sample of just under half a million adults from the UK Biobank (BMD subsample n = 274,457; body MRI subsample n = 9796). Our analysis revealed significant associations of the oxytocin signalling pathway polygenic score for BMI with abdominal subcutaneous fat tissue, HDL cholesterol, lipoprotein(a), triglycerides, and BMD. We also found an association between the oxytocin signalling pathway polygenic score for loneliness and apolipoprotein A1, the major protein component of HDL. Altogether, these results provide additional evidence for the oxytocin signalling pathway’s role in energy metabolism, lipid homoeostasis, and bone density, and support oxytocin’s complex pleiotropic effects.

العلاقة: http://urn.nb.no/URN:NBN:no-98545Test; Winterton, Adriano Bettella, Francesco Beck, Dani Gurholt, Tiril Pedersen Steen, Nils Eiel Rødevand, Linn Nilsen Westlye, Lars Tjelta Andreassen, Ole Quintana, Daniel . The oxytocin signalling gene pathway contributes to the association between loneliness and cardiometabolic health. Psychoneuroendocrinology. 2022; http://hdl.handle.net/10852/96039Test; 2043850; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychoneuroendocrinology&rft.volume=&rft.spage=&rft.date=2022; Psychoneuroendocrinology; 144; https://doi.org/10.1016/j.psyneuen.2022.105875Test; URN:NBN:no-98545; Fulltext https://www.duo.uio.no/bitstream/handle/10852/96039/1/The%2Boxytocin%2Bsignalling%2Bgene%2Bpathway%2Bcontributes%2Bto%2Bthe%2Bassociation%2Bbetween%2Bloneliness%2Band%2Bcardiometabolic%2Bhealth.pdfTest

الإتاحة: https://doi.org/10.1016/j.psyneuen.2022.105875Test
http://hdl.handle.net/10852/96039Test
http://urn.nb.no/URN:NBN:no-98545Test