المؤلفون: Borges, Eline Lima, Amorim, Gilmara Lopes, Miranda, Marina Barcelos de, Martins, Flaviano dos Santos, Guedes, Antônio Carlos Martins, Sampaio, Kinulpe Honorato, Spira, Josimare Aparecida Otoni, Barcelos, Lucíola da Silva

المصدر: Acta Cirúrgica Brasileira. January 2022 37(3)

مصطلحات موضوعية: Biofilms, Pseudomonas Infections, Wound Healing, Models, Animal

الوصف: Purpose: To evaluate a biofilm model of Pseudomonas aeruginosa in excisional cutaneous wound in mice. Methods: Preclinical, translational study conducted with 64 C57BL/6 mice randomly assigned to control and intervention groups. Evaluation was on days D0, D3, D5, D7 and D10 of wound making. The profile of biofilm formation and induction was evaluated using wound closure kinetics, quantitative culture, and evaluation of wounds using transmission electron microscopy (TEM). Clinical evaluation was performed by liver tissue culture, weight variation, and quantification of leukocytes in peripheral blood. Analyses were performed with GraphPad Prism software. Results: Bacterial load for induction of infection with P. aeruginosa and survival of animals was 104 UFC·mL-1. In D5 (p < 0.0001) and D7 (p < 0.01), animals in the intervention group showed a delay in the healing process and had their wounds covered by necrotic tissue until D10. Statistical differences were observed in wound cultures and weight at D5 and D7 (p < 0.01). Liver cultures and leukocyte quantification showed no statistical differences. No bacteria in planktonic or biofilm form were identified by TEM. Conclusions: The findings raise questions about the understanding of the ease of formation and high occurrence of biofilm in chronic wounds.

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المؤلفون: Araújo, Marcelo Grossi, Magalhães, Geraldo Magela, Garcia, Lucas Campos, Vieira, Érica Cristina, Carvalho-Leite, Maria de Lourdes Ribeiro de, Guedes, Antônio Carlos Martins

المصدر: Anais Brasileiros de Dermatologia. March 2021 96(2)

مصطلحات موضوعية: Papillomaviridae, Papillomavirus infections, Papillomavirus infections/diagnosis, Papillomavirus infections/drug therapy, Papillomavirus infections/pathology, Papillomavirus infections/prevention & control

الوصف: In this nonsystematic review, the complementary diagnosis, treatment, prevention, and control of human papillomavirus are discussed. The histopathology is addressed regarding its indications, main findings and limitations, as a complementary diagnostic method largely used by dermatologists. Electron microscopy is briefly reviewed, along with its contribution to the accumulated knowledge on HPV, as well as the relevance of research in using this technology for future advances in diagnosis and treatment. Molecular information about the virus is continuously increasing, and the practical applications of HPV serology, molecular identification and genotyping are discussed. Vaccines are a valuable tool in primary HPV infection prevention and are now available in many countries; their composition, indications, and adverse effects are revisited. Local and systemic treatment options are reviewed and off-label prescriptions are discussed. Finally, health education focusing on HPV infection as a sexually transmitted infection of worldwide relevance and the many barriers to improve primary and secondary prevention are addressed.

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المؤلفون: Magalhães, Geraldo Magela, Vieira, Érica Cristina, Garcia, Lucas Campos, De Carvalho-Leite, Maria de Lourdes Ribeiro, Guedes, Antônio Carlos Martins, Araújo, Marcelo Grossi

المصدر: Anais Brasileiros de Dermatologia. February 2021 96(1)

مصطلحات موضوعية: Papillomaviridae, Tumor virus infections, Tumor virus infections/complications, Tumor virus infections/diagnosis, Tumor virus infections/epidemiology

الوصف: Infection with human papilloma virus (HPV) is related to a great number of cutaneous and mucosal manifestations. The spectrum of HPV ranges from inapparent infections, through various clinical benign presentations including cutaneous and mucosal disease, to malignant and premalignant conditions. New HPV types are currently described in the literature; many of them are characterized as high-risk types due to their oncogenic potential. Knowledge regarding their epidemiology and pathogenesis is important to understand not only infection and disease processes, but also to formulate the clinical and laboratory basis for diagnosis, therapeutics, and prophylactic measures. This non-systematic review aims to discuss and to update those aspects, with an emphasis on relevant topics for dermatologists. HPV infection and related diseases in the Brazilian scenario are highlighted, including common dermatologic conditions seen at clinics as well as the condition of a public health problem as a sexually transmitted infection. The oncogenicity of the virus and the variety of clinical outcomes - especially in the immunocompromised individuals - are addressed.

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المؤلفون: Mendes, Ana Luisa Gomes, Joaquim, Heloísa Di Matteo, Zamae, Mara Inês Stefanini, Assis, Ramon Meira, Peixoto, Jéssica Renata de Moura, de Araújo, Margarida Maria Gomes, Guedes, Antônio Carlos Martins, Oliveira, Edward José, Magalhães, Vanessa Peruhype, Pascoal-Xavier, Marcelo Antônio

المصدر: Memórias do Instituto Oswaldo Cruz. January 2020 115

مصطلحات موضوعية: leprosy, inflammasome, NLRP3, caspase

الوصف: BACKGROUND Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host inflammatory and immune responses. More recently, the inflammasome has assumed a relevant role in the inflammatory response against microbiological agents. However, the involvement of inflammasome in leprosy remains poorly understood. OBJECTIVES The aim is to associate biomarkers of inflammasome with the different immunopathological forms of leprosy. METHODS We performed an observational, cross-sectional, and comparative study of the immunophenotypic expression of inflammasome-associated proteins in immunopathological forms of leprosy of 99 skin lesion samples by immunohistochemistry. The intensity and percentage of NLRP3, Caspase-1, Caspases-4/5, interleukin-1β and interleukin-18 immunoreactivities in the inflammatory infiltrate of skin biopsies were evaluated. FINDINGS Strong expression of NLRP3 and inflammatory Caspases-4/5 were observed in lepromatous leprosy (lepromatous pole). In addition, were observed low expression of caspase-1, interleukin-1β, and interleukin-18 in tuberculoid and lepromatous leprosy. The interpolar or borderline form showed immunophenotype predominantly similar to the lepromatous pole. MAIN CONCLUSIONS Our results demonstrate that the NLRP3 inflammasome is inactive in leprosy, suggesting immune evasion of M. leprae.

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المؤلفون: Spira, Josimare Aparecida Otoni, Borges, Eline Lima, Silva, Patrícia Aparecida Barbosa, Abreu, Mery Natali Silva, Guedes, Antônio Carlos Martins, Pires-Júnior, José Ferreira

المصدر: Revista Latino-Americana de Enfermagem. January 2018 26

مصطلحات موضوعية: Risk Factors, Protective Factors, Postoperative Period, Surgical Wound Dehiscence, Abdomen, Breast

الوصف: Objective: to identify factors associated with complex surgical wounds in the breasts and abdomen in outpatients. Method: observational case-control study involving 327 patients, distributed into 160 cases (complex surgical wound) and 167 controls (simple surgical wound). Data were extracted from the medical records and a binary logistic regression model was used for analysis, considering a significance level of 5%. Results: the factors associated with greater chance of occurrence of complex surgical wound were 18 to 59 years of age (p = 0.003), schooling < 8 years (p = 0.049), radiotherapy (p < 0.001), hysterectomy (p = 0.003), glycemia (≤ 99 mg/dL) and arterial hypertension (p = 0.033), while quadrantectomy (p = 0.025) served as a protective factor. Conclusion: radiotherapy was the most significant factor for surgical wound complications. Glycemic alteration was an unexpected result and shows the need for further studies related to this topic.

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المؤلفون: Baeta, Isabela Guimarães Ribeiro, Pereira, Ana Carolina Figueiredo, Guedes, Antônio Carlos Martins, Pereira, Luciana Baptista

المصدر: Anais Brasileiros de Dermatologia. June 2011 86(3)

مصطلحات موضوعية: Ceratodermia palmar e plantar, Ceratose, Ictiose

الوصف: A síndrome KLICK é uma genodermatose rara, autossômica recessiva, caracterizada pela associação de queratodermia palmo-plantar difusa e transgressiva, com esclerodactilia, placas hiperqueratóticas lineares localizadas preferencialmente em flexuras e ictiose congênita. Não há alterações em fâneros ou mucosas, assim como sintomas sistêmicos associados. O tratamento consiste no uso de queratolíticos tópicos e retinóides orais

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المؤلفون: Brandão, Flávia Vieira, Silva, Cláudia Márcia Resende, Gontijo, Bernardo, Guedes, Antônio Carlos Martins

المصدر: Anais Brasileiros de Dermatologia. December 2009 84(6)

مصطلحات موضوعية: Fibroma, Hipertrofia gengival, Mutação, Pele, Pele/lesões

الوصف: Fibromatose hialina juvenil e hialinose sistêmica infantil são desordens autossômicas recessivas, raras da infância. À histologia, há depósito de material hialino na derme e subcutâneo. As características clínicas principais são: lesões pápulo-nodulares, hipertrofia gengival, contratura articular, lesões ósseas osteolíticas e retardo no crescimento. Mutações no mesmo gene foram identificadas nas duas condições, sugerindo que sejam espectros da mesma doença.

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المؤلفون: Zanuncio, Virginia Vinha, Carvalho, Luciana Rabelo de, Guedes, Antônio Carlos Martins, Silva, Cláudia Márcia Resende, Gontijo, Bernardo

المصدر: Anais Brasileiros de Dermatologia. December 2013 88(6)

مصطلحات موضوعية: Histiocytosis, Langerhans-cell, Immunohistochemistry, Prognosis

الوصف: Langerhans cell histiocytosis is a rare, clinically heterogeneous desease. Since there is considerable clinical overlap among the four described variants (Hand-Schüller-Christian, eosinophilic granuloma, Letterer-Siwe and Hashimoto-Pritzker), the concept of spectral disease applies to this entity. The Hashimoto-Pritzker variant was first described in 1973. Characteristically, it is present at birth or during the first days of life, impairment is limited to the skin and prognosis is favorable with spontaneous resolution. We report a newborn male patient with Hashimoto-Pritzker disease presenting as a S100 + and CD1a + single congenital perianal lesion with rapid involution in two months.

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المؤلفون: Nobre, Vandack, Guedes, Antônio Carlos Martins, Proietti, Fernando Augusto, Stanciolli, Edel, Martins, Marina Lobato, Serufo, José Carlos, Antunes, Carlos Maurício, Grossi, Maria Aparecida, Lambertucci, José Roberto

المصدر: Revista da Sociedade Brasileira de Medicina Tropical. February 2005 38(1)

مصطلحات موضوعية: HTLV-1, Retrovírus, ATLL, HAM/TSP, Lesões dermatológicas, Pele

الوصف: O vírus linfotrópico humano de células T do tipo 1 (HTLV-1) é o primeiro retrovírus isolado do ser humano. Descreveu-se, em pouco tempo, o seu papel etiológico em algumas doenças, com destaque para a leucemia/linfoma de células T do adulto (ATLL), a mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP) e a uveíte associada ao HTLV-1 (HAU). Na década de 90, o HTLV-1 foi associado a eczema grave da infância, conhecido como dermatite infecciosa (DI). Desde então, diversos outros tipos de lesões cutâneas têm sido observados em pacientes infectados pelo HTLV-1, em especial, nos doentes de HAM/TSP ou de ATLL. Porém, mesmo portadores assintomáticos do vírus apresentam doenças dermatológicas. Excetuando-se a dermatite infecciosa, não há lesão da pele específica da infecção pelo HTLV-1. Aqui, os autores apresentam as principais lesões dermatológicas descritas em pacientes infectados pelo HTLV-1, destacando o valor epidemiológico e clínico desses achados.

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المؤلفون: Rocha, Vanessa Barreto, Carvalho, Saôny Victor de, Araújo, Marcelo Grossi, Guedes, Antônio Carlos Martins

المصدر: Anais Brasileiros de Dermatologia. June 2003 78(3)

مصطلحات موضوعية: diagnóstico, diagnóstico diferencial, hanseníase, linfoma não Hodgkin

الوصف: Os autores relatam caso de linfoma não Hodgkin em paciente do sexo feminino, de 28 anos, ressaltando o diagnóstico diferencial com formas multibacilares de hanseníase. Além de achados clínicos passíveis de confusão, a histologia mostrava, de modo não usual, infiltrado inflamatório mononuclear perineural e perianexial.

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