المؤلفون: Guddeti, Rohith Kumar, Pacharla, Himavani, Yellapu, Nanda Kumar, Karyala, Prashanthi, Pakala, Suresh B.

المصدر: Medical Oncology ; volume 40, issue 3 ; ISSN 1559-131X

مصطلحات موضوعية: Cancer Research, Oncology, Hematology, General Medicine

الإتاحة: https://doi.org/10.1007/s12032-023-01974-2Test

المؤلفون: Guddeti, Rohith Kumar, Thomas, Liz, Kannan, Anbarasu, Karyala, Prashanthi, Pakala, Suresh B.

المساهمون: Nebreda, Angel

المصدر: FEBS Letters ; volume 595, issue 9, page 1289-1302 ; ISSN 0014-5793 1873-3468

الوصف: Microrchidia family CW‐type zinc finger 2 (MORC2) is a recently identified chromatin modifier with an emerging role in cancer metastasis. However, its role in glucose metabolism, a hallmark of malignancy, remains to be explored. We found that MORC2 is a glucose‐inducible gene and a target of c‐Myc. Our meta‐analysis revealed that MORC2 expression is positively correlated with the expression of enzymes involved in glucose metabolism in breast cancer patients. Furthermore, overexpression of MORC2 in MCF‐7 and BT‐549 cells augmented the expression and activity of a key glucose metabolism enzyme, lactate dehydrogenase A (LDHA). Conversely, selective knockdown of MORC2 by siRNA markedly decreased LDHA expression and activity and in turn reduced cancer cell migration. Collectively, these findings provide evidence that MORC2, a glucose‐inducible gene, modulates the migration of breast cancer cells through the MORC2–c‐Myc–LDHA axis.

الإتاحة: https://doi.org/10.1002/1873-3468.14062Test

المؤلفون: Guddeti, Rohith Kumar, Chutani, Namita, Pakala, Suresh B.

المصدر: Biophysical Reviews ; volume 13, issue 4, page 507-514 ; ISSN 1867-2450 1867-2469

مصطلحات موضوعية: Molecular Biology, Structural Biology, Biophysics

الإتاحة: https://doi.org/10.1007/s12551-021-00812-xTest

المؤلفون: Guddeti, Rohith Kumar, Bali, Prerna, Karyala, Prashanthi, Pakala, Suresh B.

المساهمون: Indian Institute of Science Education and Research (IISER) Tirupati, SERB, New Delhi, University of Sydney, Australia, IISER Tirupati

المصدر: Biochemical and Biophysical Research Communications ; volume 520, issue 1, page 54-59 ; ISSN 0006-291X

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry, Biophysics

الإتاحة: https://doi.org/10.1016/j.bbrc.2019.09.078Test
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