المؤلفون: Guanhua Fang, Heng Lu, Liangwan Chen, Qingsong Wu, Yue Shen, Yunnan Hu, Zhihuang Qiu

المصدر: Annals of Thoracic and Cardiovascular Surgery. 2024, 30(1)00131

المؤلفون: Xiaofang Cai, Jiana Chen, Maohua Chen, Xiaotong Xia, Guanhua Fang, Jinhua Zhang

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: thrombus, dose calculator, warfain, INR, TTR, bleeding, Therapeutics. Pharmacology, RM1-950

الوصف: Background: Warfarin has a narrow therapeutic window and individual variation, and patients require regular follow-up and monitoring of the International Normalized Ratio (INR) for dose adjustment. The calculation method of Warfarin Dosing Calculator (WDC) software is based on the European and American populations, and its accuracy in the Chinese population is yet to be verified.Objective: This study was to evaluate the feasibility of applying Warfarin Dosing Calculator software intervention in a real-world clinical research setting in China.Methods: The pilot study divided the included patients after valve replacement into an experimental group and a control group, with 38 cases in each group. In the control group, the initial dose was fixed at 2.5 mg/d and the dose was adjusted empirically during the study period; in the experimental group, the Warfarin Dosing Calculator software was applied to guide the dosing, and patients in both groups were followed up for 3 months. Analysis of the incidence anticoagulation outcomes and excessive anticoagulation events in both groups. Kaplan-Meier survival curves were used to analyze the correlation between different dosing regimens and first International Normalized Ratio attainment, and Logrank tests were performed.Results: The mean time required for first International Normalized Ratio compliance in the experimental group was 4.38 days less than in the control group, and the mean number of tests was 1.43 less (p < 05). Time in therapeutic range (TTR) was significantly higher in the experimental group than in the control group (p < 05). Kaplan-Meier survival curve analysis showed that the first International Normalized Ratio attainment rate was significantly higher in the experimental group than in the control group (p = 01). No major bleeding events occurred in either group, but other excessive anticoagulation events (INR>3.5 and minor bleeding) were significantly reduced in the experimental group compared with the control group (p < 05).Conclusion: Application of Warfarin Dosing Calculator software to guide individualized warfarin dosing may be better than a fixed dose of 2.5 mg/d. It may be shorten the time to first International Normalized Ratio attainment, and the attainment rate in the same time, and can better improve the mean Time in therapeutic range level value and reduce excessive anticoagulation events, which improves the safety of warfarin anticoagulation therapy in clinical practice.Clinical Trial Registration:https://www.chictr.org.cn/showproj.html?proj=52793Test, ChiCTR2000032393.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2023.1235331/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/f1656711aa434fcca3b11d6a43c0ff2eTest

المؤلفون: Ting Lei, Lei-Lai Shao, Yu-Qing Zheng, Gregory Pitner, Guanhua Fang, Chenxin Zhu, Sicheng Li, Ray Beausoleil, H.-S. Philip Wong, Tsung-Ching Huang, Kwang-Ting Cheng, Zhenan Bao

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: Science

الوصف: Carbon nanotube thin-film transistor is promising for solution-processed, large-scale flexible electronics, but the device yields remain poor to date. Lei et al. show low-voltage flexible digital and analog circuits based on high-purity and high-yield separation of semiconducting carbon nanotubes.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/23d00df723b1411fb85bb4ffeb728362Test

المؤلفون: Guanhua Fang, Heng Lu, Liangwan Chen, Qingsong Wu, Yue Shen, Yunnan Hu, Zhihuang Qiu

المصدر: Annals of Thoracic and Cardiovascular Surgery. 00131

المؤلفون: Guanhua Fang, Yanming Shen, Dongshan Liao

المصدر: Cell Stress and Chaperones. 28:253-263

مصطلحات موضوعية: Cell Biology, Biochemistry

الوصف: This study aimed to elucidate the molecular mechanisms of hypoxia/reoxygenation (H/R) injury in human cardiac microvascular endothelial cells (HCMECs) by regulating ferroptosis. H/R model was established with HCMECs and before the reperfusion, ferroptosis inhibitor ferrostatin-1 or ferroptosis inducer erastin was all administered. Wound-healing assay was performed to detect the migration ability of cells in each group, and the angiogenesis ability was determined by tube formation assay. The level of reactive oxygen species (ROS) was detected by flow cytometry. Transmission electron microscopy (TEM) was used to observe the state of mitochondria. The expressions of related proteins in HCMECs were assessed by Western blot. From the results, H/R injury could inhibit the migration and angiogenesis, induce the ROS production, and cause the mitochondrial damage of HCMECs. Ferroptosis activator erastin could aggravate H/R injury in HCMECs, while the ferroptosis inhibitor ferrostatin-1 could reverse the effects of H/R on HCMECs. Western blot results showed that H/R or/and erastin treatment could significantly induce ACSL4, HGF, VEGF, p-ERK, and uPA protein expression and inhibit GPX4 expression. The addition of ferrostatin-1 resulted in the opposite trend of the proteins expression above to erastin treatment. What is more, overexpression of ENPP2 markedly suppressed the damaging effect of H/R on HCMECs and reversed the effects of H/R or erastin treatment on the expression of related proteins. These results demonstrated a great therapeutic efficacy of ENPP2 overexpression in preventing the development of H/R injury through inhibiting oxidative stress and ferroptosis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b08a6408ce1e574bc5e61b9d446cfba0Test
https://doi.org/10.1007/s12192-023-01324-1Test

المؤلفون: Liangwan Chen, Zhihuang Qiu, Yunnan Hu, Yue Shen, Guanhua Fang, Heng Lu, Qingsong Wu

المصدر: Annals of Thoracic & Cardiovascular Surgery; 2024, Vol. 30 Issue 1, p1-8, 8p

المؤلفون: Sujay Bhatt, Guanhua Fang, Ping Li, Gennady Samorodnitsky

المصدر: 2022 IEEE Information Theory Workshop (ITW).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::714ffa5f508e37e3687019f239c736f9Test
https://doi.org/10.1109/itw54588.2022.9965820Test

المؤلفون: Yunfeng Cai, Guanhua Fang, Ping Li

المصدر: 2022 IEEE International Symposium on Information Theory (ISIT).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::595c03b3ccdda94c3a337192e3e6b2c7Test
https://doi.org/10.1109/isit50566.2022.9834364Test

المؤلفون: Zhihuang Qiu, Guanhua Fang, Liang-Wan Chen, Jun-yi Chen

المصدر: The Annals of Thoracic Surgery. 111:e205-e207

مصطلحات موضوعية: Reoperation, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Fistula, Heart Diseases, Radiofrequency ablation, medicine.medical_treatment, 030204 cardiovascular system & hematology, law.invention, Esophageal Fistula, 03 medical and health sciences, Esophagus, 0302 clinical medicine, Posterior wall, Left atrial, law, Atrial Fibrillation, Cardiopulmonary bypass, Humans, Medicine, Heart Atria, cardiovascular diseases, Cardiac Surgical Procedures, business.industry, Surgery, medicine.anatomical_structure, Esophagus surgery, 030228 respiratory system, Median sternotomy, Catheter Ablation, cardiovascular system, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business

الوصف: Herein we described a novel repair approach for a left atrial esophageal fistula. Complete mediastinal debridement and simultaneous primary repairs of the left atrial posterior wall and the esophagus were completed under a median sternotomy, central cardiopulmonary bypass, left atrial circular incision around four pulmonary veins, inflamed left atrial posterior wall removal, and posterior pericardial opening.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad541ab9a228041ae21944349fbede1dTest
https://doi.org/10.1016/j.athoracsur.2020.07.091Test

المؤلفون: Haochen Xu, Guanhua Fang, Zhiliang Ying

المصدر: British Journal of Mathematical and Statistical Psychology. 73:474-505

مصطلحات موضوعية: Statistics and Probability, Topic model, Theoretical computer science, Process (engineering), Computer science, Bayesian probability, 01 natural sciences, 010104 statistics & probability, 0504 sociology, Arts and Humanities (miscellaneous), Cluster Analysis, Humans, Air Conditioning, Computer Simulation, 0101 mathematics, Cluster analysis, Hidden Markov model, Problem Solving, General Psychology, Structure (mathematical logic), Likelihood Functions, Models, Statistical, 05 social sciences, 050401 social sciences methods, Bayes Theorem, Numerical Analysis, Computer-Assisted, General Medicine, Markov Chains, Educational Measurement, State (computer science), Computational problem, Algorithms

الوصف: We propose a latent topic model with a Markov transition for process data, which consists of time-stamped events recorded in a log file. Such data are becoming more widely available in computer-based educational assessment with complex problem-solving items. The proposed model can be viewed as an extension of the hierarchical Bayesian topic model with a hidden Markov structure to accommodate the underlying evolution of an examinee's latent state. Using topic transition probabilities along with response times enables us to capture examinees' learning trajectories, making clustering/classification more efficient. A forward-backward variational expectation-maximization (FB-VEM) algorithm is developed to tackle the challenging computational problem. Useful theoretical properties are established under certain asymptotic regimes. The proposed method is applied to a complex problem-solving item in the 2012 version of the Programme for International Student Assessment (PISA).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44efb249f58be2271f6c947e615f1fbTest
https://doi.org/10.1111/bmsp.12197Test