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1مؤتمر
المؤلفون: Priou, Sonia, Lamé, Guillaume, Flicoteaux, R., Guével, E., Chatellier, G., Tournigand, Christophe, Kempf, Emmanuelle
المساهمون: Laboratoire Génie Industriel (LGI), CentraleSupélec-Université Paris-Saclay
المصدر: Revue d'Épidémiologie et de Santé Publique ; Congrès national Emois 2023 ; https://hal.science/hal-04013109Test ; Congrès national Emois 2023, Mar 2023, Nancy, France. pp.101464, ⟨10.1016/j.respe.2023.101464⟩
مصطلحات موضوعية: Cancer, COVID-19, EDS, TAL, Analyse de survie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
الوصف: International audience ; IntroductionL'impact de la pandémie de COVID-19 sur le retard de prise en charge des cancers est débattue. Nous étudions l'intérêt des algorithmes de traitement automatique du langage (TAL) en plus des données médico-administratives (PMSI) dans le cancer du pancréas (CP).MéthodesNous avons identifié dans l'entrepôt de données de l'AP-HP les patients nouvellement adressés pour un CP entre 01/2019 et 12/2020. Nous avons analysé le PMSI, les données de mortalité extrahospitalières et les comptes rendus (CR) analysés par TAL. Différents jeux de données ont été annotés par un oncologue pour développer puis valider les algorithmes de TAL (sélection des CR et évaluation du contenu).RésultatsAu total, 1442 patients (736 en 2019 et 706 en 2020) sont suivis jusqu'en 02/2022. Le nombre de nouveaux patients a baissé de 24 % entre mars-mai 2019 et 2020. Les taux de patients traités par chirurgie, chimiothérapie ou soins palliatifs exclusifs étaient comparables en 2020 et 2019 (32 % versus 30 %, p=0,46; 49% versus 52 %, p=0,24; 19 % versus 18 %, p=0,57). Parmi les 1175 patients avec traitement actif, 70 % et 21 % ont un CR de concertation pluridisciplinaire (RCP) avant puis après le premier traitement, respectivement. Un CR scanner à baseline est trouvé pour 40 %. Parmi les 344 patients opérés sans traitement néoadjuvant, 95 % ont un CR d'anatomopathologie et 82 % un score pTNM. Les taux de pTNM péjoratif, pTxN1-2, (50 % versus 51 %, p=0,95), de stade métastatique (38 % versus 34 %, p=0,32) et le délai RCP-premier traitement (21 jours EIQ [12-40]) versus 21 jours EIQ [12-42], p=0,77) sont stables. Les taux de survie à 1 an des patients en 2019 ou 2020 sont comparables chez les patients opérés (92 % versus 92 %, p=0,99) ou traités par chimiothérapie exclusive (60 % versus 52 % p=0,04).Discussion/ConclusionGrâce à des méthodes de TAL, nous avons pu compléter le PMSI et montrer que le taux d'adressage des nouveaux patients pour CP a diminué sans impact sur leur stade tumoral ni sur le délai de prise en ...
العلاقة: hal-04013109; https://hal.science/hal-04013109Test
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2مؤتمر
المؤلفون: Guével, E., Priou, S., Lamé, Guillaume, Flicoteaux, R., Tournigand, Christophe, Chatellier, G., Kempf, E.
المساهمون: CentraleSupélec, Laboratoire Génie Industriel (LGI), CentraleSupélec-Université Paris-Saclay
المصدر: Revue d'Épidémiologie et de Santé Publique ; Congrès national Emois 2023 ; https://hal.science/hal-04013120Test ; Congrès national Emois 2023, Mar 2023, Nancy, France. pp.101468, ⟨10.1016/j.respe.2023.101468⟩
مصطلحات موضوعية: Cancer, EDS, TAL, Indicateurs de qualité et de sécurité des soins, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
الوصف: International audience ; IntroductionL'obtention des certifications qualité impose le recueil d'indicateurs de qualité et de sécurité des soins (IQSS) définis par des groupes d'experts. Notre objectif est de déterminer comment les algorithmes de traitement automatique des langues (TAL) peuvent complémenter les données médico-administratives (PMSI) pour automatiser le calcul des IQSS.MéthodesNous avons identifié dans l'entrepôt de données de santé de l'AP-HP les patientes nouvellement adressées pour un cancer du sein entre 01/2019 et 06/2021. Le PMSI et les comptes-rendus (CR) ont été identifiés en vue du calcul des IQSS publiés par l'Institut national du cancer (INCa) et l’« European Society of Breast Cancer Specialist » (EUSOMA). Différents jeux de données ont été annotés par un oncologue pour développer et valider des algorithmes de TAL basés sur des règles et concernant: le stade pTNM post-opératoire des tumeurs réséquées et le stade métastatique au bilan d'extension initial à partir des CR de pet-scanner (examen de référence dans cette indication).RésultatsDes 5807 patientes (60,9 ans IQR [50,0-71,9]) suivies jusqu'en 02/2022, 5452 (93,9 %) ont des actes thérapeutiques liés au cancer du sein dans le PMSI dont 3787 (65,2 %) ont au moins une chirurgie, 4991 (85,9 %) ont des CR d'anatomopathologie (CRA) et 4349 (78,1 %) ont des CR de réunions de concertation pluridisciplinaire (RCP). Le score pTNM post-opératoire et le stade métastatique ont pu être extraits pour 2139 et 811 patientes, respectivement. Des 14 IQSS de l'INCa calculés avec les données PMSI seules, 5 concernent des soins possiblement ambulatoires et pourraient être extraites par TAL à partir de CR de RCP. Des 34 IQSS de l'EUSOMA, 11 sont calculables avec les données médico-administratives seules, 7 le deviennent en utilisant les codes ADICAP, les données immunohistochimiques, le stade et la taille de la tumeur, et 3 avec les dates de diagnostic et de traitements (analyse des CR RCP).Discussion/ConclusionLe TAL permet d'augmenter le nombre ...
العلاقة: hal-04013120; https://hal.science/hal-04013120Test
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3مؤتمر
المؤلفون: Priou, Sonia, Guével, E., Lamé, Guillaume, Wassermann, J., Bey, R., Uzan, C., Chatellier, G., Belkacémi, Y., Tannier, X., Guillerm, S., Flicoteaux, R., Gligorov, J., Cohen, A., Benderra, M-A., Teixeira, L., Daniel, C., Tournigand, Christophe, Kempf, Emmanuelle
المساهمون: Laboratoire Génie Industriel (LGI), CentraleSupélec-Université Paris-Saclay, The AP-HP foundation and ARC Foundation for cancer research (grant reference COVID202001343).
المصدر: ESMO2023 ; https://hal.science/hal-04253192Test ; ESMO2023, Oct 2023, Madrid, Spain. Annals of Oncology, 34 (S2), pp.S376, 2023, ⟨10.1016/j.annonc.2023.09.639⟩
مصطلحات موضوعية: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
جغرافية الموضوع: Spain
الوقت: Madrid, Spain
الوصف: International audience ; BackgroundThe Sars Cov-2 pandemic and the national lockdowns disrupted healthcare systems in 2020. We assessed the impact on care pathways and clinical outcomes for new breast cancers (BCs) in Paris area.MethodsWe performed a retrospective multicenter cohort study on the data warehouse of Greater Paris University Hospitals (APHP). We identified pts newly referred with BC between Jan 2019, and Dec 2020. We assessed the delays of care management, the initial tumor stage from pathology and baseline PET/CT and CT-scan reports, and the trt categories: breast surgery, exclusive systemic therapy, exclusive radiation therapy, or exclusive best supportive care (BSC). We calculated pts’ 1-year overall survival (OS) and compared indicators for 2019 and 2020.ResultsIn 2019 and 2020, 2,303 and 2,258 patients were newly referred with a BC diag among whom 2,055 and 1,988 female patients underwent a BC treatment, respectively. During the 1st and the 2nd lockdowns, the number of BC diag varied by -18% and by +23% compared to the same periods of 2019. Between 2019 and 2020, the rate of de novo metastatic disease (respectively 15% and 15%, p=0.95) did not differ, neither did the pTNM and the ypTNM distributions (p=0.37 and p=0.31). The time from 1st multidisciplinary meeting to trt did not differ (p=0.23). Pts’ access to reconstructive surgery (15% and 17%, p=0.08) and distribution across trt categories did not vary: tumor resection (73% and 72%), exclusive systemic trt (13% and 14%), exclusive radiation trt (9% and 9%), and exclusive BSC (5% and 5%) (p=0.8), respectively. Age-based subgroup analyses yielded to similar results (p=0,95). The rate of neoadjuvant trt for resected pts was lower in 2019 (16%) compared to 2020 (20%) (p=0.02), especially in patients aged < 50 years (15% vs 21%, p=0,01), respectively. The 1-year OS rates in 2019 vs. 2020 were 99.3% vs. 98.9% (HR=0.96; 95% CI, 0.77-1.2), 72.6% vs. 76.6% (HR=1.28; 95% CI, 0.95-1.72), 96.6% vs. 97.8% (HR=1.09; 95% CI, 0.61-1.94), and 15.5% vs. ...
العلاقة: hal-04253192; https://hal.science/hal-04253192Test
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4مؤتمر
المؤلفون: Marty, S., Lamé, Guillaume, Guével, E., Priou, Sonia, Chatellier, G., Tournigand, Christophe, Kempf, Emmanuelle
المساهمون: Laboratoire Génie Industriel (LGI), CentraleSupélec-Université Paris-Saclay
المصدر: Annals of Oncology ; ESMO 2023 ; https://hal.science/hal-04253195Test ; ESMO 2023, Oct 2023, Madrid, Spain. pp.S925, ⟨10.1016/j.annonc.2023.09.2644⟩
مصطلحات موضوعية: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
جغرافية الموضوع: Spain
الوقت: Madrid, Spain
الوصف: International audience ; BackgroundSars Cov-2-related disruptions to health services might have impaired the initial clinical presentation of new solid tumor patients. The aim of this systematic review was to compare the initial tumor stage of solid cancer diagnoses before and after the Sars Cov-2 outbreak.MethodsFollowing PRISMA and MOOSE guidelines, we systematically reviewed articles in MEDLINE and EMBASE on the tumor stage of new solid cancer diagnoses before and after the initial Sars Cov-2 pandemic waves. A random-effects meta-analysis was conducted to compare the rate of metastatic tumors at initial presentation. Subgroup analyses were performed per primary tumor site, and per study country. Interstudy heterogeneity and subgroup differences were assessed with I2 and X2 tests, respectively.ResultsFrom 2,013 studies published between January 2020 and April 2022, we included 58 studies including 109,996 patients. The rate of metastatic tumors was higher after than before the pandemic (OR: 1.29 (95% confidence interval (95%CI), 1.06-1.57) with a I2 of 89% (95%CI, 86%-91%). OR (95%CI) were 1,51 (1.07-2,12) for breast cancers, 1.51 (1.04-2.18) for gynecologic cancers, 0.79 (0.18-3.52) for lung cancers, 1.15 (0.89-1.49) for colorectal cancers, 1.45 (0.62-3.42) for other digestive cancer, 2.26 (0.51-10,05) for prostate cancer, 12.07 (0.57-253,68) for genitourinary cancers and 1.01 (0.59-1.75) for other types of cancer (X2 = 24,60, p<0.01). Only 2 countries out of 17 studied showed a significantly higher rate of metastasis after the pandemic: Italy (OR (95%CI) = 1.55 (1.01-2.39)) and Spain (1.14 (1.02-1.29)) Conversely, Taiwan and Canada showed a significantly lower rate of metastasis after the pandemic: OR (95%CI): 0,51 (0,28-0,93) and 0,14 (0,07-0,29).ConclusionsDespite inter-study heterogeneity, our meta-analysis showed a higher rate of metastatic tumors at initial presentation after the Sars Cov2 outbreak. The burden of social distancing policies might explain those results, as patients may have delayed ...
العلاقة: hal-04253195; https://hal.science/hal-04253195Test
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5دورية أكاديمية
المؤلفون: PARLAKYILDIZ, FATMA, GÜVEL, E. ALPER
المصدر: Volume: 8, Issue: 4 29-39 ; 1308-4208 ; 1308-4216 ; Niğde Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi
مصطلحات موضوعية: Fikrî Mülkiyet Hakları,AR-GE Yatırımları,Ekonomik Büyüme
الوصف: factor that affects the countries technological development, after than international trade relations, investment decisions and finally economic growth. In this study, first of all Intellectual Property Rights’s historical development, definition, connection with economic growth and importance of maintaining this rights economically are given. Later, related literature about Intellectual Property Rights protection investigated.The result obtained from the related literature is that Intellectual Property Rights protection has both positive and negative effect on R&D investment and economic growth ; Yaratıcı çaba sonucunda oluşan her türlü gayri maddi varlık şeklinde tanımlanan Fikri Mülkiyet; ülkelerin öncelikle teknolojik ilerlemelerini, sonrasında uluslararası ticari ilişkilerini, yatırım kararlarını ve tüm bunların sonucu olarak da ekonomik büyümelerini etkileyen önemli bir unsurdur. Bu çalışmada öncelikle Fikri Mülkiyet Hakları’nın tarihsel gelişimi, tanımı, ekonomik büyüme ile ilişkisi ve bu hakları korumanın ekonomik önemi belirtilmiştir. Sonrasında Fikri Mülkiyet Hakları korumasına ilişkin literatür araştırılmıştır. Konuya ilişkin literatürden elde edilen sonuç, Fikrî Mülkiyet Hakları korumasının AR-GE yatırımları ve ekonomik büyüme üzerinde hem olumlu hem olumsuz etkilerinin olduğu yönündedir.
وصف الملف: application/pdf
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6دورية أكاديمية
المؤلفون: Guével, E., Madani, R., Conso, F., Causse, E., Choudat, D.
المصدر: Archives des Maladies Professionnelles et de l'Environnement ; volume 65, issue 5, page 438-441 ; ISSN 1775-8785
مصطلحات موضوعية: Public Health, Environmental and Occupational Health
الإتاحة: https://doi.org/10.1016/s1775-8785Test(04)93484-4
https://api.elsevier.com/content/article/PII:S1775878504934844?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1775878504934844?httpAccept=text/plainTest -
7دورية أكاديمية
المؤلفون: Terrier, F., Le Guével, E., Chatrousse, A. P., Moutiers, G., Buncel, E.
المصدر: Chemical Communications ; issue 5, page 600-601 ; ISSN 1359-7345 1364-548X
الإتاحة: https://doi.org/10.1039/b212160nTest
http://pubs.rsc.org/en/content/articlepdf/2003/CC/B212160NTest -
8دورية
المؤلفون: Priou, S., Lamé, G., Flicoteaux, R., Guével, E., Chatellier, G., Tournigand, C., Kempf, E.
المصدر: Revue d Epidemiologie et de Sante Publique; March 2023, Vol. 71 Issue: 1, Number 1 Supplement 1
مستخلص: L'impact de la pandémie de COVID-19 sur le retard de prise en charge des cancers est débattue. Nous étudions l'intérêt des algorithmes de traitement automatique du langage (TAL) en plus des données médico-administratives (PMSI) dans le cancer du pancréas (CP).
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9رسالة جامعية
المؤلفون: Parlakyıldız, Fatma Merve
المساهمون: Güvel, E. Alper, Çukurova Üniversitesi, Sosyal Bilimler Enstitüsü, İktisat Anabilim Dalı
مصطلحات موضوعية: Fikri Mülkiyet Hakları, Teknolojik Yenilik, AR-GE Faaliyetleri, Ekonomik Büyüme, Intellectual Property Rights, Technological Innovation, R&D Activities, Economic Growth
الوصف: TEZ8412 ; Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2011. ; Kaynakça (s.119-126) var. ; xi, 127 s. ; 29 cm. ; At the last quarter of 20th century, 'globalization process' due to rapid development in the communication and transportation network gave rise an international character to capital, goods and services. At the same time, communication and information technologies have also developed. This rapid development form a concept called 'knowledge economy'. In the base of knowledge economy, there are technology intense products and R&D investments resulting in creative ideas. Nowadays, countries give importance to technological innovations and R&D activities for economic growth. Therefore, the importance of the intellectual property rights is the base of providing technological development by maintaining creative ideas in the knowlege economy. Through the globalization process, importance for maintaining the IPR has been increased. This is because intellectual property defining as all sorts of intangible property due to the product of creative effort, is the factor that affects the countries technological development and international trade relations. In this thesis, first of all IPR's historical development, definition, connection with economic growth and importance of maintaining this rights are given. Next, eceonometric analysis is done for implying this rights on G8 countries economic growth. As a result of eceonometric analysis, it is found that there is a positive relationship between IPR protection, economic growth and R&D investments for G8 countries. ; 20. yüzyılın son çeyreğinde iletişim ve ulaşım ağındaki hızlı gelişmelerle oluşan 'küreselleşme süreci' sermayenin, mal ve hizmetlerin uluslararası bir nitelik kazanmasına neden olmuştur. Bu süreçte iletişim ve bilgi teknolojileri de çok hızlı gelişmiştir. İletişim ve bilgi teknolojilerindeki hızlı gelişmeler beraberinde 'bilgi ekonomisi' kavramını oluşturmuştur. Bilgi ekonomisinin temelinde iseyaratıcı fikirlerin bir sonucu olan ...
العلاقة: Tez; Parlakyıldız, Fatma Merve. (2011). Fikri mülkiyet haklarının ekonomik büyümeye etkileri : G8 ülkeleri üzerine bir uygulama. (Yayınlanmamış yüksek lisans tezi). Çukurova Üniversitesi, Sosyal Bilimler Enstitüsü, İktisat Anabilim Dalı, Adana.; http://library.cu.edu.tr/tezler/8412.pdfTest; https://hdl.handle.net/20.500.12605/29600Test
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10رسالة جامعية
المؤلفون: Koç, Aylin
المساهمون: Güvel, E. Alper, Çukurova Üniversitesi, Sosyal Bilimler Enstitüsü, İktisat Anabilim Dalı
مصطلحات موضوعية: Public Deficit, Developing Countries, Economic and Social Factors, Political Factors, Cross-Section Analysis, Kamu Açığı, Gelişmekte Olan Ülkeler, Ekonomik ve Sosyal Faktörler, Politik Faktörler, Yatay Kesit Analizi
الوصف: TEZ7801 ; Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2009. ; Kaynakça (s. 191-205) var. ; xi, 206 s. : res. ; 29 cm. ; Nowadays, public deficit is one of the most important macroeconomic problems encounted in both developed and developing countries. Deficit has becomes a chronic problem in developing countries specially in early beginnig of 1970. After middle of 1980, in spite of substantial progress obtained with fiscal reforms, many developing countries faced with the large recurrent budget deficits. Economic literature on the explanation of public deficits has been focusing on two main issues. On one hand, the accumulation of public debts in recent decades and, on the other hand, the large observed cross-countries differences on public deficits and debt. Conventional economic arguments alone are not sufficient to explain this behavior. Therefore, recent political economy literature emphasizes the role of political and institutional factors in the explanation of the fiscal policy and, in particular, of the budget balances behavior. Literature on fiscal politics has developed theories to explain how political and institutional factors determine fiscal outcomes and has provided supporting empirical evidence. However, the existing empirical studies are mostly on OECD countries. The purpose of this study to investigate effects of political and institutional factors on budget deficit in developing countries. And in this paper, an empirical study for 33 developing countries included Turkey using cross-section is given. According to estimated results, such as opennes, economic growth rate and per capita income level as well as economic factors there is significant statistical relationship between budget deficit and economic freedom level, rule of law, burden of government regulation, wastefulness of government spending and political stability. The empirical analysis conducted in this study shows that the budget deficits stem from the various economic and political decisions and accordingly the political factors ...
العلاقة: Tez; Koç, Aylin. (2009). Kamu açıklarının ekonomik, politik ve sosyal belirleyicileri: gelişmekte olan ülkeler üzerine bir uygulama. (Yayınlanmamış doktora tezi). Çukurova Üniversitesi, Sosyal Bilimler Enstitüsü, İktisat Anabilim Dalı, Adana.; http://library.cu.edu.tr/tezler/7801.pdfTest; https://hdl.handle.net/20.500.12605/33530Test
