المؤلفون: Maier, A., Toner, Y.C., Munitz, J., Sullivan, N.A.T., Sakurai, K., Meerwaldt, A.E., Brechbühl, E.E.S., Prévot, G., Elsas, Y. van, Maas, R.J.F., Ranzenigo, A., Soultanidis, G., Rashidian, M., Pérez-Medina, C., Heo, G.S., Gropler, R.J., Liu, Y, Reiner, T., Nahrendorf, M., Swirski, F.K., Strijkers, G.J., Teunissen, A.J.P., Calcagno, C., Fayad, Z.A., Mulder, W.J.M., Leent, M.M.T. van

المصدر: JACC-Basic to Translational Science, 8, 7, pp. 801-816

مصطلحات موضوعية: All institutes and research themes of the Radboud University Medical Center, Radboudumc 19: Nanomedicine RIMLS: Radboud Institute for Molecular Life Sciences

الوصف: Contains fulltext : 295921.pdf (Publisher’s version ) (Open Access) ; In the past 2 decades, research on atherosclerotic cardiovascular disease has uncovered inflammation to be a key driver of the pathophysiological process. A pressing need therefore exists to quantitatively and longitudinally probe inflammation, in preclinical models and in cardiovascular disease patients, ideally using non-invasive methods and at multiple levels. Here, we developed and employed in vivo multiparametric imaging approaches to investigate the immune response following myocardial infarction. The myocardial infarction models encompassed either transient or permanent left anterior descending coronary artery occlusion in C57BL/6 and Apoe(-/-)mice. We performed nanotracer-based fluorine magnetic resonance imaging and positron emission tomography (PET) imaging using a CD11b-specific nanobody and a C-C motif chemokine receptor 2-binding probe. We found that immune cell influx in the infarct was more pronounced in the permanent occlusion model. Further, using (18)F-fluorothymidine and (18)F-fluorodeoxyglucose PET, we detected increased hematopoietic activity after myocardial infarction, with no difference between the models. Finally, we observed persistent systemic inflammation and exacerbated atherosclerosis in Apoe(-/-) mice, regardless of which infarction model was used. Taken together, we showed the strengths and capabilities of multiparametric imaging in detecting inflammatory activity in cardiovascular disease, which augments the development of clinical readouts. ; 01 juli 2023

العلاقة: https://repository.ubn.ru.nl//bitstream/handle/2066/295921/295921.pdfTest; https://repository.ubn.ru.nl/handle/2066/295921Test

الإتاحة: https://doi.org/10.1016/j.jacbts.2022.12.014Test
https://repository.ubn.ru.nl//bitstream/handle/2066/295921/295921.pdfTest
https://repository.ubn.ru.nl/handle/2066/295921Test

المؤلفون: Fernandez-Mayola, M., Hess, A., Willmann, M., Diekmann, J., Ross, T.L., Gropler, R.J., Bengel, F.M., Liu, Y., Thackeray, J.T.

المصدر: 60. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin ; Nuklearmedizin - NuclearMedicine ; ISSN 2567-6407

الإتاحة: https://doi.org/10.1055/s-0042-1745991Test

المؤلفون: Gropler, R.J., Nagueh, S., Arbab-Zadeh, A., Barasch, E., Cademartiri, F., Delgado, V., Hoit, B., Kusunose, K., Nahrendorf, M., Sinusas, A., Reichek, N., Circulation Cardiovasc Imaging

المصدر: Circulation: Cardiovascular Imaging

الوصف: Cardiology

العلاقة: lumc-id: 177699097; https://hdl.handle.net/1887/3567801Test

الإتاحة: https://doi.org/10.1161/CIRCIMAGING.121.013894Test
https://hdl.handle.net/1887/3567801Test

المؤلفون: Liu, Y., Li, W., Luehmann, H.P., Zhao, Y., Detering, L., Sultan, D.H., Hsiao, H.-M., Krupnick, A.S., Gelman, A.E., Combadiere, C., Gropler, R.J., Brody, S.L., Kreisel, D.

المساهمون: National Institutes of Health, Veterans Administration Merit Review

المصدر: American Journal of Transplantation ; volume 16, issue 10, page 3016-3023 ; ISSN 1600-6135

مصطلحات موضوعية: Pharmacology (medical), Transplantation, Immunology and Allergy

الإتاحة: https://doi.org/10.1111/ajt.13907Test
https://api.elsevier.com/content/article/PII:S1600613522007353?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1600613522007353?httpAccept=text/plainTest

المؤلفون: Robinson, C.G., Samson, P., Moore, K.M.S., Hugo, G.D., Knutson, N., Mutic, S., Goddu, S.M., Cooper, D.H., Faddis, M., Noheria, A., Smith, T.W., Woodard, P.K., Gropler, R.J., Hallahan, D.E., Rudy, Y., Cuculich, P.

المصدر: International Journal of Radiation Oncology*Biology*Physics ; volume 105, issue 3, page 682 ; ISSN 0360-3016

الإتاحة: https://doi.org/10.1016/j.ijrobp.2019.08.032Test
https://api.elsevier.com/content/article/PII:S0360301619336673?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0360301619336673?httpAccept=text/plainTest

المؤلفون: Vedala, G., Kates, A.M., Herrero, P., Gropler, R.J., Davila-Roman, V.G.

مصطلحات موضوعية: Abstracts

الوصف: The clinical manifestations of LVH worsen with age. Experimental models of aging suggest that this may be mediated, at least in part, by abnormalities in myocardial blood flow (MBF) and intermediary metabolism (i.e. fatty acids). Furthermore, animal models of LVH have shown a reduction in myocardial fatty acid utilization (MFAU). To determine whether abnormalities in MFAU are present in the normal elderly (E) and in patients with hypertension and LVH, measurements of MBF (ml/g/min), myocardial oxygen consumption (MVO2, μmol/g/min), and fasting MFAU (μmol/g/min) were measured at rest using positron emission tomography in 4 patients with hypertension and LVH (age 63 ± 8; 3 male; LV mass index 106 ± 13 g/m2), 6 normal elderly subjects (age 64 ± 4; 4 male), and 3 normal young (Y) subjects (age 24 ± 1; 3 male). All groups had normal exercise stress echocardiograms, fasting lipid and glucose levels, and were nondiabetic and nonsmokers. Levels of MBF, MVO2, and plasma free fatty acids were similar for all groups (p=NS for all). The MFAU (corrected for MVO2) in the normal elderly was lower compared with normal young (3.2 × 10−2 ± 5.3 × 10−3 vs. 4.1 × 10−2 ± 7.1 × 10−3, p=0.03, respectively), and was even lower in the hypertension and LVH patients (2.3 × 10−2 ± 4.2 × 10−3, p=0.04 vs E and p<0.01 vs Y, see figure). These results demonstrate altered metabolic function in normal aging, and these alterations are even more marked in patients of similar age with hypertension and LVH. Thus, the myocardial metabolic response to aging may predispose to the clinical cardiovascular manifestations of LVH.

وصف الملف: text/html

العلاقة: http://ajh.oxfordjournals.org/cgi/content/short/13/S2/3ATest; http://dx.doi.org/10.1016/S0895-7061Test(00)00308-3

الإتاحة: https://doi.org/10.1016/S0895-7061Test(00)00308-3
http://ajh.oxfordjournals.org/cgi/content/short/13/S2/3ATest

المؤلفون: Oellerich, W.F., Li, D., Haacke, E.M., Gropler, R.J.

المصدر: Journal of the American College of Cardiology ; volume 31, page 164-165 ; ISSN 0735-1097

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/s0735-1097Test(98)81360-0
https://api.elsevier.com/content/article/PII:S0735109798813600?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0735109798813600?httpAccept=text/plainTest

المؤلفون: Gropler, R.J., Lee, K.J., Moerlein, S.M., Siegel, B.A., Geltman, E.M.

المصدر: Journal of the American College of Cardiology ; volume 15, issue 2, page A80 ; ISSN 0735-1097

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/0735-1097Test(90)92035-z
https://api.elsevier.com/content/article/PII:073510979092035Z?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:073510979092035Z?httpAccept=text/plainTest

المؤلفون: Lau, Jeffrey M.C., Laforest, R., Sotoudeh, H., Nie, X., Sharma, S., McConathy, J., Novak, E., Priatna, A., Gropler, R.J., Woodard, P.K.

المصدر: Journal of Nuclear Cardiology ; volume 24, issue 3, page 839-846 ; ISSN 1071-3581

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging

الإتاحة: https://doi.org/10.1007/s12350-015-0197-1Test
https://api.elsevier.com/content/article/PII:S1071358123065418?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1071358123065418?httpAccept=text/plainTest

المؤلفون: Gould, K.L., Johnson, N.P., Bateman, T.M., Beanlands, R.S., Bengel, F.M., Bober, R., Camici, P.G., Cerqueira, M.D., Chow, B.J.W., Di Carli, M.F., Dorbala, S., Gewirtz, H., Gropler, R.J., Kaufmann, P.A., Knaapen, P., Knuuti, J., Merhige, M.E., Rentrop, K.P., Ruddy, T.D., Schelbert, H.R., Schindler, T.H., Schwaiger, M., Sdringola, S., Vitarello, J., Williams, K.A., Gordon, D., Dilsizian, V., Narula, J.

المصدر: Gould , K L , Johnson , N P , Bateman , T M , Beanlands , R S , Bengel , F M , Bober , R , Camici , P G , Cerqueira , M D , Chow , B J W , Di Carli , M F , Dorbala , S , Gewirtz , H , Gropler , R J , Kaufmann , P A , Knaapen , P , Knuuti , J , Merhige , M E , Rentrop , K P , Ruddy , T D , Schelbert , H R , Schindler , ....

العلاقة: https://research.vumc.nl/en/publications/dd8bb472-3ea1-4ed1-aabb-49ebea7d00d2Test

الإتاحة: https://doi.org/10.1016/j.jacc.2013.07.076Test
https://research.vumc.nl/en/publications/dd8bb472-3ea1-4ed1-aabb-49ebea7d00d2Test