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1دورية أكاديمية
المؤلفون: Chalandon, Y, Sbianchi, G, Gras, L, Koster, L, Apperley, J, Byrne, J, Salmenniemi, U, Sengeloev, H, Aljurf, M, Helbig, G, Kinsella, F, Choi, G, Remenyi, P, Snowden, JA, Robin, M, Lenhoff, S, Mielke, S, Passweg, J, Broers, AEC, Kroger, N, Yegin, ZA, Tan, S, Hayden, PJ, McLornan, DP, Yakoub-Agha, I
المصدر: American journal of hematology. 98(1):112-121
مصطلحات موضوعية: Medicin och hälsovetenskap
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2دورية أكاديمية
المؤلفون: Garderet, L., Gras, L., Koster, L., De Wreede, L., Montserrat, R., Vincent, L., Fenk, R., Karunanithi, K., Deeren, D., Kaufmann, M., Kuball, J., Ozdogu, H., Cascon, M.J.P., Passweg, J., Rye, A., Salmenniemi, U., Snowden, J., Hansen, C.T., Leleu, X., Gastaud, L., Sokolowska, J.D., Raj, K., Beksac, M., Schönland, S., Hayden, P., McLornan, D.
الوصف: There is little long-term outcome data on the efficacy of autologous hematopoietic stem cell transplantation (ASCT) in light chain deposition disease (LCDD). We identified 51 LCDD patients in the EBMT registry who had undergone upfront ASCT between 1995 and 2021. The median serum creatinine was 280 μmol/L and 45% required renal replacement therapy (RRT) at time of transplant. The melphalan dose was 100mg/m2 in 23%, 140mg/m2 in 55% and 200 mg/m2 in 21%. The rate of very good partial response or better improved from 41% pre-transplant to 66% at Day +100 post-ASCT. In RRT-independent patients, there was a modest improvement in renal function within the first 3 months; the median eGFR increased from 44 to 51 ml/min/1.73 m2. There was no further change between 3 and 12 months post- ASCT. No patient who was RRT-independent at ASCT became RRT dependent by Day + 100 post-ASCT. Median follow-up post-ASCT was 84 months (IQR: 46-122). At 6-years post ASCT, overall survival (OS) was 88% (95% CI: 78-98%) and PFS was 44% (95% CI: 28-60%). The 2-year cumulative incidence of relapse and non-relapse mortality (NRM) was 17% (95% CI: 6-27%) and 2% (95% CI: 0-6%), respectively. The cumulative incidence of renal transplantation at 4 years after ASCT was 27% (95% CI 13-41) with renal transplantation performed between 6.3 and 52.9 months post-ASCT (median 24.7 months). ASCT represents a feasible option for LCDD patients even if RRT dependent at time of transplant. Outcomes are favourable with low NRM and good long-term OS.
وصف الملف: text
العلاقة: https://eprints.whiterose.ac.uk/213171/1/11520-Article%20Text-83998-1-10-20240328.pdfTest; Garderet, L., Gras, L., Koster, L. et al. (23 more authors) (2024) Long-term outcomes and renal responses following autologous hematopoietic stem cell transplantation for light chain deposition disease: a retrospective study on behalf of the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation. Haematologica. ISSN 0390-6078
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3دورية أكاديمية
المؤلفون: Franch-Gras, L., Hahn, C., García Roger, Eduardo M., Carmona Navarro, María José, Serra Galindo, Manuel, Gómez, A.
المصدر: Franch-Gras, L. Hahn, C. García Roger, Eduardo Moises Carmona Navarro, Maria Jose Serra Galindo, Manuel Gómez, A. 2018 Genomic signatures of local adaptation to the degree of environmental predictability in rotifers Scientific Reports 8 1 16051
مصطلحات موضوعية: adaptació (biologia), UNESCO::CIENCIAS DE LA VIDA
الوصف: Environmental fluctuations are ubiquitous and thus essential for the study of adaptation. Despite this, genome evolution in response to environmental fluctuations ¿and more specifically to the degree of environmental predictability- is still unknown. Saline lakes in the Mediterranean region are remarkably diverse in their ecological conditions, which can lead to divergent local adaptation patterns in the inhabiting aquatic organisms. The facultatively sexual rotifer Brachionus plicatilis shows diverging local adaptation in its life-history traits in relation to estimated environmental predictability in its habitats. Here, we used an integrative approach ¿combining environmental, phenotypic and genomic data for the same populations- to understand the genomic basis of this diverging adaptation. Firstly, a novel draft genome for B. plicatilis was assembled. Then, genome-wide polymorphisms were studied using genotyping by sequencing on 270 clones from nine populations in eastern Spain. As a result, 4,543 high-quality SNPs were identified and genotyped. More than 90 SNPs were found to be putatively under selection with signatures of diversifying and balancing selection. Over 140 SNPs were correlated with environmental or phenotypic variables revealing signatures of local adaptation, including environmental predictability. Putative functions were associated to most of these SNPs, since they were located within annotated genes. Our results reveal associations between genomic variation and the degree of environmental predictability, providing genomic evidence of adaptation to local conditions in natural rotifer populations.
وصف الملف: application/pdf
العلاقة: Scientific Reports, 2018, vol. 8, num. 1, p. 16051; Franch-Gras, L., Hahn, C., García-Roger, E. M., Carmona, M. J., Serra, M., & Gómez, A. (2018). Genomic signatures of local adaptation to the degree of environmental predictability in rotifers. En Scientific Reports (Vol. 8, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-018-34188-yTest; https://hdl.handle.net/10550/92710Test; 129368
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4دورية أكاديمية
المؤلفون: Tarazona, E., Hahn, C., Franch-Gras, L., García Roger, Eduardo M., Carmona Navarro, María José, Gómez, A.
المصدر: Tarazona, E. Hahn, C. Franch-Gras, L. García Roger, Eduardo Moises Carmona Navarro, Maria Jose Gómez, A. 2019 Ecological genomics of adaptation to unpredictability in experimental rotifer populations Scientific Reports 9 1 19646
مصطلحات موضوعية: adaptació (biologia), UNESCO::CIENCIAS DE LA VIDA
الوصف: Elucidating the genetic basis of phenotypic variation in response to different environments is key to understanding how populations evolve. Facultatively sexual rotifers can develop adaptive responses to fluctuating environments. In a previous evolution experiment, diapause-related traits changed rapidly in response to two selective regimes (predictable vs unpredictable) in laboratory populations of the rotifer Brachionus plicatilis. Here, we investigate the genomic basis of adaptation to environmental unpredictability in these experimental populations. We identified and genotyped genome-wide polymorphisms in 169 clones from both selective regimes after seven cycles of selection using genotyping by sequencing (GBS). Additionally, we used GBS data from the 270 field clones from which the laboratory populations were established. This GBS dataset was used to identify candidate SNPs under selection. A total of 76 SNPs showed divergent selection, three of which are candidates for being under selection in the particular unpredictable fluctuation pattern studied. Most of the remaining SNPs showed strong signals of adaptation to laboratory conditions. Furthermore, a genotype-phenotype association approach revealed five SNPs associated with two key life-history traits in the adaptation to unpredictability. Our results contribute to elucidating the genomic basis for adaptation to unpredictable environments and lay the groundwork for future evolution studies in rotifers.
وصف الملف: application/pdf
العلاقة: Scientific Reports, 2019, vol. 9, num. 1, p. 19646; Tarazona, E., Hahn, C., Franch-Gras, L., García-Roger, E. M., Carmona, M. J., & Gómez, A. (2019). Ecological genomics of adaptation to unpredictability in experimental rotifer populations. En Scientific Reports (Vol. 9, Issue 1). Springer Science and Business Media LLC. https://doi.org/10.1038/s41598-019-56100-yTest; https://hdl.handle.net/10550/92706Test; 136792
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5دورية أكاديمية
المؤلفون: Franch-Gras, L., García Roger, Eduardo M., Serra Galindo, Manuel, Carmona Navarro, María José
المصدر: Franch-Gras, L. García Roger, Eduardo Moises Serra Galindo, Manuel Carmona Navarro, Maria Jose 2017 Adaptation in response to environmental unpredictability Proceedings of the Royal Society of London Series B-Biological Sciences 284 20170427
مصطلحات موضوعية: adaptació (biologia), UNESCO::CIENCIAS DE LA VIDA
الوصف: Understanding how organisms adaptively respond to environmental fluctuations is a fundamental question in evolutionary biology. The Mediterranean region typically exhibits levels of environmental unpredictability that vary greatly in habitats over small geographical scales. In cyclically parthenogenetic rotifers, clonal proliferation occurs along with occasional bouts of sex. These bouts contribute to the production of diapausing eggs, which allows survival between growing seasons. Here,we studied two diapause-related traits in rotifers using clones from nine Brachionus plicatilis natural populations that vary in the degree of environmental unpredictability.We tested the hypothesis that the level of environmental unpredictability is directly related to the propensity for sex and inversely related to the hatching fraction of diapausing eggs.We found significant levels of genetic variation within populations for both traits. Interestingly, a positive correlation between pond unpredictability¿quantified in a previous study from satellite imagery¿and the propensity for sex was found. This correlation suggests a conservative, bet-hedging strategy that provides protection against unexpectedly short growing seasons. By contrast, the hatching fraction of diapausing eggswas not related to the level of environmental predictability. Our results highlight the ability of rotifer populations to locally adapt to time-varying environments, providing an evolutionarily relevant step forward in relating life-history traits to a quantitative measure of environmental unpredictability.
وصف الملف: application/pdf
العلاقة: Proceedings of the Royal Society of London Series B-Biological Sciences, 2017, vol. 284, p. 20170427; Franch-Gras, L., García-Roger, E. M., Serra, M., & José Carmona, M. (2017). Adaptation in response to environmental unpredictability. En Proceedings of the Royal Society B: Biological Sciences (Vol. 284, Issue 1868, p. 20170427). The Royal Society. https://doi.org/10.1098/rspb.2017.0427Test; https://hdl.handle.net/10550/92693Test; 121160
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6دورية أكاديمية
المؤلفون: Rovó, A, Gras, L, Piepenbroek, B, Kroeger, N, Reinhardt, HC, Radujkovic, A, Blaise, D, Kobbe, G, Niityvuopio, R, Platzbecker, U, Sockel, K, Hunault-Berger, M, Cornelissen, JJ, Forcade, E, Bourhis, JH, Chalandon, Y, Kinsella, F, Nguyen-Quoc, S, Maertens, J, Elmaagacli, A, Mordini, N, Hayden, P, Raj, K, Drozd-Sokolowska, J, de Wreede, LC, Mclornan, DP, Robin, M, Yakoub-Agha, I, Onida, F
المصدر: Rovó , A , Gras , L , Piepenbroek , B , Kroeger , N , Reinhardt , HC , Radujkovic , A , Blaise , D , Kobbe , G , Niityvuopio , R , Platzbecker , U , Sockel , K , Hunault-Berger , M , Cornelissen , JJ , Forcade , E , Bourhis , JH , Chalandon , Y , Kinsella , F , Nguyen-Quoc , S , Maertens , J , Elmaagacli , A , Mordini , N , Hayden , P , Raj , K , Drozd-Sokolowska , J , de Wreede , ....
الوصف: Although CMML since long has been separated from MDS, many studies continue to evaluate the outcomes of both diseases after hematopoietic cell transplantation (allo-HCT) together. Data evaluating outcomes of a large CMML cohort after allo-HCT compared to MDS are limited. We aim to compare outcomes of CMML to MDS patients who underwent allo-HCT between 2010 and 2018. Patients ≥18 years with CMML and MDS undergoing allo-HCT reported to the EBMT registry were analyzed. Progression to AML before allo-HCT was an exclusion criterion. Overall survival (OS), progression/relapse-free survival (PFS), relapse incidence (including progression) (REL), and non-relapse mortality (NRM) were evaluated in univariable and multivariable (MVA) Cox proportional hazard models including interaction terms between disease and confounders. In total, 10832 patients who underwent allo-HCT were included in the study, there were a total of 1466 CMML, and 9366 MDS. The median age at time of allo-HCT in CMML (median 60.5, IQR 54.3–65.2 years) was significantly higher than in the MDS cohort (median 58.8, IQR 50.2–64.5 years; p < .001). A significantly higher percentage of CMML patients were male (69.4%) compared to MDS (61.2%; p < .001). There were no clinically meaningful differences in the distribution of Karnofsky score, Sorror HCT-CI score at allo-HCT, and donor type, between the CMML and MDS patients. RIC platforms were utilized in 63.9% of CMML allo-HCT, and in 61.4% of MDS patients (p = .08). In univariable analyses, we found that OS, PFS, and REL were significantly worse in CMML when compared with MDS (all p < .0001), whereas no significant difference was observed in NRM (p = .77). In multivariable analyses, the HR comparing MDS versus CMML for OS was 0.81 (95% CI, 0.74–0.88, p < .001), PFS 0.76 (95% CI 0.70–0.82, p < .001), relapse 0.66 (95% CI 0.59–0.74, p < .001), and NRM 0.87 (95% CI 0.78–0.98, p = .02), respectively. The association between baseline variables and outcome was found to be similar in MDS and CMML (all ...
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.1002/ajh.27150Test
https://pure.eur.nl/en/publications/28445213-bfbe-4f2b-a19f-8491fdb2556aTest
https://pure.eur.nl/ws/files/122277334/American_J_Hematol_-_2023_-_Rov_-_Outcomes_of_CMML_patients_undergoing_allo_HCT_are_significantly_worse_compared_to_MDS_a.pdfTest
http://www.scopus.com/inward/record.url?scp=85177890776&partnerID=8YFLogxKTest -
7دورية أكاديمية
المؤلفون: Chalandon, Y., Sbianchi, G., Gras, L., Koster, L., Apperley, J., Byrne, J., Salmenniemi, U., Sengeloev, H., Aljurf, M., Helbig, G., Kinsella, F., Choi, G., Reményi, P., Snowden, J. A., Robin, Marie, Lenhoff, S., Mielke, S., Passweg, J., Broers, A. E. C., Kröger, N., Yegin, Z. A., Tan, S. M., Hayden, P. J., Mclornan, D. P., Yakoub-Agha, Ibrahim
المساهمون: Université de Lille, Inserm, CHU Lille, Hopital Saint-Louis AP-HP AP-HP, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
الوصف: Following the introduction of tyrosine kinase inhibitors (TKI), the number of patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) for chronic phase (CP) chronic myeloid leukemia (CML) has dramatically decreased. Imatinib was the first TKI introduced to the clinical arena, predominantly utilized in the first line setting. In cases of insufficient response, resistance, or intolerance, CML patients can subsequently be treated with either a second or third generation TKI. Between 2006 and 2016, we analyzed the impact of the use of 1, 2, or 3 TKI prior to allo-HCT for CP CML in 904 patients. A total of 323-, 371-, and 210 patients had 1, 2, or 3 TKI prior to transplant, respectively; imatinib (n = 778), dasatinib (n = 508), nilotinib (n = 353), bosutinib (n = 12), and ponatinib (n = 44). The majority had imatinib as first TKI (n = 747, 96%). Transplants were performed in CP1, n = 549, CP2, n = 306, and CP3, n = 49. With a median follow-up of 52 months, 5-year OS for the entire population was 64.4% (95% CI 60.9–67.9%), PFS 50% (95% CI 46.3–53.7%), RI 28.7% (95% CI 25.4–32.0%), and NRM 21.3% (95% CI 18.3–24.2%). No difference in OS, PFS, RI, or NRM was evident related to the number of TKI prior to allo-HCT or to the type of TKI (p = ns). Significant factors influencing OS and PFS were > CP1 versus CP1 and Karnofsky performance (KPS) score > 80 versus ≤80, highlighting CP1 patients undergoing allo-HCT have improved survival compared to >CP1 and the importance of careful allo-HCT candidate selection. ; 98
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العلاقة: American Journal of Hematology; Am J Hematol; http://hdl.handle.net/20.500.12210/100712Test
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8دورية أكاديمية
المؤلفون: Drozd-Sokołowska, J., Gras, L., Zinger, N., Snowden, J. A., Arat, M., Basak, G., Pouli, A., Crawley, C., Wilson, K. M. O., Tilly, Hervé, Byrne, J., Bulabois, Claude E., Passweg, J., Ozkurt, Z. N., Schroyens, W., Lioure, Bruno, Colorado Araujo, M., Poiré, X., Van Gorkom, G., Gurman, G., De Wreede, L. C., Hayden, P. J., Beksac, M., Schönland, S. O., Yakoub-Agha, Ibrahim
المساهمون: Université de Lille, Inserm, CHU Lille, Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen CLCC Henri Becquerel, Université Grenoble Alpes UGA, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
الوصف: Autologous hematopoietic cell transplantation (auto-HCT) may be performed in multiple myeloma (MM) patients relapsing after a previous auto-HCT. For those without an adequate dose of stored stem cells, remobilization is necessary. This retrospective study included patients who, following disease relapse after the first auto-HCT(s), underwent stem cell remobilization and auto-HCT performed using these cells. There were 305 patients, 68% male, median age at salvage auto-HCT was 59 years. The median time to relapse after the first-line penultimate auto-HCT(s) was 30.6 months, the median follow-up after salvage auto-HCT 31 months. The 2- and 4-year non-relapse mortality (NRM) after the salvage auto-HCT was 5 and 9%, the relapse incidence 56 and 76%, respectively. Overall survival (OS) after 2 and 4 years was 76 and 52%, progression-free survival (PFS) 39 and 15%. In multivariable analysis an increasing interval between the penultimate auto-HCT and relapse was associated with better OS and PFS, later calendar year of salvage auto-HCT with better OS. In conclusion, salvage auto-HCT performed with cells remobilized after a previous auto-HCT was associated with acceptable NRM. The leading cause of failure was disease progression of MM, which correlated with a shorter interval from the penultimate auto-HCT to the first relapse. ; 57
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العلاقة: Bone Marrow Transplantation; Bone Marrow Transplant; http://hdl.handle.net/20.500.12210/100892Test
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9دورية أكاديمية
المؤلفون: Chihara, D., Gras, L., Zinger, N., Kröger, N., Mayer, J., Passweg, J., De Latour, Régis Peffault, Byrne, J., Krüger, W., Bohn, J. P., Platzbecker, U., Blau, I. W., Bonifazi, F., Helbig, G., Mcdonald, A., Mistrik, M., Mohty, Mohamad, Ram, R., Sanz, J., Llamas, C. V., Kreitman, R. J., Hayden, P. J., Mclornan, D., Tournilhac, Olivier, Van Gelder, M., Yakoub-Agha, Ibrahim
المساهمون: Université de Lille, Inserm, CHU Lille, Hopital Saint-Louis AP-HP AP-HP, Centre de Recherche Saint-Antoine CRSA, CHU Estaing Clermont-Ferrand, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
الوصف: 108;6
وصف الملف: application/octet-stream; application/rdf+xml; charset=utf-8; application/pdf
العلاقة: Haematologica; http://hdl.handle.net/20.500.12210/100672Test
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10دورية أكاديمية
المؤلفون: Hernández-Boluda, J. C., Pereira, A., Kröger, N., Cornelissen, J. J., Finke, J., Beelen, D., De Witte, M., Wilson, K., Platzbecker, U., Sengeloev, H., Blaise, D., Einsele, H., Sockel, K., Krüger, W., Lenhoff, S., Salaroli, A., Martin, H., García-Gutiérrez, V., Pavone, V., Alvarez-Larrán, A., Raya, J. M., Zinger, N., Gras, L., Hayden, P., Czerw, T., Mclornan, D., Yakoub-Agha, Ibrahim
المساهمون: Université de Lille, Inserm, CHU Lille, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
الوصف: Allogeneic hematopoietic cell transplantation (allo-HCT) is increasingly used in older myelofibrosis (MF) patients, but its risk/benefit ratio compared to non-transplant approaches has not been evaluated in this population. We analyzed the outcomes of allo-HCT in 556 MF patients aged ≥65 years from the EBMT registry, and determined the excess mortality over the matched general population of MF patients ≥65 years managed with allo-HCT (n = 556) or conventional drug treatment (n = 176). The non-transplant cohort included patients with intermediate-2 or high risk DIPSS from the Spanish Myelofibrosis Registry. After a median follow-up of 3.4 years, the estimated 5-year survival rate, non-relapse mortality (NRM), and relapse incidence after transplantation was 40%, 37%, and 25%, respectively. Busulfan-based conditioning was associated with decreased mortality (HR: 0.7, 95% CI: 0.5–0.9) whereas the recipient CMV+/donor CMV- combination (HR: 1.7, 95% CI: 1.2–2.4) and the JAK2 mutated genotype (HR: 1.9, 95% CI: 1.1–3.5) predicted higher mortality. Busulfan-based conditioning correlated with improved survival due to less NRM, despite its higher relapse rate when compared with melphalan-based regimens. Excess mortality was higher in transplanted patients than in the non-HCT cohort in the first year of follow-up (ratio: 1.93, 95% CI: 1.13–2.80), whereas the opposite occurred between the fourth and eighth follow-up years (ratio: 0.31, 95% CI: 0.18–0.53). Comparing the excess mortality of the two treatments, male patients seemed to benefit more than females from allo-HCT, mainly due to their worse prognosis with non-transplant approaches. These findings could potentially enhance counseling and treatment decision-making in elderly transplant-eligible MF patients.
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العلاقة: American Journal of Hematology; Am J Hematol; http://hdl.handle.net/20.500.12210/101123Test
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