المؤلفون: Breeze E. Cavell, John Spencer, Brian D. Marsden, Simon J. Coles, Graham J. Tizzard, Graham Packham, Minghua Wang, Sharifah Sakinah Syed Alwi, Peter Coxhead, Ramesh Boddiboyena, Jahangir Amin, James E. Bradner, Ronald M. Paranal, Matthew Guille, Tom D. Heightman

مصطلحات موضوعية: Pharmacology, Cell cycle checkpoint, biology, Chemistry, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, Tubulin, Ferrocene, Acetylation, Drug Discovery, Click chemistry, biology.protein, Molecular Medicine, Moiety, Histone deacetylase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a5fa1c0ed6fc8fffe9abe945e0a09aTest
https://doi.org/10.1039/c1md00203aTest

المؤلفون: Lindsay A. Wilson, L C Chaplin, Emilie Horvilleur, Simon D. Wagner, Graham Packham, Inderjeet Dokal, Thomas Sbarrato, Sandrine Jayne, Tom Vulliamy, Mark Stoneley, Ruth V. Spriggs, Tuija Pöyry, Daniel O. Beck, Martin J. S. Dyer, Alison Yeomans, Martin Bushell, Anne E. Willis, Kirsti Hill

المساهمون: Willis, Anne [0000-0002-1470-8531], Apollo - University of Cambridge Repository

المصدر: Cell Death & Disease

مصطلحات موضوعية: Ribosomal Proteins, 0301 basic medicine, Cancer Research, Immunoblotting, Immunology, Down-Regulation, Cell Cycle Proteins, Biology, Ribosome, Dyskerin, 03 medical and health sciences, Cellular and Molecular Neuroscience, Ribosomal protein, Eukaryotic initiation factor, hemic and lymphatic diseases, medicine, Humans, Eukaryotic Initiation Factors, Gene Expression Regulation, Leukemic, Microarray analysis techniques, Gene Expression Profiling, Nuclear Proteins, RNA, Cell Biology, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Survival Analysis, Gene expression profiling, Leukemia, Treatment Outcome, 030104 developmental biology, RNA, Ribosomal, Polyribosomes, Protein Biosynthesis, Cancer research, Original Article, Ribosomes, Cell Nucleolus

وصف الملف: text; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2dff346550208d1eb02e236e2ab1eb0Test
https://eprints.soton.ac.uk/404867Test/

المؤلفون: Sergey Krysov, Freda K. Stevenson, Stephen M. Thirdborough, Adam Linley, Andrew J. Steele, Beatriz Valle-Argos, Graham Packham, Elodie Leonard, Mark J. Coldwell, Marina Sánchez Hidalgo, Simon D. Wagner, Alison Yeomans, Anne E. Willis, Francesco Forconi, Muhammad Ishfaq

مصطلحات موضوعية: 0301 basic medicine, Chronic lymphocytic leukemia, Immunology, B-cell receptor, Syk, Receptors, Antigen, B-Cell, Biochemistry, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Piperidines, hemic and lymphatic diseases, Cell Line, Tumor, Translational regulation, Protein biosynthesis, Agammaglobulinaemia Tyrosine Kinase, Tumor Cells, Cultured, Medicine, Humans, Syk Kinase, RNA, Messenger, Protein Kinase Inhibitors, B-Lymphocytes, business.industry, Gene Expression Regulation, Leukemic, Adenine, breakpoint cluster region, Intracellular Signaling Peptides and Proteins, Translation (biology), Cell Biology, Hematology, Protein-Tyrosine Kinases, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Antibodies, Anti-Idiotypic, 030104 developmental biology, Pyrimidines, eIF4A, Protein Biosynthesis, Cancer research, Pyrazoles, business

وصف الملف: text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deffc4746e3cbcd7cef5320e8b1dc44eTest
http://hdl.handle.net/11365/1005509Test

المؤلفون: Beatriz Valle-Argos, Breeze E. Cavell, Graham Packham, Elodie Leonard, Mark J. Coldwell, Freda K. Stevenson, Francesco Forconi, Sergey Krysov, Anne E. Willis, Alison Yeomans, Marina Sánchez Hidalgo, Sarah Wilmore, Andrew J. Steele, Elizabeth Lemm

المساهمون: Universidad de Sevilla. Departamento de Farmacología, Willis, Anne [0000-0002-1470-8531], Apollo - University of Cambridge Repository

المصدر: idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Oncotarget

مصطلحات موضوعية: 0301 basic medicine, mRNA translation, Transcription, Genetic, Cell Survival, Eukaryotic Initiation Factor-2, Genes, myc, eIF2α, Receptors, Antigen, B-Cell, MYC, mTORC1, phenethylisothiocyanate, Mechanistic Target of Rapamycin Complex 1, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Stress granule, Isothiocyanates, Stress, Physiological, Cell Line, Tumor, Protein biosynthesis, Humans, Medicine, RNA, Messenger, Phosphorylation, Genetics, Leukemia, Dose-Response Relationship, Drug, Gene Expression Regulation, Leukemic, business.industry, Kinase, Translation (biology), medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Antibodies, Anti-Idiotypic, 030104 developmental biology, Oncology, Cell culture, Protein Biosynthesis, 030220 oncology & carcinogenesis, MCF-7 Cells, Cancer research, business, Carcinogenesis, Research Paper

وصف الملف: application/pdf; text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce63a65bdd238d904beeb88e4e1729aTest
http://hdl.handle.net/11365/1005501Test

المؤلفون: Christoph Plass, Annalisa D'Avola, Andrew J. Steele, Samantha Drennan, Graham Packham, Marta Larrayoz, Freda K. Stevenson, Isla Henderson, Laura Chiecchio, Matthew J. J. Rose-Zerilli, Peter M. W. Johnson, Ian Tracy, Christopher C. Oakes, Jonathan C. Strefford, Francesco Forconi

مصطلحات موضوعية: 0301 basic medicine, Immunoglobulin gene, Chronic lymphocytic leukemia, Immunology, Immunoglobulin Variable Region, Biology, medicine.disease_cause, Biochemistry, 03 medical and health sciences, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Receptor, Notch1, neoplasms, Regulation of gene expression, Mutation, Gene Expression Regulation, Leukemic, Cell Biology, Hematology, Methylation, DNA Methylation, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Phenotype, 030104 developmental biology, Immunoglobulin M, DNA methylation, Disease Progression, Calcium, Immunoglobulin Heavy Chains, IGHV@

وصف الملف: text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425c4d1418c028068aeb1502958ce5e5Test
http://hdl.handle.net/11365/1005504Test

المؤلفون: Richard Mitter, Mariko Ikuo, Simona Rossi, Muller Fabbri, Ivan Vannini, Kimberly Vincent, Cornelia Braicu, Hui Ling, Krishna Bojja, Stanley R. Hamilton, Alex H. Mirnezami, Alexandru Irimie, Claudio Isella, Lianchun Xiao, Milena S. Nicoloso, Jian H. Song, Scott Kopetz, Cristina Ivan, Calin Ionescu, Xuemei Wang, Xinna Zhang, Marc D. Bullock, Martin Pichler, George A. Calin, Riccardo Spizzo, Valentina Pileczki, Kevin Liu, Verena Stiegelbauer, Enzo Medico, John N. Primrose, Roberta Gafà, Gerald Hoefler, Patrick A. Zweidler-McKay, Graham Packham, Karen Pickard, Francesca Fanini, Annie Hsiao, Ioana Berindan-Neagoe, Giovanni Lanza, Maria Inês Almeida

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Colorectal cancer, MICROSATELLITE INSTABILITY, Kaplan-Meier Estimate, SMAD4, Metastasis, Mice, 0302 clinical medicine, Aged, 80 and over, COLORECTAL CANCER, medicine.diagnostic_test, Gastroenterology, Middle Aged, Gene Expression Regulation, Neoplastic, Prediction algorithms, Italy, Austria, 030220 oncology & carcinogenesis, Female, DNA microarray, Colorectal Neoplasms, Adult, medicine.medical_specialty, RNA EXPRESSION, Adenocarcinoma, In Vitro Techniques, Biology, Sensitivity and Specificity, survival, Article, NO, LIVER METASTASES, 03 medical and health sciences, microsatellite stability, Western blot, MOLECULAR GENETICS, Predictive Value of Tests, In vivo, Internal medicine, microRNA, Biomarkers, Tumor, medicine, Animals, Humans, Neoplasm Invasiveness, Aged, Romania, miR-224, SMAD4, microsatellite stability, colorectal cancer, survival, miR-224, medicine.disease, United Kingdom, digestive system diseases, MicroRNAs, 030104 developmental biology, Biological significance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbe922453efbd299deb3728cce903d1Test
http://hdl.handle.net/2318/1615636Test

المؤلفون: Inês Graça, Simon J. Crabb, Carmen Jerónimo, Rui Henrique, Eva Pereira-Silva, Graham Packham

المساهمون: Repositório Científico do Instituto Politécnico do Porto

المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Clinical Epigenetics

مصطلحات موضوعية: 0301 basic medicine, Male, Antineoplastic Agents, Review, Epigenesis, Genetic, Histones, 03 medical and health sciences, Prostate cancer, Mice, 0302 clinical medicine, Histone modulators, Genetics, medicine, Animals, Humans, Epigenetics, DNA (Cytosine-5-)-Methyltransferases, Enzyme Inhibitors, Molecular Biology, Gene, Genetics (clinical), Clinical Trials as Topic, biology, Cancer, Prostatic Neoplasms, DNA Methylation, medicine.disease, Survival Analysis, Human genetics, Clinical trial, Gene Expression Regulation, Neoplastic, Histone Deacetylase Inhibitors, 030104 developmental biology, Histone, Treatment Outcome, 030220 oncology & carcinogenesis, DNA methylation, Cancer research, biology.protein, DNMTi, Developmental Biology

وصف الملف: application/pdf; text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b323e3cab43a51996e36901dbb8740efTest
https://hdl.handle.net/10400.22/9336Test

المؤلفون: Alison Donlevy, Graham Packham, Sharifah Sakinah Syed Alwi, Breeze E. Cavell, Christopher G. Proud

المصدر: Journal of Natural Products. 75:1051-1057

مصطلحات موضوعية: Phenethyl isothiocyanate, Immunoblotting, Pharmaceutical Science, Antineoplastic Agents, P70-S6 Kinase 1, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biology, Analytical Chemistry, Mice, chemistry.chemical_compound, Isothiocyanates, Tuberous Sclerosis Complex 2 Protein, Drug Discovery, Animals, Humans, Protein kinase B, PI3K/AKT/mTOR pathway, Pharmacology, Molecular Structure, TOR Serine-Threonine Kinases, Tumor Suppressor Proteins, Organic Chemistry, Proteins, AMPK, Fibroblasts, Hypoxia-Inducible Factor 1, alpha Subunit, Complementary and alternative medicine, chemistry, Biochemistry, Multiprotein Complexes, Molecular Medicine, Phosphorylation, Female, biological phenomena, cell phenomena, and immunity, Growth inhibition

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be531f3ecb8147ac0cd3c88e3d36dbadTest
https://doi.org/10.1021/np300049bTest

المؤلفون: Graham Packham, Melanie Lee, Catalina Alarcón de la Lastra, Marina Sánchez-Hidalgo, Juan M. Guerrero

المصدر: Journal of Pineal Research. 53:366-373

مصطلحات موضوعية: Caspase-9, biology, Cell growth, Caspase 3, medicine.disease, Jurkat cells, Cell biology, Lymphoma, Melatonin, Endocrinology, Apoptosis, biology.protein, Cancer research, medicine, Receptor, hormones, hormone substitutes, and hormone antagonists, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::45e22e52692eca97bcf260b689943d32Test
https://doi.org/10.1111/j.1600-079x.2012.01006.xTest

المؤلفون: Gianluca Gaidano, Emanuele Cencini, Kathleen N. Potter, Isla Henderson, Graham Packham, Freda K. Stevenson, Riccardo Bomben, Davide Rossi, Valter Gattei, Elisa Sozzi, Francesco Forconi

المصدر: Blood. 119:2106-2109

مصطلحات موضوعية: Chronic lymphocytic leukemia, Immunology, Naive B cell, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Immunoglobulin Variable Region, Biology, Biochemistry, Pathogenesis, Antigen, hemic and lymphatic diseases, medicine, Humans, genetics, Amino Acid Sequence, Chronic, Gene, B cell, Gene Rearrangement, B-Lymphocytes, Leukemia, Repertoire, B-Lymphocyte, B-Cell, Cell Biology, Hematology, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Molecular biology, Lymphocytic, V(D)J Recombination, Amino Acid Sequence, B-Lymphocytes, metabolism, Gene Rearrangement, Heavy Chain, genetics, Humans, Immunoglobulin Heavy Chains, genetics, Immunoglobulin Variable Region, genetics, Leukemia, genetics, Sequence Alignment, V(D)J Recombination, medicine.anatomical_structure, IGHD, Immunoglobulin Heavy Chains, metabolism, Sequence Alignment

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2b67c5fb2c57f5a89dccdafd762ee0Test
https://doi.org/10.1182/blood-2011-08-375501Test