المؤلفون: Perfezou, Pascale, Hall, Nolwenn, Duthe, Jean-Charles, Abdi, Basma, Seang, Sophie, Arvieux, Cédric, Lamaury, Isabelle, Menard, Amélie, Marcelin, Anne-Geneviève, Katlama, Christine, Palich, Romain, Chirouze, C, Bouiller, K, Bozon, F, Brunel, A, Hustache-Mathieu, L, Lagoutte, J, Lepiller, Q, Marty-Quinternet, S, Pépin-Puget, L, Rosolen, B, Tissot, N, Jaffuel, S, Ansart, S, Quintric, Y, Rezig, S, Quaesaet, L, Gazeau, P, Jacomet, C, Mrozek, N, Theis, C, Vidal, M, Richaud, C, Anglade, F, Sauvat, L, Corbin, V, Aumeran, C, Baud, O, Goncalvez, E, Mazzocolin, D, Mirand, A, Brebion, A, Henquell, C, Lamaury, I, Breugnon, E, Chéret, A, Curlier, E, Duvallon, E, Fabre, I, Herrmann-Storck, C, Markowicz, S, Marquet, M, Ouissa, R, Pradat-Paz, L, Samar, K, Tressieres, B, Merrien, D, Bollangier, O, Boucher, D, Guimard, T, Laine, L, Leautez, S, Morrier, M, Perré, P, Point, P, Roncato-Saberan, M, Pouget-Abadie, X, Chapuzet, C, Faba, L, Faucher, J, Cypierre, A, Ducroix-Roubertou, S, Durox, H, Genet-Villeger, C, Pascual, J, Pinet, P, Codde, C, Rogez, S, Woillard, J, Benoist, C, Alfaiate, D, Becker, A, Cotte, L, Ader, F, Brochier, C, Brunel-Dalmas, F, Cannesson, O, Conrad, A, Degroodt, S, Ferry, T, Godinot, M, Icard, V, Livrozet, J, Makhloufi, D, Perpoint, T, Roux, S, Trabaud, M, Triffault-Fillit, C, Valour, F, Batalla, A, Lardot, H, Simon, M, Javaux, C, Ravaux, I, Ménard, A, Belkhir, Y, Colson, P, Dhiver, C, Martin-Degioanni, M, Meddeb, L, Mokhtari, M, Motte, A, Tissot-Dupont, H, Toméi, C, Brégigeon, S, Zaegel-Faucher, O, Laroche, H, Dos Santos, M, Ducassou, M, Galie, S, Ivanova, A, Jaquet, I, Obry-Roguet, V, Orticoni, M, Ressiot, E, Ritleng, A, Benkouiten, S, Cabié, A, Abel, S, Bigeard, B, Bidelogne, C, Cabras, O, Carnino, L, Cuzin, L, Fagour, L, Gros-Dubois, A, Guitteaud, K, Lahuna, C, Louis-Michel, E, Métais, A, Quenard, F, Pierre-François, S, Robert, C, Cavalli, Z, Bucy, L, Genet, R, Schneifer, C, Perez, P, Reynes, J, Bistoquet, M, Delaporte, E, Le Moing, V, Lejeune, J, Meftah, N, Merle de Boever, C, Montes, B, Montoya Ferrer, A, Pansu, N, Tuaillon, E, Lefèvre, B, André, M, Baronnet, G, Bevilacqua, S, Boyer, L, Bouillon, M, Charmillon, A, Delestan, M, Emilie, C, Frentiu, E, Goehringer, F, Hénard, S, Jeanmaire, E, Rabaud, C, Radjabaly-Mandjee, A, Raffi, F, Allavena, C, André-Garnier, E, Asquier-Khati, A, Billaud, E, Biron, C, Bonnet, B, Bouchez, S, Boutoille, D, Brunet-Cartier, C, Cavellec, M, Deschanvres, C, Drumel, T, Gaborit, B, Grégoire, M, Jovelin, T, Lefebvre, M, Lecomte, R, Mahot, R, Morineau, P, Paredes, E, Reliquet, V, Soria, A, Pugliese, P, Bréaud, S, Buscot, M, Carles, M, Chirio, D, Cua, E, Dellamonica, P, Demonchy, E, de Monte, A, Durant, J, Ferrando, S, Naqvi, A, Perbost, I, Pradier, C, Prouvost-Keller, B, Risso, K, Touitou, I, Viot, A, Wehrlen-Pugliese, S, Sunder, S, Schepers, K, Goudet, V, dos Santos, A, Rzepecki, V, Hocqueloux, L, Béraud, G, Gubavu, C, Legros, V, Mille, C, Peira, F, Prazuck, T, Sève, A, Goujard, C, Castro-Gordon, A, David-Chevallier, P, Godard, V, Quertainmont, Y, Teicher, E, Jaureguiberry, S, Joly, V, Charpentier, C, Descamps, D, Digumber, M, Gervais, A, Ghosn, J, Julia, Z, Landman, R, Lariven, S, Le Gac, S, Louni, F, Peiffer-Smadja, N, Peytavin, G, Rioux, C, Yazdanpanah, Y, Duvivier, C, Amazzough, K, Benabdelmoumen, G, Bossi, P, Cessot, G, Charlier, C, Consigny, P, de la Porte Des Vaux, C, Garzaro, M, Gomes-Pires, E, Hochedez, P, Jidar, K, Lafont, E, Lanternier, F, Lortholary, O, Louisin, C, Lourenco, J, Melenotte, C, Pacoud, O, Parize, P, Ruyno, F, Rouzaud, C, Taieb, F, Palich, R, Valantin, M, Katlama, C, Faycal, A, Agher, R, Dudoit, Y, Hamani, N, Qatib, N, Qzaibri, I, Lenclume, L, Schneider, L, Seang, S, Tubiana, R, Hall, N, Perfezou, P, Duthe, J, Drevillon, F, Talarmin, J, Khatchatourian, L, Bani-Sadr, F, Berger, J, Brodard, V, Hentzien, M, Kmiec, I, Lambert, D, Marty, H, N’guyen, Y, Arvieux, C, Baldeyrou, M, Benezit, F, Chapplain, J, Dupont, M, Duthé, J, Ismaël, S, Lebot, A, Lemaitre, F, Luque-Paz, D, Maillard, A, Morlat, C, Patrat-Delon, S, Picard, L, Poisson-Vannier, M, Pronier, C, Revest, M, Tattevin, P, Vivent, J, Gagneux-Brunon, A, Botelho-Nevers, E, Frésard, A, Pouvaret, A, Ronat, V, Rey, D, Cheneau, C, Bernard-Henry, C, de Mautort, E, Fafi-Kremer, S, Fischer, P, Gantner, P, Mélounou, C, Ursenbach, A, Klee, P, Hansmann, Y, Lefebvre, N, Ruch, Y, Danion, F, Hoellinger, B, Lemmet, T, Gerber, V, Bourne-Watrin, M, Delobel, P, Alvarez, M, Biezunski, N, Boumaza, X, Debard, A, Delpierre, C, Garnier, C, Lelièvre, L, Martin-Blondel, G, Piffaut, M, Rastoll, C, Saune, K, Robineau, O, Aïssi, E, Alcaraz, I, Alidjinou, E, Baclet, V, Bocket, L, Boucher, A, Derdour, V, Lafon-Desmurs, B, Meybeck, A, Pradier, M, Tetart, M, Valette, M, Viget, N, Diarra, A, Corvaisier, G, Brière, M, de la Chapelle, M, Gousseff, M, Le Goff, M, Thierry, M

المساهمون: CH de Quimper, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, CHU Pointe-à-Pitre/Abymes Guadeloupe, Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

المصدر: ISSN: 0305-7453.

مصطلحات موضوعية: [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology

الوصف: International audience ; Background: Two-drug regimens based on integrase strand transfer inhibitors (INSTIs) and boosted PIs have entered recommended ART. However, INSTIs and boosted PIs may not be suitable for all patients. We aimed to report our experience with doravirine/lamivudine as maintenance therapy in people living with HIV (PLWH) followed in French HIV settings.Methods: This observational study enrolled all adults who initiated doravirine/lamivudine between 1 September 2019 and 31 October 2021, in French HIV centres participating in the Dat'AIDS cohort. The primary outcome was the rate of virological success (plasma HIV-RNA < 50 copies/mL) at Week (W)48. Secondary outcomes included: rate of treatment discontinuation for non-virological reasons, evolution of CD4 count and CD4/CD8 ratio over follow-up.Results: Fifty patients were included, with 34 (68%) men; median age: 58 years (IQR 51-62), ART duration: 20 years (13-23), duration of virological suppression: 14 years (8-19), CD4 count: 784 cells/mm3 (636-889). Prior to switching, all had plasma HIV-RNA < 50 copies/mL. All but three were naive to doravirine, and 36 (72%) came from a three-drug regimen. Median follow-up was 79 weeks (IQR 60-96). Virological success rate at W48 was 98.0% (95% CI 89.4-99.9). One virological failure occurred at W18 (HIV-RNA = 101 copies/mL) in a patient who briefly discontinued doravirine/lamivudine due to intense nightmares; there was no resistance at baseline and no resistance emergence. There were three strategy discontinuations for adverse events (digestive disorders: n = 2; insomnia: n = 1). There was no significant change in CD4/CD8 ratio, while CD4 T cell count significantly increased.Conclusions: These preliminary findings suggest that doravirine/lamivudine regimens can maintain high levels of viral suppression in highly ART-experienced PLWH with long-term viral suppression, and good CD4+ T cell count.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37303236; hal-04341611; https://univ-rennes.hal.science/hal-04341611Test; https://univ-rennes.hal.science/hal-04341611/documentTest; https://univ-rennes.hal.science/hal-04341611/file/PERFEZOU%20et%20al-2023-Doravirine%20plus%20lamivudine%20%28DOR%2B3TC%29%20two-drug%20regimen%20as%20a%20maintenance%20antiretroviral.pdfTest; PUBMED: 37303236

الإتاحة: https://doi.org/10.1093/jac/dkad185Test
https://univ-rennes.hal.science/hal-04341611Test
https://univ-rennes.hal.science/hal-04341611/documentTest
https://univ-rennes.hal.science/hal-04341611/file/PERFEZOU%20et%20al-2023-Doravirine%20plus%20lamivudine%20%28DOR%2B3TC%29%20two-drug%20regimen%20as%20a%20maintenance%20antiretroviral.pdfTest

المؤلفون: Moraly, J., Rossignol, J., Rouzaud, C., Gabas, T., Bouktit, H., Lhermitte, L., Canioni, D., Fraitag, S., Bruneau, J., Barete, S., Suarez, F., Ballul, T., Meni, C., Polivka, L., Terriou, Louis, Launay, David, Bouillet, L., Gaudy-Marqueste, C., Gousseff, M., Le Mouel, E., Neel, A., Ranta, D., Jaussaud, R., Guilpain, P., Frenzel, L., Agopian, J., Dubreuil, P., Greco, C., Dimicoli-Salazar, S., Heiblig, M., Gourguechon, C., Tournilhac, O., Javier, R. M., Castelain, F., Cabrera, Q., Gourin, M. P., Wierzbicka-Hainaut, E., Torregrosa-Diaz, J. M., Bulai, C., Lavigne, C., Hoarau, C., Arock, M., Damaj, G., Lortholary, O., Hermine, O.

المساهمون: Université de Lille, Inserm, CHU Lille, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

العلاقة: Am J Hematol; http://hdl.handle.net/20.500.12210/114089Test

الإتاحة: https://doi.org/20.500.12210/114089Test
https://hdl.handle.net/20.500.12210/114089Test

المؤلفون: Rossignol, J., Canioni, D., Aouba, A., Bulai-Livideanu, C., Barete, S., Lancesseur, C., Polivka, L., Madrange, M., Ballul, T., Neuraz, A., Greco, C., Agopian, J., Brenet, F., Dubreuil, P., Lemal, R., Tournilhac, O., Terriou, Louis, Launay, David, Bouillet, L., Gourguechon, C., Frenzel, L., Meni, C., Gaudy-Marqueste, C., Gousseff, M., Le Mouel, E., Hamidou, M., Neel, A., Ranta, D., Jaussaud, R., Guilpain, P., Molina, T. J., Bruneau, J., Lhermitte, L., Garcelon, N., Javier, R. M., Pelletier, F., Castelain, F., Retornaz, F., Cabrera, Q., Zunic, P., Gourin, M. P., Wierzbicka-Hainaut, E., Viallard, J. F., Lavigne, C., Hoarau, C., Durieu, I., Heiblig, M., Dimicoli-Salazar, S., Torregrosa-Diaz, J. M., Soria, A., Arock, M., Lortholary, O., Bodemer, C., Pol, S., Mallet, V., Hermine, O., Damaj, G.

المساهمون: Université de Lille, Inserm, CHU Lille, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

مصطلحات موضوعية: advanced systemic mastocytosis, fibrosis, liver, mast cells, nodular regenerative hyperplasia, portal hypertension

العلاقة: Liver Int; http://hdl.handle.net/20.500.12210/114096Test

الإتاحة: https://doi.org/20.500.12210/114096Test
https://hdl.handle.net/20.500.12210/114096Test

المؤلفون: Hites, M, Lapique, EL, Massonnaud, CR, Belhadi, D, Jamard, S, Goehringer, F, Danion, F, Reignier, J, de Castro, N, Garot, D, Lacombe, K, Tolsma, V, Faure, E, Malvy, D, Staub, T, Courjon, J, Cazenave-Roblot, F, Dyrhol Riise, AM, Leturnier, P, Martin-Blondel, G, Roger, C, Akinosoglou, K, Moing, VL, Piroth, L, Sellier, P, Lescure, X, Trøseid, M, Clevenbergh, P, Dalgard, O, Gallien, S, Gousseff, M, Loubet, P, Vardon-Bounes, F, Visée, C, Belkhir, L, Botelho-Nevers, É, Cabié, A, Kotanidou, A, Lanternier, F, Rouveix-Nordon, E, Silva, S, Thiery, G, Poignard, P, Carcelain, G, Diallo, A, Mercier, N, Terzic, V, Bouscambert-Duchamp, M, Gaymard, A, Trabaud, MA, Destras, G, Josset, L, Billard, N, Han, TH, Guedj, J, Couffin-Cadiergues, S, Dechanet, A, Delmas, C, Esperou, H, Fougerou-Leurent, C, Mestre, SL, Métois, A, Noret, M, Bally, I, Dergan-Dylon, S, Tubiana, S, Kalif, O, Bergaud, N, Leveau, B, Eustace, J, Greil, R, Hajdu, E, Halanova, M, Paiva, JA, Piekarska, A, Rodriguez Baño, J, Tonby, K, Trojánek, M, Tsiodras, S, Unal, S, Burdet, C, Costagliola, D, Yazdanpanah, Y, Peiffer-Smadja, N, Mentré, F, Ader, F, DisCoVeRy study group

المساهمون: Instituto de Saúde Pública

الوصف: This work received funding from several sources: the European Commission (EU-Response, Grant 101015736), the DIM One Health Île-de-France (R20117HD) and Astra-Zeneca. We thank all participants who consented to enroll in the trial, as well as all study and site staff whose indispensable assistance made the conduct of the DisCoVeRy trial possible (all listed in the appendix, pp 27-36)

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/EC/H2020/101015736/EU; J Infect. 2024 Feb 16;88(3):106120. doi:10.1016/j.jinf.2024.106120. Online ahead of print.; https://www.journalofinfection.com/article/S0163-4453Test(24)00054-9/fulltext; https://hdl.handle.net/10216/157559Test

الإتاحة: https://doi.org/10.1016/j.jinf.2024.106120Test
https://hdl.handle.net/10216/157559Test

المؤلفون: Loncle, A., Piau, C., Ndeikoundam Ngangro, N., Gousseff, M., Cattoir, V., Allory, E., Lorléac, A., Dupont, M., Goubard, A., Tattevin, P.

المساهمون: CHP Saint Grégoire, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Santé publique France - French National Public Health Agency Saint-Maurice, France, Centre hospitalier Bretagne Atlantique (Morbihan) (CHBA), Département de Médecine Générale Rouen (DMG), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Université de Rennes (UR), Département de médecine générale Université de Rennes (DMG Rennes), Institut Alfred Fournier, Hôpital Broussais, None

المصدر: ISSN: 2666-9919 ; Infectious Diseases Now ; https://hal.science/hal-03285409Test ; Infectious Diseases Now, 2021, 51 (2), pp.201-204. ⟨10.1016/j.idnow.2020.11.010⟩.

مصطلحات موضوعية: General practitioner, Neisseria gonorrhea, Population-based study, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Objective: To characterize the current profile of gonococcal infections in France, and to describe their management. Patients and method: A population-based retrospective study of all gonococcal infections documented by PCR in two French departments (Île-et-Vilaine, Morbihan), in 2014–2016. Cases were identified through hospital databases and the Rénago sentinel network. Results: We enrolled 245 patients (96 females, 149 males), with a median age of 25 years [interquartile range, 21–33]. The incidence rate was estimated at 4.54 per 100,000 inhabitants-year. Cases were diagnosed mostly by a general practitioner (n = 122, 49.8%) or a gynecologist (n = 45, 18.4%). The main clinical presentations included urethritis (n = 59), pelvic inflammatory disease (n = 40), cervicitis (n = 12), and anorectitis (n = 11). The main coinfections were Chlamydia trachomatis (n = 40) and HIV (n = 8). Ceftriaxone MIC was ≤ 0.12 mg/L in 146/147 patients with positive culture. Treatment was appropriate in 52/74 (70.2%) patients with available data. Conclusions: In France, general practitioners are at the front line in management of gonococcal infections. © 2020 Elsevier Masson SAS

العلاقة: hal-03285409; https://hal.science/hal-03285409Test; https://hal.science/hal-03285409/documentTest; https://hal.science/hal-03285409/file/S2666991920000202.pdfTest; PII: S2666-9919(20)00020-2

الإتاحة: https://doi.org/10.1016/j.idnow.2020.11.010Test
https://hal.science/hal-03285409Test
https://hal.science/hal-03285409/documentTest
https://hal.science/hal-03285409/file/S2666991920000202.pdfTest

المؤلفون: Sebillotte, M., Boutoille, D., Declerck, C., Talarmin, J.P., Lemaignen, A., Piau, C., Tattevin, P., Gousseff, M.

المصدر: Infectious Diseases Now ; volume 51, issue 5, page S1 ; ISSN 2666-9919

مصطلحات موضوعية: Infectious Diseases

الإتاحة: https://doi.org/10.1016/j.idnow.2021.06.015Test
https://api.elsevier.com/content/article/PII:S2666991921001317?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666991921001317?httpAccept=text/plainTest

المؤلفون: Gousseff, M., Botelho-Nevers, E., Conrad, A., Gallay, L., Goehringer, F., Lemaignen, A., Lescure, F., Penot, P., Salmon, D., Pozzetto, B.

المصدر: Médecine et Maladies Infectieuses ; volume 50, issue 6, page S96 ; ISSN 0399-077X

مصطلحات موضوعية: Infectious Diseases

الإتاحة: https://doi.org/10.1016/j.medmal.2020.06.195Test
https://api.elsevier.com/content/article/PII:S0399077X20303590?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0399077X20303590?httpAccept=text/plainTest

المؤلفون: Mamou, Z., Pronier, C., Lemaitre, F., Gousseff, M., Lorleac’h, A., Perfezou, P., Valence, M., Thibault, V., Arvieux, C., Maillard, A.

المصدر: Médecine et Maladies Infectieuses ; volume 50, issue 6, page S193 ; ISSN 0399-077X

مصطلحات موضوعية: Infectious Diseases

الإتاحة: https://doi.org/10.1016/j.medmal.2020.06.414Test
https://api.elsevier.com/content/article/PII:S0399077X20305783?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0399077X20305783?httpAccept=text/plainTest

المؤلفون: Vignier, N., Tetart, M., Lesourd, A., Macaux, L., Alloui, C., Leroy, P., Risso, K., Hitoto, H., Mosnier, E., Gousseff, M.

المصدر: Médecine et Maladies Infectieuses Formation ; volume 2, issue 2, page S117-S118 ; ISSN 2772-7432

الإتاحة: https://doi.org/10.1016/j.mmifmc.2023.03.276Test
https://api.elsevier.com/content/article/PII:S2772743223003033?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2772743223003033?httpAccept=text/plainTest

المؤلفون: Ghosn, J., Bachelet, D., Livrozet, M., Cervantes-Gonzalez, M., Poissy, Julien, Goehringer, F., Gandonniere, C. S., Maillet, M., Bani-Sadr, F., Martin-Blondel, G., Tattevin, P., Launay, O., Surgers, L., Dudoignon, E., Liegeon, G., Zucman, D., Joseph, C., Senneville, Eric, Yelnik, C., Roger, P. M., Faure, Karine, Gousseff, M., Cabie, A., Duval, X., Chirouze, C., Laouenan, C.

المساهمون: Université de Lille, CHU Lille, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

مصطلحات موضوعية: Cohort, Emerging infectious diseases, Moderate to severe COVID-19, Post-acute COVID-19 symptoms, SARS-CoV-2

العلاقة: Clin Microbiol Infect; http://hdl.handle.net/20.500.12210/89976Test

الإتاحة: https://doi.org/20.500.12210/89976Test
https://hdl.handle.net/20.500.12210/89976Test